184 results about "Respiratory tract" patented technology

The invention provides a probe set and method for detecting respiratory tract infection pathogenic microorganisms and application of the probe set and method. The probe group is high in specificity and sensitivity, capable of accurately capturing target species in a pathogen spectrum and efficiently enriching the target species, meanwhile, few library fragments of non-target species are introduced, pathogenic microorganisms are convenient to identify, the detection sensitivity is high, the accuracy is good, the time cost is saved, the coverage degree is wide, and the application prospect is wide. Various bacteria, fungi, viruses and other pathogenic microorganisms related to respiratory tract infection can be covered.

The invention relates to a model training method and a respiratory tract infection pathogen identification method and system, and the method comprises the steps: obtaining the clinical data of a respiratory tract infection pathogen; preprocessing the clinical data to obtain a training set; training a respiratory tract infection pathogen recognition model by using the training set to obtain the trained respiratory tract infection pathogen recognition model; wherein the trained respiratory tract infection pathogen identification model is used for identifying the respiratory tract infection pathogen based on the index detection data of the respiratory tract infection pathogen. Compared with the prior art, the method has the advantages of good recognition effect, low sampling requirement, high treatment efficiency and the like.

The invention discloses a nucleic acid combination product, a kit and a method for detecting various respiratory tract pathogenic bacteria. The nucleic acid combination product comprises a primer pair and a probe, wherein the sequences of the primer pair and the probe are respectively shown as SEQ ID NO: 1-SEQ ID NO: 24. The nucleic acid combination product realizes synchronous detection of various pathogens through a one-tube eight-color fluorescent PCR, freeze-drying and ultrasonic direct diffusion method technology, significantly reduces experimental operation steps, shortens detection time, reduces the complexity of result interpretation, and has strong anti-interference capability and high sensitivity.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, those within the respiratory tract, particularly the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The systems may be used to treat pathogens, such as bacteria and viruses, particularly coronaviruses.

The invention belongs to the technical field of biological medicine, and relates to application of an OXTR agonist in preparation of a medicine for treating chronic sinusitis (CRS) and respiratory ciliary injury. CRS is treated based on targeted OXTR, and it is found that the OXTR agonist has an excellent treatment effect on promotion of nasal mucosa cilia regeneration and improvement of chronic sinusitis and can promote cilia repair, reduce infiltration of neutrophils and eosinophils and improve the inflammatory environment. In addition, an intranasal treatment dosage form aiming at OXTR is already applied to clinical application of nervous system diseases, the clinical application range of the medicine is expanded, practical feasibility is achieved by improving a better dosage form, and good industrialization prospects are achieved.

A hydrogel composition for intranasal delivery of an antifungal (amphotericin B) at an infection site, specifically the nasal mucosa and upper respiratory tract.

The invention discloses application of a cytisine type alkaloid and a derivative thereof in preparation of a medicine for preventing or treating respiratory syncytial virus infection, and relates to the technical field of respiratory syncytial virus prevention and treatment. The research finds that the natural product cytisine shows good anti-respiratory syncytial virus infection activity in vivo and in vitro, and finds that the cytisine can obviously relieve lung injury caused by virus infection and reduce lung inflammation; the invention provides an experimental basis for developing an efficient and safe drug for resisting respiratory syncytial virus (RSV) infection. As a natural product, the cytisine reduces the social burden caused by treatment of respiratory syncytial virus infection and reduces the treatment cost.

The present disclosure relates to RNA molecules encoding a respiratory syncytial virus (RSV) polypeptide. The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA molecules, RNA-LNPs and compositions for the treatment and / or prevention of RSV infection-induced acute respiratory tract illness, including pneumonia and bronchitis.

The present invention provides a Lactiplantibacillus plantarum strain capable of resisting Streptococcus pneumoniae infection in the respiratory tract, with a deposit number of CCTCC NO: M2022359. The Lactiplantibacillus plantarum VHProbi P06 strain provided by the present invention has a strong adhesion effect on nasal epithelial cells and can colonize in the nasal cavity; and can significantly inhibit the adhesion effect of Streptococcus pneumoniae, the main pathogenic microorganism of sinusitis, on nasal epithelial cells; it also has an inhibitory effect on the growth of most other pathogenic microorganisms of sinusitis, including β-hemolytic streptococcus, Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, etc. The Lactiplantibacillus plantarum VHProbi P06 strain provided by the present invention has no toxic effect on the body and has good safety. It can be added to drugs for preventing respiratory diseases or improving respiratory symptoms caused by bacterial infections, and has broad application prospects.

The invention relates to the field of public health, in particular to an intelligent identification and real-time early warning system for unknown pathogens in respiratory tract samples of fever outpatient service, which comprises a data quality control processing module for performing quality control and standardized preprocessing on metagenome original sequencing data to obtain pure microorganism reading length; the known pathogen identification and annotation module is used for identifying known pathogens, classifying non-host reads, constructing a classification database according to a classification result, and annotating reads with low classification confidence or unclassified reads in the classification result to obtain an annotation table; the recognition model training module is used for constructing a positive and negative sample data set and training a recognition model; and the unknown pathogen identification module is used for identifying potential unknown pathogens in the metagenome of the pure microorganism read length by adopting the trained identification model according to the classification database and the annotation list. According to the invention, identification, classification and dynamic monitoring of known and unknown respiratory pathogens can be realized.

The invention belongs to the technical field of molecular biology, and particularly relates to a construction method and application of a streptococcus pneumoniae pneumonia animal model. The invention provides a construction method of a streptococcus pneumoniae infected rat pneumonia and kidney injury model. The method comprises the following steps: S1, applying a streptococcus pneumoniae liquid into the respiratory tract of a rat by adopting an atomization bacterium feeding mode; and S2, verifying whether the rat treated in the step S1 is infected with pneumonia or not and whether kidney injury exists or not. According to the method, whether pneumonia is infected or not is judged by detecting inflammatory factors in alveolar lavage and lung HE staining, and whether kidney injury exists or not is judged by detecting the urine protein / creatinine ratio in a rat urine sample and detecting kidney HE staining. The construction method provided by the invention is convenient to operate, accurate in model construction and high in survival rate.

The invention relates to the technical field of biology, in particular to a primer probe combination product for respiratory tract infection detection. A plurality of specific primers and self-quenching probes are integrated in a single reaction system; simultaneous, rapid and rapid detection on 15 respiratory pathogens (including influenza A virus, influenza B virus, respiratory syncytial virus, severe acute respiratory syndrome coronavirus 2, mycoplasma pneumoniae, parainfluenza virus, rhinovirus, enterovirus, coronavirus, adenovirus, metapneumovirus, bordetella pertussis, bocavirus, chlamydia pneumoniae and chlamydia psittaci) is realized. The detection is accurate.

The application is directed to a method of inhibiting or reducing growth of clinical isolate bacteria comprising contacting the clinical isolate with a composition comprising glutathione, a glutathione derivative, a glutathione conjugate, a pharmaceutically-acceptable salt thereof, or any combination thereof.

A method for treating viral infections caused by viruses whose survival time depends on temperature (e.g., cold viruses, flu viruses, COVID-19, etc.) is based on administrating to a subject an effective amount of thermal energy transferred from a hotter liquid product to the colder subject using a predetermined combination of the temperature of the liquid product, the duration of time of supplying the liquid product, and the amount of the liquid product. This method of treatment inactivates viruses in the upper respiratory tract and gastrointestinal tract of the subject and enhances the response of the immune system, thereby preventing complications and accelerating the recovery of the infected subject.

The application discloses a nucleic acid combination product, a kit and a method for detecting multiple respiratory tract pathogenic bacteria. The nucleic acid combination product comprises a primer pair and a probe, wherein the sequences of the primer pair are respectively shown as SEQ ID NO:1-SEQ ID NO:24. The nucleic acid combination product realizes the synchronous detection of multiple pathogenic bacteria through one-tube eight-color fluorescence PCR, freeze-drying and ultrasonic direct extension technology, significantly reduces the experimental operation steps, shortens the detection time, reduces the complexity of result interpretation, and has strong anti-interference ability and high sensitivity.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

In an aspect, a method for applying beta-alanine to a tissue surface is described. The method may comprise applying a composition comprising from about 0.01 % w / w to about 5.0 % w / w beta-alanine to a tissue surface. The beta-alanine may comprise between about 0.08 % w / w to about 2 % w / w. The tissue surface may be suffering from a condition. The tissue surface may be from the group consisting of epidermis, mucosal membrane, respiratory tract lining, urinary tract lining, and reproductive tract lining. In another aspect a composition may comprise from about 0.01 % w / w to about 5.0 % w / w beta-alanine; water; an emulsifying component; and a fat. The fat may be an emollient or a moisturizing component.

The utility model discloses an aerosol inhalation device convenient for tracheal intubation and tracheostomy intubation patients, which comprises an atomization medicine storage cup, an intubation connecting seat and a connecting tube, the atomization medicine storage cup is connected with the intubation connecting seat through the connecting tube, and the atomization medicine storage cup comprises a cup body and a cup cover. The lower surface of the cup cover is connected with the top end of the conical cover through a stand column and two connecting rods, a middle partition plate is arranged between the two connecting rods, drainage grooves are formed in the two sides of the inner wall of the conical cover, liquid inlet grooves are formed in the positions, located at the drainage grooves, of the bottom of the conical cover, and a sealing plug is arranged at a bypass opening in the top end of the cannula connecting base. On the premise that a trachea cannula or a tracheostomy cannula is not pulled out, a patient can inhale enough atomized liquid medicine, secretions and sputum in the respiratory tract are effectively removed, respiratory tract infection and other complications are effectively prevented, the operation of the fiberoptic bronchoscope is smoother, meanwhile, the liquid medicine can be completely pulled out, and residue and waste of the liquid medicine cannot be caused.

The present invention relates to the technical field of nanomaterials for vaccines, and particularly relates to a sepiolite in-situ grown nanozyme, a preparation method thereof and an application thereof. The preparation method is to mix ferric chloride, ethylene glycol and sodium acetate to form a suspension, and then mix sepiolite with the suspension, and react at a temperature of 180-200 °C to obtain a black precipitate. After washing and drying, sepiolite in-situ grown nanozyme is obtained. The sepiolite nanozyme realizes the in-situ growth of iron-based nanozyme on the surface of sepiolite rod-like nanostructures under hydrothermal conditions, significantly enhancing the peroxidase activity. After Sep@IONzyme is connected with inactivated influenza virus, the complex forms an appropriate positive charge distribution, enhancing the adhesion ability of the antigen to nasal mucosa. Immunizing mice with it as a nasal drop vaccine significantly improves the levels of respiratory mucosal specific sIgA antibody and serum specific IgG antibody, and can completely protect against the lethal attack of influenza virus.

Methods of treating or preventing a disease resulting from a respiratory syncytial virus (RSV) infection in a human subject is disclosed. The methods disclosed include administering to the human subject a compound of Formula (I), or pharmaceutical composition including a compound of Formula (I). In certain embodiments, the compound is celgosivir.

The invention belongs to the technical field of molecular detection, and particularly relates to a respiratory tract pathogen detection kit based on capillary electrophoresis and application of the respiratory tract pathogen detection kit, the kit can detect common pathogens which are possibly infected by respiratory tract patients and cannot be detected and determined through a conventional technology or a kit, and the kit at least has the technical advantages of being high in sensitivity and specificity.

The invention discloses a child emergency treatment respiratory tract foreign matter rapid removing device, relates to the technical field of respiratory tract foreign matter removing, and aims to solve the technical problem that existing negative pressure suction equipment is too large in negative pressure and prone to directly adsorbing laryngeal mucosa to cause injury. Comprising a hose adaptively communicated with the input end of a negative pressure suction tube, a leakage connector, an annular groove, a removing mechanism, a collecting assembly and an angle adjusting assembly. By means of meshing or non-meshing switching of the transmission rod and the conveying cylinder, the two working states of lower cone rotating collection and upper cone sealing extraction of the guide sealing module can be flexibly adjusted and controlled, in the non-meshing state, the guide sealing module is in a lower cone shape and rotates with a gap reserved, throat mucus can be actively drawn in, and hard extrusion to the delicate throat is avoided; during meshing, the module moves upwards to be in a sealed upper cone shape, negative pressure extraction and spiral groove path optimization are matched, discomfort of the throat of a child caused by too high local negative pressure is prevented, high-viscosity mucus fracture can be avoided, and it is guaranteed that mucus is rapidly and thoroughly discharged.

The present invention relates to a tongue muscle neuromuscular stimulator, comprising a tongue muscle contact assembly, an electrode assembly and a battery assembly. The electrode assembly comprises a first electrode, a second electrode, a wire and a conductive connecting block. There are two first electrodes and two second electrodes respectively. The tongue muscle contact assembly comprises a tongue muscle contactor and a second electrode movable block. Through the tongue-mimicking structure of the tongue muscle contact assembly, the tongue muscle contactor can be placed in the oral cavity to contact the tongue. The first electrode and the second electrode of the electrode assembly can stimulate the muscles outside and inside the tongue of the upper respiratory tract to achieve a therapeutic effect on the tongue muscle. In addition, under the elastic deformation action of the first spring, the second electrode movable block not only effectively fits the lower end of the tongue to adapt to different tongue muscle shapes before treatment, but also further improves the therapeutic effect of the tongue muscle, thereby solving the problem that the tongue muscle trainer achieves the purpose of treatment or recovery by training the tongue muscle strength, has a long treatment or recovery cycle, and is difficult to train the tongue muscle nerves.

The present application relates to the technical field of component detection, in particular to a rapid detection system for respiratory tract sputum components of severe patients based on mass spectrometry. The system can realize the following steps through the cooperation between multiple modules: obtaining a target mass spectrum corresponding to a respiratory tract sputum sample of a patient to be detected, and identifying a target characteristic peak and its corresponding isotope peak cluster in the target mass spectrum; determining a pathogen compliance index, protein flooding possibility and isotope peak distribution rationality corresponding to each target characteristic peak; screening protein flooding characteristic peaks from all target characteristic peaks; segmenting target pathogen peaks from the protein flooding characteristic peaks, and detecting respiratory tract sputum components according to the target characteristic peaks and the segmented target pathogen peaks. The present application realizes the segmentation of protein flooding characteristic peaks by analyzing the protein flooding condition in the characteristic peaks, thereby facilitating the identification of the flooded pathogen, and further improving the accuracy of respiratory tract sputum component detection.

The invention discloses a tool for sampling pathogenic microorganisms in the respiratory tract of a pig, and relates to the technical field of pig respiratory tract sampling, the tool comprises a cover body, the middle position of the front end of the cover body is detachably connected with a spray collection assembly, and the two sides of the front end of the cover body are provided with cough induction assemblies; the spray collecting assembly and the cough inducing assembly both face the mouth and nose of a pig, and a fixing assembly is arranged on the peripheral side of the mask body and used for fixing the mask body to the mouth and nose of the pig. The mask body is fixed on the mouth and nose of a pig through the fixing assembly; a pig is stimulated to sneeze by driving the cough inducing assembly, and sprayed matter is collected through the sprayed matter collecting assembly, so that the aim of actively collecting pathogenic microorganisms in the respiratory tract of the pig is achieved. In the sampling process, the pigs do not need to be controlled manually, labor is saved, the stress probability of the pigs is reduced, and harm to the pigs is small.

The invention relates to the technical field of medical instruments, in particular to an oral cavity and upper respiratory tract sterilizing and purifying device which comprises an occlusion piece, an oral cavity pipe fitting, a nasal cavity pipe fitting and a superoxide supply device, a hinged frame U-shaped pipe is hinged to the hinged frame occlusion piece in a limited mode along the transverse axis, and the hinged frame U-shaped pipe can be switched between a use position and an idle position in a swinging mode; in the use position of the hinge frame, the second output ends of the two hinge frames swing upwards to the positions corresponding to the nostrils of a patient of the hinge frame; when the hinge frames are in idle positions, the second output ends of the two hinge frames swing downwards to the positions far away from the nostrils of the patient with the hinge frames, and the device has the advantages that through the integrated design, disinfection and killing of the oral cavity and the upper respiratory tract are achieved, and the treatment efficiency is improved. The occlusion piece, the oral cavity pipe fitting, the nasal cavity pipe fitting and the superoxide supply device are organically combined, so that a disinfecting and killing mode which is convenient to use and comprehensive in function is realized.

This invention relates to retroviral gene transfer vectors, particularly lentiviral vectors, pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).

Multiantigenic human papillomavirus (HPV) molecular vaccine constructs for use and treatment of HPV-related disorders and conditions, e.g., HPV molecular vaccines targeting HPV6 and HPV11-associated recurrent respiratory papillomatosis (RRP).

The invention belongs to the technical field of health-care products, and particularly relates to a probiotic composition for improving health of an oral cavity and an upper respiratory tract and a preparation method of the probiotic composition. Oral health is an important component of whole body health. Bacterial infections in the oral cavity, such as caries and periodontal diseases, not only influence the oral cavity, but also possibly harm the whole body health and influence the quality of life. The oral cavity is a portal of the respiratory tract, and bad oral hygiene may cause the accumulation of tartar, plaque, soft dirt and the like in the oral cavity and becomes a repository of pathogenic bacteria of the respiratory tract. When the immunity is low, the bacteria may enter the lung through the respiratory tract to cause respiratory tract and even lung infection. The invention discloses a probiotic composition for improving health of oral cavity and upper respiratory tract, which has the effects of resisting inflammation, resisting infection, preventing decayed teeth, protecting oral mucosa, preventing and treating bad breath and the like through the synergistic effect of streptococcus salivarius subsp. Thermophilus K12, lactobacillus rhamnosus CRL1505, lactobacillus salivarius NHNK612, lactobacillus mucus NHNK606 and the like.

The invention discloses respiratory tract infectious virus prevention and treatment equipment which comprises an oral cavity part, a throat part and a chest part, the oral cavity part comprises a spherical infrared radiation shell, an electric heating layer is attached to the inner layer of the spherical infrared radiation shell, and a holding tube communicated with the interior of a spherical cavity is fixedly installed at the lower end of the spherical infrared radiation shell; the present invention provides a device for preventing and treating new coronal influenza, influenza A, pandemic influenza and recently found respiratory infectious viruses such as HMPV.