6 results about "Nerve axon" patented technology

The invention relates to the technical field of microbial medicines, and particularly discloses application of intestinal golden thread bacteria in preparation of a medicine for preventing or treating peripheral nerve injury. A mouse model proves that the intestinal golden thread bacteria can regulate the injury microenvironment in the peripheral nerve injury repair process, guide nerve axons to extend in the expected direction and reduce uncontrolled axon growth and wrong dominance, so that the structural accuracy of nerve regeneration is improved.

This invention discloses an anisotropic piezoelectric thin film, its preparation method, and its applications, belonging to the field of biomedical materials technology. The anisotropic piezoelectric thin film provided by this invention has a surface with parallel, periodically repeating wavy folds; the surface of the anisotropic piezoelectric thin film also has a porous structure, forming a network of interconnected pores. The anisotropic piezoelectric thin film provided by this invention has a regular structure with high order and anisotropy, simulating the parallel arrangement of nerve fiber bundles in vivo, exhibiting good biomimicry, and can effectively guide the directional regeneration of nerves. Using the anisotropic piezoelectric thin film provided by this invention for drug loading and nerve repair combines the effects of physical guidance, release of biochemical factors, and electrical stimulation, effectively promoting the directional growth of nerve axons and the regeneration and repair of nerve tissue.

The utility model provides a multi-electrode cell electrical stimulation device which comprises a multi-electrode plate, the multi-electrode plate comprises a flexible substrate and electrodes, the flexible substrate is provided with a first electrode area and a second electrode area, six electrodes are respectively arranged in the first electrode area and the second electrode area, one end of each electrode is provided with a wire connecting end, and the other end of each electrode is provided with a wire connecting end. The wire connecting end is connected with an external wire, the external wire is communicated with the wire connecting end to complete access operation of the electrode operation end, the multi-electrode plate, the resistor and the waveform function generator are sequentially connected in series to form a series electric control circuit, and the two ends of the series electric control circuit are connected with an external power source to form the electrical stimulation device. Two rows of twelve electrode arrays are arranged, multi-path and multi-direction electrical stimulation scheme adjustment is achieved by controlling the electrodes on the two sides to discharge, growth of nerve axons can be promoted, re-myelination of the axons can be promoted, recovery of nerve functions is accelerated, and popularization and application are facilitated.

The invention belongs to the technical field of medicines, and particularly discloses application of a secretory protein derived from Ackermann muciniphila in preparation of a medicine for treating and / or repairing spinal cord injury, so that the secretory protein (AmTARS) derived from Ackermann muciniphila can effectively repair and / or treat the spinal cord injury. The treatment medicine disclosed by the invention can effectively promote physiological and functional recovery after spinal cord injury; regeneration and germination of nerve axons are promoted, neurons are prevented from being reduced after spinal cord injury, and the integrity of nervous tissue structures is enhanced, so that the overall repair efficiency is improved; the therapeutic drug can be massively expressed and synthesized by using a biosynthesis method, is mature in preparation process, stable in quality, convenient for standardized production, easy to obtain, safe and economical, and has a good application prospect in the aspect of treating and / or repairing spinal cord injury.

The application discloses application of a compound INF195 in treatment of diseases related to nerve axon injury. 17 H 22 ClNO3.The application proves through research that the compound INF195 can significantly promote axon regeneration of DRG neurons at a concentration of 5 muM, and has no significant effect on neuron activity at the concentration.Further based on an axon injury model of Xona microfluidic chip, it is proved that the INF195 can promote regeneration and extension of axons after injury.Therefore, the compound INF195 can inhibit NLRP3 inflammasome activity, and is an important compound molecule for promoting axon regeneration and repair after nerve injury, and has a good application prospect in preparation of drugs for treating diseases related to nerve axon injury, including peripheral nerve injury and central nerve injury.

The invention provides an application of Dubosiella Newyorkensis in preparation of a medicine for promoting nerve regeneration after peripheral nerve injury. The Dubosiella Newyorkensis can be prepared into an oral liquid preparation. Experiments show that the bacterial strain can improve the barrier function of the intestinal tract after injury, significantly down-regulate the expression of proinflammatory factors, and activate regeneration promoting signal channels such as p-Akt / Akt and beta-catenin, thereby effectively promoting nerve axon regeneration and motor function recovery. The invention provides a brand new microbial therapy strategy for repairing the peripheral nerve injury.