37 results about "Nasal cavity" patented technology

The invention describes a method including the administration of a pharmaceutical composition. The administration includes dispensing a pharmaceutical filler composition comprising an active agent from a soft gel capsule into a patient's nasal cavity for nasal absorption or into the patient's oral cavity for pregastric absorption.

The invention discloses a controllable endoscope for nasopharyngeal carcinoma postoperative rehabilitation examination, and belongs to the technical field of endoscopes, the controllable endoscope comprises an endoscopic examination tube, a lens bearing part, a lens part, a sealing assembly, a pushing assembly and an angle adjusting assembly.When the controllable endoscope is used, a sealing air pump inflates a transparent sealing air bag, the pushing air bag is in an uninflated state, and the angle adjusting assembly is used for adjusting the angle of the lens part; when the endoscopic examination tube is inserted into one end of a nasal cavity and reaches an operation part, the sealing air pump deflates the transparent sealing air bag, the pushing air pump inflates the pushing air bag, so that the end of the lens part moves out of the inner cavity through the opening, and then the deflection air bag part moves out of the inner cavity through the deflection air pump part under the action of the deflection air pump part. The deflection angle of the lens part is adjusted, so that multi-angle examination can be carried out on the surgical site and the periphery, a basis is provided for an examiner to accurately judge the rehabilitation condition, the operation convenience of the examiner is improved, the frequency of adjusting the position of the endoscope is reduced, and the discomfort of a patient and the possibility of secondary injury are reduced.

A respiratory system for providing respiratory support to a patient, the system comprising: a nasal interface and a gas conduit for delivering a flow of gases to an outlet of the nasal interface, and a flow controller for selectively controlling the flow of gas into nasal interface, the flow controller configured to operate when a pressure in the system is above a predetermined value to restrict or prevent the flow of gas into the nasal interface from the gas conduit.

The present application relates to the technical field of sleep intervention, in particular to an intelligent sleep instrument and a sleep instrument control method, the system comprising a respiratory mutation recognition module, a slow wave initiation linkage module, a pharyngeal cavity contraction evaluation module, an intervention section positioning module and a delay trigger control module. In the present application, the extreme points densely appearing in the continuous cycle are accurately positioned as the key nodes of respiratory abnormalities through the identification of the mutation of nasal respiratory flow, and the slow wave initiation stage closely related to the respiratory mutation is screened out and marked as the linkage period in combination with the power curve change trend of the electroencephalogram signal. The pharyngeal cavity state is dynamically evaluated through the change of acoustic echo in the period, the intelligent postponement and delay processing of the intervention behavior are realized through the comparison of the trigger point of the intervention action and the boundary of the platform section, the accuracy of the sleep intervention timeliness and the adaptability of the intervention execution are improved, and the respiratory event control effect and the sleep continuity are significantly improved.

The invention provides a traditional Chinese medicine preparation for treating or improving chronic rhinitis, and relates to the field of traditional Chinese medicine pharmacy, and the traditional Chinese medicine preparation comprises patrinia, herba siegesbeckiae, Japanese metaplexis pericarp, oroxylum indicum, adenophora stricta, radix ophiopogonis, radix polygonati officinalis, rhizoma sparganii, fructus kochiae, schizonepeta, cortex dictamni, cortex lycii radicis and salvia chinensis. The traditional Chinese medicine preparation can effectively inhibit LPS-induced excessive inflammatory response of HNEpC, also can significantly reduce VAS score, SNOT-20 score and nasal endoscopic Lund-Kenne score of chronic rhinitis patients, effectively relieves core symptoms such as nasal obstruction, running nose and hypoolfaction, relieves negative effects of diseases on sleep, emotion and daily activities of the patients, relieves nasal mucosa edema, reduces abnormal secretions, and has a good treatment effect on chronic rhinitis. The repair of damaged mucosa is promoted, and the organic lesion of the nasal cavity is effectively improved. The traditional Chinese medicine preparation has high total clinical treatment rate, provides a better and safer new scheme for clinical treatment of chronic rhinitis, and has important clinical application value.

An air extraction device and a nasal aspirator. The air extraction device includes a cylinder body and a variable-volume body. The cylinder body defines a cavity and a first air hole, and the first air hole is in communication with the cavity. The variable-volume body is arranged within the cavity. The variable-volume body is configured such that, through a change in a volume of the variable-volume body within the cavity from large to small, an air pressure within the cavity is reduced, for providing a suction force externally through the first air hole.

Described herein are devices, systems, and methods for applying a tension force to various tissues. The devices may be delivered in a minimally invasive fashion and used to manipulate tissues in the nose (e.g., nasal septum, nasal turbinates), ear, and throat. Force may be maintained by the devices for a time period that allows shaping, compression, and / or approximation of tissues.

The application discloses a recombinant adenovirus vector tumor vaccine and a preparation method and application thereof, wherein the antigen coded by the recombinant adenovirus vector tumor vaccine comprises any one or a combination of more than two antigen peptide epitopes of KRAS protein. The recombinant adenovirus vector tumor vaccine of the application codes multiple KRAS tumor-specific antigen peptides, and has a good killing effect on KRAS mutation-driven tumors, especially lung tumors. The vaccine can be inhaled in a form of atomization, injected into muscles first and then inhaled in a form of atomization, inhaled in a form of atomization first and then injected into muscles, injected into muscles, or simultaneously injected into muscles and administered in a form of atomization. After atomization, the vaccine can be inhaled through a nasal cavity or an oral cavity to reach the lungs, generate an anti-tumor protective immune response on the respiratory tract, the lungs and the whole body, and enhance the utilization rate and the treatment effect of the vaccine.

The invention relates to the technical field of spray nasal irrigators, in particular to a positive-pressure electric spray nasal irrigator, which comprises a main machine part, a positive-pressure pump, a negative-pressure pump, a negative-pressure pump, a negative-pressure pump, a positive-pressure pump and a negative-pressure pump, a nose head part and a limiting nest arranged on the nose head part are included, a spray head is rotationally installed in the limiting nest in a limited mode, a central atomization cavity is formed in the spray head, part of the outer wall of the spray head is exposed out of the limiting nest, the spray head is associated with a positive pressure pump, and an atomization module is installed in the central atomization cavity. Radial atomizing holes communicated with the outside are formed in the inner wall of the central atomizing cavity so as to spray functional fog drops to a cleaning area in the nasal cavity; before spray impact, pre-tightening lifting stress can be generated on viscous secretions, the viscous secretions are loosened, the adhesive force between the viscous secretions and mucous membranes is weakened, spray flushing is facilitated, and falling objects and waste liquid wrapped by fog drops can be captured from the periphery and recycled and collected.

The invention discloses a fluorescent visual tracheal intubation method and related equipment, and relates to the field of medical nursing, the method comprises the following steps: spraying or injecting a fluorescent dye into the trachea of a patient to enable the fluorescent dye to cover the trachea opening area; a flexible fluorescent bronchoscope with an exciting light source is adopted to enter an oral cavity or a nasal cavity, and near-infrared exciting light is emitted to excite a fluorescent dye to generate a fluorescent signal; the method comprises the following steps: acquiring a common light image and a fluorescence image, and transmitting the common light image and the fluorescence image to terminal equipment; the terminal device processes the common light image and the fluorescence image, and identifies the position of the trachea opening with enhanced fluorescence based on the processed common light image and fluorescence image; according to the tracheal opening position, an operator is guided or a flexible bronchoscope is driven to complete tracheal intubation, and the tracheal catheter is placed into the trachea of a patient. The trachea opening can be positioned more stably, reliably and efficiently in a complex airway environment, the success rate of trachea intubation is remarkably increased, and complications are reduced.

The utility model provides a nasopharyngeal tumor radiotherapy flushing device belongs to medical instrument technical field. Including liquid storage bottle, the two sides of liquid storage bottle are equipped with the holding area, the bottom fixed connection of liquid storage bottle has the connecting pipe, the top of liquid storage bottle is connected with the flushing pipe threadedly, adjusting assembly, adjusting assembly is used for changing the area of liquid medicine flushing, adjusting assembly is connected with the flushing pipe, prevent backflow assembly, prevent backflow assembly is used for preventing the water backflow after flushing, prevent backflow assembly is connected with liquid storage bottle, can change the flushing area through setting adjusting assembly, utilize the initial state of shower nozzle to carry out the flushing in the inside of nasal cavity, through the rotation sealing sleeve, the shower nozzle extends upward, and the spout opens, realizes the overall flushing to the four around of nasal cavity, ensures that there is no flushing dead angle. When encountering blood scab and other difficult cleaning material, still can pass through the reverse rotation sealing sleeve, enhances the water pressure of shower nozzle port, promotes the cleaning effect.

The application provides a tear duct indwelling drug delivery wearable device and a use method, and solves the problems of low drug utilization rate, easy tear duct adhesion and poor controllability of drug delivery pressure of existing tear duct indwelling medical devices in the field of ophthalmology; wherein the tear duct indwelling drug delivery wearable device comprises: a circulating flow pipeline, the circulating flow pipeline comprises a three-way pipe, an indwelling pipeline and a backflow pipeline, the three-way pipe comprises a first communication pipe, a second communication pipe and a third communication pipe which are in communication with each other at one end, the backflow pipeline is connected with the first communication pipe and the second communication pipe at two ends, the indwelling pipeline comprises a drug slow-release pipe and a circulating pipe which are in communication with each other at one end, the other end of the drug slow-release pipe is connected with the third communication pipe; the third communication pipe is arranged in the lacrimal canaliculus of a patient, the drug slow-release pipe is arranged in the lacrimal sac, the other end of the circulating pipe is connected with the backflow pipeline outside the body from the nasal cavity of the patient, and a drug flow loop is formed; a head-mounted support and a drug delivery assembly arranged on the head-mounted support.

The utility model relates to the technical field of medical instruments, and discloses a disposable nasopharyngeal airway which comprises an airway body, a first air vent is arranged at the left end of the airway body, a second air vent is arranged at the right end of the airway body, and a soft rubber block is arranged on the outer wall of the left end of the airway body. According to the nasopharyngeal airway, one end of the first ventilation opening of the airway body is inserted into the nasal cavity of a patient, the nose wing of the patient can be clamped between the connecting rod and the airway body, the effect of stably fixing the nasopharyngeal airway is achieved, the soft rubber block is arranged at the first ventilation opening, the discomfort of the patient is reduced, and the situation that the patient moves randomly is avoided; the discomfort of the patient is reduced, and the comfort of the patient is enhanced.

This invention discloses a nasal delivery system for PF4 mRNA, comprising mesenchymal stem cell exosomes encapsulating PF4 mRNA and pharmaceutically acceptable excipients, wherein the nucleotide sequence of the PF4 mRNA is shown in SEQ NO:1. This invention utilizes MSC-Exo to deliver PF4 mRNA via nasal administration. Thus, the MSC-Exo encapsulating PF4 mRNA can bypass the BBB and efficiently enter the brain through the olfactory bulb. Furthermore, PF4 mRNA and MSC-Exo can exert a synergistic effect, significantly reducing Aβ-induced inflammatory responses and improving cognitive function in AD mice. The nasal delivery system for PF4 mRNA provided by this invention can be used to prepare drugs for treating neurodegenerative diseases, preferably, for preparing drugs for treating Alzheimer's disease.

The utility model relates to the technical field of negative pressure tubes, in particular to a straight barrel type spiral negative pressure tube which comprises a drainage tube, a thin catheter, a tube cap and a negative pressure permeation tube. A thin catheter is connected to the inner wall of the drainage tube in a penetrating mode, the thin catheter abuts against the outer side of the drainage tube, the end of the thin catheter is connected with a tube cap through a pull rope, the drainage tube and the thin catheter are sleeved with a negative pressure permeation tube, and the negative pressure permeation tube is connected to the outer side of the drainage tube and the outer side of the thin catheter through a suture. A flow guide groove is formed in the inner wall of the negative pressure permeation tube, and a conveying mechanism is connected to the interior of the drainage tube. According to the straight barrel type spiral negative pressure tube, wound seepage and nasal cavity secretions on the inner wall of the esophagus are filtered through the seepage tube, the filtered wound seepage and nasal cavity secretions flow along the flow guide groove and are sucked into the drainage tube 1 from the end of the drainage tube, the driving motor is started to drive the soft packing auger to rotate, large impurities are discharged out of the drainage tube, and the drainage tube is used for drainage. And therefore, the straight barrel type spiral negative pressure pipe is capable of discharging liquid and preventing blockage.

Several methods of supporting respiratory function of a patient before, during and / or after a medical procedure are disclosed. In certain arrangements, supporting respiratory function while a patient is under general anaesthesia can include providing a high gas flow a high gas flow that is greater than 15 L / min while the patient is under general anaesthesia. In certain arrangements, a method of providing ventilation while a patient is under general anaesthesia involves providing only a gas flow delivered through a nasal interface that is greater than 15 L / min while the patient is under general anaesthesia.

The invention discloses a traditional Chinese medicine composition for treating children adenoid hypertrophy, a pharmaceutical preparation and application, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating children adenoid hypertrophy comprises the following components in parts by weight: 10-20 parts of centipeda minima, 8-15 parts of magnolia flower, 8-15 parts of scutellaria baicalensis, 3-8 parts of radix angelicae, 8-15 parts of paris polyphylla, 8-15 parts of selfheal, 8-15 parts of astragalus membranaceus, 2-5 parts of pseudo-ginseng and 5-15 parts of mussel extract. According to the invention, the traditional Chinese medicine composition and the mussel extract which are ingeniously compatible are creatively combined to prepare the novel preparation for treating the child adenoid hypertrophy, the preparation can be applied in a dripping or gently smearing manner, and the medicine is tightly attached to the nasal cavity and nasopharynx mucosa by utilizing the strong adhesion of the mussel extract, so that the effect of treating the child adenoid hypertrophy is achieved. A long-acting medicine protection film is formed, and the treatment effect is continuously achieved.

The invention discloses a non-craniotomy implanted double-coil targeted brain stimulation device and method, and belongs to the technical field of nerve regulation and control, and the device comprises magnetoelectric particles which are used for generating local current stimulation to a target brain region under the action of an alternating magnetic field; the non-craniotomy implantation assembly is used for conveying the magnetoelectric particles to a target brain area through an endovascular intervention path or a nasal cavity-brain path; the focusing magnetic stimulation device is used for generating an external magnetic field excitation source and providing an alternating magnetic field for the magnetoelectric particles; the image navigation and positioning module is used for positioning the focusing center of the alternating magnetic field to the center of a target brain region, and the focusing center corresponds to the position where the magnetoelectric particles are conveyed; and the magnetic stimulation control module is used for adjusting stimulation parameters of the focusing magnetic stimulation device so as to regulate and control the alternating magnetic field to generate local induction current stimulation in the target brain area through the magnetoelectric particles. The method is used for brain stimulation based on the device. The problem that it is difficult to accurately stimulate the deep brain area without craniotomy is solved.

This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. An implant is configured to fit inside of the middle meatus of a human nasal cavity. The implant includes a therapeutic-agent formulation containing a layer of over 2000 micrograms of mometasone furoate. The implant releases the mometasone furoate for more than 12 weeks. A second implant can also be provided configured to fit inside the middle meatus. The second implant also includes a therapeutic-agent formulation containing a layer of over 2000 micrograms of mometasone furoate, and releases the mometasone furoate for more than 12 weeks.

The present application relates to a kind of recombinant adenovirus vector vaccine inhalation delivery system, the delivery system is by the modification of adenovirus vector itself and cooperate specific formulation prescription, vaccine is inhaled after inhalation administration, can reach lung by nasal cavity or oral inhalation, to generate protective immune response including mucosal immunity, while solving adenovirus pre-existing immunity, enhance the effective utilization rate of vaccine, improve the effect of vaccine.

Described herein are devices, systems, and methods for applying a tension force to various tissues. The devices may be delivered in a minimally invasive fashion and used to manipulate tissues in the nose (e.g., nasal septum, nasal turbinates), ear, and throat. Force may be maintained by the devices for a time period that allows shaping, compression, and / or approximation of tissues.

The utility model discloses an oxygen control valve structure and relates to the technical field of oxygen control valves. An oxygen control valve structure comprises a valve ring provided with a gas inlet end pipe, a first gas outlet end pipe and a second gas outlet end pipe. The mounting cavity is formed in the middle of the valve ring; the ring cover is provided with a fixing block, and the ring cover is rotationally mounted in the mounting cavity; the arc-shaped pipe groove is formed in the periphery of the ring cover; the proportion of the ring cover occupying the device is large, and the button plate is long, so that a user can easily adjust the opening and closing of the first air outlet end pipe and the second air outlet end pipe during adjustment; besides, a connecting plate arranged in the arc-shaped pipe groove can scatter the oxygen passing through the arc-shaped pipe groove, and after the oxygen is scatted, the oxygen and the air are mixed more uniformly, so that the utilization rate of the oxygen is increased, and the oxygen uptake effect is better; secondly, the scattered oxygen flows more softly, the discomfort caused by the fact that the oxygen directly impacts the nasal cavity or the respiratory tract is reduced, and the comfort level of oxygen inhalation experience is improved.

The invention discloses a multi-balloon imbedded nasopharyngeal tamponade device, which comprises a tamponade body, the tamponade body comprises a flexible outer layer and a support catheter, the support catheter extends along the axial direction, and the flexible outer layer wraps the support catheter; the ends, facing the filling body, of the air bag units extend to form inflation openings, and the multiple air bag units are arranged between the flexible outer layer and the supporting catheter and distributed in the circumferential direction; the air inflation assembly is arranged at one end of the filling body and communicates with the air inflation opening, and the air inflation assembly can be used for independently inflating each air bag unit; a breathing channel is formed in the packing body and penetrates through the flexible outer layer and the supporting catheter. The technical scheme can adapt to the irregular nasopharyngeal cavity form, multi-point independent pressure regulation and control are provided to achieve uniform compression hemostasis, and meanwhile smooth ventilation of the nasal cavity is guaranteed.

A device and method for increasing infection resistance in a patient includes providing to the patient an intraoral vibration device having a mouthpiece for contacting the an oral cavity of the patient, wherein the intraoral vibration device has a frequency tuned to stimulate production of nasal nitric oxide (NO). Instructions are provided for using the intraoral vibration device by placing the mouthpiece over at least one portion of the oral cavity, and applying a vibratory force at the frequency to stimulate production of nasal NO.

The invention discloses a cow early pregnancy monitoring device, which comprises a main control module, a body module and an acquisition module, the cow early pregnancy monitoring device is a wearable device, the acquisition module comprises two symmetrical sensor probes, and the sensor probes are arranged to be arranged at the opening of the nasal cavity of a cow and are used for acquiring body temperature information from the diaphragm of the nasal cavity of the cow; the acquisition module is connected to the machine body module, and a main control module is arranged on the machine body module and used for transmitting information acquired by the acquisition module to the main control module. The cow early pregnancy monitoring device is flexible to wear, sensitive and reliable in data acquisition, beneficial to early discovery of pregnancy signs of cows and capable of ensuring the feeding effect.

The utility model relates to medical instrument technical field, concretely relates to a kind of anti-drop fixing device for medical intubation, comprising: flexible belt, fixed component, limiting component, flexible belt is used to set in human brain, and flexible belt is close to the setting of buffer pad in the back of human body, the both ends of flexible belt are located in the side of human brain, and one end of flexible belt is provided with hook face, and the other end of flexible belt is provided with hair face, and the both ends of flexible belt are detachably connected by hook face and hair face, fixed component is set on the side of flexible belt away from buffer pad, fixed component is set correspondingly to nasal cavity, and the side wall of fixed component is fixedly connected with flexible belt, fixed component is used to be connected with intubation, the top of fixed component is provided with a plurality of concave points, the bottom of one end of limiting component is provided with the convex point matched with a plurality of concave points, limiting component is connected with the plurality of concave points on fixed component by a plurality of convex points, and the other end of limiting component is adhesively connected with intubation, and it is important tool to improve medical quality and safety.

The application discloses a kind of nasal drops based on drug-loaded pollen for rhinitis and its preparation method and application, belong to the field of biomedical materials;The nasal drops include drug-loaded pollen microcarrier and pharmaceutically acceptable adjuvant;The drug-loaded pollen microcarrier is natural sunflower pollen particle with hollow cavity and surface thorn structure, and the cavity is loaded with the drug for treating allergic rhinitis.In the preparation method, sunflower pollen is washed, defatted with acetone diethyl ether, and treated with phosphoric acid cleavage to obtain pollen microcarrier with hollow outer thorn;Then, small molecule drugs are loaded under vacuum and reduced pressure;Finally, the adjuvant is mixed to prepare the drops.The application utilizes the natural "internal cavity and external thorn" structure of pollen, realizes efficient adhesion and sustained-release drug delivery in nasal cavity, and effectively resists cilia clearance.The pollen microcarrier removes allergenic proteins, has good biocompatibility, and does not aggravate allergic rhinitis.The application is low in cost and simple in operation, and provides a safe and efficient new platform for nasal drug delivery.

The invention provides a traditional Chinese medicine preparation for improving the cold treatment effect, namely a cold virus killing agent. The preparation method comprises the following steps: selecting several traditional Chinese medicinal materials with disinfection, sterilization and anti-inflammation functions, namely chrysanthemum indicum, asarum, coptis chinensis, scutellaria baicalensis, pepper, isatis root and liquorice, adding water, boiling twice, mixing the medicine liquids obtained by decocting twice, adding edible white vinegar accounting for 10% of the total medicine amount and an edible preservative accounting for 1% of the total medicine amount, and uniformly stirring. Viruses and bacteria in the nasal cavity can be directly killed; the main path of cold infection is the respiratory tract, the nasal cavity is the leading edge of virus infection, and then cold enters the whole body to cause morbidity; during treatment, the anti-cold drug is orally taken, the drug efficacy spreads all over the whole body, viruses can be quickly killed, but the drug efficacy of nasal mucosa and nasal liquid is difficult to enter, and at the moment, the nasal cavity becomes the base of the anti-cold drug from the leading edge of infection; at the moment, viruses in the nasal cavity can be killed by applying the cold virus killing agent to the nasal cavity, so that the treatment time is saved; the preparation is applied locally, and the efficacy of the preparation cannot reach the whole body, so that a patient must take at least one cold medicine when using the preparation, the cold virus killing agent can be independently used for treating rhinitis, but three medicines, namely magnolia flower, divaricate saposhnikovia root and solidago decurrens, for treating rhinitis must be added.

Nasal interface, comprehensive a gas inlet, a first spout and a second spout that are asymmetrical to each other, and a gas flow path from the gas inlet to the first nozzle and the second nozzle, wherein the first nozzle has a larger internal cross-sectional area in a direction transverse to the gas flow through the first nozzle than a corresponding internal cross-sectional area of ​​the second nozzle, and wherein the first nozzle is located downstream of the second nozzle in the gas flow path.

An animal model (10) for veterinary and medical exercises comprises a set of visceral organs (20) and a body frame (40), where the set of visceral organs (20) is placed within the body frame (40). The utility model relates to an animal model (10) for veterinary and medical exercises, comprising a set of visceral organs (20), including a lung (200), a stomach (220) and a set of urinary and reproductive organs (230), where each visceral organ is attached to one another and wrapped by rubber (700), where the animal model (10) for veterinary and medical exercises is made predominantly of natural rubber, where the preferred natural rubber is Para rubber, and where the natural rubber is a natural rubber. And important clinical skills can be practiced through at least three openings. If each opening or all three openings need to be subjected to clinical skill practice together, the following operations can also be performed: passing through the oral cavity from the head and neck, inserting a medical device into the lung in the chest or placing the stomach in the abdominal cavity, inserting the medical device into the lung or stomach in the body frame from the nasal cavity, opening from the urinary organ of the male, and performing clinical skill practice. A medical device may be inserted into the bladder disposed in the pelvis.