106 results about "Artificial lung" patented technology

The present invention is directed to a photolytic cell, and to a photolytic artificial lung incorporating such a cell. The photolytic artificial lung converts water to oxygen for blood absorption, regulates pH, the removes carbon dioxide, and co-produces electrical power. The photolytic artificial lung includes a photolytic cell where all of the chemical reactions occur. Additionally, the present invention relates to photolytically sensitive materials for oxygen generation. These materials are useful for gas-free artificial lung fabrication. The photolytic cell disclosed herein can also be used to direct chemical reactions in organs other than the lung. It can also be used to maintain breathing air in confined systems.

The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

The present invention relates to the implantation of one or more prosthetic valve(s) in the pulmonary vein(s) of a subject as a means of decreasing or preventing an increase in pulmonary venous pressure. The present invention accordingly provides for novel treatment strategies for the treatment of medical disorders associated with elevated pulmonary venous pressure, including congestive heart failure, as well as for prosthetic pulmonary vein valves and their delivery systems. Expandable as well as fixed-dimension non-expandable pulmonary vein prosthetic valves for implantation by a variety of surgical and percutaneous procedures are also described.

In an artificial lung system, a gas exchange membrane separates a blood side from an air side, the gas exchange membrane comprising in each case, on the blood side and on the air side, a foreign surface that is colonized on the blood side and / or on the air side with biological cells. The artificial lung system can be used to produce an extracorporeal or implantable lung assist system or to produce a lung model system for the examination of airway stresses.

Pulsatile flow in synchronization with the systole and diastole of a patient's own pulse is generated during auxiliary circulation therapy administered to a patient under cardiac dysfunction. As a result, the diastole augmentation function is maintained, blood flow to the coronary artery is increased, and the therapeutic effect of intending to restore cardiac function without applying after-loading to the heart is improved.Pulsatile flow generation control device Y incorporated in a pulsation-type auxiliary circulation system (X) as an apparatus system having an electromagnetic valve 7 in blood supply lines (4, 6, 8) on the delivery side of artificial lung 5 and a control means 11 for performing control-output relating to the opening and closing operation of the electromagnetic valve 7. The control means 11 has at least a delay circuit and is such that the electromagnetic valve 7 is actuated to close and is maintained closed for a predetermined time interval based on delay detection and is actuated to open based on delay cancellation so that blood flow is periodically interrupted.

The present invention belongs to the field of polymer film preparing technology, and is especially extruding and stretching process for preparing crystalline microporous polymer film. High molecular weight crystalline polymer and low molecular weight crystalline polymer in certain ratio are molten and blended, the mixture is fusing extruded and quick stretched to obtain the microporous film precursor, and the microporous film precursor is annealed, stretched and settled to obtain the microporous polymer film. The technological process has relatively relaxed conditions, and the prepared film has average pore size of 0.05-0.4 micron and high air permeability and may find its wide application in water treatment, micro filtering, artificial lung, cell diaphragm, etc.

A system for providing access to at least one heart chamber for delivering and / or removing a fluid includes a selectively occludable conduit defining a lumen for providing access to an interior of at least one heart chamber from an exterior of a chest wall of the patient, and a dual lumen cannula adapted for passing through an interior lumen of the conduit. The selectively occludable conduit includes at least one balloon closure for substantially sealing an end of the conduit in fluid communication with the chamber of the heart. The dual lumen cannula includes a first, drainage lumen having at least one aperture for removing a fluid from the interior of the heart chamber, and a second, delivery lumen for delivering a fluid into the interior of the heart chamber. The delivery lumen may include an extendable infusion sleeve for delivering a fluid into an interior of the heart.

The invention relates to a polypropylene composition for preparing a polypropylene microporous membrane. The melt flow rate of the polypropylene composition is 2.5-8.0g / 10min; the oxidation induction time is not lower than 10min; beta-crystal content (KDSC Kimmage Development Studies Centre) is not lower than 90%. The invention further relates to a preparation method for the polypropylene composition. The polypropylene composition provided by the invention improves the moulding processability of the microporous membrane effectively and particularly is suitable for the polypropylene microporous membrane formed by a dry-process dual-elongation technology. The microporous membrane obtained from the polypropylene composition provided by the invention has excellent air permeability, smaller thickness volatility, more excellent tensile strength and puncture resistance. The polypropylene composition can be applied to a lithium-ion battery separator and fields of an artificial kidney dialysis membrane, an artificial lung membrane, aseptic filtration and an aseptic packaging membrane, an air purification membrane, a gas separation membrane, a food preservation membrane, etc.

A hollow fiber membrane type artificial lung comprising a hollow fiber bundle composed of multiple porous hollow fiber membranes (8) arranged in one direction; a heat exchange pipe bundle composed of multiple heat exchange pipes (9) arranged in one direction across the hollow fiber membranes and piled one upon another, the heat exchange pipe bundle disposed in parallel to the hollow fiber bundle; and potting materials (10) charged over regions including both end portions of the hollow fiber membranes and heat exchange pipes, which potting materials define a blood flow channel extending across the hollow fiber membranes and heat exchange pipes. Further, there is provided a housing comprising blood ports (3a,3b) facing both ends of the blood flow channel; gas headers (4a,4b) facing both ends of the hollow fiber membranes and providing gas ports (5a,5b); and heat exchange headers (6a,6b) facing both ends of the heat exchange pipe bundle and providing heat exchange liquid ports (7a,7b). Blood is caused to flow through the blood flow channel, and an oxygen-containing gas is passed through the cavity of the hollow fiber membranes to thereby carry out gas exchange. A heat exchange liquid is passed through the cavity of the heat exchange pipes to thereby carry out heat exchange. There can be provided a hollow fiber membrane type artificial lung having a heat exchange part annexed to a gas exchange part without any superfluous increase of charged blood quantity.

An oxygenator includes: a housing; a hollow fiber membrane layer that is stored in the housing and has multiple integrated hollow fiber membranes 31 with a gas exchange function; a gas inlet portion and a gas outlet portion that are provided on the upstream and downstream of gas passages in lumens of the hollow fiber membranes 31, respectively; and a blood inlet portion and a blood outlet portion that are provided on the upstream and downstream of blood passages outsides of the hollow fiber membranes 31, respectively. The hollow fiber membranes 31 in the hollow fiber membrane layer are fixed to each other at one end portions and the other end portions thereof. Conditions 30 ‰¤ µ ‰¤ 60 and OD ‰¤ 4.5 × µ are met where µ [µm] is an average separation distance between the adjacent hollow fiber membranes 31 at a fixed portion of the hollow fiber membrane layer and OD [µm] is the outer diameter of the hollow fiber membranes 31,.

The invention discloses a CT image lung nodule detection method, apparatus and device and a readable storage medium. The CT image lung nodule detection method comprises the following steps: when receiving a medical record processing instruction, obtaining a target CT image corresponding to the medical record processing instruction; acquiring and adjusting display parameters of the target CT imageto obtain an adjusted image; through the pre-stored three-dimensional convolution neural pixel segmentation network and the three-dimensional convolution neural network classifier, analyzing the adjustment image to determine the nodular region, obtaining and outputting the determined nodular region of the adjustment image, and obtaining the first analysis information of the determined nodular region. The invention solves the technical problems of low detection efficiency and low accuracy of the existing artificial lung nodules.

The nanometer carbonic anhydrse grain for biological catalysis of polymer and its preparation process belongs to the field of chemical modification of enzyme. The nanometer carbonic anhydrse grain with bioactivity is a core-shell structure with core of carbonic anhydrse, shell of crosslinked polymer material and chemical bond connection between the core and the shell, and possesses high catalytic activity, high heat stability and no aggregation. This kind of nanometer carbonic anhydrse grain has wide application foreground in CO2 absorption and separation and artificial lung system, etc. Its preparation process includes introducing C-C double bond radical with enzyme modifier to the surface of carbonic anhydrse and subsequent free radical polymerization with the olefin monomer with C-C double bond as material.

Semi-crystalline polymer blended gas or chemical separation membranes are obtained by melting and processing 50-99 wt % of a thermoplastic resin, 1-50 wt % of a semicrystalline polymer and 0.1-10 wt % of a compatibilixer. A method for fabricating semi-crystalline polymer blended gas or chemical separation membrane includes the steps of: mixing 50-99 wt % of thermoplastic resin, 1-50 wt % of semi crystalline polymer and 0.1-10 wt % of compatibilizer; and axially drawing the resulting blend melt coming from an extrusion die. The separation membrane exhibits high selectivity when applied in a gas separation process exceeding the limit value which has been seldom overcome by the existing separation membranes as well as high permeability enough to be applied in real gas separation processes. This enhanced selectivity is ascnbed to the morphology of the ternary blends and different interaction between the compatibilizer and diffusing molecules. The membrane prepared by this method can be used for chemical separation processes (such as reverse osmosis, artificial kidney, artificial lung, drug delivery, drug release, to name a few) as well as liquids and gas separation processes.

The invention provides a comprehensive performance detection system of a breathing apparatus. The comprehensive performance detection system comprises a detection platform, an actuating mechanism control system and a detected data processing device; the detection platform mainly comprises a compression chamber, an air control system which is communicated with the compression chamber, an artificial lung for simulating body breathing, valves for connecting the breathing apparatus and sensors of the valves; the actuating mechanism control system comprises an industrial personal computer, wherein the industrial personal computer is used for controlling the controlled valves to open and close, starting a breathing apparatus motor of the artificial lung to work and controlling the pressure variation of the compression chamber, and an actuating mechanism is used for controlling through buttons on a software interface; and the detected data processing device comprises a computer processing system and a printing device. The detection system can simulate the working condition of an underwater breathing apparatus in the deepwater pressure environment, the pressures and flow parameters of all the valves are detected through the sensors and are digitally displayed, so that factors of man-made misreading, misinformation and the like are reduced, and results are more intuitively and accurately. The system detects the working conditions of all the valves of the breathing apparatus at 120 meters or less under the water, and is particularly suitable for tests for detecting the performance parameters of underwater rescue breathing apparatuses.

The invention discloses a high-precision constant-temperature perfusion instrument for isolated organs. The high-precision constant-temperature perfusion instrument comprises an organ solution perfusion module, a state monitoring module and a GPS positioning module. The organ solution perfusion module comprises: a control unit; a fresh liquid storage case, an artificial lung filtering container, a first peristaltic pump, an organ accommodating case, a pH meter container, a second peristaltic pump and a used liquid storage case which are communicated in sequence; and a temperature sensor acquisition module, an ultrasonic measurement module, a display output module and a stepping motor which are electrically connected with the control unit; wherein the stepping motor is in transmission connection with the first peristaltic pump and the second peristaltic pump, the temperature sensor acquisition module is arranged in the organ accommodating case, measured temperature information is used for acoustic velocity temperature compensation, and the ultrasonic measurement module is used for measuring the flow velocity of a solution in a catheter. The high-precision constant-temperature perfusion instrument can monitor other physiological parameters of the organs and accurately control temperature and a perfusion speed; and due to introduction of a GPS positioning function, accurate conveying of the isolated organs is facilitated, an optimal path may be selected, and conveying time can be saved.

Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and / or between said stromal cell layer and said endothelial lung cell layer.

An extracorporeal circulator comprising a line for extracting blood from a patient, a pump for supplying blood, an artificial lung section performing gas exchange on blood, a line for supplying blood passed through the artificial lung section to the patient, a unit for removing bubbles mixed into the blood, a controller for controlling the flow rate of blood being supplied such that bubbles are not fed to the patient, and a line for detouring blood delivered from the blood pump to return it to the blood pump.

The invention discloses a polypropylene composition. The polypropylene composition consists of the following components: 100 parts of a propylene polymer, 0.05 to 0.15 part of a main antioxidant, 0.1 to 0.3 part of an auxiliary antioxidant, 0.01 to 0.05 part of a halogen absorbing agent and 0.05 to 0.3 part of a beta crystal nucleating agent. The invention also discloses a preparation method of the propylene polymer. The preparation method is simple and suitable for large-scale production; a polypropylene microporous film is prepared through melt drawing formation of the polypropylene composition provided by the invention, the microporous film has excellent formation processing performance and mechanical performance, and the film has few crystal points and defects, so that the strict requirements of the film comprising a lithium battery diaphragm can be met; the polypropylene composition can be applied to the polypropylene microporous film manufactured through dry double-drawing pore forming, and the film can be applied in the fields of artificial kidney dialysis membranes, artificial lung membranes, sterile filtering and sterile packaging membranes, lithium battery diaphragms, air purifying membranes, films for water treatment, films for gas separation, food preservative films and the like.

The invention provides a dual-channel hollow fibre film type artificial lung and a method thereof. The artificial lung includes a case and an inner-placed hollow fibre bundle consisted of hollow fibre, the case is made of gradient earthenware pipe and inner wall of the case is coated with ionomer film; the hollow fibre outside surface is coated with liquid crystal / silicon rubber crosslinking film. The invention also provides a method for manufacturing the artificial lung which mainly includes a coating technics of the hollow fibre and gradient earthenware pipe. The invention firstly discloses that O2 and CO2 have a dual-channel type artificial lung respectively, compared with the artificial lung with single channel, oxygen gas transmitting rate is larger and pressure fall is lower, working life is more longer and better oxygenation effect can be obtained.

The present invention is directed to a photolytic cell, and to a photolytic artificial lung incorporating such a cell. The photolytic artificial lung converts water to oxygen for blood absorption, regulates pH, the removes carbon dioxide, and co-produces electrical power. The photolytic artificial lung includes a photolytic cell where all of the chemical reactions occur. Additionally, the present invention relates to photolytically sensitive materials for oxygen generation. These materials are useful for gas-free artificial lung and / or pulmonary capillary fabrication. The photolytic cell disclosed herein can also be used to direct chemical reactions in organs other than the lung.

This artificial lung includes: a housing; a hollow fiber membrane layer that is housed inside the housing and in which a multitude of hollow fiber membranes having a gas exchange function are integrated; a gas inflow section and a gas outflow section that employ the lumen of each hollow fiber membrane as a gas flow path and that are provided respectively on the upstream side and the downstream side of the gas flow paths; a blood inflow section and a blood outflow section that employ the outside of the hollow fiber membranes as a blood flow path and that are provided respectively on the upstream side and the downstream side of the blood flow path; a first filter member that is provided in contact with the surface of the hollow fiber membrane layer on the side of the blood outflow section and covers almost the entire surface, the first filter member having the function of capturing bubbles in the blood; and a second filter member spaced away from the first filter member and arranged between the first filter member and the blood outflow section, the second filter member having the function of capturing bubbles in the blood.

The invention relates to an artificial lung for simulating the stress by a user when testing a breathing apparatus, particularly a compressed air breathing apparatus, comprising a housing, which surrounds a pulmonary space for the breathing air and has a connection for supplying the breathing air to the breathing apparatus. In order to be able to variably control the volume flow for generating a certain respiration curve, the housing (2) surrounding the pulmonary space for the breathing air is provided with an inlet (5) and with an outlet (6) for the breathing air, a fan (7, 8) is connected to the inlet and outlet (5, 6), respectively, for supplying and removing the breathing air, and a cover (13), which can be actuated by way of a drive (16) and encloses the pulmonary space (3), is disposed in the housing (2), which cover controls the volume flow of the breathing air between the inlet (5) for the breathing air and the connection (4) for the supply of the breathing air to the breathing apparatus, and / or between the connection (4) and the outlet (6) for removing the breathing air, so as to generate the breathing curve.

The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.

Fry breeding method and apparatus are provided by which growth irregularity and lethal rate are reduced and a remarkably quick growth is enabled. A closed type fry breeding water tank 1 has a fry isolating function by meshes 1b, 1c. Breeding water prepared to have a high dissolved oxygen concentration by an artificial lung 3 is supplied into the fry breeding water tank 1 in a low flow rate that has little influence on the fry. The fry, especially those immediately after the hatching on which the dissolved oxygen is very influential, are bred in the streaming water, not in the stationary water as so far considered a common sense in the conventional case. Thereby, the growth irregularity that has so far not been overcome is suppressed and a remarkably quick, safe and secure growth is enabled.

A dual lumen cannula includes a first lumen having at least one aperture for removing a fluid from the interior of the heart right atrium, and a second lumen for delivering a fluid into the interior of the pulmonary artery or the heart left atrium. The second lumen includes a distal selectively curvable portion having a length of from about 4 cm to about 22 cm to position an end thereof within the interior of the pulmonary artery lumen or the human heart left atrium interior when a distal end of the first lumen is positioned within a right atrium of the human heart. The second lumen may also include a distal anchoring structure for preventing inadvertent withdrawal from a surgical site.

The invention relates to a method for removing PM2.5 by artificial lung surface active substances, including the modification of silk fibroin, the preparation of fiber membranes and the adsorption of dust, and the silk fibroin and artificial lung surface active The spinning solution of the substance is prepared into a nanofiber membrane for removing heavy metal ions. The nanofiber membrane is prepared by electrospinning in the present invention, which can effectively control the porosity of the fiber membrane and remove PM2.5 particles of different particle sizes. The invention adopts natural silk fibroin and artificial lung surface active substance, can effectively increase the contact area between the adsorbent and metal ions, and remove heavy metal ions. The film prepared by the invention has the advantages of convenient application, simple method and strong operability.