17 results about "Venous line" patented technology

To provide an estimation method of a recirculation rate enabling estimation of a recirculation rate without being limited by a preparation location of a blood marker or an arrangement location of detection means of the blood marker.SOLUTION: An estimation method of a recirculation rate includes the steps of: acquiring data representing an amount of change in blood concentration after recirculation when a blood marker is added to blood to be extracorporeally circulated, data representing a relation between an amount of change in blood concentration after recirculation and blood concentration, and data representing a relation between the amount of change in blood concentration after recirculation and a blood flow rate; creating a model by multivariate analysis or machine learning to obtain a regression equation or a conversion model, with the amount of change in blood concentration after recirculation, blood concentration and a blood flow rate used as an explanatory variables and the recirculation rate as an objective variable; acquiring data representing the amount of change in blood concentration, blood concentration and a blood flow rate of blood flowing through an arterial line or a venous line; and inputting treatment data to the regression equation or the conversion model to estimate the recirculation rate.SELECTED DRAWING: Figure 3A

An extracorporeal and drug delivery system includes (i) a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including (a) an effluent pump for pumping effluent from the blood filter at an effluent flowrate, and at least one of (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, (c) a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or (d) a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; (ii) an infusion pump operable to deliver an intravenous (“IV”) drug to the patient at an IV drug flowrate; and (iii) a coordinating logic implementor configured to adjust the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate.

An extracorporeal and drug delivery system includes a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including an effluent pump for pumping effluent from the blood filter, and at least one of a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; an infusion pump operable to deliver an intravenous (“IV”) drug to the patient; and a coordinating logic implementor configured to determine if a formulation adjustment should be made to the IV drug when a constituent of the IV drug exists in the dialysis fluid, the predilution replacement fluid, and / or the postdilution replacement fluid.

Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber: an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber.

The present disclosure describes systems and methods for blood return in a hemodialysis machine using an adjustable valve that includes a first portion having a first port configured to be connected to a machine arterial line and a second port configured to be connected to a machine venous line, and a second portion of the adjustable valve having an arterial inlet port configured to be connected to a patient arterial access line, a venous outlet port configured to be connected to a patient venous access line, and a substitution inlet port configured to be connected to a substitution fluid line. The first portion can be movable relative to the second portion to selectively connect the first port and the second port with a selected combination of two of the arterial inlet port, the venous outlet port, or the substitution inlet port to adjust a flow of fluid therethrough.

In one aspect a medical fluid connector functions as both a recirculation connector to connect arterial and venous lines during priming of an extracorporeal blood circuit as well as a clamp to occlude a fluid tube. In one aspect, the connector includes a tubular body with luer connections and a clamping arm that extends longitudinally along a tubular body to apply clamping force.

An extracorporeal and drug delivery system includes: (i) a renal failure treatment machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including: (a) an effluent pump for pumping effluent from the blood filter at an effluent flow rate; and at least one of: (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flow rate; (c) a pre-dilution pump for pumping replacement fluid into the arterial line at a pre-dilution flow rate; or (d) a post-dilution pump for pumping replacement fluid into the venous line at a post-dilution flow rate; (ii) an infusion pump operable to deliver an intravenous ("IV") drug to a patient at an IV drug flow rate; and (iii) a coordination logic implementer configured to adjust the IV drug flow rate based on an amount of the IV drug removed via the effluent flow rate.

An example medical system includes a hemodialysis device configured to receive blood from vasculature of a patient via an arterial line and to deliver blood to the vasculature of the patient via a venous line. The medical system includes a hematocrit sensor configured to generate a signal indicative of a hematocrit level of blood in at least one of the arterial line or the venous line. The medical system also includes processing circuitry configured to determine a change in blood volume of the patient over time based on the signal indicative of the hematocrit level, determine a threshold blood volume reduction over time for the patient, compare the change in the blood volume of the patient over time to the threshold blood volume reduction over time, and based on the comparison, generate an indication of vascular access recirculation.

Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the bioartificial airway organs. The bioreactor comprises: an organ chamber: an ingres line connecting the organ chamber and a reservoir system and comprising an arterial line, a venous line and a tracheal line; an egress line connecting the chamber and the reservoir system, pumps in ingress and egress lines; a controller to control fluid exchange; a chamber pressure sensor connected to the organ chamber.

The present disclosure describes systems and methods for blood return in a hemodialysis machine using an adjustable valve that includes a first portion having a first port configured to be connected to a machine arterial line and a second port configured to be connected to a machine venous line, and a second portion of the adjustable valve having an arterial inlet port configured to be connected to a patient arterial access line, a venous outlet port configured to be connected to a patient venous access line, and a substitution inlet port configured to be connected to a substitution fluid line. The first portion can be movable relative to the second portion to selectively connect the first port and the second port with a selected combination of two of the arterial inlet port, the venous outlet port, or the substitution inlet port to adjust a flow of fluid therethrough.

The system (1) for dialysis comprises: - one dialysis machine (2) provided with a pumping device (3) and configured to perform a dialysis treatment on a patient's blood; - one transfer circuit (4) associated with the dialysis machine (2) in a removable manner in a predefined configuration of use and adapted to transfer blood between the dialysis machine (2) and the patient, where the transfer circuit (4) comprises at least one arterial line (6) adapted to convey the arterial blood of the patient and provided with at least one pump tubing (7) installable on the pumping device (3) and at least one venous line (8) adapted to convey the venous blood of the patient and provided with at least one venous tray (9); wherein the transfer circuit (4) comprises joining means (16) adapted to fix the arterial line (6) to the venous line (8) in the predefined configuration of use.

The present invention provides a control method for a blood purification device, a blood purification device, and a computer-readable storage medium. The control method for the blood purification device includes: detecting the blood flow in the arterial line to obtain a first detection flow Q1, and detecting the plasma flow at the input end of the plasma adsorption branch to obtain a second detection flow Q2; calculating to obtain the separation ratio of the plasma separator to determine whether K>Δk is satisfied, and if so, controlling the bypass branch to be connected to the venous line; if not, controlling the blood purification branch to be connected to the venous line; wherein Δk is a first preset ratio. The control method for the blood purification device of the present invention can adaptively adjust the structure of the extracorporeal blood purification circuit, and has high adjustment flexibility, thereby improving the efficiency and effect of blood purification treatment, making blood purification treatment safer and more reliable, and improving the compatibility and scope of application of the blood purification device.

An example medical system includes a hemodialysis device configured to receive blood from vasculature of a patient via an arterial line and to deliver blood to the vasculature of the patient via a venous line. The medical system includes a hematocrit sensor configured to generate a signal indicative of a hematocrit level of blood in at least one of the arterial line or the venous line. The medical system also includes processing circuitry configured to determine a change in blood volume of the patient over time based on the signal indicative of the hematocrit level, determine a threshold blood volume reduction over time for the patient, compare the change in the blood volume of the patient over time to the threshold blood volume reduction over time, and based on the comparison, generate an indication of vascular access recirculation.

This application discloses a convective material exchange bioartificial liver system: a plasma separation pathway including a plasma separator, an arterial line, and a venous line; a biological purification pathway including a first bioreactor, a solid-liquid separator, a pre-purification line connecting the first inlet of the first bioreactor to the original plasma outlet of the plasma separator, a post-purification line connecting the purified outlet of the first bioreactor to the separation inlet of the solid-liquid separator, and a return line connecting the net plasma outlet of the solid-liquid separator to the venous line; and a biological regeneration pathway including a second bioreactor, a hepatocyte recovery line connecting the recovery inlet of the second bioreactor to the hepatocyte outlet of the solid-liquid separator, and a biological supply line connecting the regeneration outlet of the second bioreactor to the second inlet of the first bioreactor; the first inlet and the second inlet are opposite each other in the first bioreactor, thereby creating a convective material exchange state inside the first bioreactor.

The present invention provides a pressure calibration method for a blood purification device, a blood purification device, and a computer-readable storage medium. The pressure calibration method for the blood purification device includes: detecting the temperature of the blood in the venous line to obtain the blood return temperature; determining whether the blood return temperature is within a first preset temperature range, and if so, controlling a first pressure monitor to detect the pressure of the blood in the venous line to obtain a first pressure detection value; selecting a corresponding preset temperature-pressure fitting formula according to the blood return temperature, and calibrating the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a first calibrated pressure detection value. The pressure calibration method for the blood purification device of the present invention can effectively reduce the interference error caused by temperature variation on the pressure detection of the blood in the extracorporeal circulation circuit, improve the pressure detection precision and accuracy of the blood in the extracorporeal circulation circuit, ensure the control safety of the blood purification device, and make blood purification treatment safer and more reliable.

An apparatus for quantifying a cardiac output of a patient operably connected to an extracorporeal blood oxygenation circuit (100); the extracorporeal blood oxygenation circuit (100) having a venous line (110) withdrawing blood from a circulatory system of the patient, a blood oxygenator (120), a pump (130), and an arterial line (140) returning oxygenated blood to a venous portion of the circulatory system; the apparatus comprising: a controller (160) configured to connect to one of the blood oxygenator (120) and the pump (130), the controller (160) configured to calculate a cardiac output (CO) of the patient based on: (i) a first measured flow rate of blood from the extracorporeal blood oxygenation circuit (100); (ii) a first arterial value or surrogate of a blood parameter in an arterial portion of the patient circulatory system and a first value or surrogate of a blood parameter in the blood delivered to the patient circulatory system corresponding to a first gas removal rate in the blood oxygenator (120) in the extracorporeal blood oxygenation circuit (100); and (iii) a second arterial value or surrogate of a blood parameter in an arterial portion of the patient circulatory system and a second value or surrogate of a blood parameter in the blood delivered to the patient circulatory system corresponding to a second gas removal rate in the blood oxygenator (120) in the extracorporeal blood oxygenation circuit (100).

A dialysis system with post dialysis aseptic blood return including a fluid source, a dialyzer, a pump, a venous line, an arterial line, a bridge line coupled between the venous line and the arterial line, and a fluid source line coupled between the fluid source and a fluid port of the arterial line downstream for the bridge line. Aseptic blood return after dialysis is performed by blocking the arterial line between the bridge line and the fluid port, unblocking the bridge line, unblocking the fluid source line, and operating the pump in a forward direction to produce fluid flow from the fluid source, through the dialyzer, and through the bridge line to force venous blood in the venous line toward the patient venous access and arterial blood in the arterial line toward the patient arterial access.