26 results about "Hypoglossal nerve" patented technology

A device includes at least one first element in operative relation to at least one target tissue from a set of target tissues to treat sleep disordered breathing, which may include obstructive sleep apnea. The operative relation may include sensing and / or stimulation. The at least one target tissue may comprise diaphragm-related tissue, respiratory tissue-related nerves, and / or upper airway patency-related tissue. Example tissue in the set of target tissues includes hypoglossal nerve, infrahyoid muscle (IHM)-innervating nerve, IHMs, glossopharyngeal nerve, an internal superior laryngeal (iSL) nerve, phrenic nerve, diaphragm, pudendal nerve, among other nerves and muscles. In some example, multiple target tissue may be selected for stimulation and / or sensing.

The system includes an array of electrodes and a stimulator coupled to the array of electrodes by at least one flexible wire. The array of electrodes are disposed on a flexible carrier configured to wrap around a hypoglossal nerve of a patient. The array of electrodes include a first electrode, a second electrode, and a third electrode. The stimulator includes a control circuit configured to generate a stimulation signal. The stimulator is configured to receive a communication from an external device for selecting at least one of the first electrode, the second electrode, and the third electrode that will participate in stimulating the hypoglossal nerve of the patient.

The application discloses an obstructive sleep apnea device and method; the device comprises a mouthpiece carrier, an electrode stimulation module and a control unit, the electrode stimulation module comprises an integrated flexible circuit board transmission link, the transmission link is integrated with a stimulation electrode with a nickel-titanium alloy support strip on the inner side of the mouthpiece carrier, and the stimulation electrode can apply electric stimulation to the genioglossus muscle or hypoglossal nerve; the external control unit is provided with a microcontroller and an acoustic sensor; the method first collects an environmental background signal, processes the signal to generate a signal determination threshold, then collects a human respiratory acoustic vibration signal in real time, processes the signal to generate a respiratory sound energy value, compares the two to determine an abnormal respiratory event; after determining the abnormality, a gradient output electric stimulation is output, and a dynamic feedback mechanism is combined to adjust the stimulation intensity; when the stimulation intensity is zero and there is no abnormal signal, it is determined that the intervention is completed and the standby state is entered; the application can adapt to environmental noise, avoid current mutation discomfort, closed-loop control intervention intensity, and is suitable for sleep apnea auxiliary intervention.

This disclosure describes a system including a needle configured to percutaneously insert into skin and form a path for inserting a lead, the needle including a pointed distal end for percutaneously inserting the needle for placement near a hypoglossal nerve of a patient, and an elongated body comprising an inner lumen, wherein the elongated body defines one or more openings connecting an outer surface of the elongated body to the inner lumen. The lead may be configured to be disposed within the inner lumen of the elongated body and may include a shaft and one or more electrodes disposed on the shaft, configured to be placed near the hypoglossal nerve, and configured to stimulate the hypoglossal nerve for treating obstructive sleep apnea (OSA), wherein locations of the one or more electrodes on the shaft at least partially correspond to the one or more openings of the needle.

Methods and systems are provided to improve SDB in a patient suffering therefrom by delivering an electrical neuromodulation signal to at least a target site comprising an efferent fiber of the glossopharyngeal nerve that innervates pharyngeal constrictor muscles or the stylopharyngeus muscle. Methods include further delivering electrical neuromodulation signals to other sites including one or more combinations of the ansa cervicalis, the hypoglossal nerve, the palatoglossus muscle, and / or the palatopharyngeus muscle. The electrical neuromodulation signal delivered to efferent fibers of the glossopharyngeal nerve can be done independent of a detected sensory or input signal that measures the neuromuscular state of the patient's airway.

This utility model discloses an electrical stimulation control circuit and an anti-snoring device, relating to the field of medical device technology. The electrical stimulation control circuit includes: an electrical pulse output circuit, the output terminal of which is electrically connected to an electrode plate; and a main control circuit, which is electrically connected to the electrical pulse output circuit. The main control circuit controls the electrical pulse output circuit to output electrical pulses of a preset frequency and a preset pulse width to the electrode plate. The electrode plate is used to conduct the electrical pulses to the human jaw to stimulate the hypoglossal nerve. The preset frequency ranges from 18kHz to 22kHz, and the preset pulse width ranges from 45μs to 55μs. This utility model aims to solve the technical problem that existing anti-snoring devices often cannot effectively stimulate the hypoglossal nerve, thus affecting the user experience.

A method for titrating a stimulation parameter for one or more electrode contacts in a system for stimulating a hypoglossal nerve of a patient includes activating one of the one or more electrode contacts to stimulate the hypoglossal nerve of the patient, obtaining a first and / or second physiological measurement from the patient, comparing the first and / or second physiological measurement to a first and / or second predetermined target value, adjusting a stimulation parameter for the one of the one or more electrode contacts if the first and / or second physiological measurement differs from the first and / or second predetermined target value.

Disclosed herein is a method for electrical nerve (510) stimulation, the method comprising: generating an electrical stimulation pattern (100) comprising a plurality of successive pulse trains (110), wherein each pulse train (110) has a pulse train amplitude (111); delivering the electrical stimulation pattern (100) to a subjects hypoglossal nerve (510) with a stimulator (300) having at least one electrode (310); modulating the electrical stimulation pattern (100), wherein modulation of the electrical stimulation pattern (100) comprises gradually increasing the pulse train amplitude (111) from one pulse train (110) to a successive pulse train (110) at stimulation onset (101) until a determined target stimulation amplitude (130) is reached; characterized in that modulation of the electrical stimulation pattern (100) further comprises decreasing the target stimulation amplitude (130) to a defined step-down amplitude (140) within each pulse train (110) after the target stimulation amplitude (130) was reached.

Wireless power transfer devices and associated systems and methods are disclosed herein. Various embodiments of the present technology relate to devices, systems, and methods for delivering power to an implantable device, such as an implantable neuromodulation device configured to modulate a hypoglossal nerve of a patient. According to some embodiments, the present technology includes an external system comprising a control unit coupled to an external device. The external device can comprise a carrier carrying an antenna configured to conduct electrical current such that the antenna generates an electromagnetic field. When the implantable neuromodulation device is positioned within the electromagnetic field generated by the antenna, current can be induced in an antenna of the implantable neuromodulation device such that power is delivered to the implantable neuromodulation device.

The invention provides a hypoglossal nerve stimulation control system and a portable stimulator, and the system comprises a data collection module which is used for collecting the three-axis acceleration data of a detected object at the current moment, and determining the roll angle and the pitch angle of the detected object based on the three-axis acceleration data; the posture recognition module is used for determining the posture of the detected object based on the roll angle and the pitch angle; the respiration detection module is used for determining a respiration signal source based on the posture and identifying an apnea event based on the respiration signal source; the respiration signal source comprises a roll angle and / or a pitch angle; and the stimulation control module is used for responding to the apnea event and triggering hypoglossal nerve electrical stimulation. The apnea event is identified based on the respiratory signal source, the opportunity of hypoglossal nerve electrical stimulation can be accurately identified, the respiratory signal source is determined based on the posture, the more accurate respiratory signal source is selected, and the effectiveness of hypoglossal nerve electrical stimulation is improved.

Systems and methods for hypoglossal nerve stimulation. Certain embodiments include a pulse generator, circuitry configured to receive an energy signal, a communication module, and a programming module. In certain embodiments, the first pulse generator comprises a first electrode and a second electrode, a pulse generator coil, and circuitry configured to receive an energy signal. In particular embodiments, the first pulse generator can be configured to be implanted directly on a hypoglossal nerve on a first side of the patient and configured to deliver stimulation energy to activate at least one branch of the hypoglossal nerve on the first side of the patient. The communication module can include a communication coil configured to communicate with the pulse generator coil in specific embodiments. The programming module can be configured to communicate programming instructions to the communication module, the programming instructions defining an attribute of the stimulation energy.

The application discloses a control method and device of a hypoglossal nerve stimulation device, equipment and a medium, the method comprises: acquiring a physiological characteristic signal for characterizing the breathing state of a detected object; based on the delay corresponding to the physiological characteristic signal, a breathing state space model of the physiological characteristic signal is constructed, so as to compensate for the delay when estimating the target respiratory phase of the detected object at the current time; based on the breathing state space model, the physiological characteristic signal is filtered by a specified filter to estimate the target respiratory phase; determine whether the target respiratory phase is within the preset stimulation window; if yes, output the stimulation signal; if not, return to the step of acquiring the physiological characteristic signal. Thus, by introducing delay compensation when constructing the breathing state space model, the accuracy of the stimulation signal output is improved. In addition, through real-time target respiratory phase estimation and preset stimulation window judgment, the breathing state of the detected object is tracked, and the accuracy of the respiratory phase synchronous control is improved.

Methods of treating obstructive sleep apnea according to the disclosure can include providing an implant comprising: a substantially planar central body portion having a top side and a bottom side; at least two adjustable wing portions; and at least two connecting members each extending from opposite sides of the central body portion, each of the at least two connecting members configured to flexibly connect each of the at least two wing portions to the central body portion on opposite sides; forming a surgical opening to expose a genioglossus muscle; exposing a hypoglossal nerve branch on at least one side of the genioglossus muscle for stimulation by the implant; forming at least one pocket on at least one side of the genioglossus muscle; sizing the pocket to receive at least one of the at least two wing portions of the implant device; inserting the implant device through the surgical opening such that the central body extends over the genioglossus muscle and each of the wing portions is received in a respective at least one pocket; and securing the implant device to the muscle.

The invention provides a system and method for improving sleep breathing disorder based on nerve stimulation, and belongs to the technical field of medical treatment. Comprising a mask for collecting nasopharyngeal airflow, snore and vibration signals; the nerve stimulation module is used for stimulating hypoglossal nerves and phrenic nerves through electric pulses; the fixed flow positive pressure support module is used for providing continuous positive airway pressure ventilation; the multi-source data acquisition module is used for acquiring respiratory movement amplitude data and blood oxygen saturation data; the control unit module comprises a data processing core and a double-closed-loop controller; the data processing core is used for identifying a respiratory event type based on an LSTM model and establishing a stimulation-ventilation response relation matrix; the double-closed-loop controller is used for adjusting the stimulation intensity of the nerve stimulation module in real time. By dynamically adjusting parameters, reducing sequential control errors and realizing multi-signal synchronization, the limitation of single nerve stimulation is effectively solved, and the accuracy and effectiveness of intervention are ensured.

A method for titrating a stimulation parameter for one or more electrode contacts in a system for stimulating a hypoglossal nerve of a patient includes activating one of the one or more electrode contacts to stimulate the hypoglossal nerve of the patient, obtaining a first and / or second physiological measurement from the patient, comparing the first and / or second physiological measurement to a first and / or second predetermined target value, adjusting a stimulation parameter for the one of the one or more electrode contacts if the first and / or second physiological measurement differs from the first and / or second predetermined target value.

Disclosed herein is a method for electrical nerve (510) stimulation, the method comprising: generating an electrical stimulation pattern (100) comprising a plurality of successive pulse trains (110), wherein each pulse train (110) has a pulse train amplitude (111); delivering the electrical stimulation pattern (100) to a subject's hypoglossal nerve (510) with a stimulator (300) having at least one electrode (310); modulating the electrical stimulation pattern (100), wherein modulation of the electrical stimulation pattern (100) comprises gradually increasing the pulse train amplitude (111) from one pulse train (110) to a successive pulse train (110) at stimulation onset (101) until a determined target stimulation amplitude (130) is reached; characterized in that modulation of the electrical stimulation pattern (100) further comprises decreasing the target stimulation amplitude (130) to a defined step-down amplitude (140) within each pulse train (110) after the target stimulation amplitude (130) was reached.

The present disclosure relates to wireless power transmission devices and related systems and methods. Embodiments of the present technology relate to devices, systems, and methods for powering an implantable device, such as an implantable neuromodulation device configured to modulate a patient's hypoglossal nerve. According to certain embodiments, the technology includes an external system including a control unit connected to an external device. The external device can include a carrier carrying an antenna configured to conduct a current, the antenna generating an electromagnetic field. When the implantable neuromodulation device is placed within the electromagnetic field generated by the antenna, a current is induced in the antenna of the implantable neuromodulation device, thereby powering the implantable neuromodulation device.

Implantable electrodes with power delivery wearable for treating sleep apnea, and associated systems and methods are disclosed herein. A representative system includes non-implantable signal generator worn by the patient and having an antenna that directs a mid-field RF power signal to an implanted electrode. The implanted electrode in turn directs a lower frequency signal to a neural target, for example, the patient's hypoglossal nerve. Representative signal generators can have the form of a mouthpiece, a collar or other wearable, and / or a skin-mounted patch.

Obstructive sleep apnea, causing daytime drowsiness and comorbidities like hypertension, often stems from soft palate collapse or genioglossus muscle retrusion. This can be due to muscle exhaustion (heightened activation, more type II fibers) or insufficient hypoglossal nerve innervation. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

A method of providing a sleep apnea nerve stimulation therapy to a subject may include detecting a respiratory waveform of the subject with a sensor. The sensor may be configured for coupling to the subject. The respiratory waveform may include a plurality of respiratory cycles each corresponding to at least one of a breath and an attempted breath of the subject. The method may also include identifying a breathing pattern within the respiratory waveform over a period of time. The breathing pattern may include a repeating pattern of a plurality of respiratory cycles followed by at least one respiratory cycle corresponding to a disordered breathing event. The method may also include generating a series of stimulation pulses with an implantable nerve stimulator configured for coupling to a hypoglossal nerve of the subject. The series of stimulation pulses may be coordinated with the breathing pattern.

The invention discloses a non-invasive hypoglossal nerve in-vitro electrical stimulation snore stopping system which comprises a detection module, a control module, a stimulation module, a power supply module and an interaction module, the control module establishes a bidirectional communication chain with the detection module and the stimulation module, and the system is characterized in that the detection module collects snore intensity and blood oxygen data and feeds back the snore intensity and blood oxygen data to the control module; the control module analyzes the current upper airway collapse degree of a user through a preset algorithm and generates personalized stimulation parameters according to the analysis result of the control module, the stimulation module converts the parameters generated by the control module into electrical stimulation signals, and the stimulation module is further connected with an impedance detection circuit used for detecting contact impedance in real time. The non-invasive body surface stimulation scheme eliminates the risks of bleeding, infection and the like caused by surgical implantation, and the universality of the device is improved.

Examples include a treatment system for providing disordered breathing therapy to a sleeping patient, the system comprising at least one first stimulation lead, at least one second stimulation lead, and an implanted therapy controller configured to couple to the leads and to provide at least one phrenic-nerve electrical stimulation to a phrenic nerve of a patient via the at least one first stimulation lead, provide at least one hypoglossal-nerve electrical stimulation to a hypoglossal nerve of the patient via the at least one second stimulation lead, and coordinate a relative timing of the electrical stimulation to the hypoglossal nerve with the electrical stimulation to the phrenic nerve of the patient.

A system and methods for stimulating two or more nerves to treat obstructive sleep apnea includes an implantable nerve stimulator (e.g., an implantable pulse generator) with a single current source for generating a time-multiplexed signal. The time-multiplexed signal includes first pulses defined interleaved with second pulses. The first and second pulses are defined by respective sets of pulse parameters stored in memory. The processor controls at least one switch to selectively steer each first pulse to a first nerve and each second pulse to a second nerve. In some examples, the first and second nerves are selected from a group of nerves consisting of the ansa cervicalis, the phrenic nerve, and the hypoglossal nerve.

Methods and systems of treating sleep disordered breathing in a patient suffering therefrom by activating one or more infrahyoid strap muscles are provided. Activation of one or more infrahyoid muscles can be accomplished by stimulating an ansa cervicalis, including one or both of the superior root and the inferior root of the ansa cervicalis, alone or in combination with stimulating the hypoglossal nerve.

Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied on the neck, in conjunction with one or more tiny injectable objects that concentrates the induced electric or magnetic field to the hypoglossal nerve and protects the user by limiting and charge-balancing the output. Additional and non-invasive neural stimulator systems apply alternating current at one skin electrode and receive oppositely rectified currents at two other skin electrodes.

The utility model relates to a tongue cap device for electrically stimulating hypoglossal nerve, include: external casing, it is configured to have inner chamber and the opening for the tongue department to extend into, internal casing, it is arranged in the inner chamber of external casing and is connected with external casing, so that internal casing will the inner chamber of external casing divide into the closed first accommodating cavity between external casing and internal casing and the second accommodating cavity for accommodating the tongue department, can pass through the opening and communicate with the outside, and stimulating circuit has the power, controller and electrode terminal that electrically connected with one another, the power and controller are arranged in the first accommodating cavity, and the electrode terminal is arranged on internal casing and is at least with its stimulating face exposed in the second accommodating cavity, wherein, internal casing is made at least partially by shape memory polymer, and is arranged in the first accommodating cavity with actuating device, and the actuating device can make internal casing change between the shrinkage state and the inflation state.