An
extracorporeal and
drug delivery system includes a renal failure therapy
machine operable with a blood filter in fluid communication with an arterial line and a
venous line, the
machine including an
effluent pump for pumping
effluent from the blood filter, and at least one of a
dialysis fluid pump for pumping
dialysis fluid to the blood filter at a
dialysis fluid flowrate, a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or a postdilution pump for pumping replacement fluid into the
venous line at a postdilution flowrate; an
infusion pump operable to deliver an intravenous (“IV”)
drug to the patient; and a coordinating logic implementor configured to determine if a formulation adjustment should be made to the IV
drug when a constituent of the IV drug exists in the
dialysis fluid, the predilution replacement fluid, and / or the postdilution replacement fluid.