64 results about "Diastole" patented technology

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

The invention relates to the technical field of medical monitoring and intelligent decision making, and particularly discloses an intraoperative noninvasive real-time blood flow monitoring and medication intervention analysis system. Pulse wave oscillation harmonic component characteristics and diastolic attenuation characteristic characteristics are extracted by using variational mode decomposition and a polynomial fitting algorithm; the multi-dimensional features are fused and then input into a deep learning classification model, and accurate recognition of insufficient heart pump efficiency, abnormal peripheral vascular tension and circulation capacity imbalance states is achieved; time sequence prediction and grading early warning are carried out based on the hidden Markov model and the individualized baseline safety interval, and finally a targeted medication scheme is output through the intervention strategy knowledge base.

The invention relates to the technical field of biomedical engineering. The invention discloses a triggering method and device of magnetic resonance imaging equipment based on multi-modal signal fusion, terminal equipment and a storage medium. The accuracy of triggering the magnetic resonance imaging equipment to collect images can be improved. The method comprises the following steps: acquiring a first morphological characteristic of a heart vibration signal of a target object, a second morphological characteristic of a jugular vein pulse signal and a third morphological characteristic of a photoelectric volume pulse wave signal; constructing a heterogeneous graph based on the first morphological feature, the second morphological feature and the third morphological feature; performing global graph feature vector extraction processing on the heterogeneous graph by adopting a heterogeneous graph attention network to obtain a target global graph feature vector; and performing time prediction processing on the target global map feature vector by adopting a trigger control model to obtain target time, and triggering magnetic resonance imaging equipment to collect images when the target object is in the middle and later period of cardiac diastole based on the target time.

Methods, systems, and devices for cardiovascular health metric determination are described. A system may be configured to receive a photoplethysmogram (PPG) signal representative of a pulse waveform for a user. The pulse waveform may include a first local maximum, a downward slope following the first local maximum, and a curved feature representative of a transition from a systolic phase to a diastolic phase of a cardiac cycle. Additionally, the system may extract one or more morphological features from the pulse waveform and compare the one or more morphological features with one or more features from a plurality of baseline PPG signal morphologies associated with a plurality of chronological ages. The system may determine a cardiovascular health metric that indicates a cardiovascular health of the user relative to a chronological age of the user and cause a graphical user interface to display an indication of the cardiovascular health metric.

A device for non-invasive venous-pressure sensing comprises an occlusive element (OC) configured to be applied to a proximal portion of a human limb in order to apply an occlusion pressure thereto, and a dilation-sensing element (VS) configured to be applied to a distal portion of a human limb in order to detect an extent of dilation thereof. The device likewise comprises a control circuit (10) coupled to the occlusive element (OC) and to the dilation-sensing element (VS). The control circuit (10) is configured to: —i) control (104, 106) the occlusive element (OC) in order to apply at least one sub-diastolic occlusion pressure and maintain it for a certain occlusion interval; —ii) obtain (108a, 108b) from the dilation-sensing element (VS) a sensing signal; —iii) carry out a check on the sensing signal for a certain variation of the dilation of the distal portion resulting from the fact that the occlusion pressure is removed; and —iv) issue a signal (102) indicating a venous pressure that is lower than the applied occlusion pressure (P0c) as a result of the fact that said check indicates a variation in the dilation of the distal portion of the limb resulting from the fact that the occlusion pressure has been removed.

The invention discloses a myocardial stress determination method, device and equipment based on cardiac ultrasound and a medium, and relates to the field of myocardial stress evaluation.The method adopts a double-mapping network mode and comprises the steps that a cardiac medical image is acquired and labeled, and a feature database of the cardiac bimodal image in the systolic period and the diastolic period is constructed; constructing a first mapping network and performing training, and then performing segmentation and three-dimensional reconstruction on a to-be-processed cardiac ultrasound image to obtain a double-ventricle three-dimensional model; obtaining a finite element simulation model of the double ventricles and carrying out finite element simulation calculation to obtain a ventricle wall stress-strain simulation result; constructing a heart model-simulation result pairing database; constructing a second mapping network; training the second mapping network based on the heart model-simulation result pairing database; and determining a myocardial stress result based on the trained second mapping network. According to the method, the current situation that the myocardial stress cannot be effectively measured and evaluated by a traditional cardiac ultrasound method is effectively improved.

A medical system configured to deliver a plurality of pacing signals to a heart of patient. In examples, the medical system is configured to provide at least first pacing signal to cause or assist in causing a first cardiac cycle of the heart and a second pacing signal to cause and / or assist in causing a second cardiac cycle of the heart. The medical system the medical system includes processing circuitry configured to control an interval separating the first pacing signal and the second pacing signal to cause the second pacing signal to be subsequent to a diastole indicator of the first cardiac cycle.

This invention discloses an intelligent psychological guidance system for harmonizing the Qi of the internal organs based on TCM emotional differentiation, belonging to the field of medical electronic equipment. The system includes a multi-node physiological signal acquisition module, a central control and data processing module, and an acoustic intervention output module. The system synchronously acquires multi-channel bioimpedance, volumetric pulse wave, and electrocardiogram signals, extracts pulse wave conduction time and local blood perfusion index, constructs Qi characteristic parameters, and maps them to generate emotional tags. The central control module locks the target resonance unlocking frequency according to the tags, modulates low-frequency vibrations with reference audio to synthesize a multimodal signal, and further combines physiological pulse transmission delay to perform phase compensation, controlling the precise output of the intervention signal during ventricular diastole. Steady-state determination and closed-loop tracking are performed based on the dynamic gradient of impedance variance. This invention achieves objective quantification of TCM differentiation and ensures high-precision physical alignment between intervention energy and the hemodynamic state of the internal organs.

The present invention discloses a system for determining fractional flow reserve, the system comprising: a first pressure sensing medical device for measuring a first pressure distal of an intravascular stenosis; a second pressure sensing medical device for measuring a second pressure proximal of an intravascular stenosis; a processor coupled to the first pressure sensing medical device and coupled to the second pressure sensing medical device; and a display for displaying data received from the first pressure sensing medical device and from the second pressure sensing medical device and plots of the pressure data as generated by the processor; wherein the processor is configured to: determine fractional flow reserve by monitoring data received from the first pressure sensing medical device and from the second pressure sensing medical device during specific windows during the diastolic period of the cardiac cycle.

The embodiment of the invention discloses a method, device and equipment for determining the position of an indication balloon and a medium, and belongs to the technical field of indication balloons.The method comprises the steps that a blood pressure sequence collected by the balloon at a blocking position is collected; determining a dicrotic wave peak according to the blood pressure sequence; determining a diastole by using the dicrotic wave peak, and generating a diastole blood pressure sequence; calculating a blood pressure time attenuation parameter according to the diastolic blood pressure sequence; and according to the blood pressure time decay parameter, determining a current plugging area of the balloon. The balloon plugging area can be accurately determined and indicated without participation of imaging equipment such as digital subtraction angiography (DSA) and ultrasonic examination.

Methods, systems, and devices for cardiovascular health metric determination are described. A system may be configured to receive a photoplethysmogram (PPG) signal representative of a pulse waveform for a user. The pulse waveform may include a first local maximum, a downward slope following the first local maximum, and a curved feature representative of a transition from a systolic phase to a diastolic phase of a cardiac cycle. Additionally, the system may extract one or more morphological features from the pulse waveform and compare the one or more morphological features with one or more features from a plurality of baseline PPG signal morphologies associated with a plurality of chronological ages. The system may determine a cardiovascular health metric that indicates a cardiovascular health of the user relative to a chronological age of the user and cause a graphical user interface to display an indication of the cardiovascular health metric.

Methods, systems, and devices for determining cardiovascular health indicators are described. The system may be configured to receive a photoplethysmogram (PPG) signal representing a pulse waveform of a user. The pulse waveform may include a first local maximum, a downward slope following the first local maximum, and a bending feature representing a transition from a systolic phase to a diastolic phase of the cardiac cycle. Further, the system may extract one or more morphological features from the pulse waveform and compare the one or more morphological features to one or more features from a plurality of baseline PPG signal morphologies associated with a plurality of real foot ages. The system may determine a cardiovascular health indicator indicative of a cardiovascular health condition of the user relative to the user's real foot age, and cause the graphical user interface to display an indication of the cardiovascular health indicator.

The invention relates to an SCG feature point recognition method based on ECG reference and waveform curvature features, belongs to the technical field of SCG signal feature extraction, and solves the problems that in the prior art, the robustness is reduced, the feature point recognition application range is limited, and the recognition precision is low due to the fact that the form of an SCG signal changes along with different parameters such as motion artifacts, respiratory cycles, gender and age. The method comprises the following steps: acquiring synchronous ECG and SCG signals, and preprocessing the ECG and SCG signals; performing single-period waveform extraction on the SCG preprocessed signal based on the ECG preprocessed signal to obtain a single-period waveform of the SCG signal; performing curvature method processing on the single-period waveform of the SCG signal to obtain curvature characteristics of the single-period waveform; dividing the curvature characteristics into a systolic period area SCG1 and a diastolic period area SCG2 according to the period length proportion of the predicted systolic period to the equal-length SCG signal segments; and feature point marking is carried out through an extreme value taking method after peak searching. Accurate mapping of heart mechanical activities is realized.

The invention discloses an intelligent echocardiography heart function accurate evaluation system and method, and the system collects a heart image through an ultrasonic instrument, determines the ventricular diastole and contraction period through a data processing module, employs an image segmentation technology to extract the heart image, employs a cubic interpolation method to standardize the size of the image, and achieves the accurate evaluation of the heart function. The system constructs a graph model, spatial and temporal features of a heart image are extracted through a spatial and temporal feature extraction module by using a 3D convolutional neural network of a C3D structure fusing spatial and temporal features, a graph convolutional network module performs feature aggregation and message passing on the image through a multi-layer edge condition convolution ECC layer to obtain feature descriptors fusing all cavity information, and the feature descriptors are used for analyzing the cavity information. The ejection fraction prediction module inputs the characteristics into a full-connection layer for ejection fraction prediction; the invention innovatively provides an intelligent analysis framework based on a cardiac ultrasound dynamic image video, and aims to realize comprehensive and accurate evaluation of cardiac functions.

A physical treatment device for rehabilitation of an old cardia-cerebrovascular disease patient belongs to the technical field of physical treatment instruments and comprises a bed body, an electrocardiogram monitor is arranged on one side of the bed body, a mattress is placed at the top of the bed body and comprises a first supporting pad and a second supporting pad, and the first supporting pad and the second supporting pad are hinged through a rotating shaft at the joint. The second supporting pad is provided with a physical treatment assembly used for assisting the elderly patient in rehabilitation treatment, through cooperation with the cardiac cycle of the patient, in the diastolic period, the driving motor is meshed with the synchronous rack through an incomplete gear, the air bag is sequentially inflated from the far end of the limb to the near end of the limb, blood vessels are pressed, and blood is driven back to the aorta; important blood vessel perfusion is added, myocardial ischemia and other symptoms are relieved, the device automatically exhausts air after the diastolic period ends, it is ensured that blood smoothly flows to the lower limbs, meanwhile, the whole device is combined with a bed body, and good rehabilitation treatment exercise can be achieved for paralyzed and disabled patients.

Use of darutoside in preparing a drug for preventing and treating hereditary hypertrophic cardiomyopathy. The darutoside is used for directly treating hypertrophic cardiomyocytes in vitro. It is found that the darutoside significantly reduces the area of cardiomyocytes, and reduces the increase of myocardial hypertrophy marker expression caused by angiotensin II; meanwhile, feed containing the darutoside is applied to feed Tnnt2R109Q mice, such that the weight of the left ventricle and heart of the mice is reduced, the heart volume and the thickness of the myocardial wall during diastole and systole are reduced, and myocardial tissue fibrosis of the mice with hypertrophic cardiomyopathy is effectively inhibited. The darutoside can be used for preparing a drug for preventing and treating hereditary hypertrophic cardiomyopathy and provides a new way and means for treating hypertrophic cardiomyopathy.

The invention relates to the technical field of medicine, in particular to a composition containing an angiotensin II receptor blocker and application of the composition in heart disease dilation medicine. The composition comprises an angiotensin converting enzyme inhibitor and an angiotensin II receptor blocker, and a small dose of ACEI and a large dose of ARB are combined to be used for dilating the heart disease. The traditional Chinese medicine composition has excellent effects in the aspects of reducing the left ventricular end diastolic anterior-posterior diameter or left-right diameter, plasma brain natriuretic peptide precursor (NT-pro BNP) plasma level, pulmonary arterial pressure and left ventricular ejection fraction, does not influence the normal levels of physiological indexes such as blood potassium, serum creatinine, urea nitrogen, alanine aminotransferase (ALT) and asparaginic acid aminotransferase (AST), and can be used for preparing a medicine for treating the left ventricular end diastole. The medicine can be applied to heart disease dilation medicines.

This invention discloses a method and apparatus for heart sound segmentation based on a Hidden Markov Model (HMM) cardiac cycle. The method involves: extracting the signal envelope from the heart sound signal using Hilbert's algorithm; obtaining the peak positions of the first heart sound (S1) and the second heart sound (S2) after Hilbert envelope extraction based on preset baselines for different leads; locating the peaks based on the cardiac cycle; extracting the diastolic phase based on an improved HMM; locating the optimal time span of heart sound signals S1 and S2 using an improved Viterbi algorithm; and segmenting the original heart sound signal using the time span and the peak positions of S1 and S2. This invention employs an improved HMM and an improved Viterbi forward algorithm to calculate the duration of heart sound intervals S1 and S2, combined with the cardiac cycle, to accurately locate the peak positions of heart sound intervals, thus improving the performance of heart sound segmentation.

The present invention discloses a thermal strain imaging method, system and device, which belongs to the field of ultrasonic imaging. The method collects ultrasonic images of the detection object before and after heating; extracts the baseline displacement of the characteristic points; finds the typical frames of the detection object at the end of contraction and diastole as the global reference frame i0; finds the data of each group after heating i1. n Typical frames i of the detected object at the end of systole and diastole n ; Calculate typical frame i n The correlation coefficient between the global reference frame i0 and the typical frame i is calculated n The relative displacement with the global reference frame i0 generates the displacement gradient map G according to the correlation coefficient and relative displacement n ; Convert the displacement gradient map into a strain map to obtain thermal strain imaging of the cross section of the test object. Utilize the echo displacement gradient caused by the change in sound velocity due to temperature increase to detect the offset of water-containing tissues and lipids in the echo signal, thereby determining the gradient distribution of sound velocity changes, discriminating tissue composition, and improving the accuracy of tissue and organ detection.

The present application relates to the field of electrical impedance imaging, and discloses a regional lung perfusion delay time analysis method, an electronic device and a storage medium. A dynamic image of conductivity change caused by blood perfusion in a human thoracic cavity is obtained. A blood perfusion image of a heart region and a blood perfusion image of a lung region are separated. A reference curve of conductivity change of the heart region is obtained according to the dynamic image of blood perfusion conductivity change and the blood perfusion image of the heart region. A conductivity change curve of each pixel point in the blood perfusion image of the lung region is obtained according to the dynamic image of blood perfusion conductivity change and the blood perfusion image of the lung region. The conductivity change curve is divided by a sliding time window, and a regional lung perfusion delay time is calculated in each time window. The time resolution advantage of electrical impedance imaging technology is fully utilized, and the time delay of the time when the local blood volume of the lung reaches the maximum relative to the end of the ventricular diastole is reflected by calculating the regional lung perfusion delay time.

The present application provides novel tetrahydropyrane (THP) substituted bicyclic pyrimidinedione compounds useful in the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and / or symptoms associated therewith. Synthesis and characterization of the compounds are described, as well as methods of treating HCM and other forms of heart disease.

The invention relates to the technical field of ultrasonic-assisted screening, in particular to an antenatal ultrasonic-assisted screening method and system for congenital heart diseases. The method comprises the following steps: firstly, acquiring a frame image sequence of a four-cavity heart tangent image of a fetus, matching all suspected heart cavity areas among different frame images, and acquiring a matching sequence of all the areas; then, based on the diastole and systole laws of cardiac pulsations, evaluating the cardiac cavity confidence coefficient of each region matching sequence, so as to screen out all cardiac cavity matching sequences; the normal index of each cardiac cavity area in the cardiac cavity matching sequence is further analyzed and evaluated, and then abnormal frame images are screened out from all the frame images; and finally, reconstructing a four-cavity tangent plane diagram based on all abnormal frame diagrams. According to the method, the abnormal heart cavity in each frame of the four-cavity heart tangent diagram is analyzed and screened based on the characteristic that the heart beat causes the regular change of the heart cavity, and then the normal heart cavity and the abnormal heart cavity are distinguished for reconstruction, so that the condition that the reconstruction result cannot reflect the abnormal structure of the fetal heart is avoided, and the auxiliary screening effect of antenatal ultrasound is improved.

This invention relates to the field of bio-optical imaging technology, specifically to an organ status assessment method and organ perfusion system based on laser speckle imaging. The method utilizes high-frame-rate laser speckle imaging technology combined with a physiological signal gating algorithm. It extracts the original speckle image only during the diastolic window when organ motion is minimal. The original speckle image is then preliminarily corrected using a vibration-speculiar distortion model. Subpixel-level registration is then performed on the preliminarily corrected speckle image using optical flow, generating a high signal-to-noise ratio microcirculation perfusion distribution map free of motion artifacts. Based on the microcirculation perfusion distribution map, perfusion heterogeneity indices for each target assessment region are calculated to determine whether local blood flow abnormalities exist in the transported organ, thus achieving status assessment and real-time monitoring of the transported organ. This assessment method is applicable not only to organ transport but also to organ quality evaluation and immediate post-transplant assessment scenarios.

The application discloses a blood pressure calculation method and equipment based on cross-scale fluid-solid coupling and considering nonlinear biomechanical characteristics of an aorta, and the method comprises the following steps: establishing a three-dimensional ideal aorta geometric model; establishing a zero-dimensional heart lumped parameter model to simulate the process that the heart pumps blood to the aorta inlet through periodic contraction and diastole; establishing a zero-dimensional three-element Windkessel model of small arteries to simulate blood flow microcirculation of peripheral small arteries; establishing a blood vessel wall biomechanical model containing residual stress of the aorta wall and active contraction of smooth muscle cells to obtain a pressure-radius relationship of the aorta wall as a fluid wall boundary condition to simulate the change process of the aorta radius in blood circulation; and coupling the three-dimensional ideal geometric model of the aorta, the zero-dimensional heart lumped parameter model and the zero-dimensional three-element Windkessel model to construct a cross-scale fluid-solid coupling system of hemodynamics, and the blood pressure in the aorta is calculated through iterative solution.

The utility model discloses a corrugated pipe extrusion type ointment extruder, belongs to the field of medical instruments, and particularly relates to a corrugated pipe extrusion type ointment extruder which comprises a protective shell, a handle and a corrugated pipe, specifically, a cavity is formed in the protective shell, an eduction tube is arranged on the upper portion of the protective shell, and the handle rotates relatively with a supporting frame as a fulcrum. The corrugated pipe can be made of a plastic elastic material; the compression and relaxation of the corrugated pipe are controlled through the pressing handle and the rebound effect of the corrugated pipe, so that the extrusion of ointment is controlled, the structure is simple, the operation is convenient, meanwhile, the extrusion amount of each time is accurate, and the ointment can be used for the maximum times.

Systems and methods for accurate determination of the position of an anatomic part of a subject in robotic assisted image-based surgery, using an inertial measurement unit (IMU) to determine the position and orientation of the anatomical part of the subject. The intrinsic drift of the IMU, which would make the IMU position measurements inaccurate, can be reset to zero regularly, at points of time when the subject's body is stationary. This can be achieved when motion from the subject's breathing and from the heartbeat are essentially zero. Such positions occur respectively when the respiratory signal shows the position of the breathing cycle to be at the end of the expiration phase, and the heartbeat signal represents a time in the diastole period of the subject's electrocardiographic cycle. When these two signal moments coincide, the IMU is essentially stationary, and its drift reset to zero.

A vascular imaging system, method and device, and an electronic device and a storage medium. The vascular imaging system comprises: an ultrasound device, which is used for collecting intravascular ultrasound images of a target object; an angiography device, which is used for collecting coronary angiography images of the target object; and a processing device, which is connected to both the ultrasound device and the angiography device, and is used for: determining a waveform-free interval of a diastolic phase within a cardiac cycle of the target object; respectively acquiring, from the images respectively collected by the ultrasound device and the angiography device, a target ultrasound image and a target angiography image of a target blood vessel of the target object within the waveform-free interval of the diastolic phase; performing vascular reconstruction on the basis of the target ultrasound image and the target angiography image, so as to generate a vascular model for the target blood vessel; and determining a fractional flow reserve of the target blood vessel on the basis of vascular parameters in the vascular model. The solution can reduce the discomfort of a subject, save on the test costs of the subject, and facilitate an improvement in the calculation precision of the fractional flow reserve of the target blood vessel.

A device for protecting debris from entering coronary arteries, the device including an expandable frame, and a debris blocking obstacle, wherein the expandable frame is shaped and sized to expand against walls of an ascending aorta. A method of reducing damage to the heart during a vascular procedure including identifying a potentially debris-causing event, and reducing debris carried by backflow from an aorta into a coronary artery during diastole in response to the identifying. A method for protecting debris from entering coronary arteries during a medical procedure, the method including inserting a device for protecting debris from entering coronary arteries into an aorta of a patient, positioning the device to protect debris from entering the coronary arteries, and performing the medical procedure on a heart of the patient. Related apparatus and methods are also described.

Devices, systems and methods affect cardiac function of a patient by delivering a stimulation to a right hemisphere of a diaphragm of the patient during a diastolic phase of a cardiac cycle of the patient, wherein the stimulation results in an asymptomatic, transient, partial contraction of the right hemisphere of the diaphragm; and delivering a stimulation to the left hemisphere of the diaphragm during a systolic phase of the cardiac cycle, wherein the stimulation results in an asymptomatic, transient, partial contraction of the left hemisphere of the diaphragm.

The invention relates to the technical field of heart valve testing, in particular to multifunctional combined type heart valve testing experimental equipment which comprises a base station, a base body, a pressure adjusting assembly, a pace-making assembly and a circulation assembly, the base body, the pressure adjusting assembly, the pace-making assembly and the circulation assembly are fixedly installed above the base station, and the base body comprises an atrium simulation area, a ventricle simulation area and an artery simulation area. An atrium simulation area is formed in the upper part of the base body, a ventricle simulation area is fixedly communicated with the lower portion of the atrium simulation area, an artery simulation area is fixedly communicated with the lower portion of the ventricle simulation area, the communicating pipe is communicated with the atrium simulation area, the ventricle simulation area is communicated with the pace-making assembly, and the artery simulation area is communicated with the circulation assembly. Therefore, under the dynamic pressure, whether the multifunctional combined type heart valve leaks or not is tested, meanwhile, the diastole and contraction of the heart are simulated, then the trans-valve pressure difference of the multifunctional combined type heart valve is monitored in real time, and the problem that it is difficult to accurately test the trans-valve pressure difference and leakage or not of the multifunctional combined type heart valve under the dynamic pressure is solved.