197 results about "Blood vessel injury" patented technology

The described invention provides pharmaceutical compositions for treating an infarct area injury and methods of treating or repairing the infarct area injury in a revascularized subject in the aftermath of an acute myocardial infarction resulting from a natural disease process by administering to the subject parenterally through a catheter a sterile pharmaceutical composition containing a therapeutically effective amount of a nonexpanded sterile isolated chemotactic hematopoietic stem cell product as a first therapeutic agent and optionally a therapeutically effective amount of at least one compatible second therapeutic agent. The infarct area-improving amount of the sterile isolated chemotactic hematopoietic stem cell product comprises an enriched population of isolated autologous CD34+ cells containing a subpopulation of potent cells expressing CXCR-4 and having CXCR-4-mediated chemotactic activity such that the enriched population of isolated autologous CD34+ hematopoietic stem cells provides at least 0.5×10⁶ potent CD34⁺ cells expressing CXCR-4 and having CXCR-4 mediated chemotactic activity.

The invention discloses a cutting device for a blood vessel plaque. The cutting device comprises a plaque cutting system, a pressurized expansion system and a delivering device, wherein the cutting system comprises a plurality of cutting wires or cutting blades which are connected with a far-end cutting indicating ring and a near-end cutting indicating ring; the pressurized expansion system consists of a balloon and a balloon indicating ring; the delivering device comprises a long and thin hollow near-end pipe body connected with the pressurized expansion system, a stress transition pipe and a pressure connecting seat. The cutting device for the blood vessel plaque, disclosed by the invention, has the following characteristics that the positions of the cutting wires or the cutting blades can be seen in the cutting operation process of the blood vessel plaque, the convenience in operation is realized, and bending of the balloon is avoided; the cutting device can be used for cutting the blood vessel plaque, in particular a heavily-calcified or fibrous plaque at lower pressure without less damage to blood vessels.

A hemodialytic angioacess device for implantation in dialysis patients, comprising an arteriovenous (AV) shunt, anastomotic valves that connect the AV shunt to blood vessels, a valve control system and an integrated surveillance system that measures flow conditions in the blood vessels at the AV shunt, preferably when the valves are closed and the patient is not undergoing dialysis treatment. The flow condition data, which may include data representing the flow rate, pressure, volume and velocity of blood flowing through the vessels, is stored in a memory and transmitted to a health care provider or technician on demand. The data can be used to calculate and monitor important physiological parameters, such as compliance and resistance, for the blood vessels, and help detect and identify dangerous conditions, such as turbulence and stasis, which can contribute to AV shunt failure, vessel injury and other serious complications for the patient.

The invention relates to a preparation and using method of medical biocompatible stent material. The medical biocompatible stent material is prepared by applying the small intestine submucosal and the tendon tissue of people or animals as the raw materials. The invention has good biocompatibility, appropriate porosity and mechanical strength and stable spatial structure, and the invention contains various growth factors to induce the tissue for regeneration and reconstruction, thereby improving the success rate of the repair of the various tissue defects and the reconstruction of tissue structures, therefore, the invention is an ideal tissue engineering material. The medical biocompatible stent material which is provided by the invention is applicable to the preparation of various tissue engineering equipments and the application in the repair of various tissue defects and injuries, including skin, blood vessels, nerves, tendons, bones, cartilages, abdominal walls, urinary tracts, oral mucosa and so on, and the invention can be used in the treatment of trauma, abdominal external hernia, anal fistula, rectovaginal fistula, rectum anterior protrusion, bone and cartilage defects, vascular injuries, nerve injuries, tendon injuries, oral mucosal injuries, relaxed pelvic floor, urinary tract injuries and other diseases.

An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40–90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1–5 microns.

The present invention comprises methods and systems for treating a cardiac arrhythmia in a mammal by administering gated or pulsed radiofrequency current or other ablative energy to the mammal during one or more time periods of increased coronary blood flow. Preferred embodiments of the invention comprise, without limitation, the gated or pulsed administration of radiofrequency current in association with the formation of the dicrotic notch in the arterial blood pressure curve of the mammal. In accordance with the invention, the thermal effects of ablative energy application on the coronary artery are avoided or mitigated due to rapid coronary blood flow resulting in heat loss and minimization of damage to blood vessels.

This invention relates to use of inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4) in treating, preventing, or reducing fibrosis, cancer, and vascular injuries.

The invention discloses a blood volume controllable vessel occlusion device. The blood volume controllable vessel occlusion device comprises a fracture outer ring and an air charging device, wherein the fracture outer ring can be opened and closed, a fracture air bag is fixedly arranged on the inner side of the fracture outer ring along the peripheral direction, the fracture positions of the fracture outer ring and the fracture air bag coincide to achieve simultaneous opening and closing, and the air charging device is communicated with the air bag. An operator can pressurize a blood vessel through the air bag according to practical need, and the pressure borne by the vessel at the time when the vessel is occluded, namely, the measured pressure value, can be read on a pressure display device, so as to judge the degree, by which the blood flow is occluded. By adopting the vessel occlusion device, not only can the blood flow occlusion to any degree be achieved according to practical need in an operation so as to more accurately and more intuitively measure the blood flow occlusion conditions for the blood vessels at different thicknesses and types, but also the blood flow occlusion manner is less in injury on the blood vessel to achieve the reversible operation on increasing and reducing the blood flow amount so as to facilitate the blood flow detection relevant assay or treatment control.

The invention relates to a cannula assembly for cerebral vascular intervention through radial artery approach, which comprises an outer cannula, a middle passage catheter and a guide wire; the outer cannula is provided with a first bending section, a first linear section, a second bending section, a second linear section, a third bending section, an outer cannula linear section and an outer cannula joint; the second bending section is bent towards the far-end direction, and the bending curvature of the far-end section of the second bending section is larger than that of the near-end section of the second bending section; the second linear section is longer than the first linear section and has larger inclination; the middle passage catheter is provided with a head end section, a neck section, a middle passage catheter linear section and a middle passage catheter joint; and the hardness of the outer cannula is greater than that of the middle passage catheter. The cannula assembly can improve the convenience and success rate of whole cerebral vascular hyperselection through the radial artery approach, avoids vascular injury, is suitable for approach of any one of left and right radial arteries, and can be used for cerebral angiography and cerebral vascular disease interventional therapy.

The invention provides an interventional ultrasonic thrombolysis device. The interventional ultrasonic thrombolysis device comprises a catheter body, an ultrasonic transducer and an insulating shell, wherein the catheter body comprises an outer tube and an inner tube, and the outer tube is arranged on the outer side of the inner tube in a sleeving mode; the ultrasonic transducer is arranged at the end of the catheter body in a sleeving mode, and is suitable for generating ultrasonic waves in the radial direction of the catheter body; and the insulating shell seals a shell of the ultrasonic transducer. According to the device, the ultrasonic transducer polarized in the thickness direction is used for applying ultrasound to the end of the thrombus, the ultrasound generates a cavitation effect to tear the thrombus, ultrasonic energy promotes permeation of a thrombolysis drug to the thrombus, the action area of the thrombolysis drug is increased, thrombolysis is accelerated, and the thrombus is dissolved from head to tail; and with adoption of non-plug-in mode for thrombolysis, the device has small damage to blood vessels and is especially suitable for old thrombus.