15 results about "Treatment sleep" patented technology

Described are compositions comprising a compound of formula I: in which R represents H, or optionally substituted C1-15 alkyl, C1-15 alkenyl or C1-15 alkynyl; or a pharmaceutically acceptable salt, solvate, metabolite, prodrug, bioisostere, or protected form thereof, for use in the treatment or prevention of a sleep disorder, together with methods of treating or preventing a sleep disorder in a subject or of treating or preventing a symptom or co-morbidity associated with a sleep disorder.

A system for administering medical procedures to patients is provided. [Solution] The system includes at least one of an energy delivery device, a long-term energy delivery device, and / or a power supply device. In particular, the system may be configured to treat and / or diagnose patients suffering from sleep apnea. Methods and apparatus for treating sleep apnea and other medical conditions are also provided.

This article provides a method for treating sleep disorders (e.g., narcolepsy) in subjects who require it by administering a composition containing a triple reuptake inhibitor to the subject.

A system for managing a sleep disorder of a subject is provided, the system comprising: a sensor assembly for detecting movement and / or the orientation of part or all of the body of the subject and / or movement of the subject during sleep; an emitter for stimulating the subject to change the orientation of their body; and a processor configured to: receive a signal from the sensor assembly, the signal comprising data relating to the orientation and / or movement of the subject; process the data received from the sensor assembly; and transmit a signal to the emitter to apply a stimulus to the subject to provoke the subject to alter the orientation of part or all of their body. The system may also comprise a sensor for detecting sounds emitted by the subject while sleeping. A method for managing a sleep disorder of a subject is also provided, the method comprising: i) sensing the position in which the subject is sleeping; ii) determining if the position is related to a sleep disorder; and iii) if the position is related to a sleep disorder, applying a stimulus to the subject to provoke the subject to change their sleeping position.

Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of (i) a norepinephrine reuptake inhibitor (NRI) and (ii) a non myorelaxing hypnotic and / or 5-HT2A inverse agonist or antagonist.

A Mandibular Advancement Device (MAD) is disclosed which is useful for the treatment of snoring and Obstructive Sleep Apnea (OSA). The improved MAD design comprises upper and lower splints which can be set at an advanced protrusive position (as desired for snoring / OSA therapy), but which also permits some degree of lateral mandibular movement. The amount of protrusive mandibular advancement is adjustable.

The present subject matter relates to a method of diagnosing and treating sleep apnea (SA) in a patient. The method may include determining whether the patient needs a polysomnography (PSG) by obtaining a biological sample from the patient to determine if the subject has a protein selected from the group consisting of B3GNT2, LDHA, and H6PD / G6PE. The expression of one of the proteins may be associated with the presence of SA in a patient. If the patient has a protein associated with the presence of SA, then the method includes conducting a Polysomnography (PSG) on the patient to further determine if the patient has SA. If the patient is further determined to have SA, the method may then include treating the patient with a treatment of SA selected from the group consisting of ENT multilevel surgery, continuous positive airway pressure (CPAP) therapy, and bariatric surgery.

An oral appliance and method for treating a sleep disorder in a subject is disclosed. The appliance includes, among other elements, a palate overlay element that engages a portion of the dorsal surface of the subject's tongue and stabilizes the tongue in an upward direction toward the hard palate. The method generally involves stabilizing the dorsal surface of the subject's tongue in an upward direction toward the subject's hard palate.

This invention discloses a device for precise detection and treatment of sleep apnea under continuous airflow support. This device can simultaneously perform precise identification and treatment of sleep apnea. It integrates precise detection of apnea and hypopnea events during sleep, accurately distinguishing between central and obstructive apnea events, and effectively treating obstructive sleep apnea and hypopnea. It generates a constant positive pressure airflow through a positive pressure airflow generating component consisting of a blower, pressure control assembly, and pressure airflow sensor. This positive pressure airflow is continuously input into an open-face mask equipped with a respiratory flow sensor, enabling the identification of sleep apnea-hypopnea events and the determination of the nature of the apnea. Continuously inputting positive pressure airflow into a nearly sealed nasal mask through the positive pressure airflow generating component can treat or adjust the pressure required for treating sleep apnea.

Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB). Also provided herein are methods of making the pharmaceutical compositions and formulations, and methods of their use for the treatment of sleep disorders such as apnea, sleep time disturbances, narcolepsy, cataplexy, sleep paralysis, hypnagogic hallucination, sleep arousal, insomnia, and nocturnal myoclonus.

This invention relates to a levotetrahydropalmatine citrate, its preparation method, and its applications, belonging to the field of pharmaceutical technology. This invention provides a levotetrahydropalmatine citrate. Studies have shown that compared to other salt forms, the citrate form of levotetrahydropalmatine significantly improves its solubility. Furthermore, research has confirmed that levotetrahydropalmatine citrate can significantly reduce drug relapse preferences, with efficacy comparable to or even better than the injectable form, without causing significant adverse reactions and exhibiting good safety. Simultaneously, the sedative effect of levotetrahydropalmatine citrate is far superior to other salt forms. In addition, levotetrahydropalmatine citrate has therapeutic effects on sleep disorders, effectively shortening sleep onset time, increasing sleep duration, and improving sleep quality. Therefore, the levotetrahydropalmatine citrate provided by this invention has broad application prospects in the preparation of drugs for sedation, analgesia, treatment of sleep disorders, and treatment of drug addiction.

An apparatus (100) for treating sleep apnea or other respiratory disorders is provided. The apparatus (100) includes an upper portion (101), a lower portion (102), and a middle portion (103). The upper portion (101) is configured to be placed on at least one tooth of the patient's upper jaw, while the lower portion (102) is configured to be placed on at least one tooth of the patient's lower jaw. The middle portion (103) is configured to connect the upper portion (101) and the lower portion (102) together when the upper portion (101) and the lower portion (102) are placed on the teeth of the patient's upper and lower jaws to maintain a fixed position of the upper and lower jaws. The apparatus (100) also includes at least one fastening member, such as dental floss, a nickel-titanium alloy wire, an elastic band, or the like. The fastening member is configured to engage at least one interdental space of each of the upper and lower jaws to fasten the upper portion (101) and the lower portion (102) to the teeth of the upper and lower jaws, respectively. Thus, the apparatus of the present invention provides an improved oral appliance for treating sleep apnea, particularly obstructive sleep apnea, which is capable of maintaining the upper and lower jaws of the patient in a fixed position to keep the airway unobstructed.

An eye mask system for providing respiratory pressure therapy (RPT) for treatment of sleep disordered breathing, comprising: an eye mask configured to cover the user's eyes in use; one or more transducers configured to influence the user's sleep and / or detect characteristics of the user or the user's sleep. The eye mask system may comprise: a connection port to receive a pressurised flow of air or a flow generator; the eye mask system may comprise a plenum chamber, a seal-forming structure to form a seal with a region of the user's face and a vent to allow flow of gases exhaled by the user to ambient. The eye mask system may operate in a non-treatment mode in which RPT is not provided to the user, and a treatment mode in which RPT is provided to the user.

The present technology is generally directed to methods for addressing a patient's sleep apnea. At least some of the methods can include one or more of percutaneously inserting an implantable signal delivery device at an insertion point on the patient's neck, moving the signal delivery device in a medial-to-lateral direction toward an ansa cervicalis nerve of the patient, and implanting the signal delivery device at a target location at least proximate to the ansa cervicalis nerve. The signal delivery device can include at least one electrode positioned to deliver a modulation signal to tissue at least proximate to the target location, such as a portion of the ansa cervicalis nerve. In some embodiments, delivery of the modulation signal can induce caudal traction in the patient and thereby address the patient's sleep apnea.