89 results about "Blood inflow" patented technology

A prosthetic valve having a stent structure with a prosthetic valve component secured therein is disclosed that includes a device for restricting expansion, i.e., an expansion restrictor device, disposed at a blood inflow end of the stent structure. The expansion restrictor device defines a deployed diameter of the stent structure to prevent the prosthetic valve from being over-sized upon initial deployment and / or from continued expansion in vivo. The expansion restrictor device may be a loop of suture, flexible line, thread or cord for defining or constraining a circumference of the prosthetic valve with a loop diameter that is less than or substantially equal to a diameter of the treatment site in which the prosthetic valve is to be deployed in vivo.

A medical device for interposition between a first flow path and at least one second flow path is provided. The device includes a first surface facing toward the opening of at least one second flow path; and a second surface facing away from the opening of at least one second flow path. When the device is in the operative position, it extends less than the complete circumference of the first flow path and substantially covers the opening of at least one second flow path. The device contains one or more surface features to facilitate chronic implantation. The device further has one or more characteristic porosities. Different configurations are indicated depending on the pathophysiology being treated and dictate the characteristic porosity of the device. In some, cases blood is prevented from reaching the second flow path and in other cases, particulates traveling within the blood are prevented from reaching the second flow path. Methods of preventing emboli or blood flow into the second flow path are also provided. Methods and devices for delivery are also provided.

Methods and apparatus for removing emboli during an endarterectomy procedure are provided. The present invention provides a proximal catheter disposed proximal to a stenosis and a distal catheter disposed distal to the stenosis. Each catheter may selectively communicate with a venous return catheter via a manifold having a setting controlled by a physician. Blood flows into an aspiration lumen of the distal catheter and is reperfused into a remote vein via the venous return catheter. Additionally, emboli generated during the procedure are removed via an aspiration lumen of the proximal catheter, and filtered blood then is reperfused into the remote vein.

A prosthetic venous valve includes a frame and leaflets. The frame includes: (i) a generally hollow base disposed at a blood inflow end; (ii) a plurality of struts connected with the base and extending generally parallel to a direction of forward flow of blood from the generally hollow base to a blood outflow end; and (iii) inwardly oriented flanges disposed at the blood outflow ends of the struts. The leaflets are disposed in gaps between the struts and are supported by the frame. The leaflets are arranged to close into the vein lumen to substantially seal against backflow of blood from the blood outflow end to the blood inflow end. The inwardly oriented flanges of the struts enhance the sealing.

Methods and apparatus are provided for removing emboli during an angioplasty, stenting or surgical procedure comprising a catheter having a funnel-shaped occlusion balloon of uniform thickness disposed on a distal end of the catheter. The occlusion balloon is fused to the distal end so that it provides a substantially seamless flow transition into a working lumen of the catheter. Additionally, a distal edge of the occlusion balloon is configured to be in close proximity with an inner wall of a vessel to facilitate blood flow into the catheter and efficiently remove emboli.

A method for the integrated facilitization of blood flow and monitoring of blood analyte concentration (for example, blood glucose concentration) includes implanting a stent configured to facilitate blood flow into a cardiovascular system of a user's body with the stent having attached thereto a continuous blood analyte determination module of a blood analyte monitoring system. The method also includes disposing a reader module of the blood analyte monitoring system external to the user's body and in proximity to a portion of the user's skin layer and monitoring blood analyte concentration via (i) emitting an RF carrier signal from the reader module toward the stent; (ii) receiving the RF carrier signal at a reflection antenna of the continuous blood analyte determination module; (iii) reflecting a modulated signal by the reflection antenna with the modulated signal being encoded with a blood analyte concentration determined by a sensor of the continuous blood analyte determination module; (iv) receiving the modulated signal by the reader module; and (v) decoding the analyte concentration from the modulated signal by the reader module.

Apparatus and methods for the extracorporeal treatment of blood are described. The apparatus includes a dialyzer which is separated into a first and second chamber by a semipermeable membrane, wherein the first chamber is disposed in a dialysis fluid path and the second chamber can be connected to the blood circulation of a patient by way of a blood inflow conduit and a blood outflow conduit, a feed for fresh dialysis fluid, a discharge for spent dialysis fluid, a measuring device disposed within the discharge for determining the absorption of the spent dialysis fluid flowing through the discharge, wherein the measuring device has at least one radiation source for substantially monochromatic electromagnetic radiation, and a detector system for detecting the intensity of the electromagnetic radiation, wherein means are provided to compensate for changes that occur in the intensity of the electromagnetic radiation of the radiation source and / or the sensitivity of the detector system.

Methods and apparatus are provided for removing emboli during an angioplasty, stenting or surgical procedure comprising a catheter having a funnel-shaped occlusion balloon of uniform thickness disposed on a distal end of the catheter. The occlusion balloon is fused to the distal end so that it provides a substantially seamless flow transition into a working lumen of the catheter. Additionally, a distal edge of the occlusion balloon is configured to be in close proximity with an inner wall of a vessel to facilitate blood flow into the catheter and efficiently remove emboli.

This invention describes apical access methods and devices that enable repair, modification, removal, and / or replacement of a defective heart valve while allowing the beating heart to deliver blood flow through the defective valve annulus for an extended period of time in volumes sufficient to sustain life. The invention is comprised of a flow housing having a blood inflow opening, a blood outflow opening, and a one-way valve disposed within the flow housing between the inflow and outflow openings.

A method for the integrated facilitization of blood flow and monitoring of blood analyte concentration (for example, blood glucose concentration) includes implanting a stent configured to facilitate blood flow into a cardiovascular system of a user's body with the stent having attached thereto a continuous blood analyte determination module of a blood analyte monitoring system. The method also includes disposing a reader module of the blood analyte monitoring system external to the user's body and in proximity to a portion of the user's skin layer and monitoring blood analyte concentration via (i) emitting an RF carrier signal from the reader module toward the stent; (ii) receiving the RF carrier signal at a reflection antenna of the continuous blood analyte determination module; (iii) reflecting a modulated signal by the reflection antenna with the modulated signal being encoded with a blood analyte concentration determined by a sensor of the continuous blood analyte determination module; (iv) receiving the modulated signal by the reader module; and (v) decoding the analyte concentration from the modulated signal by the reader module.

A prosthetic venous valve includes a frame and leaflets. The frame includes: (i) a generally hollow base disposed at a blood inflow end; (ii) a plurality of struts connected with the base and extending generally parallel to a direction of forward flow of blood from the generally hollow base to a blood outflow end; and (iii) inwardly oriented flanges disposed at the blood outflow ends of the struts. The leaflets are disposed in gaps between the struts and are supported by the frame. The leaflets are arranged to close into the vein lumen to substantially seal against backflow of blood from the blood outflow end to the blood inflow end. The inwardly oriented flanges of the struts enhance the sealing.

A method is provided for detecting filter clogging which are able to keep track of the filter clogging with precision and in detail. At least one pressure selected from the group consisting of a pressure Pa in a blood inflow portion (32a), a pressure Pv in a blood outflow portion (32b), a pressure Pf1 in a filtrate inflow portion (32c), and a pressure Pf2 in a filtrate outflow portion (32d) is measured continuously, then a variation (pressure waveform) of the pressure is analyzed, a clogging of a filter (32) is detected using the analyzed result. Thereby a clogging of a filter is detected early. As a result, it is possible to prevent from developing of the filter clogging by controlling a dosage amount of anti-coagulant properly and changing a flow rate of blood. The variation of the pressure wave may be analyzed by subjecting the variable to Fast Fourier Transform.

Method for calculating a clogging factor of a filter composed of hollow-fiber membrane, which has a blood inflow portion 32a and a blood outflow portion 32b, by passing a blood, the method including the steps of measuring at least two pressure selected from the group consisting of a pressure (Pa) in said blood inflow portion, a pressure (Pv) in said blood outflow portion, a filtering pressure (Pf1) in said blood inflow portion, and a filtering pressure (Pf2) in said blood outflow portion and calculating a filter clogging factor in vertical direction and / or a filter clogging factor in lateral direction using at least two of the measured pressures, flow rate information, biometric information (viscosity information and so on), and structure information.

A replacement heart valve structure including a structure of tissue which is an intact, mammalian heart valve that has been harvested and treated to preserve it. A conventional fabric sleeve is typically disposed concentrically around the outside of the tissue structure. A support structure is included to facilitate implanting the heart valve by somewhat increasing the stability of the heart valve structure, but without unduly rigidifying it. An annular sewing cuff may be added adjacent the blood inflow end of the valve structure to facilitate making the annular suture line that is required at that end.

A blood sample container (1A) according to the present invention includes: a container body section (2) having an internal space (3) for storing initial flow blood to be used for testing; a blood inflow port (5) that allows the initial flow blood to flow in; a blood outflow port (6) that allows the initial flow blood to flow out; and an exhaust section (7) having a hydrophilic and bacteria-impermeable filter (12) that allows the air in the internal space (3) to be discharged, the exhaust section (7) being positioned at an upper end of the container body section (2) when the container body (1A) is used in a manner such that the blood outflow port (6) faces in a vertical direction and having a small-diameter tubular passage (11) that allows the air in the internal space (3) to be discharged by a predetermined amount of the initial flow blood that has flown into the passage (11).

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical datafrom the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

A method is provided for detecting filter clogging which are able to keep track of the filter clogging with precision and in detail. At least one pressure selected from the group consisting of a pressure Pa in a blood inflow portion (32a), a pressure Pv in a blood outflow portion (32b), a pressure Pf1 in a filtrate inflow portion (32c), and a pressure Pf2 in a filtrate outflow portion (32d) is measured continuously, then a variation (pressure waveform) of the pressure is analyzed, a clogging of a filter (32) is detected using the analyzed result. Thereby a clogging of a filter is detected early. As a result, it is possible to prevent from developing of the filter clogging by controlling a dosage amount of anti-coagulant properly and changing a flow rate of blood. The variation of the pressure wave may be analyzed by subjecting the variable to Fast Fourier Transform.

The invention provides a centrifugal blood pump which rotates stably. The centrifugal blood pump comprises a shell and an impeller installed in the shell, and the portion, right facing the center of the impeller, of the shell is provided with a locating shaft matched with a center hole of the impeller; the impeller is installed in the center of a spiral type blood channel between an upper cover and a lower cover; the upper cover and the lower cover are provided with a blood inflow pipe and a blood outflow pipe which are communicated with the blood channel respectively; blades in the impeller comprise main blades and subsidiary blades connected to the outer end of the main impellers; the main blades are uniformly distributed along the circumference of a rotor, and the included angles between the main blades and the blood rotating and circulating direction of the blood channel are obtuse angles. Through the optimized designed impeller and the relevant structural design, the centrifugal blood pump has high pumping efficiency at a low rotation speed, the blood arterial pressure is guaranteed, the low rotation speed lowers wear, the service life of the blood pump is prolonged, the energy consumption is also lowered, the cruising capability of the blood pump is improved, the low rotation speed also lowers the control difficulty of the work pressure of the blood pump, and the centrifugal blood pump is also simpler and more convenient to use and operate.

The extracorporeal blood circulating apparatus of the present invention includes: a closed-type venous reservoir having a blood storage chamber and a volume adjusting chamber that are disposed adjacently by partitioning a closed space formed by a housing; an adjusting liquid tank for storing an adjusting liquid that is connected to the volume adjusting chamber; and a blood pump that is connected to the blood storage chamber. In the housing, an inflow port for allowing blood to inflow and an outflow port for allowing blood to outflow are provided so as to communicate with the blood storage chamber, and an adjusting port for injecting and ejecting the adjusting liquid is provided so as to communicate with the volume adjusting chamber. The blood pump is connected via the outflow port, and the adjusting liquid tank is connected via the adjusting port. The closed space is partitioned by a flexible septum member so as to form the blood storage chamber and the volume adjusting chamber, and the adjusting liquid tank and the adjusting port are connected by a conduit member having a configuration that can adjust a flowing amount. Control of a blood storage amount to be most appropriate and easy adjustment are possible throughout all steps from before starting an extracorporeal blood circulation to terminating it.

The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising:an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous generation of measuring values and is arranged upstream of the citrate supply point (213) and the controller (225) is adapted to continuously carry out a regulation of the metering of the citrate and of the substitution medium in consideration of a target value or target value range, which can be predetermined in the controller (225) downstream from the citrate supply point (213). The invention further relates to a method for detecting the ion concentration.

The invention relates to an intravascular blood pump. The blood pump comprises a pump section having a proximal portion with a blood flow inlet and a distal portion with a blood flow outlet and an impeller for causing blood to flow into the blood flow inlet and towards the blood flow outlet. The blood pump further comprises at least one filter connected to the proximal portion of the pump section and arranged with respect to the blood flow inlet so as to filter the blood before it enters the blood flow inlet. The filter may comprise an expandable mesh structure made of a shape-memory material.

A surgical apparatus for treating a blood clot in a vessel of a patient having an elongated member having an outer wall, a first hole at a distal portion and a second hole spaced proximally from the first hole positioned in a side wall. A first lumen is provided within the elongated member for blood flow through the second hole, through the lumen and exiting the first hole to maintain blood flow during treatment of the blood clot. An energy emitter emits energy to the blood clot or hardenings and a connector connects the energy emitter to an external energy source, wherein blood flows into the second hole positioned proximal of the blood clot and exits the first hole distal of the blood clot during activation of the energy emitter. In some instances when the apparatus is introduced from a retrograde ‘upstream” approach blood may flow through the device in the opposite direction.

This artificial lung includes: a housing; a hollow fiber membrane layer that is housed inside the housing and in which a multitude of hollow fiber membranes having a gas exchange function are integrated; a gas inflow section and a gas outflow section that employ the lumen of each hollow fiber membrane as a gas flow path and that are provided respectively on the upstream side and the downstream side of the gas flow paths; a blood inflow section and a blood outflow section that employ the outside of the hollow fiber membranes as a blood flow path and that are provided respectively on the upstream side and the downstream side of the blood flow path; a first filter member that is provided in contact with the surface of the hollow fiber membrane layer on the side of the blood outflow section and covers almost the entire surface, the first filter member having the function of capturing bubbles in the blood; and a second filter member spaced away from the first filter member and arranged between the first filter member and the blood outflow section, the second filter member having the function of capturing bubbles in the blood.

The present invention relates to a filter built into a blood purification column, and aims to dramatically improve the removal of air that gets into the column and to prevent blood activation due to air remaining inside of the column and decreased absorption performance due to decreased contact surface between blood and an absorbent. This blood purification column has an absorbent and a casing, both ends of which are open ends, and the absorbent is housed inside of the casing. Of the two ends of the casing, one is the blood inflow end and the other is the blood outflow end. A filter is arranged on the blood inflow end and / or the blood outflow end of the casing, and this filter fulfils the following conditions. (1) The opening ratio of the filter is 5-80% (2) The equivalent diameter of the openings in the filter is 1-5000μm (3) The ratio of the equivalent diameter of the openings to the average circle equivalent diameter of the gaps in the absorbent is 45% or greater.

Blood fluidity is measured in a short time. A blood fluidity measurement system, which measures blood fluidity by flowing blood into a channel, is equipped with a TV camera which photographs the blood stream in the channel and an image processing part which detects the state of the blood stream in the channel as blood fluidity from the image taken by the TV camera.

A humor sampling implement includes a detection unit having a main frame part possessing a blood transfer channel to collect blood through a blood inflow port and transfer the blood to a blood outflow port, and a test paper for detecting glucose in the blood transferred through the blood transfer channel. The main frame part is furnished with a projection protruding in the blood transfer channel toward the blood outflow port. The blood transfer channel can be configured to include a first blood transfer channel opening to the blood inflow port and a second blood transfer channel connected to the first blood transfer channel, wherein the direction of blood transfer is different from that in the first blood transfer channel, and the projection is provided at an end portion of the first blood transfer channel on blood outflow port side so as to protrude in the second blood transfer channel.

A container for testing blood (1A) is provided with: a main container body (2) having an internal space (3) for storing an initial blood flow to be used for testing; a blood inflow port (5) that allows the initial blood flow to flow in; a blood outflow port (6) that allows the initial blood flow to flow out; and an exhaust part (7) that has a hydrophilic bacteria-impermeable filter (12), and allows air in the internal space (3) to be discharged. The container for testing blood (1A) is characterized in that the exhaust part (7) is positioned at the upper end of the main container body (2) when the blood outflow port (6) is used in such a manner as to be in the vertical direction, and has a small-diameter tubular passage (11) that allows air in the internal space (3) to be discharged after a prescribed amount of the initial blood flow has entered.

A safety syringe for a vacuum specimen tube having a stopper. The syringe includes a shroud with a double ended needle and a sheath slidably positioned over the needle's external end. The sheath's tip can be hypodermically inserted with the needle. The sheath moves between an exposed position where the sharp point of the needle's external end is exposed and a covered position where the sharp point of the needle's external end is inside the sheath. After the needle and sheath are inserted into the patient, the vacuum tube is seated in the shroud, piercing the stopper with needle's internal end and allowing blood to flow into the tube. As the tube is seated, it will also preferably engage an arm extending from the sheath to advance the sheath into the covered position. Thus, the sheath is in the covered position before the syringe is removed from the patient.

A cardiotomy reservoir, comprising an outer wall provided, at the lid, with connectors for the inflow of blood to be filtered and, at the bottom, with a connector for the outflow of the filtered blood, a filtering mass being provided which divides the space delimited by the outer wall into a portion that is connected to the inflow connectors and a portion that is connected to the outflow connector; the cardiotomy reservoir comprises a layer of material adapted to retain fats present in blood, and further comprises a first partition and a second partition, which are adapted to delimit at different distances the region that comprises the blood outflow connector and are provided with ports for the passage of the blood in its path for accessing the connector which are arranged at differentiated levels with respect to the bottom, the ports that are provided in the first partition that lies closest to the outflow connector being located at a height, from the bottom, that is greater than the height of the ports provided in the second partition, detachable elements for blocking the blood outflow connector being further provided.

The invention discloses a heart valve external-stent and a heart valve prosthesis. The heart valve external-stent comprises a mesh-tube-shaped external-stent body, the external-stent body is providedwith a blood outflow end and a blood inflow end, the blood outflow end is of a waveform structure, and one or more wave peaks are bent at an interval of one or more peaks in the waveform structure tothe external-stent body to form a bending part, and the unbent wave peaks are connected with outward barbs or connected with outward barbs at intervals. According to the heart valve external-stent andthe artificial heart valve, the waveform structure is designed on the blood outflow end of the external-stent body, and the wave peaks in the waveform structure are bent inwards at intervals, an outflow end opening formed by the inward bending wave peaks is inclined to the posterior lobe of a mitral valve, the inward bending wave peaks are connected with an internal stent, a valve is arranged inan attached mode, and good fixation is ensured while an outflow tract is prevented from obstruction.