The invention discloses a
lipoic acid-
dopamine synergistically toughened
fibroin composite coating applicable to a paranasal sinus
stent, and a preparation method and application thereof, and belongs to the field of
surface modification of biomedical materials. The preparation method comprises the following steps: firstly, dissolving
lipoic acid and
dopamine in a
Tris-HCl solution to prepare a
lipoic acid-
dopamine mixed solution; dissolving water-soluble silk
fibroin in
ultrapure water to prepare a silk
fibroin aqueous solution; and finally, mixing the two solutions to prepare a
composite coating preparation solution,
coating the surface of a to-be-coated structure with the
composite coating preparation solution, and
drying to form the composite
coating. The composite
coating is applied to the paranasal sinus
stent, and the paranasal sinus
stent with the composite coating on the surface is obtained. The silk fibroin-polylipoic acid-polydopamine ternary synergistic cross-linking
system constructed by the invention can realize long-term stability of a flexible
polymer network; the preparation method is low in cost and easy and convenient to operate, and the composite coating is compact, uniform and excellent in flexibility and can cooperate with the stent to achieve expansion deformation. The coating has the capabilities of promoting healing by photothermal, efficiently resisting oxidation and inhibiting
fibroblast proliferation; the material has a
corrosion protection function, and provides a new path for
surface modification of paranasal sinus stent materials.