Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

73 results about "Nasal cavity" patented technology

The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The nasal septum divides the cavity into two fossae. Each fossa is the continuation of one of the two nostrils. The nasal cavity is the uppermost part of the respiratory system and provides the nasal passage for inhaled air from the nostrils to the nasopharynx and rest of the respiratory tract.

ENT instrument with deformable guide having translatable imaging feature

An apparatus includes a body, a shaft assembly, and a visualization assembly. The body includes first and second actuators. The shaft assembly extends distally from the body and includes a rigid proximal portion and a steerable distal portion. The steerable distal portion is positioned distally relative to the rigid proximal portion. The first actuator is operable to drive the steerable distal portion to deflect laterally relative to a longitudinal axis defined by the rigid proximal portion. The steerable distal portion is configured to fit within a nasal cavity of a patient. The visualization assembly is disposed within the shaft assembly. The visualization assembly includes a camera. The second actuator is operable to drive longitudinal translation of the visualization assembly relative to the shaft assembly.
Owner:ACCLARENT INC +1

Breath-synchronized extracorporeal phrenic nerve electrical stimulator

The present application relates to a kind of respiratory synchronous diaphragm nerve electric stimulator in vitro, belong to medical equipment technical field.The technical scheme of a kind of diaphragm nerve electric stimulation based on real-time breathing signal synchronization trigger is proposed for the problems of high weaning failure rate and quality of life decline caused by VIDD.The technical scheme points include: detecting inspiration negative pressure signal through nasal cavity air pressure sampling tube, control unit dynamically adjusts trigger threshold according to negative pressure signal, when negative pressure is lower than preset value and waveform slope meets the standard, trigger electric stimulation module to output biphasic pulse, pulse parameters include positive and negative alternating waveform, width 0.1ms to 1ms, frequency 10Hz to 50Hz and current intensity 5mA to 30mA, and strictly limit electric stimulation to be only output in inspiration cycle, and expiration cycle is completely blocked stimulation by hardware switch circuit.It is mainly suitable for intensive care and rehabilitation therapy scene, effectively prevent and treat VIDD, improve patient weaning success rate and quality of life.
Owner:GUANGZHOU XUELIANG BIOTECHNOLOGY DEVELOPING CO LTD +1

Nasal administration preparation for cerebral diseases as well as preparation method and application of nasal administration preparation

The invention provides a nasal delivery preparation for cerebral diseases as well as a preparation method and application of the nasal delivery preparation, and relates to the technical field of pharmaceutical preparations. The nasal delivery preparation for the cerebral diseases comprises gelatin derivative chitosan microspheres coated with stem cell exosomes, and the microspheres are prepared through the method that the stem cell exosomes are coated with gelatin derivatives of a specific structure and then cross-linked with chitosan. The gelatin derivative used in the invention has good surface activity, and can be well compatible with cells and active factors to form a stable inner core coating structure; meanwhile, the surface of the chitosan of which the outer layer is crosslinked with the gelatin derivative is positively charged and can be combined with anions in nasal mucus, so that the retention time of the microspheres in the nasal cavity can be effectively prolonged. Therefore, the nasal delivery preparation not only can slowly release the stem cell exosome, but also improves the absorption efficiency of the stem cell exosome by the nasal cavity, so that the stem cell exosome can reach the brain more effectively.
Owner:JILIN HUIRONG BIOTECHNOLOGY CO LTD

Anti-falling oxygen therapy nasal plug for senile disease cardiology heart failure patient

ActiveCN223601810URespiratorsNasal cavityNose
The utility model relates to the technical field of oxygen therapy nasal plugs, and discloses an anti-falling oxygen therapy nasal plug for senile cardiology heart failure patients, which comprises a connecting tube and a nasal plug tube, oxygen delivery tubes are mounted on two sides of the connecting tube, and branch tubes are arranged at the top ends of the oxygen delivery tubes. According to the anti-falling oxygen therapy nasal plug for the senile cardiology heart failure patient, the elastic hanging rope is arranged, the sliding sleeve slides outside the oxygen delivery pipe to adjust the position of the elastic hanging rope, and after the elastic hanging rope is adjusted to the proper position, the elastic hanging rope can be hung on the ear of the patient; the oxygen delivery pipe is limited to prevent the nasal plug pipe and the nose plug on the connecting pipe from accidentally falling off from the nasal cavity of a patient, the limiting sleeve is pulled to slide at the top end of the outer portion of the oxygen delivery pipe through the reserved groove, and therefore the oxygen delivery pipe can be further limited, and the problem that the nasal plug pipe and the nose plug are prone to falling off from the nasal cavity of the patient is solved. And hidden dangers are easy to increase.
Owner:JILIN PEOPLES HOSPITAL

Controllable endoscope for postoperative rehabilitation examination of nasopharyngeal carcinoma

The invention discloses a controllable endoscope for nasopharyngeal carcinoma postoperative rehabilitation examination, and belongs to the technical field of endoscopes, the controllable endoscope comprises an endoscopic examination tube, a lens bearing part, a lens part, a sealing assembly, a pushing assembly and an angle adjusting assembly.When the controllable endoscope is used, a sealing air pump inflates a transparent sealing air bag, the pushing air bag is in an uninflated state, and the angle adjusting assembly is used for adjusting the angle of the lens part; when the endoscopic examination tube is inserted into one end of a nasal cavity and reaches an operation part, the sealing air pump deflates the transparent sealing air bag, the pushing air pump inflates the pushing air bag, so that the end of the lens part moves out of the inner cavity through the opening, and then the deflection air bag part moves out of the inner cavity through the deflection air pump part under the action of the deflection air pump part. The deflection angle of the lens part is adjusted, so that multi-angle examination can be carried out on the surgical site and the periphery, a basis is provided for an examiner to accurately judge the rehabilitation condition, the operation convenience of the examiner is improved, the frequency of adjusting the position of the endoscope is reduced, and the discomfort of a patient and the possibility of secondary injury are reduced.
Owner:JIANGSU CANCER HOSPITAL

A user interface and system for supplying gases to an airway

A respiratory system for providing respiratory support to a patient, the system comprising: a nasal interface and a gas conduit for delivering a flow of gases to an outlet of the nasal interface, and a flow controller for selectively controlling the flow of gas into nasal interface, the flow controller configured to operate when a pressure in the system is above a predetermined value to restrict or prevent the flow of gas into the nasal interface from the gas conduit.
Owner:FISHER & PAYKEL HEALTHCARE LTD

Intelligent sleep instrument and sleep instrument control method

The present application relates to the technical field of sleep intervention, in particular to an intelligent sleep instrument and a sleep instrument control method, the system comprising a respiratory mutation recognition module, a slow wave initiation linkage module, a pharyngeal cavity contraction evaluation module, an intervention section positioning module and a delay trigger control module. In the present application, the extreme points densely appearing in the continuous cycle are accurately positioned as the key nodes of respiratory abnormalities through the identification of the mutation of nasal respiratory flow, and the slow wave initiation stage closely related to the respiratory mutation is screened out and marked as the linkage period in combination with the power curve change trend of the electroencephalogram signal. The pharyngeal cavity state is dynamically evaluated through the change of acoustic echo in the period, the intelligent postponement and delay processing of the intervention behavior are realized through the comparison of the trigger point of the intervention action and the boundary of the platform section, the accuracy of the sleep intervention timeliness and the adaptability of the intervention execution are improved, and the respiratory event control effect and the sleep continuity are significantly improved.
Owner:GUANGDONG IFEI HEALTH TECHNOLOGY CO LTD

Traditional Chinese medicine preparation for treating or improving chronic rhinitis

The invention provides a traditional Chinese medicine preparation for treating or improving chronic rhinitis, and relates to the field of traditional Chinese medicine pharmacy, and the traditional Chinese medicine preparation comprises patrinia, herba siegesbeckiae, Japanese metaplexis pericarp, oroxylum indicum, adenophora stricta, radix ophiopogonis, radix polygonati officinalis, rhizoma sparganii, fructus kochiae, schizonepeta, cortex dictamni, cortex lycii radicis and salvia chinensis. The traditional Chinese medicine preparation can effectively inhibit LPS-induced excessive inflammatory response of HNEpC, also can significantly reduce VAS score, SNOT-20 score and nasal endoscopic Lund-Kenne score of chronic rhinitis patients, effectively relieves core symptoms such as nasal obstruction, running nose and hypoolfaction, relieves negative effects of diseases on sleep, emotion and daily activities of the patients, relieves nasal mucosa edema, reduces abnormal secretions, and has a good treatment effect on chronic rhinitis. The repair of damaged mucosa is promoted, and the organic lesion of the nasal cavity is effectively improved. The traditional Chinese medicine preparation has high total clinical treatment rate, provides a better and safer new scheme for clinical treatment of chronic rhinitis, and has important clinical application value.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV

Air extraction device and nasal aspirator

An air extraction device and a nasal aspirator. The air extraction device includes a cylinder body and a variable-volume body. The cylinder body defines a cavity and a first air hole, and the first air hole is in communication with the cavity. The variable-volume body is arranged within the cavity. The variable-volume body is configured such that, through a change in a volume of the variable-volume body within the cavity from large to small, an air pressure within the cavity is reduced, for providing a suction force externally through the first air hole.
Owner:ZHONGSHAN XINGFU IND & TRADE CO LTD

Binding elastic head sleeve suitable for puncture intervention operation

ActiveCN223640774UTourniquetsNasal cavityPressure bandage
The utility model provides a binding elastic retaining cap suitable for puncture intervention post-operation, which relates to the technical field of post-operation binding tools and comprises a retaining cap body, a connecting band a connected to one end of the retaining cap body in a sewing manner, a connecting band b connected to the other end of the retaining cap body in a sewing manner and a fixing component arranged between the connecting band a and the retaining cap body and between the connecting band b and the retaining cap body. The fixing assembly is used for fixing, pressurizing and bandaging the head of a child patient and comprises an opening, a hook-and-loop fastener a and a hook-and-loop fastener b. The pressure bandaging position of the head of a child patient can be tightly wrapped through the head sleeve body, the head sleeve body is fixed to the head of the child patient through the fixing assembly, the good supporting and fixing effects can be achieved when pressure bandaging is needed for special parts such as ear backs, jaw backs and head tops, and the stability of the fixing mode of the head sleeve is good; the problems that an existing elastic bandage is prone to loosening and slipping, the nasal cavity of a child patient is prone to being blocked, breathing of the child patient is affected, and postoperative recovery of the child patient is affected are solved.
Owner:WUHAN CHILDRENS HOSPITAL

Traditional Chinese medicine composition and application thereof in preparation of medicine for treating obstructive sleep apnea hypopnea syndrome

The invention discloses a traditional Chinese medicine composition and application thereof in preparation of medicine for treating obstructive sleep apnea hypopnea syndrome, and the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 6 parts of rhizoma acori graminei, 6 parts of agastache rugosus, 6 parts of radix angelicae, 6 parts of bamboo shavings, 6 parts of ligusticum wallichii, 3 parts of mint and 1.5 parts of borneol. Research finds that the traditional Chinese medicine composition has the effects of inducing resuscitation, inducing resuscitation and resolving dampness with aromatics, can remarkably improve clinical symptoms (including fatigue, sleepiness, headache in the morning, awakening at night, dry mouth, amnesia, low emotion and the like) of OSAHS patients (especially moderate and severe patients), remarkably reduces the peripheral blood CRP level of the OSAHS patients (especially moderate and severe patients) and the CRP and IL-6 level in nasal cavity flushing fluid, and has the advantages of being free of toxic and side effects, free of toxic and side effects and the like. The inflammation reaction of the upper respiratory tract and the life quality of patients are improved. And a safe, effective, easy-to-implement and more easily accepted way for the improvement of OSAHS is provided.
Owner:丽水市中医院

A recombinant adenovirus vector tumor vaccine and a preparation method and application thereof

The application discloses a recombinant adenovirus vector tumor vaccine and a preparation method and application thereof, wherein the antigen coded by the recombinant adenovirus vector tumor vaccine comprises any one or a combination of more than two antigen peptide epitopes of KRAS protein. The recombinant adenovirus vector tumor vaccine of the application codes multiple KRAS tumor-specific antigen peptides, and has a good killing effect on KRAS mutation-driven tumors, especially lung tumors. The vaccine can be inhaled in a form of atomization, injected into muscles first and then inhaled in a form of atomization, inhaled in a form of atomization first and then injected into muscles, injected into muscles, or simultaneously injected into muscles and administered in a form of atomization. After atomization, the vaccine can be inhaled through a nasal cavity or an oral cavity to reach the lungs, generate an anti-tumor protective immune response on the respiratory tract, the lungs and the whole body, and enhance the utilization rate and the treatment effect of the vaccine.
Owner:BRITIE BIOTECH CO LTD

Chitosan-containing anti-allergic powder for nose and preparation method of chitosan-containing anti-allergic powder

The invention relates to chitosan-containing nasal anti-allergic powder and a preparation method thereof, belongs to the technical field of medicines, and solves the problem that a barrier film formed by an existing nasal anti-allergic product is relatively short in residence time in a nasal cavity. The nasal antiallergic powder is prepared from modified chitosan containing-NH3 < + >, carboxymethyl chitosan, a soothing agent and a preservative, the anti-allergic powder for the nose is prepared from the following components in parts by weight: 30 to 70 parts of modified chitosan containing-NH < 3 + >, 30 to 50 parts of carboxymethyl chitosan, 0.1 to 2 parts of a soothing agent and 0.0001 to 0.1 part of a preservative. The nasal antiallergic powder can stay in a nasal cavity for a long time, and can instantly expand to form a film when being in contact with the moist nasal cavity.
Owner:河南健康广济生物技术有限公司

Lacrimal passage indwelling administration wearable device and use method

The invention provides a lacrimal passage indwelling administration wearable device and a use method. The problems that in the field of ophthalmology medical treatment, an existing lacrimal passage indwelling medical device is low in medicine utilization rate, a lacrimal passage is prone to bonding, and administration pressure controllability is poor are solved. The lacrimal passage indwelling administration wearable equipment comprises a circulating flow pipeline, the circulating flow pipeline comprises a three-way pipe, an indwelling pipeline and a backflow pipeline, the three-way pipe comprises a first communicating pipe, a second communicating pipe and a third communicating pipe, one ends of the first communicating pipe, one end of the second communicating pipe and one end of the third communicating pipe are communicated, and the two ends of the backflow pipeline are connected with the first communicating pipe and the second communicating pipe correspondingly; the indwelling pipeline comprises a medicine slow-release pipe and a circulating pipe of which one ends are communicated with each other, and the other end of the medicine slow-release pipe is connected with the third communicating pipe; the third communicating pipe is arranged in the lacrimal ductule of the patient, the medicine slow-release pipe is arranged in the lacrimal sac, and the other end of the circulating pipe penetrates out of the body from the nasal meatus of the patient and is connected into the backflow pipeline to form a medicine flowing loop; the invention discloses a head-mounted support and a drug delivery assembly arranged on the head-mounted support.
Owner:SHANGHAI EYE DISEASE PREVENTION & TREATMENT CENTER +1

Positive-pressure electric spray nasal irrigator

The invention relates to the technical field of spray nasal irrigators, in particular to a positive-pressure electric spray nasal irrigator, which comprises a main machine part, a positive-pressure pump, a negative-pressure pump, a negative-pressure pump, a negative-pressure pump, a positive-pressure pump and a negative-pressure pump, a nose head part and a limiting nest arranged on the nose head part are included, a spray head is rotationally installed in the limiting nest in a limited mode, a central atomization cavity is formed in the spray head, part of the outer wall of the spray head is exposed out of the limiting nest, the spray head is associated with a positive pressure pump, and an atomization module is installed in the central atomization cavity. Radial atomizing holes communicated with the outside are formed in the inner wall of the central atomizing cavity so as to spray functional fog drops to a cleaning area in the nasal cavity; before spray impact, pre-tightening lifting stress can be generated on viscous secretions, the viscous secretions are loosened, the adhesive force between the viscous secretions and mucous membranes is weakened, spray flushing is facilitated, and falling objects and waste liquid wrapped by fog drops can be captured from the periphery and recycled and collected.
Owner:TAIZHOU TONG WEI SHI EYE HEALTH TECH CO LTD

Fluorescent visual tracheal intubation method and related equipment

The invention discloses a fluorescent visual tracheal intubation method and related equipment, and relates to the field of medical nursing, the method comprises the following steps: spraying or injecting a fluorescent dye into the trachea of a patient to enable the fluorescent dye to cover the trachea opening area; a flexible fluorescent bronchoscope with an exciting light source is adopted to enter an oral cavity or a nasal cavity, and near-infrared exciting light is emitted to excite a fluorescent dye to generate a fluorescent signal; the method comprises the following steps: acquiring a common light image and a fluorescence image, and transmitting the common light image and the fluorescence image to terminal equipment; the terminal device processes the common light image and the fluorescence image, and identifies the position of the trachea opening with enhanced fluorescence based on the processed common light image and fluorescence image; according to the tracheal opening position, an operator is guided or a flexible bronchoscope is driven to complete tracheal intubation, and the tracheal catheter is placed into the trachea of a patient. The trachea opening can be positioned more stably, reliably and efficiently in a complex airway environment, the success rate of trachea intubation is remarkably increased, and complications are reduced.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Method for evaluating aroma component and method for preparing fragrance composition

PCT designated stageWO2025263532A1ConfectionerySweetmeatsBiotechnologyNasal cavity
According to the present invention, the effects of an aroma component contained in a food and discharged from the nose through the posterior nasal cavity when the food is eaten on the flavor of the food are evaluated by taking the actual eating environment into account, and a fragrance composition in which the expression of retronasal aroma is controlled and which is suitable for products is provided. The effects of an aroma component contained in a food on the flavor of the food are evaluated by: (1) measuring changes in concentration of the aroma component over time, the changes varying in accordance with the breathing cycle; (2) dividing the whole eating time into arbitrary time intervals, and calculating, with respect to each interval, a peak top average concentration, which is the average value of concentrations at peak tops included in each interval; and (3) setting an arbitrary ratio with respect to the maximum value of the peak top average concentrations as a reference concentration of the aroma component, and defining, as an index (Tonset), the interval where the reference concentration is exceeded for the first time since the start of eating. On the basis of the obtained evaluation result, the blending ratio of aroma components contained in the food is adjusted to prepare a fragrance composition.
Owner:TAKASAGO INTERNATIONAL CORP

Nasal soft mist delivery device, method and use

ActiveCN119158124BSenses disorderNervous disorderNasal cavityPreservative free
The application discloses a nasal cavity soft mist drug delivery device, method and application, relates to the technical field of drug delivery, and comprises a drug delivery main body and a spray adapter. The method comprises the following steps: assembling the drug delivery main body and the spray adapter; placing or inverting the assembled device, and inserting the top end of the spray adapter into the nasal cavity; and extruding the cavity filled with air of the drug delivery main body, so that the drug generates soft mist through a micropore chip built in the spray adapter, and the soft mist enters the nasal cavity to deliver the drug. The nasal cavity soft mist drug delivery device can be applied to rhinitis, allergy, vomiting and central nervous system related indications. The single-dose sterile solution or suspension liquid without preservatives produced through blowing, filling and sealing can be efficiently and rapidly atomized into slow-moving soft mist, the atomized liquid droplets are small in size and uniform in distribution, and can be diffused and deposited in all intranasal regions.
Owner:LEXENPHARM (SUZHOU) LTD

Sinus and nasal stent

PCT designated stageWO2025199445A1StentsNose implantsNasal cavityBiomedical engineering
A nasal stent includes an elongated tubular body having proximal and distal ends extending along a longitudinal axis. The elongated body includes a repeating pattern of W-shaped members extending around the tubular body separated by longitudinally-oriented and offset struts. The elongated tubular body is selectively transitionable between an expanded configuration and a crimped configuration, wherein the pattern of W-shaped members and struts interleave allowing the elongated tubular body to maintain substantially the same length when disposed in the expanded configuration and the crimped configuration.
Owner:INTERSECT ENT INC

A nasopharyngeal tumor radiotherapy flushing device

ActiveCN224540583UNasal cavityNasopharyngeal tumors
The utility model provides a nasopharyngeal tumor radiotherapy flushing device belongs to medical instrument technical field. Including liquid storage bottle, the two sides of liquid storage bottle are equipped with the holding area, the bottom fixed connection of liquid storage bottle has the connecting pipe, the top of liquid storage bottle is connected with the flushing pipe threadedly, adjusting assembly, adjusting assembly is used for changing the area of liquid medicine flushing, adjusting assembly is connected with the flushing pipe, prevent backflow assembly, prevent backflow assembly is used for preventing the water backflow after flushing, prevent backflow assembly is connected with liquid storage bottle, can change the flushing area through setting adjusting assembly, utilize the initial state of shower nozzle to carry out the flushing in the inside of nasal cavity, through the rotation sealing sleeve, the shower nozzle extends upward, and the spout opens, realizes the overall flushing to the four around of nasal cavity, ensures that there is no flushing dead angle. When encountering blood scab and other difficult cleaning material, still can pass through the reverse rotation sealing sleeve, enhances the water pressure of shower nozzle port, promotes the cleaning effect.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY

Lacrimal passage indwelling administration wearable device and use method

The application provides a tear duct indwelling drug delivery wearable device and a use method, and solves the problems of low drug utilization rate, easy tear duct adhesion and poor controllability of drug delivery pressure of existing tear duct indwelling medical devices in the field of ophthalmology; wherein the tear duct indwelling drug delivery wearable device comprises: a circulating flow pipeline, the circulating flow pipeline comprises a three-way pipe, an indwelling pipeline and a backflow pipeline, the three-way pipe comprises a first communication pipe, a second communication pipe and a third communication pipe which are in communication with each other at one end, the backflow pipeline is connected with the first communication pipe and the second communication pipe at two ends, the indwelling pipeline comprises a drug slow-release pipe and a circulating pipe which are in communication with each other at one end, the other end of the drug slow-release pipe is connected with the third communication pipe; the third communication pipe is arranged in the lacrimal canaliculus of a patient, the drug slow-release pipe is arranged in the lacrimal sac, the other end of the circulating pipe is connected with the backflow pipeline outside the body from the nasal cavity of the patient, and a drug flow loop is formed; a head-mounted support and a drug delivery assembly arranged on the head-mounted support.
Owner:SHANGHAI EYE DISEASE PREVENTION & TREATMENT CENTER +1

Disposable nasopharyngeal airway

ActiveCN223874226UTracheal tubesNasal cavityNasopharyngeal airway
The utility model relates to the technical field of medical instruments, and discloses a disposable nasopharyngeal airway which comprises an airway body, a first air vent is arranged at the left end of the airway body, a second air vent is arranged at the right end of the airway body, and a soft rubber block is arranged on the outer wall of the left end of the airway body. According to the nasopharyngeal airway, one end of the first ventilation opening of the airway body is inserted into the nasal cavity of a patient, the nose wing of the patient can be clamped between the connecting rod and the airway body, the effect of stably fixing the nasopharyngeal airway is achieved, the soft rubber block is arranged at the first ventilation opening, the discomfort of the patient is reduced, and the situation that the patient moves randomly is avoided; the discomfort of the patient is reduced, and the comfort of the patient is enhanced.
Owner:HANGZHOU TRIFANZ MEDICAL DEVICE CO LTD

Nasopharyngeal adenoid collector

The invention discloses a nasopharyngeal adenoid collector. The nasopharyngeal adenoid collector comprises an inner-layer sampling structure, a middle-layer sampling structure and an outer-layer protection structure. The inner-layer sampling structure comprises a metal wire, a base and a brush sampling head. The middle-layer sampling structure comprises a metal tube, a middle-layer tube seat and a net bag sampling structure. And the outer-layer protection structure comprises an outer-layer tube seat and a sheath tube. In a use state, the middle-layer tube seat is rotated to be clamped on the outer-layer tube seat, the driving structure arranged between the middle-layer tube seat and the outer-layer tube seat is extruded by pressing the base, so that the brush sampling head and the net bag sampling structure are popped up, and the base is rotated to be clamped on the outer-layer tube seat. The base is rotated, so that the brush sampling head and the net bag sampling structure are used for sampling. According to the embodiment, the sampling steps can be simplified, the sampling time is shortened, the situation that the sample is polluted in the nasal cavity and the sample is polluted in the air is reduced, and the user experience feeling is improved.
Owner:BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

PF4 mRNA delivery system administered via nasal cavity, its preparation method and application

This invention discloses a nasal delivery system for PF4 mRNA, comprising mesenchymal stem cell exosomes encapsulating PF4 mRNA and pharmaceutically acceptable excipients, wherein the nucleotide sequence of the PF4 mRNA is shown in SEQ NO:1. This invention utilizes MSC-Exo to deliver PF4 mRNA via nasal administration. Thus, the MSC-Exo encapsulating PF4 mRNA can bypass the BBB and efficiently enter the brain through the olfactory bulb. Furthermore, PF4 mRNA and MSC-Exo can exert a synergistic effect, significantly reducing Aβ-induced inflammatory responses and improving cognitive function in AD mice. The nasal delivery system for PF4 mRNA provided by this invention can be used to prepare drugs for treating neurodegenerative diseases, preferably, for preparing drugs for treating Alzheimer's disease.
Owner:ZHUJIANG HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY

Gel for nasal allergy and preparation method thereof

The invention relates to the technical field of gels, in particular to a gel for nasal cavity allergy and a preparation method thereof.The gel for nasal cavity allergy is prepared from, by weight, 15-20 parts of temperature-sensitive matrix; 1.5 to 3.0 parts of aldehyde cellulose / chitosan composite fiber; 0.5 to 1.0 part of a non-ionic surface active agent; 4.5 to 5.5 parts of glycerol; 0.1 to 0.2 part of disodium ethylene diamine tetraacetate; 0.1 to 0.3 part of p-hydroxyacetophenone; 2.0 to 3.0 parts of trehalose; and 60-80 parts of water. According to the application, the particularity of the nasal cavity is combined, the formyl cellulose / chitosan composite fiber is introduced into the system, a main body system with the temperature-sensitive matrix as a continuous phase and the formyl cellulose / chitosan composite fiber reinforced phase is formed, a physical network is formed to intercept cilia swing and reduce the removal rate, and the adhesive strength of the gel is enhanced through chemical combination; therefore, the residence time is prolonged through physical and chemical dual effects.
Owner:JIANGSU ASPIDISTRA ELATIOR BLUME BIO-MEDICAL TECH CO LTD

Straight barrel type spiral negative pressure pipe

The utility model relates to the technical field of negative pressure tubes, in particular to a straight barrel type spiral negative pressure tube which comprises a drainage tube, a thin catheter, a tube cap and a negative pressure permeation tube. A thin catheter is connected to the inner wall of the drainage tube in a penetrating mode, the thin catheter abuts against the outer side of the drainage tube, the end of the thin catheter is connected with a tube cap through a pull rope, the drainage tube and the thin catheter are sleeved with a negative pressure permeation tube, and the negative pressure permeation tube is connected to the outer side of the drainage tube and the outer side of the thin catheter through a suture. A flow guide groove is formed in the inner wall of the negative pressure permeation tube, and a conveying mechanism is connected to the interior of the drainage tube. According to the straight barrel type spiral negative pressure tube, wound seepage and nasal cavity secretions on the inner wall of the esophagus are filtered through the seepage tube, the filtered wound seepage and nasal cavity secretions flow along the flow guide groove and are sucked into the drainage tube 1 from the end of the drainage tube, the driving motor is started to drive the soft packing auger to rotate, large impurities are discharged out of the drainage tube, and the drainage tube is used for drainage. And therefore, the straight barrel type spiral negative pressure pipe is capable of discharging liquid and preventing blockage.
Owner:GUANGZHOU MAILPAI TECHNOLOGY CO LTD

Anastomosis tube for dacryocystorhinostomy

ActiveCN115068205BEye surgeryNasal cavityLacrimal sac mucosa
The application provides an anastomotic orifice shaping tube for dacryocystorhinostomy, which comprises a lacrimal passage guide tube and an inflatable support sleeve, one end of the lacrimal passage guide tube is fixedly connected with a probe, the other end is provided with a lacrimal point fixing plug which is detachably connected, a positioning point and a fissure are arranged in the middle of the lacrimal passage guide tube, the fissure is arranged between the positioning point and the lacrimal point fixing plug, the inflatable support sleeve comprises a hollow main shaft and an inflatable layer which is wrapped on the shaft surface of the hollow main shaft, and the lacrimal passage guide tube penetrates through the hollow main shaft in the use state; the anastomotic orifice shaping tube can be fixed to the anastomotic orifice and conveniently taken out, can provide sufficient support for the anastomotic orifice, and can be micro-plastic shaped according to the shape of the anastomotic orifice to make the lacrimal sac mucosa and the nasal mucosa produce sufficient contact, which is beneficial to incision healing and anastomotic orifice formation.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Methods and apparatus for high gas flow

Several methods of supporting respiratory function of a patient before, during and / or after a medical procedure are disclosed. In certain arrangements, supporting respiratory function while a patient is under general anaesthesia can include providing a high gas flow a high gas flow that is greater than 15 L / min while the patient is under general anaesthesia. In certain arrangements, a method of providing ventilation while a patient is under general anaesthesia involves providing only a gas flow delivered through a nasal interface that is greater than 15 L / min while the patient is under general anaesthesia.
Owner:FISHER & PAYKEL HEALTHCARE LTD