35 results about "Adventitia" patented technology

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

The invention relates to the technical field of medical apparatus and instruments, and discloses a nerve repair fixing cannula, a flexible connection sheet can be bent into a tubular shape, so that two ends of the flexible connection sheet respectively wrap the peripheries of two nerve broken ends, the inner side of the flexible connection sheet is provided with a growth space, a tubular structure for nerve bridging is established, nerve axons grow directionally, and the two nerve broken ends are kept aligned; the multiple microneedles are arranged at the two ends of the flexible connecting piece at intervals, the connecting tension of the nerve bundle layer and the flexible connecting piece is dispersed, and the pain feeling of a patient is relieved; a needle head of the microneedle is used for being inserted into an adventitia so as to fix the bent flexible connecting piece to the nerve broken end, a needle rod penetrates through the flexible connecting piece, and the needle rod and the outer tangent plane of the bent flexible connecting piece at the needle threading position are obliquely arranged at a first preset angle, so that the mechanical stability of the nerve repair fixing sleeve installed on the nerve broken end is improved; the nerve broken end can be quickly and conveniently fixed, meanwhile, the damage to nerve tracts is reduced, and the situation that the nerve function recovery is affected by scars is avoided.

The invention relates to the technical field of medical animal model construction, in particular to a construction method and application of a cardiomyopathy animal model induced by a circulating system. According to the invention, the Abeta25-35 is injected into the adventitia, so that the animal model of the cardiomyopathy induced by the Abeta25-35 through the tissue fluid circulatory system of the adventitia is constructed in the SD rat for the first time. In the model, A beta 25-35 is subjected to myocardial perfusion through lower limb vascular adventitia to induce myocardial diffuse fibrosis and ejection fraction reduction of SD rats, which are in accordance with epidemiological research data. The model can be used for subsequently researching the pathogenic mechanism of A beta25-35 induced cardiomyopathy and a novel treatment method taking vascular adventitia tissue fluid transmission as a way, and also provides a brand new view angle for researching the pathogenic mechanism of AD or cerebrovascular diseases and a diagnosis and treatment method.

A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The utility model discloses a tissue separation pad beneficial to microvascular anastomosis, which comprises a pad, an air cushion is arranged on the inner wall of the pad, a support is arranged in the air cushion, two suture pads are arranged above the pad, and the two suture pads can be attached to each other. The utility model relates to the technical field of vascular anastomosis, in particular to a tissue separation pad beneficial to microvascular anastomosis, which can play a role in physically separating tissues around a blood vessel from a lumen of the blood vessel through the matching of a gasket, an air cushion, a winding rope, a titanium alloy layer and a bracket, and provides a relatively pure anastomosis environment. In the process, some easily-coagulated substances, fat particles, vascular adventitia and other tissues are effectively prevented from entering a vascular lumen in the anastomosis process, vascular embolism is prevented, and the tissue separation pad beneficial to microvascular anastomosis can be expanded outwards all the time by means of the elasticity of the support, so that the tissue separation pad is more stable. And the phenomenon of vascular occlusion caused by extrusion of the tissue separation pad beneficial to microvascular anastomosis is avoided.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

Disclosed are a combined artificial vascular sheath capable of reconstructing lymph node motive force, a guiding device, and a use method. The combined artificial vascular sheath comprises an elastic sheet and a plurality of tying bands connected to the elastic sheet, wherein the elastic sheet covers a vascular bundle, and the plurality of tying bands sequentially surround and bundle the vascular bundle to form a combined artificial vascular sheath wrapping the vascular bundle. The guiding device comprises a retractor, wherein the retractor is of an arc-shaped plate structure, the front end of the retractor is provided with a guide hook, and the guide hook matches a hook hole on the tying band and the opening thereof faces backwards. According to the present invention, the combined artificial vascular sheath with low elasticity is arranged on the surface of the vascular bundle to replace the damaged or hardened vascular adventitia which has lost its function, such that the function of squeezing and stimulating the peripheral lymph nodes of the blood vessel is reconstructed, and the influence on blood vessel branches is also reduced. The guiding device enables operators to conveniently implant the combined artificial vascular sheath, and has the advantages of simple structure, convenient operation and little damage to human bodies.

An intravascular catheter for nerve activity ablation and / or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

A robotic surgical method for repair of an infrarenal aortic aneurysm with an aneurysm sac in an aorta of a patient includes introducing at least one arm and a camera of a robotic surgical system into designated ports of the patient. Then, a graft is attached to a proximal wall of the aorta. The aneurysm sac is decompressed by inflating an intravascular balloon and initiating flow in an arteriovenous circuit. Anterior posterior walls of the aneurysm sac are stapled and the robotic incisions are closed. A method for inserting a conduit includes deploying an intimal umbrella, partially expanding an expandable graft, deploying an adventitial umbrella, and fully inflating the expandable stent.

The application provides application of a DPP-4 inhibitor in preparation of a medicine for preventing and / or treating digestive tract stenosis, and belongs to the technical field of medicines. Based on morphological performance of stenosis segment esophageal tissue outer membrane scar fibrosis, it is found that a DPP-4+ fibroblast subpopulation in stenosis segment esophageal outer membrane fibrosis hyperplasia tissue is obviously highly expressed. The DPP-4 inhibitor can prevent and treat refractory stenosis after esophageal ESD operation through anti-inflammatory and anti-fibrosis effects on stenosis segment esophageal outer layer tissue, and is a powerful supplement to the current esophageal ESD postoperative stenosis which focuses on intraluminal prevention and treatment of esophageal submucosa and part of inherent muscle layer scar fibrosis.

Embodiments of the present disclosure provide a tracheal dilation device and a preparation method thereof. The device includes: a body having a C-shaped structure, the body being provided with a hole; a pulling wire, one end of which passes through and is fixed in the hole; wherein the body is configured to be disposed around the outer periphery of the trachea, and the other end of the pulling wire is fixed to the adventitia of the trachea, and the body applies an outward expanding traction force to the adventitia of the trachea via the pulling wire. The tracheal dilation device and the preparation method thereof provided by the embodiments of the present disclosure can fix the body to the outer periphery of the trachea and surround the trachea via the pulling wire, and one end of the pulling wire is fixed to the adventitia of the trachea, and the other end passes through and is fixed in the hole, so that the body can apply an outward expanding traction force to the trachea via the pulling wire, realizing the outward expansion and fixation of the trachea. Since one end of the pulling wire is fixed to the adventitia of the trachea, the inner diameter of the trachea can be increased without damaging the inner membrane of the trachea, realizing the expansion of the trachea.

This invention relates to the field of medical animal model construction technology, and in particular to a method for constructing an animal model of cardiomyopathy induced by the circulatory system and its application. This invention, through adventitia-35 injection, establishes for the first time an animal model of "Aβ25-35-induced cardiomyopathy via the adventitia-35 circulatory system" in SD rats. In this model, Aβ25-35 perfusion via the adventitia-35 myocardium of the lower limbs induces diffuse myocardial fibrosis and a decrease in ejection fraction in SD rats, consistent with epidemiological data. This model can be used to further study the pathogenic mechanism of Aβ25-35-induced cardiomyopathy and novel treatment methods using adventitia-35 transport as a pathway, while also providing a new perspective for studying the pathogenic mechanisms and diagnostic and treatment methods of AD or cerebrovascular diseases.

A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The utility model discloses an aortic cannula, and relates to the technical field of aortic cannulas. Comprising a cannula body, a first positioning airbag, a second positioning airbag and a connecting hose. The first positioning air bag and the second positioning air bag are arranged on the outer side of the cannula body and can be tightly pressed on the inner side and the outer side of an aorta adventitia respectively during use, and the problems that high-pressure blood flow enters an aorta cavity, and aorta dissection or false aneurysm is formed are solved; meanwhile, when the intubation tube body needs to be separated from extracorporeal circulation for tube drawing operation, air in the second positioning air bag is completely discharged, then the intubation tube body is pulled out, the first positioning air bag can play a role in blocking sprayed blood flow, and the operator can be effectively protected; the problems that in a traditional aortic cannula, the aortic wall structure is prone to being damaged in the cannula inserting process, and false aneurysm or aortic dissection is formed are solved; the blood pressure in the aorta blood vessel is high, the purse string is easy to avulsion, the aorta wall is damaged, and the intubation tube is easy to fall off.

The present application relates to the technical field of health risk assessment, in particular to a new-born umbilical inflammation infection risk early warning method combining umbilical secretions and ultrasound, which comprises: obtaining a target color reaction image corresponding to umbilical secretions of a new-born to be detected, and obtaining a transverse image, a sagittal image and a coronal image corresponding to the umbilical part of the new-born to be detected; analyzing the distribution of leukocyte released protease based on the target color reaction image; determining a blood vessel wall stratification index corresponding to each preset direction according to the thickness difference of the media region and the adventitia region in each preset direction; performing infection spread analysis on the sagittal image and the coronal image; and determining an umbilical inflammation infection risk early warning auxiliary value corresponding to the new-born to be detected according to the esterase activity distribution index, the spread infiltration scale index and all blood vessel wall stratification indexes. The present application improves the rationality of setting the umbilical inflammation infection risk early warning auxiliary value by analyzing multiple images.

The invention discloses an SIS-loaded polymer tubular structure artificial blood vessel, and relates to the technical field of biomedical treatment, and the SIS-loaded polymer tubular structure artificial blood vessel comprises a polymer tubular structure which is prepared from a high polymer material through an electrostatic spinning or 3D printing process, the high polymer material is selected from at least one of polycaprolactone, polylactic acid, polyurethane, a polylactic acid-glycolic acid copolymer, poly (L-lactide-caprolactone) or poly (p-dioxanone); and the SIS layer is prepared by dissolving SIS powder in 0.1-1M acetic acid solution to prepare a 1%-10% solution. The invention relates to a preparation method of an SIS-loaded polymer tubular structure artificial blood vessel. The preparation method comprises the following steps: preparing SIS: cleaning and segmenting fresh small intestine and jejunum, and scraping an outer membrane, a muscular layer and an inner mucosa; according to the invention, a physical perfusion-freeze drying method is innovatively adopted to realize efficient loading of SIS; and more than 95% of active factors in the SIS are reserved through a gradient decellularization process.

The invention provides a nerve conduit, which comprises a cannula, one end of the cannula is provided with an opening, and the other end of the cannula is provided with a folding part; the shape of the filling block is matched with the internal shape of the sleeve; when the filling block is assembled in the sleeve, the distance between one end, close to the opening, of the filling block and one end of the opening of the sleeve is preset; wherein a plurality of through holes are formed in the side wall of the sleeve, and the through holes are configured to provide passages for permeation of tissue fluid; and the filling block is made of a degradable biomedical material. According to the nerve conduit provided by the invention, a protective envelope is formed through the sleeve, replaces an adventitia, coats and limits the growth of nerve tracts, and nerves can be subjected to the action of relative mechanical stress along with the narrowing of the surrounding growth environment, so that the formation of neuroma is more quickly and stably prevented, the extrusion of surrounding muscles in a body is resisted, and the terminal nerves are protected. The nerve conduit is simple in structure and has good mechanical properties, and industrial mass production can be achieved.

A method for three-dimensional (3D) imaging of coronary arteries includes acquiring a sequence of two-dimensional (2D) intravascular (IV) images of a coronary artery, extracting a set of IV longitudinal images from the sequence of IV images, detecting a lumen border of the coronary artery and a media-adventitia (MA) border of the coronary artery based on the set of IV longitudinal images, estimating a sequence of geometric mass centers based on the lumen border and the MA border, estimating a 2D motion signal from the sequence of geometric mass centers, estimating a sequence of rotations for the sequence of 2D IV images based on the 2D motion signal, generating a sequence of transformed IV frames from the sequence of 2D IV images based on the sequence of rotations and the 2D motion signal, and reconstructing a 3D image from the sequence of transformed IV frames.

The invention provides a nerve conduit, which comprises a sleeve, one end of the sleeve is provided with an opening, and the other end of the sleeve is provided with a fixing part; the supporting frame comprises one or more supporting plates; when the supporting frame is assembled in the sleeve, the interior of the sleeve is divided into a plurality of axial limiting channels by the supporting plates, and the limiting channels are configured to provide a preset growth path; a plurality of through holes are formed in the side wall of the sleeve, and the through holes are configured to provide passages for permeation of tissue fluid. According to the nerve conduit provided by the invention, a protective envelope is formed through the sleeve, replaces an adventitia, coats and limits the growth of nerve tracts, and nerves can be subjected to the action of relative mechanical stress along with the narrowing of the surrounding growth environment, so that the formation of neuroma is more quickly and stably prevented, the extrusion of surrounding muscles in a body is resisted, and the terminal nerves are protected. The nerve conduit is simple in structure and has good mechanical properties, and industrial mass production can be achieved.

The invention discloses a preparation method of human umbilical artery stem cell induced vascular organoid, and belongs to the field of biomedical engineering. The method aims to solve the problems of limited cell source, low induction efficiency, incomplete structure function and the like in the existing vascular organ preparation. The method comprises the following steps: separating and culturing human umbilical artery adventitia stem cells, taking the third to fifth generation cells, inducing the third to fifth generation cells for 5 days through an induction culture medium containing VEGF-A, FGF-2, CHIR99021, BMP4, Y27632 and Frosklin, mixing the cell aggregate with Matrigel-Collagen I to construct a three-dimensional system, and culturing the three-dimensional system with a mature culture medium containing VEGF-A and FGF-2 for 10 days to form vascular organs. According to the method, the human umbilical artery adventitia stem cells which are rich in source and free of ethical dispute are adopted, the induction efficiency is remarkably improved through staged induction and optimized factor combination, formed vascular organs are complete in lumen, rich in branch, stable in function, easy and convenient to operate and easy to standardize, and the method can be applied to the fields of cardiovascular disease research, drug screening and regenerative medicine.

Described herein are methods and apparatuses (e.g., devices, systems, etc.) that may be used to deliver one or more agents (e.g., compounds, compositions, etc. including drugs, biologics, cells, etc.) to a target tissue in or adjacent to an adventitia through the vasa vasorum of a vessel. These methods and apparatuses may be used to deliver relatively large agents to a target tissue in or adjacent to an adventitia specifically through the vasa vasorum of arteries or veins.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The invention discloses a chronic subdural hematoma model suitable for treatment of artery embolism in meninx, and relates to the technical field of medical research, the model is constructed based on a dura mater structure, and the dura mater comprises a periosteum layer, a meninx layer and a boundary cell layer DBC; according to the method, the chronic subdural hematoma model based on the real structure of the dura mater is accurately constructed, DBC layer damage is finely simulated, the whole process from hematoma origin to intima and adventitia formation is restored, high simulation of disease occurrence and development is achieved, a reliable basis is provided for in-depth exploration of pathogenesis, and the method is suitable for large-scale popularization and application. The biodegradable microspheres are used for simulating artery embolism in the meninx, the microspheres accurately target embolism positions, clinical treatment scenes can be effectively simulated, the influence of embolism on hematoma size, morphological change and intimal and adventitious membrane blood supply can be accurately evaluated, and a multi-modal imaging technology and a data analysis model based on a machine learning algorithm are combined to achieve the purpose of accurate and accurate embolism evaluation. The comprehensive and deep research on the model is realized, and the relevant characteristics of potential disease development and treatment response are mined.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a reagent for detecting the expression level of SOCS3 in preparation of a product for evaluating the treatment effect of mesenchymal stem cells on pulmonary arterial hypertension. By integrating transcriptomics and functional experiments, the invention reveals that MSC activates the expression of SOCS3 through paracrine, and further inhibits the excessive phosphorylation of STAT3, thereby blocking the molecular mechanism of PAAF activation and ECM abnormal deposition. The expression level of the SOCS3 can be used as a marker for judging the inhibition of the mesenchymal stem cells on the activation of the pulmonary adventitia fibroblasts, and also can be used as a marker for judging the treatment effect of the mesenchymal stem cells on the pulmonary arterial hypertension. By up-regulating the expression of SOCS3, the excessive phosphorylation of STAT3 can be inhibited, the activation of pulmonary outer membrane fibroblasts and the expression of Col1 and Col3 can be inhibited, but the proliferative activity is not influenced, so that the PAH can be treated.

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. Systems, devices and methods for cooling energy delivery members are also provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

The invention provides an application of Lanifiranor or a pharmaceutically acceptable salt thereof in preparing a medicine for inhibiting the progress of abdominal aortic aneurysm, and the application is realized by the following mechanisms: (a) regulating lipid metabolism of adventitious fibroblasts and maintaining phenotypes of the adventitious fibroblasts; and / or, (b) inhibiting the transformation of adventitious fibroblasts to myofibroblasts; and / or (c) reducing the expression levels of the pro-inflammatory cytokines IL-6 and MCP-1. According to the application provided by the invention, through a multi-mechanism synergistic effect, the AAA pathological process is systematically regulated and controlled at a molecule-cell-tissue level, and a first novel treatment strategy with etiological treatment and structure protection is provided for clinic.