748 results about "Blood purification" patented technology

The invention comprises a patient information server device (10) which automatically accumulates together with time information: biological information detected by a bedside monitoring device (1) of a patient or a biological-measuring device; biological information and device information detected by a blood purification device (2, 3) which treats a blood sample taken from the patient; and blood information detected by a circulating blood volume measuring device (4) that detects blood information about a circulating blood sample taken from the patient. A client device simultaneously and chronologically displays or records the patient information stored in the patient information server device (10). Through this arrangement, it is possible to obtain on a real time basis the biological information of a human body such as a patient's body, and the device information, for example, of a blood treating device.

A blood purification device has a blood purification element divided into two chambers by a semipermeable membrane, with a first chamber as part of a dialysis fluid loop and a second chamber as part of an extracorporeal blood loop. By virtue of an analysis unit operatively connected to a sensor in the dialysis fluid loop, the device provides simple and uncomplicated determination of the blood purification performance of the blood purification element for a second material by derivation from a previously established blood purification performance for a first material. In this way, the device also determines the blood concentration of the second material during the blood treatment through measurements in the dialysis fluid without intervention in the treatment sequence.

The invention belongs to the field of chemical engineering and industry, and particularly relates to a mesoporous-macroporous carbon production method. The production method comprises: completely mixing a phenol formaldehyde resin, an epoxy resin and the like or a mixture thereof, and a curing agent according to a certain weight ratio, carrying out heating curing, adding polyvinyl alcohol and the like as pore forming agents and adding graphite powder and the like as support agents after the cured material is crushed, completely mixing, pressing to form a preform, and carrying out high temperature carbonization under the protection of gas to obtain the mesoporous-macroporous carbon. The mesoporous-macroporous carbon prepared by using the production method has advantages of simple preparation method, easy pore size control and the like, wherein the pore size of the mesoporous-macroporous carbon can be adjusted within 50 nm-10 mum, has a specific surface area of 100-1000 m<2> / g, and can be used in electrode materials of supercapacitors, electrode materials of lithium ion batteries, electrode materials of capacitance method desalination devices, blood purification, catalyst carriers, water treatments, gas purification, solvent recovery and the like.

An object of the present invention is to provide a blood purification apparatus and a priming method thereof which can firmly perform the bubble purging smoothly and in a short time during priming operation. According to the blood purification apparatus of the present invention, the tip of the arterial blood circuit can be connected to and communicated with the tip of the venous blood circuit during priming of the blood purification apparatus before dialysis, and the blood purification apparatus can perform a priming solution charging step for supplying and charging the blood circuits with priming solution under a condition in which the tip of the arterial blood circuit and the tip of the venous blood circuit are connected to and communicated with each other; and a priming solution circulating step for forcing the charged priming solution to be flowed and circulated through the blood circuits by successively changing the driving speed of the blood pump after the priming solution charging step.

Provision of a blood purification system comprising a blood purification tubing and a blood purification apparatus particularly suitable for use in continuous hemofiltration in which in the treatment of a patient with renal disease, multiple organ failure, and the like, the amount of water removed from the patient and the amount of supply to the patient can be more accurately controlled, and in which preparation operation is easy. A blood purification system comprising a blood purification tubing and a blood purification apparatus wherein the soft tubes of flow paths connecting a first planar panel and a second planar panel, and the location of the soft tubes are selected to satisfy a formula of a predetermined condition.

The invention relates to a method for preparing spherical porous carbon, wherein the spherical porous carbon is obtained through the following steps of taking commercialized spherical polyvinylidene fluoride (PVDF) resin as a raw material, carrying out defluorination stabilization at a low temperature below 150 DEG C, carrying out carbonization at high temperature, and activating. The commercial production of the spherical PVDF resin is realized, the particle diameter of the spherical PVDF resin is controllable, and the method for preparing the spherical porous carbon has the advantages that the method is simple, the degree of sphericity of a carbon sphere is good, the particle diameter is uniform, the size of the particle diameter is easy to regulate and control, and the like. The particle diameter of the spherical porous carbon is adjustable between 5 nm and 50 microns, the specific surface area is 50-3000 m<2> / g, and thus, the spherical porous carbon can be used for an electrode material of a super capacitor, an electrode material of a lithium ion battery, an electrode material of a capacitance-method desalination equipment, blood purification, a catalyst carrier, water treatment, gas purification, solvent recovery and the like.

A blood purification device allows controlling a false alarm and allows detecting accurately an abnormality in a patient who is undergoing a blood purification treatment or in the device which is running. The hemodialysis equipment includes blood circuit made of an arterial blood circuit having an arterial needle at its end and a venous blood circuit having a venous needle at its end; a blood pump; a dialyzer purifying the blood flowing in blood circuit; a venous blood pressure sensor which can detect pressure of a patient's blood flowing in the venous blood circuit; a venous blood pressure monitoring means for comparing a base value of the pressure measured by the venous blood pressure sensor or pressure predicted to be measured with a predetermined alarm-threshold. The device also has a venous blood pressure monitoring means allows updating the predetermined alarm threshold at a predetermined period of time.

The invention relates to a blood purification adsorbent with an embedding material and a preparation method of the blood purification adsorbent. The embedding material comprises zwitterionic monomer, a cross-linking agent, an initiator and a solvent, and the zwitterionic monomer comprises one or two types of zwitterionic molecules of carboxyl betaine, sulfobetaine and phosphorylcholine. The method includes: mixing the zwitterionic monomer, the cross-linking agent, the initiator and the solvent; adding activated carbon or resin to form mixed solution, wherein the mass of added activated carbon or resin is 6%-50% of that of the zwitterionic monomer; subjecting the mixed solution with activated carbon or resin to ultraviolet radiation or heating or normal-temperature standing to enable curing of the monomer on the surface of the adsorbent through cross-linking polymerization to form the adsorbent with the zwitterionic embedding material. The embedding material is excellent in protein adsorption resistance and biocompatibility and is extremely high in toxin diffusion efficiency in application to blood adsorption. The blood purification adsorbent is easy to store, and the preparation method is simple and feasible.

The invention provides an artificial hollow micro-nano motor and a preparation method thereof, relating to artificial motors and preparation methods thereof and solving the problem that the existing solid spherical motor, tubular motor and linear motor are poor in loading performance. The artificial hollow micro-nano motor is made from a polyelectrolyte double-layer skeleton and a catalyst or is made from a cationic polyelectrolyte skeleton and the catalyst; and the preparation method of the artificial hollow micro-nano motor comprises the following steps of: (1) preparing micro-nano catalyst particles; (2) synthesizing a core substrate; (3) synthesizing an artificial hollow micro-nano motor skeleton; and (4) removing the core substrate by using a template solvent so as to obtain the artificial hollow micro-nano motor. The preparation method has the advantages of simplicity and feasibility, stable process, good repeatability and convenience in mass production, and the prepared artificial hollow micro-nano motor is good in transportability and loading function, has a wide application prospect in a plurality of aspects, such as drug release control, blood purification, clinical diagnosis, and is simple in operation. The artificial hollow micro-nano motor prepared by the preparation method provided by the invention is applicable to the medical field.

Methods for treating malaria are provided, the treatment comprising the step of removing malaria-infected red blood cells from the patient s blood. Blood is drawn from the patient s circulatory system and circulated through a blood purification device that selectively eliminates the infected red blood cells from all other blood s components and replaces the cleansed blood back into the patient s circulatory system. A blood purification device, which is useful to perform the therapeutic methods of the invention, is also provided. The device leverages the magnetic properties of the hemozoin contained within the infected red blood cells and comprises one or more separation chambers (4) though which blood flows through a high-gradient magnetic field generated by an array of wires (5) separated from the chambers and not in contact with the patient blood. The magnetic field gradient acting on the cells magnetic properties displaces the infected and non-infected red blood cells on different layers of the blood flow across the chamber height. The blood flow is split into separated streams and blood streams containing infected cells are filtrated thereby trapping infected cells. Blood containing non-infected red blood cells is circulated back to the patient. The device application is not limited to the treatment of malaria and includes other blood related diseases that affect the magnetic properties of a patient's red blood cells.

A volume balancing and ultrafiltering device for cleaning blood is disclosed. Its volume balancing module has at least one internal cavity divided into dialyzing liquid chamber and waste liquid chamber by a diaphragm. Both chambers have respective liquid inlet and liquid outlet, which are equipped with electromagnetic valves for flow control. When the quantity of waste liquid coming in the waste liquid jointer is greater than the throughput of the module, the excessive waste liquid is by-passed by ultrafiltration pump via by-pass tube.

The present invention relates to a hematocrit sensor and a method for measuring hematocrit values using such a device, which comprises a hematocrit sensor in a blood circuit that measures hematocrit value, a blood purifier that purifies a patient's blood while extracorporeally circulating the patient's blood, a housing having a slot connected to a portion of the blood circuit, a slit or plurality of pores built in the slot of the housing, and a light emission means and a light reception means positioned in the housing such that both means face the blood circuit through the slit or the plurality of pores.

The invention relates to an endotoxin adsorbent, which in detail relates to a method of preparing endotoxin adsorbent for blood perfusion. The method employs spherical agarose gel with good biocompatibility as base material, employs epichlorohydrin, hexamethylene diamine, 1, 1'-carbonyldiimidazole as activating agent, and bonds polymyxin B for endotoxin removal. The invention is characterized in that it overcomes the toxicity of cyanogen bromide and instability of aglycone, improves the safty and reliability of operation, reducesnon-specific adsorption through bonding polymyxin B with 1, 1'-carbonyldiimidazole, and improves biocompatibility of adsorbent and suits for treating endotoxemia. The invention is also characterized by simple experimental procedure and high clearance for endotoxin.

The invention discloses an amphiphilic triblock copolymer with a structural general formula represented as the following. In the formula, when M1 is vinylpyrrolidone and M2 is acrylic acid, M3 is styrene or acrylonitrile or methyl methacrylate; or when M1 is vinylpyrrolidone and M2 is a chemical bond, M3 is styrene or acrylonitrile. m, n, p, q, are all lager than 1. A number-average molecular weight of the copolymer is 30000 to 100000, a glass-transition temperature of the copolymer is 90-180 DEG C, and a decomposition temperature of the copolymer is 180-430 DEG C. The invention also discloses a preparation method of the copolymer, and a polyethersulfone hollow fiber membrane blend-modified by using the amphiphilic triblock copolymer. The amphiphilic triblock copolymer provided by the invention is insoluble in water. When the amphiphilic triblock copolymer is blended with polyethersulfone and is prepared into a polyethersulfone hollow fiber membrane, the amphiphilic triblock copolymeris hard to precipitate. Therefore, the polyethersulfone hollow fiber membrane is provided with permanent hydrophilicity, protein pollution resistance and excellent blood compatibility. The polyethersulfone hollow fiber membrane can be used in the field of blood purification. The preparation method provided by the invention is simple, and is easy to operate. With the method, industrialization is easy to realize.

A blood purifying apparatus particularly suitable for continuous blood purification, and a method of controlling the same whereby the weight of body fluid removed from a patient and a feed weight to the patient can be more accurately controlled. A blood purifying apparatus 50 adapted for the continuous blood purification includes a drain C, a dialysate feed A, and a replacement fluid feed B, which are equipped with transfer pumps 5, 6, 7, respectively, reservoir containers 8, 9, and 10, respectively, that are capable of storing a predetermined volume, and fluid level sensors 11, 12, and 13, respectively. The blood purifying apparatus further includes a single weightmeter 20 capable of measuring the reservoir containers 8, 9, and 10 all at the same time.

The present invention relates to a highly water-permeable hollow fiber membrane type blood purifier which comprises hydrophobic polymer hollow fiber membranes each containing a hydrophilic polymer, wherein the hollow fiber membrane has a hydrophilic polymer content of 25 to 50 mass % and a ratio of hole areas of 8 to 25% at its outer surface, and has a thickness non-uniformity degree of 0.6 or more, a thickness of 10 to 60 μm and a burst pressure of 0.5 to 2 MPa, and which is characterized in that the blood purifier has a water permeability of 150 to 2,000 ml / m2 / hr / mmHg, and in that said blood purifier is exposed to radioactive rays on conditions that the oxygen concentration of an ambient atmosphere around the hollow fiber membranes is from 0.001% inclusive to 0.1% inclusive, and that the moisture content of the hollow fiber membrane to its weight is from 0.2 mass % inclusive to 7 mass % inclusive. The present invention also relates to a process for manufacturing the same-blood purifier.

A blood purification sorbent for antibody removal belongs to the technical field of biomedicine, which consists of the two parts of solid-phase carrier material and a petunidin fixed on the carrier by chemical coupling. The molecular structure of the petunidin is shown as above, wherein, one atom among A, B and C is N, the others are C; n is 0-2. The blood purification sorbent can adsorb the antibody component in plasma and autoantibodies such as rheumatoid factor, antinuclear antibody, etc. in heavy load, has limited nonspecific adsorption to other plasma components such as seralbumin, etc., and also has low preparation cost and stable physicochemical property. The material can be used as adsorption filler of a blood purification device for removing the autoantibody and immune complex in the plasma.

The invention discloses a method for forming a simulated cell outer layer membrane structure on the surface of cross-linked chitosan. The method comprises the following steps that: firstly, the chitosan is cross-linked by glutaraldehyde; and secondly, the surface of the cross-linked chitosan is grafted with phosphinylideyne choline groups to construct the simulated cell membrane structure, the reaction of the grafted phosphinylideyne choline groups is carried out in an anhydrous non-protonic solvent, the reaction temperature is between 40 and 80 DEG C, and the concentration of phosphorylcholine dichloride is between 0.1 and 20mg / ml. The test results show that for the surface modified by the simulated cell outer layer membrane structure, the capabilities of adsorbing protein and blood platelet are obviously reduced, and the blood compatibility is obviously improved. The modified material with the simulated cell outer layer membrane structure has wide application prospect in fields such as blood purification, body implantation materials, tissue engineering, slow release of medicines, biological sensors, and the like.

The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure. The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the surface on the blood-contacting side.

A blood purification device allows confirming whether a specific peak is provided by a means, such as a ultrafiltration pump, to concentrate the blood or not and also allows measuring certainly and accurately a blood re-circulation with reduction of parameters which can provide a ratio of re-circulating blood. The blood purification device including blood circuit route 1 composed of arterial blood circuit route 1a and venous blood circuit route 1b, blood pump 3, dialyzer 2, water removal pump 8 which can provide the specific peak in the variation of blood concentration by removing water rapidly in a short period of time, and detecting means detecting said specific peak, can measure the blood re-circulation based on the specific peak detected by the detecting means. The re-circulating blood flowing is the blood which was introduced again to arterial blood circuit route 1a after it had been returned to a patient from venous blood circuit route 1b. The detecting means includes first detecting means 5a installed in arterial blood circuit route 1a and second detecting means 5b installed in venous blood circuit route 1b.

The invention relates to a method for preparing a medicinal absorbent carrier, comprising the following: a step of preparation of cellulose solution; a step of preparation of crosslinking spherical cellulose particles, which is to add pore-forming agent and crosslinking agent into the cellulose solution for uniform dispersion, to disperse the cellulose solution in dispersant which is added with surface active agent, to increase the temperature to make the crosslinking agent perform crosslinking reaction with the cellulose solution, and then to prepare the crosslinking spherical cellulose particles provided with the pore-forming agent; a step pf aftertreatment, which is to use solvent which can dissolve the pore-forming agent to process the crosslinking spherical cellulose particles, to remove the pore-forming agent, and then to prepare medicinal absorbent carrier-multiaperture crosslinking spherical cellulose particles. The method has the advantages of superior mechanical properties, capability of high pressure resistance, capability of being applied in the blood purification field and so on.

The invention relates to a portable blood purifying system, which comprises a high throughput dialyzer with an arterial duct, a venous duct, a washing liquid tube and a transfusion tube; the arterial duct is in turn connected in series with an arterial valve, an arterial pressure sensor and a blood pump; the venous duct is in turn connected in series with a venous valve, a venous temperature sensor, a venous bubble detector and a venous pressure sensor, so that an external circulation unit is formed; the washing liquid tube is connected in series with a pre-charging valve and is communicated with a washing liquid container; the transfusion tube is in turn connected in series with a temperature controller, a transfusion tube bubble collector and a transfusion pump, and is communicated with a waste liquid container, so that a waste liquid processing unit is formed; and the system also comprises a transfusion pump, a temperature control device, a transfusion tube, a gating valve and a first transfusion branch and a second transfusion tube branch, so that a transfusion unit is formed. The system is simplified in structure and convenient to carry; and the system is suitable for patients to do short-time dialysis for several times or night dialysis treatment at home as household treatment equipment, so that toxin tolerance of dialysis patients during dialysis period is relieved while medical cost is reduced.

A blood purification apparatus includes a blood circuit, a blood purifying device, a driving device, an air bubble detection device, and a connection condition evaluation device. The blood circuit is provided with arterial and venous blood circuits, to which needles are attached at ends thereof. The blood purifying device is connected between the arterial and venous circuits. In a blood purifying treatment after a priming operation, the driving device drives the blood in the arterial blood circuit in a forward direction, and drives the blood in the venous blood circuit in a reverse direction. The air bubble detection device detects air bubbles in a liquid flowing in the arterial and venous blood circuits. The connection condition evaluation device evaluates connection conditions of the needles to the ends of the arterial and venous blood circuits based on the detection by the air bubble detection device.

The invention discloses a plasma exchanging adsorption filtration purification system provided with a plasma storage bag and an application method of the purification system. The method includes two steps of plasma components separation returning cycle and high-speed plasma purification regeneration cycle. Plasma components are separated by a selective membrane plasma separator; flow speed difference between a plasma separation cycle and a plasma purification circle is set by the specific plasma storage bag; high-speed plasma adsorption filtration purification treatment is performed by a high-throughput filter and an active carbon-resin absorptive device in a purification circle; and plasma subjected to cycle treatment for multiple times can be exchanged back to a human body through the separation returning circle. By the aid of the purification system and the application method thereof, autologous plasma waste generated in a plasma exchanging purification process can be purified continuously and effectively, and plasma consumption is reduced. The high-throughput filter and an adsorption column are connected in series to purify the plasma; load on a subsequent adsorber is reduced; and varied inflammatory factors, macromolecular toxins and the like combined by micromolecules, middle molecules and proteins which are generated from hepatic failure are eliminated as well, so that the purification efficiency of the whole system is greatly improved.