17 results about "Respiratory tract" patented technology

Multiantigenic human papillomavirus (HPV) molecular vaccine constructs for use and treatment of HPV-related disorders and conditions, e.g., HPV molecular vaccines targeting HPV6 and HPV11-associated recurrent respiratory papillomatosis (RRP).

The application discloses a recombinant adenovirus vector tumor vaccine and a preparation method and application thereof, wherein the antigen coded by the recombinant adenovirus vector tumor vaccine comprises any one or a combination of more than two antigen peptide epitopes of KRAS protein. The recombinant adenovirus vector tumor vaccine of the application codes multiple KRAS tumor-specific antigen peptides, and has a good killing effect on KRAS mutation-driven tumors, especially lung tumors. The vaccine can be inhaled in a form of atomization, injected into muscles first and then inhaled in a form of atomization, inhaled in a form of atomization first and then injected into muscles, injected into muscles, or simultaneously injected into muscles and administered in a form of atomization. After atomization, the vaccine can be inhaled through a nasal cavity or an oral cavity to reach the lungs, generate an anti-tumor protective immune response on the respiratory tract, the lungs and the whole body, and enhance the utilization rate and the treatment effect of the vaccine.

The present application relates to the technical field of medical apparatus, and particularly relates to an oral cavity and upper respiratory tract disinfection and purification device, which comprises a bite piece, an oral cavity pipe piece, a nasal cavity pipe piece and a superoxygen supply device, and the articulated frame U-shaped pipe is articulated on the articulated frame bite piece along a transverse axis and can swing between a use position and an idle position; in the articulated frame use position, the two articulated frame second output ends swing upward to positions corresponding to the nostrils of the patient; in the articulated frame idle position, the two articulated frame second output ends swing downward to positions away from the nostrils of the patient, which has the beneficial effect of realizing oral cavity and upper respiratory tract disinfection through integrated design and improving treatment efficiency. The bite piece, the oral cavity pipe piece, the nasal cavity pipe piece and the superoxygen supply device are organically combined to realize a convenient and comprehensive disinfection mode.

A mandible displacement adjusting device includes an upper braces and a lower braces, wherein the upper braces and the lower braces have an upper teeth accommodation space and a lower teeth accommodation space, the upper teeth accommodation space and the lower teeth accommodation space are made based on the tooth shape, and fits on the upper and lower dental arches of the human body respectively, and the side walls of the upper braces and lower braces extend out a first positioning part and a second positioning part corresponding to the upper molar area and the lower molar area. When the user wear the upper braces and the lower braces, the first positioning part and the second positioning part would be driven to fit together, and maintain a movable displacement space, so that when the mandible of the human body is moved forward and fixed, it will not cause the mandible of the human body due to tightening, neither cause the discomfort at the condyle, while avoiding the back of the tongue slumping down and blocking the breathing passage.

The present application provides a kind of respiratory tract sampler for collecting avian tracheal lavage fluid, belong to the technical field of poultry respiratory tract sampling instrument, including support part, flexible catheter part, positioning and fixing assembly, elastic catheter head assembly, elastic sliding sleeve assembly and inner integrated tube assembly;Support part opens poultry beak, flexible catheter part extends into trachea, insertion cylinder is recycled in head connection pipe, elastic fin supports flexible fin, avoids bending and reduces mucosa irritation;After reaching the predetermined depth, inner integrated tube assembly provides positive pressure gas, drives insertion cylinder to extend, makes limit inclined table and clamping inclined table self-locking, through-hole is exposed in trachea, positive pressure simultaneously provides oxygen for a short time;Subsequently switch to lavage mode, lavage fluid is washed trachea through through-hole, then switch negative pressure back suction to collect sample;After use, move sliding sleeve, manually push and press flexible head to make insertion cylinder reset, it is convenient to disinfect and reuse;Can reduce poultry discomfort, accurately control lavage position, realize oxygen supply, lavage, back suction multi-functional switching.

The application discloses a kind of children respiratory tract secretion negative pressure cleaning equipment, comprising: cleaning device and medicament adding device.Cleaning device includes secretion suction pipe, secretion collection tank and negative pressure generator, one end of secretion suction pipe is equipped with suction head, a plurality of suction holes are opened in the lateral wall of suction head, a plurality of suction holes are spaced distribution along the circumference of suction head, the tail end of secretion suction pipe is connected with the inlet of secretion collection tank, the outlet of secretion collection tank is connected with the inlet of negative pressure generator;Medicament adding device includes medicament injection pipe and liquid storage tank, one end of medicament injection pipe is communicated with liquid storage tank.A plurality of suction holes effectively expand the coverage of single suction, significantly reduce the risk of a single suction hole being completely blocked, ensure the continuity of suction process, while avoiding potential damage to respiratory mucosa by pressure fluctuation.By the way of lubricating mucosa, diluting viscous secretion, thereby reducing suction resistance and improving the tolerance of sick children.

The utility model discloses a device is used for otolaryngology one kind of nasal cavity humidifier, include: breathing mask, pipe, liquid storage tank and atomizer etc. The shape of breathing mask is compatible with the shape of nose and mouth, and the breathing mask is connected with the pipe, and the one end of pipe is connected with the liquid storage tank away from breathing mask, and the liquid storage tank is connected with the atomizer between pipe. The utility model discloses a device is provided with breathing mask, pipe and spray head, and the breathing mask is divided into nose cavity and mouth cavity, and two spray heads are respectively inserted into two nasal vestibules of user, reduce the risk of causing physical damage to the mucosa in the depth of nasal cavity, improve the comfort of user, still be provided with sealing strip, and the sealing strip is close to the middle part of user, so that the sealing strip divides the nose cavity and mouth cavity, avoid the gas of user mouth exhaling being inhaled into nasal cavity again, guarantee the breathing quality of user and the humidifying effect of this humidifier, reduce the risk of respiratory tract infection.

This application relates to an endovascular suture device for minimally invasive surgery of the upper respiratory tract and neck, belonging to the technical field of medical suture devices. It includes an operating handle, a puncture rod rotatably mounted on the operating handle, an anastomosis head rotatably mounted on the end of the puncture rod, and a suture assembly mounted on the anastomosis head. The anastomosis head has a suture groove on its end side, the opening width of which is greater than the width of the wound to be sutured. The anastomosis head's end side and the opposite side walls of the suture groove are located on opposite sides of the wound to be sutured. The rotation axis of the puncture rod is aligned with its length direction, and the rotation axis of the anastomosis head is perpendicular to the rotation axis of the puncture rod. This application facilitates endovascular suture of the upper respiratory tract (nasopharynx, trachea, etc.) and neck organs (thyroid, parotid gland, etc.), achieving the effects of endovascular repair and hemostasis.

A method for determining a scaled respiratory flow rate and volume during respiration of a patient includes a) successively determining a plurality of values for a difference between a pressure in at least a first location in an upper respiratory tract of the patient and a reference pressure, b) deriving the scaled respiratory flow rate from the plurality of values for the pressure difference by using a first relationship, c) deriving the scaled respiratory volume from the plurality of values for the pressure difference by using a second relationship, and d) displaying the scaled respiratory flow rate derived in step b) and the scaled respiratory volume derived in step c) or a further variable derived from the scaled respiratory flow rate and volume in a graphical representation. Step a) is performed during tidal breathing of the patient. A system for performing the aforementioned method.

This invention belongs to the food or pharmaceutical field, specifically relating to a probiotic and prebiotic composition, its preparation process, and its application. The composition includes probiotics, resistant dextrin, xylooligosaccharides, fructooligosaccharides, stachyose, erythritol, and cranberry powder, prepared using a fluidized bed spray granulation process. As an adjuvant to antibiotics, this composition has been verified in animal and clinical trials to synergistically treat upper / lower respiratory tract infections and urinary tract infections, shorten symptom duration, accelerate recovery from the primary disease, maintain intestinal flora diversity, increase the abundance of beneficial bacteria such as Bifidobacteria, reduce the incidence of adverse reactions, and alleviate antibiotic-associated diarrhea. This invention provides a microecological restoration solution for antibiotic treatment, possessing clear clinical value and technological feasibility.

The application discloses a kind of anti-bending and anti-biting closed tracheal catheter and preparation method thereof, which can ensure the smoothness of upper respiratory tract of patient by setting different density and uninterrupted reinforcing steel wire in built-in pipe section, outer pipe section and transition pipe section.The closed tracheal catheter is characterized by comprising catheter connector, outer tube, scale line, inner tube, reinforcing steel wire, air bag, insertion port, side air hole and inflation tube.The inner tube and the outer tube are of open structure at both ends, the inner tube is placed in the outer tube, the center line of the inner tube coincides with the center line of the outer tube, the inner diameter of the outer tube is larger than the outer diameter of the inner tube, and the two ends of the inner tube and the outer tube are flush.The one end of the catheter connector is embedded in one end of the inner tube, and the inner diameter of one end to one-half of the catheter connector is smaller than the inner diameter from one-half to the other end of the catheter connector.

The application discloses a new type of oral and nasal light mist suction nozzle compatible with compressed atomization and micro-network atomization, relates to the technical field of medical atomization, and comprises an oral light mist suction nozzle and a nasal light mist suction nozzle. The oral and nasal light mist suction nozzles both comprise a mist guide cavity and a light guide column. The two ends of the mist guide cavity are respectively an inlet mist port and an outlet mist port. A gas supplement hole is arranged at one end of the inlet mist port. The light guide column is arranged on the outside of the inlet mist port, and the front end of the light guide column is suspended in the outlet mist port or arranged on the inner wall or the outer wall of the outlet mist port shell. The oral light mist suction nozzle comprises an oral suction nozzle, the nasal light mist suction nozzle comprises a nasal suction nozzle, and the shapes of the oral insertion end and the nasal insertion end are different. The application fills the gap of the combination of light energy irradiation treatment and micro-network atomization treatment for human respiratory tract mucosa in the medical field, and meets the demand of patients for light energy atomization treatment at home or on the road.

The present application provides a snoring treatment instrument, comprising a vibration part. The vibration part is provided with an air inlet, a first cavity in communication with the air inlet, a second cavity in communication with the first cavity by means of a communication port, and a plurality of air outlets in communication with the second cavity, and comprises a switching valve. The switching valve is at least partially located within the communication port in a natural state and can open the communication port under the blowing of an exhalation airflow, thereby enabling the vibration part to generate a vibration sound wave with a frequency of 20-200 Hz. Using the snoring treatment instrument provided in the present application can accurately exercise the upper respiratory tract muscles, thereby strengthening the upper respiratory tract muscles and treating snoring.

This invention relates to the field of biopharmaceutical technology, specifically to a recombinant pentamer protein, polynucleotide, expression vector, host cell, preparation method, and application. The fusion protein is formed by fusing LTB or its immunogenic functional variant with the pentamer domain of COMP via a flexible linker peptide. This invention constructs the gene of this fusion protein in a eukaryotic expression vector, transfects it into CHO-K1 cells, obtains stable high-expression cell lines through pressure selection, and performs efficient secretory expression using serum-free suspension culture. The resulting protein forms a pentamer under non-reducing conditions. The sIgA level in mouse nasal lavage fluid is significantly higher than that of the antigen alone, confirming its effective activation of local immunity in the respiratory mucosa. This invention utilizes the CHO expression system to achieve large-scale preparation of structurally correct, homogeneous, and endotoxin-free LTB pentamers, which has significant application value in the development of mucosal vaccines, targeted delivery, and diagnostic reagents.

This invention provides a subunit vaccine containing Mycoplasma pneumoniae HP14 / 30 fusion antigen and a mucosal adjuvant. The subunit vaccine comprises the Mycoplasma pneumoniae HP14 / 30 fusion antigen and a mucosal adjuvant in a mass ratio of 1-5:1. The HP14 / 30 fusion antigen is a recombinant protein co-expressed by chimeric fragments of the P1 and P30 proteins, with the amino acid sequence shown in SEQ ID NO:1. This vaccine is administered via mucosal routes such as nasal drops or oral inhalation. It efficiently induces respiratory mucosal-specific IgA and humoral IgG responses, significantly reduces pathogen load in the lungs, alleviates pathological damage to lung tissue, and does not induce enhanced respiratory disease (ERD). Its safety and protective efficacy are significantly superior to traditional inactivated vaccines and intramuscular vaccines. This invention fills the technological gap in human Mycoplasma pneumoniae subunit vaccines, is suitable for the prevention of Mycoplasma pneumoniae infection in children and adults, and has significant clinical application value.

The invention belongs to the technical field of molecular detection, and particularly relates to a respiratory tract pathogen detection kit based on capillary electrophoresis and application of the respiratory tract pathogen detection kit, the kit can detect common pathogens which are possibly infected by respiratory tract patients and cannot be detected and determined through a conventional technology or a kit, and the kit at least has the technical advantages of being high in sensitivity and specificity.