11 results about "Adventitia" patented technology

The utility model discloses a tissue separation pad beneficial to microvascular anastomosis, which comprises a pad, an air cushion is arranged on the inner wall of the pad, a support is arranged in the air cushion, two suture pads are arranged above the pad, and the two suture pads can be attached to each other. The utility model relates to the technical field of vascular anastomosis, in particular to a tissue separation pad beneficial to microvascular anastomosis, which can play a role in physically separating tissues around a blood vessel from a lumen of the blood vessel through the matching of a gasket, an air cushion, a winding rope, a titanium alloy layer and a bracket, and provides a relatively pure anastomosis environment. In the process, some easily-coagulated substances, fat particles, vascular adventitia and other tissues are effectively prevented from entering a vascular lumen in the anastomosis process, vascular embolism is prevented, and the tissue separation pad beneficial to microvascular anastomosis can be expanded outwards all the time by means of the elasticity of the support, so that the tissue separation pad is more stable. And the phenomenon of vascular occlusion caused by extrusion of the tissue separation pad beneficial to microvascular anastomosis is avoided.

Disclosed are a combined artificial vascular sheath capable of reconstructing lymph node motive force, a guiding device, and a use method. The combined artificial vascular sheath comprises an elastic sheet and a plurality of tying bands connected to the elastic sheet, wherein the elastic sheet covers a vascular bundle, and the plurality of tying bands sequentially surround and bundle the vascular bundle to form a combined artificial vascular sheath wrapping the vascular bundle. The guiding device comprises a retractor, wherein the retractor is of an arc-shaped plate structure, the front end of the retractor is provided with a guide hook, and the guide hook matches a hook hole on the tying band and the opening thereof faces backwards. According to the present invention, the combined artificial vascular sheath with low elasticity is arranged on the surface of the vascular bundle to replace the damaged or hardened vascular adventitia which has lost its function, such that the function of squeezing and stimulating the peripheral lymph nodes of the blood vessel is reconstructed, and the influence on blood vessel branches is also reduced. The guiding device enables operators to conveniently implant the combined artificial vascular sheath, and has the advantages of simple structure, convenient operation and little damage to human bodies.

The application provides application of a DPP-4 inhibitor in preparation of a medicine for preventing and / or treating digestive tract stenosis, and belongs to the technical field of medicines. Based on morphological performance of stenosis segment esophageal tissue outer membrane scar fibrosis, it is found that a DPP-4+ fibroblast subpopulation in stenosis segment esophageal outer membrane fibrosis hyperplasia tissue is obviously highly expressed. The DPP-4 inhibitor can prevent and treat refractory stenosis after esophageal ESD operation through anti-inflammatory and anti-fibrosis effects on stenosis segment esophageal outer layer tissue, and is a powerful supplement to the current esophageal ESD postoperative stenosis which focuses on intraluminal prevention and treatment of esophageal submucosa and part of inherent muscle layer scar fibrosis.

The present application relates to the technical field of health risk assessment, in particular to a new-born umbilical inflammation infection risk early warning method combining umbilical secretions and ultrasound, which comprises: obtaining a target color reaction image corresponding to umbilical secretions of a new-born to be detected, and obtaining a transverse image, a sagittal image and a coronal image corresponding to the umbilical part of the new-born to be detected; analyzing the distribution of leukocyte released protease based on the target color reaction image; determining a blood vessel wall stratification index corresponding to each preset direction according to the thickness difference of the media region and the adventitia region in each preset direction; performing infection spread analysis on the sagittal image and the coronal image; and determining an umbilical inflammation infection risk early warning auxiliary value corresponding to the new-born to be detected according to the esterase activity distribution index, the spread infiltration scale index and all blood vessel wall stratification indexes. The present application improves the rationality of setting the umbilical inflammation infection risk early warning auxiliary value by analyzing multiple images.

The invention discloses an SIS-loaded polymer tubular structure artificial blood vessel, and relates to the technical field of biomedical treatment, and the SIS-loaded polymer tubular structure artificial blood vessel comprises a polymer tubular structure which is prepared from a high polymer material through an electrostatic spinning or 3D printing process, the high polymer material is selected from at least one of polycaprolactone, polylactic acid, polyurethane, a polylactic acid-glycolic acid copolymer, poly (L-lactide-caprolactone) or poly (p-dioxanone); and the SIS layer is prepared by dissolving SIS powder in 0.1-1M acetic acid solution to prepare a 1%-10% solution. The invention relates to a preparation method of an SIS-loaded polymer tubular structure artificial blood vessel. The preparation method comprises the following steps: preparing SIS: cleaning and segmenting fresh small intestine and jejunum, and scraping an outer membrane, a muscular layer and an inner mucosa; according to the invention, a physical perfusion-freeze drying method is innovatively adopted to realize efficient loading of SIS; and more than 95% of active factors in the SIS are reserved through a gradient decellularization process.

A method for three-dimensional (3D) imaging of coronary arteries includes acquiring a sequence of two-dimensional (2D) intravascular (IV) images of a coronary artery, extracting a set of IV longitudinal images from the sequence of IV images, detecting a lumen border of the coronary artery and a media-adventitia (MA) border of the coronary artery based on the set of IV longitudinal images, estimating a sequence of geometric mass centers based on the lumen border and the MA border, estimating a 2D motion signal from the sequence of geometric mass centers, estimating a sequence of rotations for the sequence of 2D IV images based on the 2D motion signal, generating a sequence of transformed IV frames from the sequence of 2D IV images based on the sequence of rotations and the 2D motion signal, and reconstructing a 3D image from the sequence of transformed IV frames.

The invention discloses a preparation method of human umbilical artery stem cell induced vascular organoid, and belongs to the field of biomedical engineering. The method aims to solve the problems of limited cell source, low induction efficiency, incomplete structure function and the like in the existing vascular organ preparation. The method comprises the following steps: separating and culturing human umbilical artery adventitia stem cells, taking the third to fifth generation cells, inducing the third to fifth generation cells for 5 days through an induction culture medium containing VEGF-A, FGF-2, CHIR99021, BMP4, Y27632 and Frosklin, mixing the cell aggregate with Matrigel-Collagen I to construct a three-dimensional system, and culturing the three-dimensional system with a mature culture medium containing VEGF-A and FGF-2 for 10 days to form vascular organs. According to the method, the human umbilical artery adventitia stem cells which are rich in source and free of ethical dispute are adopted, the induction efficiency is remarkably improved through staged induction and optimized factor combination, formed vascular organs are complete in lumen, rich in branch, stable in function, easy and convenient to operate and easy to standardize, and the method can be applied to the fields of cardiovascular disease research, drug screening and regenerative medicine.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a reagent for detecting the expression level of SOCS3 in preparation of a product for evaluating the treatment effect of mesenchymal stem cells on pulmonary arterial hypertension. By integrating transcriptomics and functional experiments, the invention reveals that MSC activates the expression of SOCS3 through paracrine, and further inhibits the excessive phosphorylation of STAT3, thereby blocking the molecular mechanism of PAAF activation and ECM abnormal deposition. The expression level of the SOCS3 can be used as a marker for judging the inhibition of the mesenchymal stem cells on the activation of the pulmonary adventitia fibroblasts, and also can be used as a marker for judging the treatment effect of the mesenchymal stem cells on the pulmonary arterial hypertension. By up-regulating the expression of SOCS3, the excessive phosphorylation of STAT3 can be inhibited, the activation of pulmonary outer membrane fibroblasts and the expression of Col1 and Col3 can be inhibited, but the proliferative activity is not influenced, so that the PAH can be treated.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. Systems, devices and methods for cooling energy delivery members are also provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

This invention relates to the field of vascular structure recognition technology, and discloses an automated method and system for recognizing vascular structures in OCT images. The method includes: Step 1, vascular layer boundary feature extraction: extracting vascular layer boundary features from OCT images based on multi-scale Hessian matrix response, including geometric and physical features, to form a feature response map; Step 2, three-layer topological structure recognition: constructing the topological relationship of the vascular structure based on the feature response map, extracting nested ring structures; identifying and outputting the initial boundary coordinate point set and structural score of the intima, media, and adventitia; Step 3, vascular structure optimization: precisely optimizing the initial boundary coordinate point set, detecting special cells within the optimized region, and generating a result report. This invention achieves fully automated recognition of OCT vascular structures, ensuring the reliability, accuracy, and interpretability of the recognition results, and ensuring the standardization and unification of vascular lesion diagnosis.