9 results about "Anticholinergic agents" patented technology

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

Compounds shown in Formula (I), pharmaceutical compositions, and methods of using related to muscarinic acetylcholine receptors. The compounds herein are typically muscarinic acetylcholine receptor antagonists, such as M3 antagonists, which can be used for treating a variety of disorders, conditions or diseases such as hyperhidrosis.

The present invention relates to a process for preparing a powder formulation for inhalation for use in a dry powder inhaler, the powder formulation comprising: (A) a carrier comprising: (a) a physiologically acceptable coarse particle fraction of the carrier having a particle size of at least 60 microns; and optionally (b) a fine particle fraction comprising a physiologically acceptable excipient wherein at least 90% of all of the fine particles have a volume diameter of less than 15 microns, (B) micronized particles of glycopyrronium bromide, an inhalation corticosteroid (ICS) and optionally a long-acting beta2-agonist (LABA) as active ingredients, wherein the method comprises: (i) preparing, by co-grinding, microparticles consisting of glycopyrronium bromide and a first portion of ICS in a weight ratio of 80: 20 to 70: 30, wherein the volume diameter of the microparticles is not greater than 15 microns; (ii) mixing a carrier, the remainder of the ICS and an optional long-acting beta2-agonist to obtain a first mixture; and (iii) adding the co-milled microparticles obtained in step (i) to the first mixture obtained in step (ii) to obtain a second final mixture.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis. 20 24 22 77 14 29 O ct 2 02 4 A B S T R A C T 2 0 2 4 2 2 7 7 1 4 2 9 O c t 2 0 2 4

Provided herein are methods of treating a skin affliction, an ophthalmological affliction, or an autoimmune disease comprising administering or applying to an individual having the skin affliction an active agent in a dosage sufficient to inactivate demodex brevis and / or demodex folliculorum mites from hair follicles and / or skin of the individual, resulting in amelioration or cessation of the manifestations of allergic and / or vasomotor responses to the mites that cause symptoms and signs of the affliction or disease in the individual. Also provided herein are pharmaceutical formulations suitable for any of the methods.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

There is provided a pharmaceutical preparation comprising an anticholinergic agent and a ternary solvent, the ternary solvent comprising 5% to 15% v / v of a diol, 60% to 70% v / v of an alcohol, and 5% to 20% v / v of water. There is also provided a method of preparing a pharmaceutical preparation as disclosed herein, comprising the step of mixing an anticholinergic agent with a mixture containing an alcohol, a diol, water, a humectant, and a pH buffer at room temperature. There is also provided a method of suppressing non-pathological body odor in a mammal. There is also provided a method of treating apocrine secretion causing odor and reducing microbial overgrowth in a mammalian subject, and the use of the pharmaceutical preparation.