37 results about "Artificial lung" patented technology

The invention provides a PMP polymer breathable film and a preparation method thereof. The preparation method specifically comprises the following steps: step 1, PES particle activation; 2, preparing a GO dispersion liquid and a polymer solution; 3, mixing the activated PES particles with a GO dispersion liquid and a polymer solution in sequence for modification; 4, preparing a spinning solution; 5, spinning to form a film; step 6, carrying out ultraviolet lithography; 7, sterilizing after a potential regulator and irradiation; through material compounding, gradient pore-foaming agent design, bionic modification and multi-process cooperation (plasma treatment, ultraviolet crosslinking and micro-channel photoetching), the air permeability, the mechanical strength, the biocompatibility and the structural controllability are obviously superior to those in the prior art. The innovation point of the composite membrane is that efficient gas exchange, long-term stability and low biological risk can be realized by directly aiming at the defects of the traditional PMP membrane, especially in the fields of artificial lung and hemodialysis.

The invention discloses a high-oxygen-permeability membrane material and a preparation method thereof, and belongs to the technical field of membrane materials. The membrane material is prepared by taking polydimethylsiloxane and polycaprolactone as organic raw materials, adding an inorganic material nano titanium dioxide or graphene, and carrying out solution preparation, cross-linking reaction, casting membrane formation, hot press molding, plasma treatment and surface modification. The polydimethylsiloxane guarantees the oxygen permeability, the polycaprolactone improves the flexibility and the biocompatibility, and the nano inorganic particles enhance the mechanical strength and the antibacterial property. The prepared membrane material is improved in oxygen permeability coefficient, greatly improved in tensile strength and elongation at break, good in hydrophilicity and biocompatibility, low in cytotoxicity and small in hemolysis rate, can be widely applied to medical products such as artificial lungs, wound dressings and contact lenses, and effectively meets the requirements of the medical field for the membrane material with high oxygen permeability and good comprehensive performance.

The invention relates to the technical field of membrane materials, in particular to an asymmetric PMP hollow fiber oxygenation membrane and a preparation method and application thereof. The PMP hollow fiber oxygenation membrane comprises a main body, one side of the main body is an inner surface facing an inner cavity, and the other side of the main body is an outer surface; the outer surface has a compact surface; the initial foaming point of hydrofluoroether of the oxygenation membrane is not lower than 2MPa, and the porosity of the oxygenation membrane is 40%-70%; the oxygen flux of the oxygenation membrane is 1 ml / (cm < 2 > * min * bar)-2.5 ml / (cm < 2 > * min * bar), and the separation ratio alpha (CO2 / O2) of carbon dioxide to oxygen of the oxygenation membrane is not lower than 1.8; the oxygenation membrane has appropriate oxygen flux and a high separation ratio alpha of carbon dioxide and oxygen, the oxygenation capacity of the oxygenation membrane is truly and greatly improved, the difference between the oxygenation membrane and the lung of the human body is shortened, and the oxygenation membrane can be used as an artificial lung to provide arterial blood for the organs of the human body and enable the organs of the human body to still work normally.

An extracorporeal circulation system (10) is provided with: a holder unit (12) integrally having a holder part (18) to which an artificial lung (100) is attached, and a pump drive part (20) for rotating a blood pump (110); and an input part (67) provided separately from the holder unit (12). The holder unit (12) has a pump control part (52) that controls the pump drive part (20) on the basis of information from a sensor for measuring physical property parameters in the circuit and information from the input part (67).

The purpose of the present invention is to provide, inter alia, a management device having a display or another display unit that is easy for a user to visually recognize. A management device (10) manages an extracorporeal circulation device (1) that has an artificial lung device (2), a pump unit (3), and an extracorporeal circulation circuit (IR). The management device (10) has a control unit (111) and a display unit (113) that displays various types of information relating to the extracorporeal circulation device (1). The control unit (111) groups together various types of information (P1) relating to the extracorporeal circulation device (1) into a plurality of groups on the basis of preset relevance information. The display unit (113) has an aggregation display region in which the various types of information belonging to the respective groups are disposed in an aggregated manner.

Provided herein are artificial lung organoids. The artificial lung organoids may include an epithelial cell layer comprising mammalian lung epithelial cells, a stromal cell layer comprising mammalian lung fibroblast cells and an endothelial cell layer comprising mammalian endothelial cells. The artificial lung organoids may optionally include a porous membrane between said epithelial cell layer and said stromal cell layer and / or between said stromal cell layer and said endothelial lung cell layer.

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

A system (100, FIG. 1) for controlling blood oxygenation of a patient using an artificial lung 200 having a gas-blood interface 240. The system (100, FIG. 1) includes a controller (150, FIG. 1) configured to receive a measurement of a physiological parameter indicative of oxygenation of the patient's blood and to calculate a difference between the measurement and a target value of the physiological parameter. The controller (150, FIG. 1) is further configured to control the gas supply device (300, FIG. 1) to supply the first oxygenated gas 242a to the first interface area 240a of the gas-blood interface 240 and the second oxygenated gas 242b to the second interface area 240b of the gas-blood interface 240, to reduce the amount of oxygen the blood is exposed to by reducing the flow rate of the second oxygenated gas 242b to reduce the difference in response to the measured value exceeding a target value, and to reduce the oxygen concentration and / or flow rate of the first oxygenated gas 242a in response to the flow rate of the second oxygenated gas 242b being reduced to a threshold value.

The second lid member (36) that constitutes the outer shell (26) of the artificial lung (10) has a second concave wall portion (88) that is recessed toward the gas exchange portion (30) side with respect to the inner surface (74a) of the second lid main body (74). A pressure adjustment hole (86) is formed in the second lid main body (74), and a sampling port (90a) for collecting the gas led out from the gas exchange portion (30) is provided in the second concave wall portion (88). The inner opening portion (92) of the sampling port (90a) faces the second outlet side end surface (31b) of the gas exchange portion (30).

The present invention discloses a microfluidic artificial lung and a manufacturing method thereof, comprising: a substrate having at least one blood flow channel, at least one first air flow channel, and at least one intersection region between the first air flow channel and the blood flow channel; and at least one biomimetic sealing microstructure array comprising a plurality of microstructures, wherein the plurality of microstructure arrays are arranged in the intersection region to form an interface between the blood in the blood flow channel and the gas in the first air flow channel. The microfluidic artificial lung of the present invention forms a biomimetic sealing microstructure array by arranging the plurality of microstructure arrays in the intersection region, so that the blood in the blood flow channel and the gas in the first air flow channel fill the gaps between the plurality of microstructures when flowing through the intersection region, thereby forming a stable interface. This prevents mixing of the blood and the gas, thereby achieving a sealing function without requiring additional control or input, while allowing blood and gas to exchange gas at the interface.

The artificial lung elbow core-pulling mold structure comprises a male mold plate and a female mold plate, a lower fixing plate is installed at the bottom of the male mold plate in a positioning mode, square iron is installed between the male mold plate and the lower fixing plate in a positioning mode, a hot runner plate is installed at the upper end of the female mold plate, and an upper fixing plate is installed at the upper end of the hot runner plate. A shovel base assembly is installed on the side edge of the male mold plate, a shovel base fixing bolt is arranged on the shovel base assembly, and an upper ejector plate and a lower ejector plate are arranged on the lower fixing plate. According to the artificial lung elbow core-pulling mold structure, the production efficiency can be improved, the injection molding period can be shortened, the product percent of pass can be improved, new requirements for automobile, electronic and electrical and medical molds in recent years can be completely met, the mold and production cost can be greatly reduced, the pollution probability of the environment and products is reduced, and the production cost is reduced. The production efficiency is improved and the injection period is shortened.

This application provides an artificial lung model and its design method. The artificial lung model includes: an air intake assembly with an internal air intake channel; one end of the air intake assembly is connected to one end of a plurality of bronchus and bronchiolar assemblies; the other end of each bronchus and bronchiolar assembly is connected to an artificial alveolar assembly. Each bronchus and bronchiolar assembly includes a tube body, which includes a first connecting section, a second connecting section, and a simulated section located between the first connecting section and the second connecting section; the sum of the internal cavities of all the simulated sections of the tube body is between 50 and 500 mL; the plurality of first connecting sections are all connected to the air intake channel, and the second connecting sections are connected to the artificial alveolar assemblies one by one, so that gas can enter the artificial alveolar assembly from the air intake channel through the tube body.

The invention relates to the technical field of medical materials, and discloses a membrane curtain for an artificial lung as well as a preparation method and application of the membrane curtain. The membrane curtain for the artificial lung comprises hollow fiber membrane filaments and braided wires, the hollow fiber membrane filaments and the weaving lines are woven into a membrane curtain through a weaving method of a leno weave; the hollow fiber membrane yarns are distributed along the weft direction and are used as weft yarns; the weaving threads are distributed in the warp direction and serve as warp threads, and the warp threads are divided into ground warp threads and cross warp threads; the ground warps and the doup warps are woven through a forward twisting method; the weft-wise density of the membrane curtain is 10-20 hollow fiber membrane filaments per centimeter, and the warp-wise density of the membrane curtain is 5-15 ground warps per 10 centimeters and 5-15 cross warps per 10 centimeters. The hollow fiber membrane filaments and the weaving threads are woven into the membrane curtain through the weaving method of leno weave structure design and weaving on a rapier loom, the shape is stable, the manufacturing cost is low, the qualification rate of manufacturing of the membrane curtain for the artificial lung can be increased, and small sample preparation is rapidly achieved.

To provide an artificial lung of a novel structure capable of stably oxygenating blood and securing safety against contamination of the blood with air bubbles.SOLUTION: In an artificial lung 10, in a use state, a gas inlet port 52 introducing supply gas into a gas passage 66 in a housing 12 is provided in an upper wall part of the housing 12, a gas outlet port 50 leading exhaust gas from the gas passage 66 is provided in a lower wall part of the housing 12, a blood inlet port 28 introducing blood into a gas exchange area 56 in the housing 12 is provided in a first side wall part 22 of the housing 12, a blood outlet port 40 leading the blood from the gas exchange area 56 is provided in a second side wall part 34 facing the first side wall part 22 of the housing 12, and the blood outlet port 40 is located in a vertically intermediate part of the second side wall part 34. The second side wall part 34 is provided with a tapered outlet side guide part 38 converged toward the blood outlet port 40.SELECTED DRAWING: Figure 4

The application discloses a dummy system and method for detecting the injury effect of infrasound waves on human bodies, and relates to the technical field of dummy systems. The dummy system comprises a dummy body and an infrasound wave detection, collection and processing device. The dummy body comprises a head, a neck, a trunk, an artificial heart and an artificial lung. The artificial heart and the artificial lung are arranged in the trunk. The head, the trunk, the artificial heart and the artificial lung are made of acoustic metamaterials. The infrasound wave detection, collection and processing device comprises acceleration sensors and a data acquisition module arranged in the dummy body respectively, infrasound wave frequency test sensors and infrasound wave sound pressure intensity test sensors arranged in the environment where the dummy body is located respectively, and an upper computer. The data acquisition module is electrically connected with the acceleration sensors. The upper computer is electrically connected with the data acquisition module, the infrasound wave frequency test sensors and the infrasound wave sound pressure intensity test sensors respectively. The dummy system can simulate the resonance and damage state of the human body under the influence of infrasound waves.

The invention belongs to the technical field of medical instruments, and discloses a full-automatic double-end artificial lung membrane yarn knitting machine which comprises two stations, a size-adjustable membrane yarn feeding device, a buffering device, a material collecting device, a material pulling device and a yarn distributing device are sequentially arranged on a table top corresponding to each station in the first direction, and the yarn distributing device is located above the knitting yarn feeding device. A bartack cutting device and a wire shifting device are further arranged between the wire distributing device and the braided wire feeding device; membrane filaments are guided to the bartacking cutting device through the buffering device and the filament distributing device in sequence, braided threads are guided to the bartacking cutting device through the filament shifting device, the membrane filaments and the braided threads can be subjected to bartacking and braiding through the bartacking cutting device to form finished products, and meanwhile the bartacking cutting device can cut the finished products. And the finished product is recovered at the material receiving device after passing through the material pulling device. According to the invention, the feeding difficulty of the braided wire is reduced, the material shaft sizes of different membrane wire raw materials can be compatible, the overall efficiency is high, and the cutting consistency is better.

The invention relates to the technical field of biomedical polymer materials, and discloses a preparation method of an artificial pulmonary membrane material. The method comprises the following steps: mixing vinyl-containing polydimethylsiloxane, a sulfydryl-containing silane monomer, a sulfonate group-containing functional monomer, a rhodamine lactam structure-containing early warning functional monomer and a hydrogen-containing silicone oil cross-linking agent to prepare a precursor solution; coating a microporous support membrane with the precursor solution, heating and curing, so that each functional monomer is integrated into a polymer network through covalent bonds; and finally, carrying out an in-situ nitrosation reaction, and converting the immobilized sulfydryl into S-nitroso mercaptan. According to the invention, functional units are stably immobilized in the form of covalent bonds, so that the problems that the existing physical coating is easy to fall off and the anticoagulant performance is quickly attenuated are solved. The prepared material can synergistically release nitric oxide and realize lasting anticoagulation by utilizing fixed negative charges, and the integrated fluorescent unit can also respond to local pH drop in the initial stage of thrombus, so that the material is endowed with in-situ real-time early warning capability for failure risk.

An extracorporeal circulation system (10) comprises: a holder unit (12) having a holder part (18) to which an artificial lung (100) for performing gas exchange is attached; and a holder (150) that can be attached to and detached from the holder unit (12) and can hold the holder unit (12). The holder (150) has an orientation-changing mechanism (164) capable of changing the orientation of the holder unit (12) with respect to the vertical direction in a connected state in which the holder (150) is connected to the holder unit (12).

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

The utility model provides a respirator detector calibration device. The respirator detector calibration device comprises a first piston device, a second piston device, a pressure sensor, an oxygen concentration mixing module, a control module and a simulated lung, the first piston device comprises one or more sets of piston systems with the same structure, and the oxygen concentration mixing module is connected with the first piston device and the second piston device through pipelines; the first piston device is communicated with the respirator detector to be calibrated through a pipeline; the pressure sensor is connected in series with the second piston device and is communicated with the respirator detector to be calibrated through a pipeline; and the simulated lung is communicated with the respirator detector to be calibrated through a pipeline. The piston type gas standard device is used as a gas flow generating device, the oxygen concentration mixing module is communicated with the first piston device and the second piston device, and the device has the advantages of being stable in breathing gas flow, adjustable in pressure, high in measuring efficiency and the like.

The present application provides a method, device, equipment and storage medium for calculating the flow field of artificial lung blood flow. The method includes: obtaining a three-dimensional model of an artificial lung containing a porous medium; establishing a fluid control equation for blood flow in the three-dimensional model; superimposing the momentum loss of blood flow in the porous medium region on the fluid control equation with a first momentum source term; and solving the fluid control equation to obtain the flow field of blood flow in the three-dimensional model. The embodiments of the present application can improve the accuracy of flow field calculation, so as to more accurately describe the flow characteristics of blood flow in the artificial lung.

The blood purification system connected to the ECMO system having an ECMO blood pump and an artificial lung includes a water removal control unit that maintains the concentration of blood circulating through the blood purification system at a predetermined concentration when the rate of change of the flow of blood in the ECMO system exceeds a predetermined threshold.

The invention discloses an organic silicon-heparin composite membrane as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: adding an organic silicon source precursor into a solvent, water and a catalyst to prepare organic silicon sol containing active groups; the preparation method comprises the following steps: loading organic silicon sol on a porous substrate membrane material by a blade coating method, and roasting to form an organic silicon membrane layer; then immersing into a solution containing a heparin material, and carrying out heating polymerization to obtain an organic silicon-heparin composite membrane; the organic silicon source precursor is selected from 1, 2-bis (triethoxysilyl) ethane or 1, 8-bis (triethoxysilyl) octane; and the porous substrate membrane material is polypropylene (PP) or polyether sulfone (PES). The prepared organic silicon-heparin composite membrane has high CO2 permeability and CO2 / O2 selectivity, the grafted heparin reduces the adsorption of the organic silicon surface to blood cells, the blood compatibility of the membrane is improved, the anticoagulation time of the membrane is prolonged, and the organic silicon-heparin composite membrane can be used in a biomedical material artificial lung.

Provided is a blood circulation circuit capable of reducing manufacturing costs and maintenance costs. A blood circulation circuit (1) includes a blood removal line (2) that removes venous blood, a blood reservoir (4) that is connected to the blood removal line (2) and stores blood that has flowed through the blood removal line (2), a negative pressure adjustment device (6) that adjusts the negative pressure inside the blood reservoir (4), a blood pump (5) that transports the blood of the blood reservoir (4), an artificial lung (7) that performs gas exchange on the blood that has been sent from the blood pump (5), and a blood recovery line (3) that is connected to the blood reservoir (4) and sucks blood from a surgical site by the negative pressure of the blood reservoir (4).

The invention belongs to the technical field of medical instruments, and discloses an artificial lung membrane filament braiding machine which comprises a machine base and a platform, the platform is located at the top of the machine base, and at least two sets of membrane filament feeding devices, membrane filament braiding equipment, braided wire feeding devices, detection devices and receiving devices are symmetrically arranged on the platform. The braided wire feeding device is used for feeding braided wires, the membrane wires and the braided wires are braided at the membrane wire braiding equipment, the membrane wire braiding equipment can rotate by any angle relative to the platform so that the braided wires and the membrane wires can be braided into a membrane curtain at an oblique angle, and the detection device can detect flaws of the membrane curtain. And one of the two groups of material receiving devices can be used for collecting the two groups of film curtains into a roll and then finishing material receiving. By means of the membrane yarn weaving equipment, the membrane yarn and the weaving line can be woven into the membrane curtain at the oblique angle, so that adjustable oblique angle weaving is achieved, the membrane yarn is prevented from being damaged, defect detection can be conducted on the membrane curtain through the detection device, and quality control is conducted.

The invention discloses a preparation method of a hydrophobin-based bifunctional modified membrane and application of the hydrophobin-based bifunctional modified membrane in the field of artificial lungs, and belongs to the technical field of modification of qi-blood exchange membranes. The modified membrane is prepared by soaking a gas-blood exchange membrane for the ECMO / ECCO2R system in a hydrophobic protein-containing modification liquid for self-assembly modification, the hydrophobic protein is I-class hydrophobic protein, namely EAS protein, and the gas-blood exchange membrane for the ECMO / ECCO2R system is a PMP hollow fiber membrane. The modified membrane shows good CO2 / O2 selectivity in an ECMO / ECCO2R system, has excellent carbon dioxide removal performance and excellent blood compatibility, and is beneficial to improving the separation capacity of membrane lung on CO2 in human blood and the anti-thrombosis capacity.

The application provides a poly-4-methyl-1-pentene (PMP) membrane with a gradient pore structure and a preparation method thereof, which is suitable for an extracorporeal membrane oxygenator (ECMO). The PMP membrane is prepared by physical blending of PMP and polyvinylidene fluoride (PVDF) and multi-stage electrospinning process, and is formed into a composite membrane with an asymmetric gradient pore structure. The dense layer effectively inhibits plasma leakage, and the porous layer optimizes the gas exchange efficiency. The preparation method of the application is carried out at normal temperature and pressure, overcomes the limitation of high-temperature processing of traditional PMP membranes, and significantly improves the mechanical strength and gas permeability of the membrane. The PMP membrane has excellent biocompatibility, long-term stability and anti-plasma leakage performance, and can meet the long-term use requirement of ECMO, and provides a better solution for artificial lung membrane technology.

The invention provides a poly (4-methyl-1-pentene) (PMP) membrane with a gradient pore structure and a preparation method of the poly (4-methyl-1-pentene) membrane. The poly (4-methyl-1-pentene) membrane is suitable for an in-vitro membrane type artificial lung (ECMO). According to the PMP membrane, PMP and polyvinylidene fluoride (PVDF) are physically blended, multi-walled carbon nanotubes are combined for reinforcement, and the composite membrane with an asymmetric gradient pore structure is prepared through a multi-stage electrostatic spinning process. Wherein the compact layer effectively inhibits plasma leakage, and the porous layer optimizes the gas exchange efficiency. The preparation method is carried out at normal temperature and normal pressure, the limitation of high-temperature processing of a traditional PMP film is overcome, and meanwhile, the mechanical strength and the gas permeability of the film are remarkably improved. The PMP membrane has excellent biocompatibility, long-term stability and plasma leakage resistance, can meet the long-term use requirement of ECMO, and provides a better solution for an artificial lung membrane technology.

Provided is a cannula with which it is possible to effectively and antegradely send blood from the ascending aorta, while reducing the diameter. This cannula, in which the distal end part thereof is disposed in the ascending aorta and blood fed from an external-membrane-type artificial lung is sent antegradely from the ascending aorta, comprises an antegrade blood return part 2 and a blood-sending tube 4, the antegrade blood return part 2 being provided at the distal end of the blood-sending tube 4. A guide wire tube 5 extending in the longitudinal direction from the base end part to the distal end part is disposed substantially at the center of the axis inside the antegrade blood-sending cannula 1. The blood-sending tube 4 is a tube provided on the base end side connected to the extracorporeal-membrane-type artificial lung.

A procedure simulator (10) comprises: an animal heart (12); a living lung reproduction module (14) that is connected to the heart (12), has a pump (52) and an artificial lung (24), adds oxygen to blood discharged from the heart (12), and sends the blood to the heart (12); and a cell metabolism reproduction module (16) that is connected to the heart (12) and has a deoxygenation unit (64) that deoxygenates the blood discharged from the heart (12). The procedure simulator sends the blood deoxygenated by the deoxygenation unit (64) to the heart (12).