33 results about "Citrate anticoagulation" patented technology

The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable soultes.

The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.

The present invention concerns a multipart fluid system for use in CRRT, wherein the multipart fluid system comprises an anticoagulation fluid and at least one fluid from the group consisting of a dialysis fluid and an infusion fluid. According to the invention the anticoagulation fluid comprises at least 8 mM citrate, and the dialysis fluid and / or infusion fluid comprises 2-8 mM citrate and 1-5 mM total calcium. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.

Disclosed are methods, compositions, and devices for improved delivery of regional citrate anticoagulation during extracorporeal blood treatments. Methods comprise quantification of the clearance of calcium and / or citrate using one or more on-line / in-line sensors, establishing a correlation between the differential conductivity between afferent and efferent dialysate and the clearance of calcium and / or citrate. The methods described herein further include quantifying citrate clearance using glucose as a surrogate.

A hemofiltration system and method for pumping blood from a patient's blood stream into an access line, introducing an anticoagulant solution into the pumped blood, filtering the pumped blood and delivering it to a return line, introducing a substitution fluid into the pumped blood, introducing a calcium and magnesium solution into the blood traveling through the return line, and returning the blood back to the patient's blood stream.

A method of performing regional citrate anticoagulant dialysis of a patient's blood includes flowing blood from and back to the patient through an extracorporeal circuit including a dialyzer having semi-permeable dialysis membranes and a dialysate chamber surrounding the membranes. The method further includes flowing a dialysate containing calcium and citrate through the dialysate chamber of the dialyzer and introducing citrate into the patient's blood upstream of the dialyzer, whereby the patient's blood is dialyzed. The method can further include predicting the concentration of systemic ionized calcium in the blood of the patient at any point in the dialysis treatment or post-dialysis, such as by a mathematical model. The method can further include statistically correcting the preliminary predicted post-dialysis concentration of systemic ionized calcium in the patient's blood to provide a final predicted post-dialysis systemic ionized calcium concentration. The method can further include statistically correcting the preliminary predicted systemic ionized calcium concentration for any time point during the dialysis treatment to provide a final predicted systemic ionized calcium concentration for that time point.

The invention relates to a formula of a blood filtration replacement fluid which is special for citrate anticoagulation, a preparation method and a usage thereof. With the components of sodium citrate, sodium chloride, potassium chloride, sodium lactate, citric acid and so on, the replacement fluid is mainly used for blood filtration and blood dialysis filtration of the patients with acute renal failure or high risk bleeding due to multiple organ failure etc., and can solve the problems of easy occurrence of hypernatremia and alkali poisoning in the prior citrate anticoagulation, thus facilitating the clinical usage. The replacement fluid has the advantages of strong applicability, exact efficacy and low toxicity and side effects; the preparation process is simple; the quality is stable, safe and effective; the feasibility is strong; the repeatability is high; and the replacement fluid is applicable to the large-scale production and the promotion of the clinical application, thus being the ideal blood filtration replacement fluid for blood filtration, blood dialysis filtration, continuous renal replacement therapy and so on. The demand of the blood dialysis increases along with the increasing number of the patients with the end-stage renal failure year by year, so the blood filtration replacement fluid can generate more tremendous economic and social benefits.

The present invention relates to a sterile calcium-free low bicarbonate dialysis concentrate composition for use in conjunction with regional citrate anti-coagulation in the context of either dialysis or hemofiltration. Methods of use of the sterile calcium free low bicarbonate dialysis concentrate compositions are also disclosed. The low bicarbonate concentrate takes into account the fact that citrate is hepatically metabolized into bicarbonate, thus minimizing metabolic complications.

The present invention concerns an anticoagulation fluid comprising 10-40 mM citrate and 0.1-4 mM phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in the dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit.

The present invention concerns an anticoagulation fluid comprising 10-40 mM citrate and 0.1-4 mM phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in a dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit.

The embodiment of the present invention discloses a fully automatic citric acid partial anticoagulant machine, which includes a sampling unit, a sample injection unit, a laboratory analysis unit, a drug administration unit and a program control unit; the sampling unit extracts blood samples online in real time and transports the blood samples Store and purify in the blood sample storage purifier; the sample injection part transports the blood sample in the blood sample storage purifier to the sample loading tank through the sample injection tube; the laboratory analysis part transports the blood sample to the analyzer through the suction tube Perform blood sample analysis; the sampling unit, sample injection unit, laboratory analysis unit and administration unit are connected to the program control unit, and the program control unit controls the work of the sampling unit, sample injection unit, and laboratory analysis unit according to the internal setting program, According to the data results obtained by the laboratory analysis department, an instruction is issued to the drug administration department. It solves the technical problems of manual calculation of the RCA method in the prior art, cumbersome and time-consuming operation steps, delay in adjusting the dosage, and high cost.

A system for extracorporeal blood treatment is disclosed that includes a haemofiltration device, a pump for pumping blood through the haemofiltration device, citrate means upstream to add citrate, calcium means downstream to add calcium solution, and a control configured to activate or inactivate the citrate addition means and / or the calcium addition means, wherein the control activates the citrate addition means at the beginning of blood treatment and for a first time period filters the blood with activated citrate addition means and continues to operate the citrate addition means until the end of blood treatment activates the calcium addition means after the first time period has elapsed when the total extracorporeal blood volume in the system has been filtered and citrate treated, continues to operate the calcium addition means in an active state during blood treatment to stably maintain a user-determined calcium addition rate, and continues to operate the calcium addition means in an active state after the end of blood treatment, until a second time period has elapsed after the end of treatment. A method of controlling such a system to ensure adequate calcium replenishment after citrate anticoagulation is also disclosed.

The present invention concerns a multipart fluid system for dialysis therapy, wherein the multipart fluid system comprises an anticoagulation fluid and at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids. According to the invention the anticoagulation fluid comprises 10-40 mM citrate, and 0.1-2.0 mM phosphate; and the at least one treatment fluid comprises 0-5 mM total calcium, 0-8 mM citrate, and 0.1-2.0 mM phosphate; with provisos that the at least one treatment fluid comprises citrate when total calcium concentration is 0 mM; and the at least one treatment fluid comprises calcium when the citrate concentration is 0 mM. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.

The invention discloses a preparing adjusting method of a CRRT local citric acid anticoagulation substitution fluid. The method comprises the steps of inputting a CRRT treating parameter and a biochemical and blood gas test result; adjusting the speed of citric acid in front of a pump, and controlling the target concentration of plasma citric acid at 3.5-4.0 mmol / L; according to the concentration of formula ionized calcium, and with the combination of the concentration of blood gas ionized calcium in front of a filter and the predicted input speed of 5% calcium chloride, adjusting a peripheral calcium supplement parameter; according to the concentration of blood gas bicarbonate, and with the combination of the concentration of blood gas bicarbonate in front of a filter, adjusting a peripheral sodium bicarbonate supplement parameter; according to the concentration of sodion, and with the combination of the concentration of blood gas sodion in front of a filter, adjusting a formula basic liquid injection water using amount. Therefore, not only can the speeds of sodium citrate and calcium supplement be accurately predicted in a personalized mode according to the CRRT treating parameter and the patient condition, but also the degree of influences of the substitution fluid on all electrolytes in blood and acid-base in the treating process can be predicated, and synchronous adjustment on a CRRT local citric acid anticoagulation substitution fluid formula is achieved.

The present invention concerns a multipart fluid system for dialysis therapy, wherein the multipart fluid system comprises an anticoagulation fluid and at least one treatment fluid from the group consisting of dialysis fluid and infusion fluids. According to the invention the anticoagulation fluid comprises 15-40 mM citrate; and the at least one treatment fluid comprises 1.5-8 mM citrate and ≥10 mM bicarbonate. The present invention further concerns a system for citrate anticoagulation in an extracorporeal blood circuit.

A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit (10) upstream of a dialyzer (11) during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium (iCa SYS ) or systemic total calcium (Ca SYS ), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium (iCa 2 , iCa 3 ) in blood at a selected location (loc2, loc3) downstream or upstream of the dialyzer (11) in the extracorporeal blood circuit (10), and presents and / or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and / or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly.

The invention discloses a citrate anticoagulation control system suitable for the CVVHD process and a citrate anticoagulation device and application. The citrate anticoagulation control system suitable for the CVVHD process comprises a first peristaltic pump velocity calculation module for calculating the infusion speed of citrate and a second peristaltic pump velocity calculation module for calculating the calcium supplement speed; the second peristaltic pump velocity calculation module comprises a second-peristaltic-pump first stage velocity calculation unit for calculating the sum of the calcium amount removed by extracorporeal dialysis and the calcium amount accumulated in the body and a second-peristaltic-pump second stage velocity calculation unit for calculating the calcium amount removed by extracorporeal dialysis. The citrate anticoagulation device comprises the citrate anticoagulation control system suitable for the CVVHD process. According to the citrate anticoagulation control system suitable for the CVVHD process and the citrate anticoagulation device and application, automatic control of a citrate pump and a calcium pump can be achieved, labor is saved, and meanwhilethe more accurate, safer and more stable aim is achieved.