129 results about "Respiratory tract" patented technology

The invention discloses a nucleic acid combination product, a kit and a method for detecting various respiratory tract pathogenic bacteria. The nucleic acid combination product comprises a primer pair and a probe, wherein the sequences of the primer pair and the probe are respectively shown as SEQ ID NO: 1-SEQ ID NO: 24. The nucleic acid combination product realizes synchronous detection of various pathogens through a one-tube eight-color fluorescent PCR, freeze-drying and ultrasonic direct diffusion method technology, significantly reduces experimental operation steps, shortens detection time, reduces the complexity of result interpretation, and has strong anti-interference capability and high sensitivity.

The invention discloses application of a cytisine type alkaloid and a derivative thereof in preparation of a medicine for preventing or treating respiratory syncytial virus infection, and relates to the technical field of respiratory syncytial virus prevention and treatment. The research finds that the natural product cytisine shows good anti-respiratory syncytial virus infection activity in vivo and in vitro, and finds that the cytisine can obviously relieve lung injury caused by virus infection and reduce lung inflammation; the invention provides an experimental basis for developing an efficient and safe drug for resisting respiratory syncytial virus (RSV) infection. As a natural product, the cytisine reduces the social burden caused by treatment of respiratory syncytial virus infection and reduces the treatment cost.

The invention relates to the field of public health, in particular to an intelligent identification and real-time early warning system for unknown pathogens in respiratory tract samples of fever outpatient service, which comprises a data quality control processing module for performing quality control and standardized preprocessing on metagenome original sequencing data to obtain pure microorganism reading length; the known pathogen identification and annotation module is used for identifying known pathogens, classifying non-host reads, constructing a classification database according to a classification result, and annotating reads with low classification confidence or unclassified reads in the classification result to obtain an annotation table; the recognition model training module is used for constructing a positive and negative sample data set and training a recognition model; and the unknown pathogen identification module is used for identifying potential unknown pathogens in the metagenome of the pure microorganism read length by adopting the trained identification model according to the classification database and the annotation list. According to the invention, identification, classification and dynamic monitoring of known and unknown respiratory pathogens can be realized.

The invention relates to the technical field of biology, in particular to a primer probe combination product for respiratory tract infection detection. A plurality of specific primers and self-quenching probes are integrated in a single reaction system; simultaneous, rapid and rapid detection on 15 respiratory pathogens (including influenza A virus, influenza B virus, respiratory syncytial virus, severe acute respiratory syndrome coronavirus 2, mycoplasma pneumoniae, parainfluenza virus, rhinovirus, enterovirus, coronavirus, adenovirus, metapneumovirus, bordetella pertussis, bocavirus, chlamydia pneumoniae and chlamydia psittaci) is realized. The detection is accurate.

A method for treating viral infections caused by viruses whose survival time depends on temperature (e.g., cold viruses, flu viruses, COVID-19, etc.) is based on administrating to a subject an effective amount of thermal energy transferred from a hotter liquid product to the colder subject using a predetermined combination of the temperature of the liquid product, the duration of time of supplying the liquid product, and the amount of the liquid product. This method of treatment inactivates viruses in the upper respiratory tract and gastrointestinal tract of the subject and enhances the response of the immune system, thereby preventing complications and accelerating the recovery of the infected subject.

The application discloses a nucleic acid combination product, a kit and a method for detecting multiple respiratory tract pathogenic bacteria. The nucleic acid combination product comprises a primer pair and a probe, wherein the sequences of the primer pair are respectively shown as SEQ ID NO:1-SEQ ID NO:24. The nucleic acid combination product realizes the synchronous detection of multiple pathogenic bacteria through one-tube eight-color fluorescence PCR, freeze-drying and ultrasonic direct extension technology, significantly reduces the experimental operation steps, shortens the detection time, reduces the complexity of result interpretation, and has strong anti-interference ability and high sensitivity.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

In an aspect, a method for applying beta-alanine to a tissue surface is described. The method may comprise applying a composition comprising from about 0.01 % w / w to about 5.0 % w / w beta-alanine to a tissue surface. The beta-alanine may comprise between about 0.08 % w / w to about 2 % w / w. The tissue surface may be suffering from a condition. The tissue surface may be from the group consisting of epidermis, mucosal membrane, respiratory tract lining, urinary tract lining, and reproductive tract lining. In another aspect a composition may comprise from about 0.01 % w / w to about 5.0 % w / w beta-alanine; water; an emulsifying component; and a fat. The fat may be an emollient or a moisturizing component.

The utility model discloses an aerosol inhalation device convenient for tracheal intubation and tracheostomy intubation patients, which comprises an atomization medicine storage cup, an intubation connecting seat and a connecting tube, the atomization medicine storage cup is connected with the intubation connecting seat through the connecting tube, and the atomization medicine storage cup comprises a cup body and a cup cover. The lower surface of the cup cover is connected with the top end of the conical cover through a stand column and two connecting rods, a middle partition plate is arranged between the two connecting rods, drainage grooves are formed in the two sides of the inner wall of the conical cover, liquid inlet grooves are formed in the positions, located at the drainage grooves, of the bottom of the conical cover, and a sealing plug is arranged at a bypass opening in the top end of the cannula connecting base. On the premise that a trachea cannula or a tracheostomy cannula is not pulled out, a patient can inhale enough atomized liquid medicine, secretions and sputum in the respiratory tract are effectively removed, respiratory tract infection and other complications are effectively prevented, the operation of the fiberoptic bronchoscope is smoother, meanwhile, the liquid medicine can be completely pulled out, and residue and waste of the liquid medicine cannot be caused.

Methods of treating or preventing a disease resulting from a respiratory syncytial virus (RSV) infection in a human subject is disclosed. The methods disclosed include administering to the human subject a compound of Formula (I), or pharmaceutical composition including a compound of Formula (I). In certain embodiments, the compound is celgosivir.

The invention belongs to the technical field of molecular detection, and particularly relates to a respiratory tract pathogen detection kit based on capillary electrophoresis and application of the respiratory tract pathogen detection kit, the kit can detect common pathogens which are possibly infected by respiratory tract patients and cannot be detected and determined through a conventional technology or a kit, and the kit at least has the technical advantages of being high in sensitivity and specificity.

The invention discloses a child emergency treatment respiratory tract foreign matter rapid removing device, relates to the technical field of respiratory tract foreign matter removing, and aims to solve the technical problem that existing negative pressure suction equipment is too large in negative pressure and prone to directly adsorbing laryngeal mucosa to cause injury. Comprising a hose adaptively communicated with the input end of a negative pressure suction tube, a leakage connector, an annular groove, a removing mechanism, a collecting assembly and an angle adjusting assembly. By means of meshing or non-meshing switching of the transmission rod and the conveying cylinder, the two working states of lower cone rotating collection and upper cone sealing extraction of the guide sealing module can be flexibly adjusted and controlled, in the non-meshing state, the guide sealing module is in a lower cone shape and rotates with a gap reserved, throat mucus can be actively drawn in, and hard extrusion to the delicate throat is avoided; during meshing, the module moves upwards to be in a sealed upper cone shape, negative pressure extraction and spiral groove path optimization are matched, discomfort of the throat of a child caused by too high local negative pressure is prevented, high-viscosity mucus fracture can be avoided, and it is guaranteed that mucus is rapidly and thoroughly discharged.

The present application relates to the technical field of component detection, in particular to a rapid detection system for respiratory tract sputum components of severe patients based on mass spectrometry. The system can realize the following steps through the cooperation between multiple modules: obtaining a target mass spectrum corresponding to a respiratory tract sputum sample of a patient to be detected, and identifying a target characteristic peak and its corresponding isotope peak cluster in the target mass spectrum; determining a pathogen compliance index, protein flooding possibility and isotope peak distribution rationality corresponding to each target characteristic peak; screening protein flooding characteristic peaks from all target characteristic peaks; segmenting target pathogen peaks from the protein flooding characteristic peaks, and detecting respiratory tract sputum components according to the target characteristic peaks and the segmented target pathogen peaks. The present application realizes the segmentation of protein flooding characteristic peaks by analyzing the protein flooding condition in the characteristic peaks, thereby facilitating the identification of the flooded pathogen, and further improving the accuracy of respiratory tract sputum component detection.

The invention discloses a tool for sampling pathogenic microorganisms in the respiratory tract of a pig, and relates to the technical field of pig respiratory tract sampling, the tool comprises a cover body, the middle position of the front end of the cover body is detachably connected with a spray collection assembly, and the two sides of the front end of the cover body are provided with cough induction assemblies; the spray collecting assembly and the cough inducing assembly both face the mouth and nose of a pig, and a fixing assembly is arranged on the peripheral side of the mask body and used for fixing the mask body to the mouth and nose of the pig. The mask body is fixed on the mouth and nose of a pig through the fixing assembly; a pig is stimulated to sneeze by driving the cough inducing assembly, and sprayed matter is collected through the sprayed matter collecting assembly, so that the aim of actively collecting pathogenic microorganisms in the respiratory tract of the pig is achieved. In the sampling process, the pigs do not need to be controlled manually, labor is saved, the stress probability of the pigs is reduced, and harm to the pigs is small.

The invention relates to the technical field of medical instruments, in particular to an oral cavity and upper respiratory tract sterilizing and purifying device which comprises an occlusion piece, an oral cavity pipe fitting, a nasal cavity pipe fitting and a superoxide supply device, a hinged frame U-shaped pipe is hinged to the hinged frame occlusion piece in a limited mode along the transverse axis, and the hinged frame U-shaped pipe can be switched between a use position and an idle position in a swinging mode; in the use position of the hinge frame, the second output ends of the two hinge frames swing upwards to the positions corresponding to the nostrils of a patient of the hinge frame; when the hinge frames are in idle positions, the second output ends of the two hinge frames swing downwards to the positions far away from the nostrils of the patient with the hinge frames, and the device has the advantages that through the integrated design, disinfection and killing of the oral cavity and the upper respiratory tract are achieved, and the treatment efficiency is improved. The occlusion piece, the oral cavity pipe fitting, the nasal cavity pipe fitting and the superoxide supply device are organically combined, so that a disinfecting and killing mode which is convenient to use and comprehensive in function is realized.

Multiantigenic human papillomavirus (HPV) molecular vaccine constructs for use and treatment of HPV-related disorders and conditions, e.g., HPV molecular vaccines targeting HPV6 and HPV11-associated recurrent respiratory papillomatosis (RRP).

The invention discloses respiratory tract infectious virus prevention and treatment equipment which comprises an oral cavity part, a throat part and a chest part, the oral cavity part comprises a spherical infrared radiation shell, an electric heating layer is attached to the inner layer of the spherical infrared radiation shell, and a holding tube communicated with the interior of a spherical cavity is fixedly installed at the lower end of the spherical infrared radiation shell; the present invention provides a device for preventing and treating new coronal influenza, influenza A, pandemic influenza and recently found respiratory infectious viruses such as HMPV.

Peptides and pharmaceutical compositions comprising the same are described for use in the treatment and / or prevention of a disease caused by a virus affecting the respiratory tract, and in particular by an influenza virus or a coronavirus, among others. Additionally, a method and a kit for determining in vitro the resistance of an individual to being infected by a virus affecting the respiratory tract by determining the level of said peptides in the saliva of said individual is described.

The present invention relates to a single cell cylindrical battery, such as a button cell or a button battery, that can be regarded to have the shape of a slice of a cylinder, and to a method preventing upper digestive and upper respiratory tract injury after accidental ingestion of the single cell cylindrical battery. It is noted that in some case ingestion has even led to the death in particular of children or small size adults, or people with a mental limitation, or people with a prior narrowing of structures in which the battery can be lodged. The structures in which the battery can be lodged are both the pharyngeal, upper digestive and upper respiratory tracts. As ingestion itself can not always be prevented, a relatively safe battery has been developed, which mitigates problems associated with ingestion.

The invention discloses an application of methyl protocatechuate in preparation of a product for treating and / or preventing respiratory syncytial virus infection. The methyl protocatechuate is a natural product, is good in permeability, small in toxic and side effects and simple in structure, can effectively inhibit replication and infection of the respiratory syncytial virus and reduce inflammatory response of a body, can target FTO and inhibit FTO protein expression, and provides a new direction for treating infection of the respiratory syncytial virus.

The utility model discloses a kind of bite that can prevent respiratory tract obstruction, it is related to medical instrument technical field. Including bite main part, bite outside extension plate, tongue depressor baffle and tongue depressor main part. Bite main part includes mouth tube and the bite inside baffle and bite outside baffle of mouth tube both sides. Bite outside baffle is connected with bite outside extension plate, another end of bite outside extension plate is connected with tongue depressor baffle, and tongue depressor baffle is equipped with the clamping groove towards bite main part side. Long hole is equipped on bite inside baffle, hole is equipped on bite outside baffle, tongue depressor main part front end passes through hole and long hole, rear end swing is clamped in the clamping groove of tongue depressor baffle. Bite inside baffle and bite outside baffle are equipped with support plate. The device has two independent channels, one is used to accommodate gastroscope tube, and the other is used to accommodate tongue depressor. They do not interfere with each other. Adjusting part is away from bite, and adjusting will not touch patient's mouth during gastroscopy. It has good clinical use effect.

The application discloses a respiratory endoscope image real-time analysis method and system based on artificial intelligence vision, comprising: acquiring a real-time video stream collected by a respiratory endoscope device, wherein the real-time video stream at least contains an image sequence in a white light imaging mode; pre-processing image frames in the real-time video stream to obtain standardized image frames, wherein the pre-processing comprises noise suppression and color space correction; inputting the standardized image frames into a pre-trained target detection neural network model for real-time inference, and simultaneously outputting lesion area recognition results, airway anatomical structure positioning results and surgical instrument detection results of the current image frames by the target detection neural network model. The method and system realize real-time accurate analysis of respiratory endoscope images and full-process operation assistance, and improve the accuracy, safety and efficiency of diagnosis and treatment.

Described herein are diazeniumdiolate nitric oxide (NO) donors encapsulated in liposomes. Also described are methods of making the liposomes and methods of treating respiratory infections, such as nontuberculosis Mycobacterium (NTM) with the NO-releasing liposomes.

The object of the invention, which relates to a speaking valve (1) and to a method for using the speaking valve (1) on a tracheotomy patient, is to provide a solution in which the speaking valve (1) is robust and can be produced easily and cost-effectively. In addition, the speaking valve (1) is intended to make it possible to control an air flow during exhalation through the upper respiratory tract. Furthermore, the dead space volume inside the speaking valve (1) is to be minimized. This object is achieved by the arrangement in that at least one air outflow opening (8) which can be sealingly closed by means of a closure element is arranged in a wall of the housing (2) of the speaking valve (1), in that the closure element is a separate hollow truncated cone (9) mounted rotatably within the housing (2) of the speaking valve (1), and in that at least one opening (16) corresponding to the air outflow opening (8) is arranged in the hollow truncated cone (9).

The invention belongs to the field of biological medicines, and particularly relates to application of a compound to preparation of a medicine for treating papilloma of the upper respiratory tract. The invention provides an application of a compound in preparation of a medicine for treating and / or preventing papilloma of the upper respiratory tract, and is characterized in that the compound comprises one or more of asperisib, crizotinib, lapatinib, osimertinib and bortezomib. Experimental results show that the asperisib, crizotinib, lapatinib, osimertinib and bortezomib can realize long-term control on the papilloma of the upper respiratory tract and reduce the recurrence risk of the papilloma of the upper respiratory tract to a certain extent, so that the life quality of patients with the papilloma of the upper respiratory tract can be improved; the invention has important scientific value and clinical application prospect in the field of upper respiratory papilloma treatment.

The invention discloses a pharmaceutical composition for rhinitis health care and respiratory tract circulation improvement and a preparation method thereof.The pharmaceutical composition is prepared from pogostemon cablin, osmanthus fragrans, geranium, wild chrysanthemum flowers, semen armeniacae amarae, astragalus membranaceus, pericarpium citri reticulatae, platycodon grandiflorum, mint and menthol through processing and liquefying, and through the synergistic effect of all the pharmaceutical ingredients, the pharmaceutical composition has the effects of inducing resuscitation with fragrance, dissolving turbidity and dredging resuscitation; the condition of unsmooth ventilation of the nose can be effectively improved, and uncomfortable symptoms such as nasal obstruction can be relieved; the spreading and descending of lung qi are regulated, and the normal physiological function of the respiratory tract is maintained; the whole resistance of the body and local qi and blood nourishing of the nose are enhanced, and repair and regeneration of nose tissues are promoted; the invasion of external heat toxin to the nose is resisted, and the inflammatory response is relieved. Long-term use of the nasal mask can significantly promote respiratory tract microcirculation, enhance the immune defense function of the nose, and effectively prevent occurrence and recurrence of nasal diseases.

This product is a lip piece for nasal breathing during sleep. Traditionally, mouthpieces are worn between the upper and lower teeth inside the mouth, but this lip piece is placed between the upper and lower gums and lips, covering the entire lip, and has a slightly elongated ring shape. It utilizes the principle that even ordinary people can achieve nasal and diaphragmatic breathing by opening their mouths wide like singers. One piece can be fitted to set two sizes, slightly elongated vertically and slightly horizontally. This allows for adjustments to the size of the person's mouth and jaw closure, adjustment of the amount of air, and multi-purpose use such as daytime fitting practice or nighttime sleep use. The material is synthetic resin, and you can choose between a harder (plastic) and a softer (elastomer) version. When this product is worn on the lips, the larynx opens, ensuring an open airway during sleep, allowing for smooth nasal breathing, and preventing snoring and sleep apnea. Furthermore, since it prevents mouth breathing even when the mouth is open, it can prevent various problems associated with mouth breathing. It can be used by a wide range of ages, from infants with underdeveloped lower jaws who grind their teeth, to adults with teeth clenching, dry mouth, temporomandibular joint disorders, and elderly people at risk of aspiration, and is harmless. Once the discomfort of wearing it is overcome, it promotes restful sleep with light and safe nasal breathing. Other benefits include improved blood flow to the muscles around the mouth, while at the same time creating a slight tension in the lips, which is good for blood flow to the brain. The lips relax and the salivary glands work, so saliva is produced, but the structure prevents saliva from spilling out of the mouth. The base of the tongue is more easily moved forward, so the epiglottis (the lid for swallowing) moves. It is also expected to help prevent silent aspiration pneumonia.

The application discloses a recombinant adenovirus vector tumor vaccine and a preparation method and application thereof, wherein the antigen coded by the recombinant adenovirus vector tumor vaccine comprises any one or a combination of more than two antigen peptide epitopes of KRAS protein. The recombinant adenovirus vector tumor vaccine of the application codes multiple KRAS tumor-specific antigen peptides, and has a good killing effect on KRAS mutation-driven tumors, especially lung tumors. The vaccine can be inhaled in a form of atomization, injected into muscles first and then inhaled in a form of atomization, inhaled in a form of atomization first and then injected into muscles, injected into muscles, or simultaneously injected into muscles and administered in a form of atomization. After atomization, the vaccine can be inhaled through a nasal cavity or an oral cavity to reach the lungs, generate an anti-tumor protective immune response on the respiratory tract, the lungs and the whole body, and enhance the utilization rate and the treatment effect of the vaccine.

The present application relates to the technical field of medical apparatus, and particularly relates to an oral cavity and upper respiratory tract disinfection and purification device, which comprises a bite piece, an oral cavity pipe piece, a nasal cavity pipe piece and a superoxygen supply device, and the articulated frame U-shaped pipe is articulated on the articulated frame bite piece along a transverse axis and can swing between a use position and an idle position; in the articulated frame use position, the two articulated frame second output ends swing upward to positions corresponding to the nostrils of the patient; in the articulated frame idle position, the two articulated frame second output ends swing downward to positions away from the nostrils of the patient, which has the beneficial effect of realizing oral cavity and upper respiratory tract disinfection through integrated design and improving treatment efficiency. The bite piece, the oral cavity pipe piece, the nasal cavity pipe piece and the superoxygen supply device are organically combined to realize a convenient and comprehensive disinfection mode.

A mandible displacement adjusting device includes an upper braces and a lower braces, wherein the upper braces and the lower braces have an upper teeth accommodation space and a lower teeth accommodation space, the upper teeth accommodation space and the lower teeth accommodation space are made based on the tooth shape, and fits on the upper and lower dental arches of the human body respectively, and the side walls of the upper braces and lower braces extend out a first positioning part and a second positioning part corresponding to the upper molar area and the lower molar area. When the user wear the upper braces and the lower braces, the first positioning part and the second positioning part would be driven to fit together, and maintain a movable displacement space, so that when the mandible of the human body is moved forward and fixed, it will not cause the mandible of the human body due to tightening, neither cause the discomfort at the condyle, while avoiding the back of the tongue slumping down and blocking the breathing passage.