23results about How to "Recovery function" patented technology

This invention discloses a method for preparing HVC NPs for the diagnosis and treatment of Parkinson's disease and their applications. The probe HV in the HVC NPs responds to H2O2 and viscosity, utilizing near-infrared fluorescence imaging capabilities to achieve real-time monitoring of Parkinson's disease biomarkers, helping us better understand the occurrence and development of Parkinson's disease. With the assistance of RVG29, the HVC NPs effectively cross the blood-brain barrier. The curcumin within them can reduce cell apoptosis, lower oxidative stress levels, scavenge excess reactive oxygen species, combat inflammation, and reduce α-synuclein aggregation, demonstrating effective anti-Parkinson's disease effects at the cellular and experimental animal levels. This nanomaterial provides a new strategy for integrated research on the diagnosis and treatment of Parkinson's disease.

This invention belongs to the field of functional substance research, specifically relating to the use of casein hydrolyzed peptide compositions in improving aging, and more specifically to their use in the preparation of products for improving aging. The casein hydrolyzed peptide compositions are obtained by enzymatically hydrolyzing casein solution using serine protease and flavor protease. Furthermore, in the casein hydrolyzed peptide compositions, the relative strength of total functional peptides is above 25%, the relative strength of casein phosphopeptides is above 9%, and the relative strength of functional peptides other than casein phosphopeptides is above 11%. This casein hydrolyzed peptide composition can effectively alleviate oxidative stress caused by aging, inhibit chronic low-grade inflammation, reduce aging-related damage to vital organs such as the liver and brain, improve the body's immune function, and improve the external phenotype of aging, thereby comprehensively exerting an anti-aging effect.

The application discloses a method and application of knocking down ubiquitin-specific peptidase 7 protein, and belongs to the field of biological medicine. The method for knocking down the USP7 protein comprises: specifically inhibiting the expression of USP7 in endothelial cells through gene intervention, and the gene intervention means comprises shRNA, siRNA or recombinant virus carrier-mediated USP7 expression down-regulation. Further provided is a USP7 knockdown reagent for preparing a drug for treating endothelial cell inflammation or a cardiovascular disease, in particular, the USP7 knockdown reagent is a USP7 knockdown virus carrier containing a Cdh5 promoter; the cardiovascular disease comprises heart failure, myocardial infarction or ischemic cardiomyopathy. The application specifically knocks down the expression of USP7 in endothelial cells through gene intervention, significantly improves the migration, tube formation capacity and reduces the apoptosis of the endothelial cells, repairs endothelial dysfunction, the USP7 knockdown virus carrier is used for preparing a drug for treating a cardiovascular disease, and has important clinical value.

This invention discloses the application of a Cav3.2 inhibitor in the preparation of a drug for treating intervertebral disc degeneration. Z944 can block the activation level of Cav3.2 in nucleus pulposus cells, effectively alleviating lipid metabolism disorders and cellular biological behavior disorders induced by abnormal mechanical stress, and ultimately reducing intervertebral disc degeneration. This demonstrates that Z944 is a drug with clinical application potential, which can be used to alleviate the pain and burden of patients with low back pain and improve their quality of life.

The invention provides a composite active dressing for neural restoration and a preparation method and application thereof, and relates to the technical field of medical materials. The composite active dressing comprises a transdermal inner layer and a small extracellular vesicle slow-release outer layer, the transdermal inner layer is of a membrane-shaped structure and comprises a composite active component and a hydrogel matrix material, and the composite active component is selected from one or more of an anti-inflammatory component, a microcirculation improving component, an antioxidant component and a neurotrophic component; the small extracellular vesicle sustained-release outer layer is of a three-dimensional network structure and comprises small extracellular vesicles and a hydrogel matrix material. According to the invention, stable loading and layered deep delivery and release of the small extracellular vesicles are realized, the inflammatory response and microcirculation state of an injured part are improved, proliferation migration and remyelination of Schwann cells can be promoted, and axon regeneration and effective repair of nerve injury can also be promoted.

This invention belongs to the field of biomedical technology and relates to the application of PAX8 gene inhibitors in the preparation of drugs for treating optic nerve degeneration. The PAX8 gene inhibitor is a shRNA that targets and inhibits the PAX8 gene or a vector expressing a shRNA that targets and inhibits the PAX8 gene. The vector uses the astrocyte-specific promoter gfabc1d. Experiments have demonstrated that by specifically inhibiting PAX8 expression in astrocytes, axoplasmic transport obstruction in the optic nerve is relieved, optic nerve degeneration is alleviated, and a new gene therapy strategy is provided for the protective treatment of optic nerve degeneration in glaucoma.

The invention relates to the technical field of medicines, in particular to a compound for targeted degradation of mIDH1 protein and application of the compound. According to the invention, a series of compounds with a 'PL-Linker-EL' ternary structure are creatively designed and synthesized, so that a fundamental treatment strategy breakthrough from traditional'protein function inhibition 'to direct'pathogenic protein removal' is realized. The compound can be combined with mutant IDH1 (mIDH1) protein and E3 ubiquitin ligase in a targeted manner at the same time, and then mIDH1 is induced to be subjected to ubiquitination modification and is thoroughly degraded through a proteasome way, so that the problem of drug resistance caused by mutation is expected to be overcome, and a new treatment choice is provided for patients who are invalid or relapse in the existing therapy.

The utility model discloses a kind of forming drilling chamfering cutters of processing new energy automobile copper charging plug, it is related to drilling chamfering cutter technical field.The utility model includes two groups of tool shank, the top end of one group of tool shank and the bottom end of another group of tool shank are all fixed with wedge block, the bottom of one group of wedge block is equipped with slot, the top of another group of wedge block is equipped with plug, fastening screw hole is set in the outer surface of plug, the utility model is equipped with clamping cylinder, wedge block, wedge slot anti -unthreaded bolt and the setting of anti -unthreaded bolt hole, when chuck is fixed when clamping drill bit cutter in actual use, staff can insert clamping cylinder into chuck, make chuck clamping force act on clamping cylinder rather than blade belt, to form reliable protection to blade belt, completely avoid the deformation, damage etc. of blade belt due to chuck directly clamping blade belt, guarantee drilling accuracy and operating efficiency, extend the service life of drill bit.

A device for root canal treatment, comprising a tube with a first taper configuration and a plurality of through holes on the tube wall. A brush is assembled in the tube, comprising bristles and a brush rod, and the bristles are attached to the brush rod at one end. A control member is used to control the shape of the brush, and the bristles attached to the brush rod are unfolded outside the tube wall, so that the brush has a second taper and is in contact with the inner wall of the root canal cavity established by the root canal file. The water generated by ultrasonic oscillation flows in the tube, and flows out from the through holes along the bristles and into the root canal prepared by the root canal file for filling. It has been verified that the device is easy to put into the root canal prepared by the root canal file, the tube wall tissue debris is used for flushing, the residual in the root canal is effectively avoided, the filling of the root canal is facilitated, the postoperative repeated infection is prevented, the recovery of the tooth function is accelerated, and the healthy oral environment is maintained.

This invention belongs to the field of civil engineering technology, specifically relating to a reinforcement device and method for reinforced concrete columns. The device includes an outer positioning component fixed to an annular groove in the column body, an anchoring component installed at the column base, and multiple circumferentially distributed energy-dissipating support components. The energy-dissipating support adopts a unique nested structure of inner and outer tubes. The two ends of the inner tube are pressed together with end plates via elastic pads and are inclinedly hinged between the positioning component and the foundation cap. The prestressing application component includes pulleys and cables. One end of the cable is anchored to the column base, and the other end is connected to the upper end of the energy-dissipating support after being turned by the pulley. A concrete reinforcement layer with a pre-reserved gap between the concrete and the column wall is poured on the outside of the column body, forming a complete protective system. This invention fundamentally solves the problems of slow start-up, easy failure, and difficult post-earthquake repair of traditional single energy-dissipating devices. With its modular and replaceable design, it achieves the dual goals of improving seismic toughness and optimizing the entire life cycle cost.

This invention belongs to the field of biomedical technology, specifically relating to an isoliquiritigenin composition for improving depression and its preparation method. The isoliquiritigenin composition for improving depression comprises the following raw materials in parts by weight: 22-40 parts isoliquiritigenin, 10-17 parts N-acetyl-D-glucosamine, and 15-20 parts β-lapaquinone. Isoliquiritigenin, N-acetyl-D-glucosamine, and β-lapaquinone constitute a multi-target synergistic isoliquiritigenin composition for improving depression. Experimental results show that by taking the isoliquiritigenin composition prepared according to this invention, it can systematically exert its effects and comprehensively improve the pathological state of depression, showing broad application prospects.

This invention discloses an oxygen-catalyzing gel microsphere for regulating mitochondrial energy metabolism and its application in tissue repair. The microsphere comprises a calcium alginate hydrogel framework and multiple separate micro-reaction chambers embedded within the calcium alginate hydrogel framework. Each micro-reaction chamber independently contains ozone oil and graphene. This invention constructs a near-infrared responsive oxygen-catalyzing gel microsphere, achieving structured regulation of local oxygen supply and effective remodeling of cellular metabolic states. The system utilizes a dual-emulsion-microfluidic electrospray strategy to construct a spatially separated multi-chamber structure. Under near-infrared stimulation, the Gr-mediated photothermal-electronic synergy promotes the in-situ, efficient, and relatively mild conversion of ozone to oxygen, providing new insights for the design of hypoxia-related bone regeneration and other tissue repair materials.

The invention discloses a post-fire slope optimization method, which belongs to the field of slope rockfall blocking, and comprises the following steps: S1, constructing a multi-source data set; s2, determining a rockfall propagation range; s3, constructing a disaster-exposure-fragility three-dimensional risk assessment model, and outputting a slope risk grade map and a risk score; s4, based on a risk assessment result, a fused interaction matrix and a weight calculation method, introducing a risk-barrier energy dynamic adaptation model, constructing a site selection adaptability-protection energy-structure parameter dynamic optimization system, and outputting a flexible barrier site selection scheme and barrier parameters; and S5, based on a real-time monitoring result, evaluating a flexible barrier site selection scheme and barrier parameters, and dynamically optimizing the step S4 according to an evaluation result. By adopting the post-fire slope optimization method, through integration of multi-source monitoring data and a dynamic simulation technology, the limitation that a traditional method is insufficient in adaptation to special working conditions after the fire is broken through, and the dual goals of safety protection and ecological restoration are achieved.

This invention discloses a parameter optimization method for inertial capacitive dampers used for vibration reduction in double-layer, three-span subway stations, belonging to the field of vibration control technology. By establishing a refined soil-structure-TID coupled finite element model, defining a multi-objective optimization function, selecting and inputting ground motion records as input for optimization analysis, applying a genetic algorithm for multi-objective parameter optimization, nested system dynamic time history analysis, and engineering decision-making based on Pareto fronts, the method comprehensively verifies and analyzes the vibration reduction and isolation performance. The complete technical process, from refined modeling, multi-objective function definition, ground motion set input, intelligent algorithm optimization to comprehensive verification and analysis, guides seismic energy towards self-dissipation, effectively protecting the main structure of the station. It fills the gap in refined optimization methods for TID parameters of complex underground structures. The optimization objectives directly correspond to the inter-story drift angle and floor acceleration, which are of most concern in engineering, and provide visual decision support through Pareto fronts, making the optimization results easily adoptable in engineering practice.

The application discloses a method for culturing sweat gland cells to obtain a sweat gland organoid and application thereof, and belongs to the technical field of bioengineering, wherein the sweat gland cells can be cultured by using a three-dimensional culture medium provided by the application, and a sweat gland organoid with high cell activity and bidirectional differentiation potential is obtained; after being transplanted into a full-thickness injury mouse on the sole and back, the sweat gland organoid not only can promote the regeneration and function recovery of the sweat gland, but also can promote the healing of the skin wound, and can be used for preparing a cell product for repairing skin injury and recovering the function of an accessory organ, and has a wide application prospect.

This invention belongs to the field of animal model technology, specifically relating to a method for constructing an animal model of aplastic anemia and premature ovarian failure (POF) and its application in mesenchymal stem cell therapy. Busulfan and cyclophosphamide were administered intraperitoneally to the animals six times in the following order: first, busulfan was administered three times consecutively, followed by cyclophosphamide three times consecutively, thus establishing an animal model of the dual pathological state of aplastic anemia and POF. Furthermore, based on this animal model, a mesenchymal stem cell therapy based on disease stages was established, achieving significant recovery of ovarian function and providing a reliable technical foundation for clinical translational research on POF in adolescents.

The application provides application of a thirteen-peptide in preparation of a product for improving cognitive impairment. The thirteen-peptide with an amino acid sequence shown in SEQ ID NO: 1 can effectively relieve oxidative damage, inhibit iron deposition, restore mitochondrial function, regulate neurotrophic factor expression, relieve nerve cell damage through multiple targets, and further effectively improve cognitive impairment.

This invention provides an oil-controlling composition, its preparation method, and its application. The composition comprises extracts from *Eryngium sibiricum*, sunflower seed, *Edelweiss*, and *Saussurea involucrata*. Cosmetic products containing this composition exhibit excellent oil-controlling, moisturizing, and soothing / repairing effects.

The utility model discloses a novel spring self-resetting friction energy dissipation steel support which comprises a resetting system and a friction energy dissipation system, and the resetting system comprises an inner cylinder, an outer cylinder, a left push-pull rod, a right push-pull rod, a spring baffle and a spiral spring. The friction energy dissipation system comprises two friction energy dissipation device sets which are symmetrically arranged on the two sides of the reset system correspondingly. The two friction energy dissipation device sets are arranged on the left push-pull rod and the right push-pull rod in a sleeving mode correspondingly and fixedly connected with the closed end plates of the outer barrels at the two ends correspondingly. According to the novel spring self-resetting friction energy dissipation steel support, a composite energy dissipation system of'structure double module-function double redundancy-regulation and control double dimensions' is innovatively constructed, rapid replacement of friction plates and field parameter adjustment of a torque wrench are supported, and the novel spring self-resetting friction energy dissipation steel support has the advantages of being recoverable in function, reasonable in stress, simple in structure and convenient and fast to manufacture. And the anti-seismic property requirements of newly-built and existing structure reinforcing projects can be met.

The utility model relates to a hinged joint, especially relates to a replaceable plastic hinged joint of reinforced hollow square steel pipe high-strength concrete column-steel beam in the technical field of building engineering structure. Including reinforced hollow square steel pipe high-strength concrete column and steel beam, the reinforced hollow square steel pipe high-strength concrete column of vertical placement is welded through outer ring plate with the cantilever beam of horizontal placement, the both sides of cantilever beam web are separately equipped with cantilever beam web reinforcing plate, the both sides of steel beam web end portion are separately equipped with steel beam web reinforcing plate, the lateral side of the cantilever beam web reinforcing plate and steel beam web reinforcing plate of same side is equipped with web connecting plate, and the upper and lower flange of cantilever beam and steel beam is connected through flange connecting plate. The utility model will appear in two beam splicing place under the structure plastic hinge of earthquake, and the upper and lower flange connecting plate will yield deformation first, and the web connecting plate and pin shaft of middle part play the role of supporting middle beam. After the earthquake, only need to replace the upper and lower flange connecting plate, to reach the function of building structure rapid recovery.

The utility model discloses a wind generating set anti-freezing anemograph wind indicator external heater which comprises heating mechanisms, a PLC control module and a relay, the two heating mechanisms are respectively installed on the surface of a cylindrical shaft seat at the bottom end of an anemograph and the surface of a cylindrical shaft seat at the bottom end of a wind indicator; the heating mechanism comprises a patch type heater fixed on the outer surface of the cylindrical shaft seat; the device further comprises a relay control circuit and a heater control circuit. According to the utility model, the patch type heater is arranged on the wind indicator of the anemograph, and the relay remotely controlled by the PLC is added, so that when the anemograph or the wind indicator is frozen, the number can be set to the PLC output port remotely, and the heater is started to heat and deice; after the wind speed or wind direction data changes, the set number is released, heating is stopped, the normal functions of the anemograph and the wind indicator can be rapidly recovered through the design, unit faults caused by freezing are avoided, the operation reliability and the power generation efficiency of the unit are improved, and the maintenance cost is reduced.