40 results about "Diaphragm muscle" patented technology

The invention discloses a critical patient diaphragm function track monitoring system and evaluation method, and belongs to the technical field of intensive care medical treatment. The method comprises the following steps: synchronously acquiring an ultrasonic image data stream related to diaphragm of a patient and a respiratory mechanics data stream related to a breathing machine of the patient; based on the ultrasonic image data stream, analyzing and generating a first time sequence physiological parameter sequence in real time; calculating and generating a second time sequence physiological parameter sequence in real time based on the respiratory mechanics data flow; based on conjoint analysis of the first time sequence physiological parameter sequence and the second time sequence physiological parameter sequence, a diaphragm function reserve index used for representing the diaphragm function reserve state of the patient is generated. According to the method, synchronous fusion and dynamic analysis are carried out on the multi-modal physiological data, a composite index capable of objectively, continuously and prospectively quantifying the anti-fatigue capacity of the diaphragm muscle is constructed, and the problems that in the prior art, machine withdrawal evaluation depends on scattered and static indexes, judgment subjectivity is high, and cognitive loads are high are solved.

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance / support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

The utility model discloses a diaphragm pacing respirator, which relates to the respirator field, and comprises a rubber bite sleeve, the outer wall of the rubber bite sleeve is bonded with a first damping sleeve, the outer wall of the first damping sleeve is attached with a connecting sleeve, the inner wall of the connecting sleeve is provided with filter cotton, the inner wall of the connecting sleeve is attached with a second damping sleeve, and the second damping sleeve is connected with the rubber bite sleeve. And an adjusting sleeve is adhered to the inner wall of the second damping sleeve. The filter cotton is clamped and fixed through the connecting sleeve, when the device is used, sucked air is conveniently filtered through the connecting sleeve and the filter cotton, meanwhile, the connecting sleeve is clamped and fixed through the adjusting sleeve, the filter cotton is conveniently and rapidly replaced through the adjusting sleeve, the usability of the device is improved, and the service life of the device is prolonged. And by arranging the adjusting sleeve, a thread adjusting effect on the air inlet sleeve is achieved, when the device is used, the air inlet and outlet amount can be conveniently and rapidly adjusted through the adjusting sleeve and the air inlet sleeve, and the usability of the device is improved.

This disclosure provides a secretion centric therapy to overcome muscle wasting. Provided are mesenchymal stem cell secretion-based therapies to overcome muscle wasting due to: old age; as a consequence of immobilization (e.g., mobility restricted or paralytics administered); due to use of ventilators (e.g., in an ICU or long-term immobilization); in microgravity during long space flights; or, resulting from drug side effects (e.g., the use of weight loss drugs, chemotherapies, etc.). This disclosure further provides methods and compositions for modulating, including regulating or altering, the structure and function of diaphragm muscle cells and / or diaphragm muscle fibers in particular, and skeletal muscle in general. In certain embodiments extracellular vesicles are applied to patients affected by muscle wasting.