The invention belongs to the technical field of biomedical materials, and provides a spraying type anti-adhesion Janus heterogeneous
hydrogel film used after cholecystectomy and a preparation method of the spraying type anti-adhesion Janus heterogeneous
hydrogel film. The
system is prepared from a tube A cationic sulfobetaine-
quaternized chitosan (QCS-SB) solution and a tube B cationic sulfobetaine-
quaternized chitosan (QCS-SB) solution, wherein the QCS-SB solution contains temperature-sensitive lipidosome for packaging
diphenhydramine and blood coagulation
peptide; and a
cartridge B anionic polycarboxy
betaine (PCB-AA) solution, wherein the
cartridge B anionic polycarboxy
betaine (PCB-AA) solution contains
calcium alginate microspheres loaded with a
cholic acid adsorbent. In the operation, after the gel is synchronously sprayed to an irregular
wound surface through a double-
barrel spray gun, a double-layer
hydrogel film is rapidly formed through electrostatic self-
assembly, wet-state strong adhesion and body temperature triggered
drug release are achieved on the cation function side, and a super-lubricating surface is constructed on the anion function side and actively captures
bile acid. The material has the functions of
physical barrier,
chemical adsorption and pharmacological intervention, the
postoperative adhesion rate and the
allergy occurrence rate can be remarkably reduced, and an intelligent, accurate and degradable barrier solution is provided for
general surgery operations.