2 results about "Nerve axon" patented technology

This invention discloses an anisotropic piezoelectric thin film, its preparation method, and its applications, belonging to the field of biomedical materials technology. The anisotropic piezoelectric thin film provided by this invention has a surface with parallel, periodically repeating wavy folds; the surface of the anisotropic piezoelectric thin film also has a porous structure, forming a network of interconnected pores. The anisotropic piezoelectric thin film provided by this invention has a regular structure with high order and anisotropy, simulating the parallel arrangement of nerve fiber bundles in vivo, exhibiting good biomimicry, and can effectively guide the directional regeneration of nerves. Using the anisotropic piezoelectric thin film provided by this invention for drug loading and nerve repair combines the effects of physical guidance, release of biochemical factors, and electrical stimulation, effectively promoting the directional growth of nerve axons and the regeneration and repair of nerve tissue.

The application discloses application of a compound INF195 in treatment of diseases related to nerve axon injury. 17 H 22 ClNO3.The application proves through research that the compound INF195 can significantly promote axon regeneration of DRG neurons at a concentration of 5 muM, and has no significant effect on neuron activity at the concentration.Further based on an axon injury model of Xona microfluidic chip, it is proved that the INF195 can promote regeneration and extension of axons after injury.Therefore, the compound INF195 can inhibit NLRP3 inflammasome activity, and is an important compound molecule for promoting axon regeneration and repair after nerve injury, and has a good application prospect in preparation of drugs for treating diseases related to nerve axon injury, including peripheral nerve injury and central nerve injury.