862 results about "Left Ventricles" patented technology

Apparatus and methods are described including placing, into a subject's body, a blood-pump tube, with an impeller disposed within the blood-pump tube. At least one blood-pressure-measurement element extends to at least an outer surface of the blood-pump tube, such that the distal end of the blood-pressure-measurement element is in direct fluid communication with a bloodstream of the subject outside the blood-pump tube at a location that is proximal to blood-inlet opening(s) defined by the blood-pump tube. Blood is pumped through the blood-pump tube, using the impeller. Pressure of the bloodstream of the subject outside the blood-pump tube is measured by measuring blood pressure at the distal end of the left-ventricular blood-pressure-measurement element. Other applications are also described.

Interatrial shunts are described herein that are designed to benefit both the left side of the heart and the right side of the heart. The interatrial shunt is anchored in the atrial septum to permit blood to flow between atrial heart chambers across the atrial septum. In accordance with some aspects, the lumen of the shunt has an effective orifice area selected to permit blood flow across the atrial septum to unload the patient's left ventricle with beneficial effects on the patient's right ventricle. The shunts are structured to be suitably anchored at the atrial septum for long-term implantation. Further, the shunts preferably have insignificant late lumen loss. The interatrial shunts are expected to treat pathologies such as heart failure and pulmonary hypertension.

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Apparatus and methods are described including a ventricular assist device that includes a tube configured to traverse a subject's aortic valve. The tube defines a generally-cylindrical central portion, and a proximal conical portion that narrows from a proximal end of the central portion to a proximal end of the tube. The tube defines one or more blood inlet openings in a vicinity of a distal end of the tube, and one or more blood outlet openings that extend axially from the central portion of the tube at least partially into the proximal conical portion of the tube. A blood pump pumps blood into the tube from the subject's left ventricle through the one or more blood inlet openings, and from the tube into the aorta through the one or more blood outlet openings. Other applications are also described.

Various systems, devices, and methods are disclosed herein for treating acute myocardial infarction (AMI) patients using a heart pump controlled in a manner that maximizes mechanical unloading of the left ventricle in the presence of cardiovascular instability and minimizes myocardial oxygen consumption (MVO2) and consequentially infarct size to prevent the development of subsequent heart failure. In a closed feedback system, the system can include a sensor configured to generate an output used to measure or calculate a left ventricular systolic pressure (LSVP) within the left ventricle of a heart and a controller coupled to a heart pump. The controller can be configured to measure or calculate the LVSP based on the output of the sensor and to control an operation of the heart pump to maximize mechanical unloading of the left ventricle based on the measured or calculated LVSP.

The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool. Providing cardiac parameters in real-time, along with warnings about adverse effects and recommendations to support cardiac function, such as increasing or decreasing the volumetric flow rate of blood pumped by the device, administering pharmaceutical therapies, and / or repositioning the blood pump allow clinicians to better support and treat cardiovascular disease.

A device comprises an implantable blood pump receivable in a sheath for percutaneous delivery. The implantable blood pump comprises a collapsible impeller mounted in a collapsible impeller cage, and a drive device mounted in a housing. The housing is in connection between a first end of a catheter and the collapsible impeller cage. The drive device is adapted for rotating the collapsible impeller. A retractable support structure is adapted to extend from the catheter. The extended retractable support structure is adapted to engage with the wall of the aorta for allowing the implantable blood pump to be secured in the left ventricle. The collapsible impeller cage comprises an inlet and an outlet. The inlet is adapted to receive blood from the left ventricle. The outlet directs blood in the direction of the atrioventricular valve.

Systems for delivering a device for regulating blood pressure across a patients atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

The invention provides a driving control mechanism which is applied to a left ventricle assisting device, the left ventricle assisting device further comprises a transmission shaft, the driving control mechanism comprises a shell, a twisting shell driving module and a mandrel driving module, the twisting shell driving module and the mandrel driving module are sequentially arranged in the shell, and the far end of the twisting shell driving module is in transmission connection with a twisting shell of the transmission shaft. The far end of the mandrel driving module is in transmission connection with a mandrel of the transmission shaft and is detachably connected with the near end of the twisting shell driving module. When the far end of the mandrel driving module is connected with the near end of the twisting shell driving module, the mandrel driving module drives the mandrel and the twisting shell to rotate synchronously. When the far end of the mandrel driving module is separated from the near end of the twisting shell driving module, the twisting shell driving module drives the twisting shell to rotate relative to the mandrel. According to the driving control mechanism, synchronous or relative rotation of the mandrel and the twisting shell can be achieved, then folding, unfolding and rotating movement of a pump head impeller in the left ventricle auxiliary device is achieved, and the use efficiency and safety of the left ventricle auxiliary device are improved.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's aorta. The device including a distal-tip element that defines a straight proximal portion, and a curved distal portion, the curved distal portion defining first and second curves with an elongated straight portion between the first and second curves. The distal-tip element is centered with respect to the aortic valve using the curved distal portion of the distal-tip element, to thereby guide the device through the subject's aortic valve atraumatically. A pump pumps blood through from the subject's left ventricle to the subject's aorta. Other applications are also described.

Apparatus and methods are described including delivering a left-ventricular assist device to a subject's left ventricle. A tube is positioned such that a proximal portion of the tube traverses an aortic valve of the subject, and a distal portion of the tube is disposed within a left ventricle of the subject. A pump pumps blood through the tube from the subject's left ventricle to the subject's aorta such as to cause the proximal portion of the tube to be maintained in an open state, and to cause at least a portion of the tube to become curved. Other applications are also described.

Apparatus and methods are described including a ventricular assist device that includes an impeller configured to be placed inside a left ventricle of a subject. A driving magnet is coupled to a motor and is rotated by the motor. A driven magnet is magnetically coupled to the driving magnet and is rotated by the driving magnet. A drive cable extends from the driven magnet and imparts rotational motion from the driven magnet to the impeller. A set of sensors is configured to detect a magnetic phase difference between the driven magnet and the driving magnet. A computer processor receives the detected magnetic phase difference and determines a physiological parameter of the subject, at least partially in response thereto. Other applications are also described.

The invention provides a preparation method of a left ventricular assist device, the left ventricular assist device comprises a micro pump head, a transmission shaft and a driving control mechanism, the micro pump head comprises a pump head impeller and a pump head transmission assembly, the transmission shaft comprises a mandrel and a twisting shell, and the driving control mechanism comprises a twisting shell driving module and a mandrel driving module. The method comprises the following steps that a pump head transmission assembly penetrates through a pump head impeller, and the far end and the near end of the pump head impeller are fixed to the far end of the pump head transmission assembly and the far end of a twisting shell correspondingly; a mandrel is inserted into the twisting shell, and the far end of the mandrel and the near end of the pump head transmission assembly are fixed; the twisting shell driving module is arranged at the far end of the mandrel driving module and is detachably connected with the mandrel driving module, and the far end of the twisting shell driving module is in transmission connection with the near end of the twisting shell; and the far end of the mandrel driving module is in transmission connection with the near end of the mandrel. According to the scheme, the left ventricle auxiliary device with the instrument micro-size and the high blood supply flow can be obtained, and the use safety and the working efficiency of the left ventricle auxiliary device are improved.

The present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect, and more particularly, to a RF ablation catheter for septal reduction therapy that is for performing RF ablation, in which RF energy is applied to an interventricular septum, for septal reduction therapy such as therapy for hypertrophic cardiomyopathy, which is a disease in which an interventricular septum of the left ventricle of the heart of the animal or human body thickens, therapy that requires reduction of an interventricular septum, or therapy for ventricular tachycardia. Also, the present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect that is for preventing carbonization of a tissue of the body (interventricular septum) around an electrode.An exemplary embodiment of the present disclosure provides a RF catheter for septal reduction therapy, the RF catheter including: an intra-septal part in which a tapered tip which becomes thinner toward an end thereof is formed at an end of a distal part and one or more electrodes are formed at positions on an outer circumferential surface that are adjacent to the tip; and a body part which is made of a soft material and has a guidewire lumen which passes through the intra-septal part from an inlet formed at the center of the end of the tip and has an outlet formed in a side surface, a coolant inlet lumen which is connected from a proximal part to an inner portion of the intra-septal part to allow a coolant to be injected from the outside and which has an open end, and a coolant outlet lumen which communicates with the coolant inlet lumen and has an exit formed in a side surface, wherein the guidewire lumen and the coolant inlet lumen do not communicate with each other and are partitioned from each other.

The invention provides a micro pump head and relates to the technical field of micro pumps, the micro pump head is applied to a left ventricular assist device, the left ventricular assist device further comprises a transmission shaft and a drive control mechanism, and the micro pump head comprises a pump head impeller and a pump head transmission assembly. The near end of the pump head impeller is in transmission connection with a twisting shell driving module of the driving control mechanism through a twisting shell of the transmission shaft, and the near end of the pump head transmission assembly is in transmission connection with a mandrel driving module of the driving control mechanism through a mandrel of the transmission shaft. The mandrel driving module drives the mandrel and the twisting shell to rotate synchronously so as to drive the far end and the near end of the pump head impeller to rotate together, and the twisting shell driving module drives the twisting shell and the mandrel to rotate relatively so as to drive the near end of the pump head impeller to rotate relative to the far end. The micro pump head can be unfolded or folded to change the outer diameter size of the micro pump head in the human body, so that the blood supply efficiency and the use safety of the auxiliary device are improved.

The invention discloses application of an RNF130 activator in preparation of a medicine for preventing and / or treating ischemic heart disease, and belongs to the technical field of biological medicine. Research results show that when an RNF130 activator is given in a mouse of a myocardial ischemia reperfusion injury model, the left ventricular ejection fraction and the left ventricular short-axis shortening rate of the mouse can be improved, myocardial tissue pathological injury can be relieved, the protein expression levels of NOX-2, BAX and TNF-alpha are reduced, the myocardial infarction area is reduced, and myocardial cell apoptosis is reduced; therefore, the RNF130 activator has prevention and treatment effects on the myocardial ischemia-reperfusion injury, that is, the RNF130 activator can be used as an effective component of the medicine for preventing or treating diabetes complicated by myocardial ischemia-reperfusion injury, and a new strategy is provided for preparation of the medicine for preventing and treating myocardial ischemia-reperfusion injury.

An implantable pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable pump, a battery, a controller, and a programmer. The implantable pump includes a flexible membrane coupled to an actuator assembly via a skirt that extends toward the inlet of the pump and curves to guide blood toward the outlet. The actuator assembly is magnetically engageable with electromagnetic coils, so that when the electromagnetic coils are energized, the actuator assembly causes wavelike undulations to propagate along the flexible membrane to propel blood from the inlet, across the skirt, and through the outlet of the implantable pump. The controller may be programmed by a programmer to operate at frequencies and duty cycles that mimic physiologic flow rates and pulsatility while operating in an efficient manner that avoids thrombus formation, hemolysis and / or platelet activation.

The present invention relates to a radiofrequency electrode ablation catheter for ventricular septal therapy with a cooling function, which is used for performing radiofrequency electrode ablation and has a cooling function for preventing carbonization of body (ventricular septum) tissue around the electrode, wherein radiofrequency energy is applied to the ventricular septum during radiofrequency electrode ablation to perform ventricular septal therapy (e.g., therapy for hypertrophic cardiomyopathy, a disease in which the left ventricular septum of the heart of an animal or human body becomes thickened, therapy requiring reduction of the ventricular septum, or ventricular tachycardia, etc.). The radiofrequency catheter for ventricular septal therapy according to a preferred embodiment of the present invention includes a septal insertion portion and a body portion.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

The invention provides a left ventricle auxiliary device which comprises a driving control mechanism, a left ventricle auxiliary device, a left ventricle auxiliary device and a right ventricle auxiliary device. The transmission shaft comprises a twisting shell and a mandrel, and the twisting shell is movably arranged outside the mandrel in a sleeving mode; the micro pump head comprises a pump head impeller and a pump head transmission assembly, the near end of the pump head impeller is in transmission connection with the twisting shell driving module through a twisting shell, the far end of the pump head transmission assembly is fixedly connected with the far end of the pump head impeller, and the near end of the pump head transmission assembly is in transmission connection with the mandrel driving module through a mandrel. The mandrel driving module drives the mandrel and the twisting shell to rotate synchronously so as to drive the far end and the near end of the pump head impeller to rotate together, so that the pump head impeller rotates at a fixed outer diameter; and the twisting shell driving module drives the twisting shell and the mandrel to rotate relatively so as to drive the near end of the pump head impeller to rotate relative to the far end, so that the pump head impeller is folded or unfolded. According to the scheme, the outer diameter of the micro pump head in the left ventricle auxiliary device can be adjusted, so that the use efficiency and safety of the micro pump head are improved.

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and / or left ventricular pressure.

The invention relates to a hypertrophic obstructive cardiomyopathy virtual resection operation curative effect evaluation method based on individualized computational fluid mechanics, which can give visual postoperative hemodynamic indexes, predict postoperative curative effects, find an optimal resection scheme and realize preoperative accurate intelligent evaluation. Comprising the following steps of: acquiring coronary artery enhanced computed tomography image data, acquiring a coronary artery enhanced computed tomography image of a patient, and outputting and storing the coronary artery enhanced computed tomography image in a DICOM (Digital Imaging and Communications in Medicine) format; preprocessing image data, and segmenting and reconstructing a left ventricle-outflow tract structure three-dimensional model; setting a virtual excision scheme at the fleshy part; constructing a surgical resection model, and importing the model into finite element analysis software for solving; and the virtual postoperative curative effect is visualized. Verification and curative effect prediction of a patient excision scheme can be realized, and the operation success rate of a hypertrophic obstructive cardiomyopathy patient is improved.

The invention provides an echocardiogram video abstraction method based on a hierarchical space-time attention mechanism, and the method comprises the steps: obtaining an echocardiogram, inputting the echocardiogram into an anatomy and physiological basic model of a key frame recognition task, and obtaining key frame information; inputting the key frame information into a multi-dimensional spatial-temporal feature extraction model to obtain feature information and frequency domain information; fusing the feature information and the frequency domain information; performing key frame enhancement processing on the fusion information by adopting an SE channel attention mechanism to obtain key frame anatomical feature expression; processing the key frame anatomical feature expression by adopting a key frame backtracking strategy and a classification network to obtain a key frame identification classification result; performing left ventricle segmentation on the classified image by adopting an improved U-Net left ventricle region segmentation network; estimating the area and volume of the left ventricle based on a segmentation result; fusing the estimated left ventricular area and volume by adopting a hierarchical attention mechanism and a cross-layer information fusion strategy to obtain a ventricular volume result; according to the method, through abstract extraction of the key information of the ultrasonic cardiac video, the clinical practicability of intelligent screening and auxiliary diagnosis of cardiovascular diseases based on ultrasonic is improved.

Devices, systems and methods deliver implantable medical devices for atrioventricular (VfA) cardiac treatment. The VfA device can be implanted in the right atrium (RA), where electrodes extend from the right atrium into the left ventricular myocardium. A flexible lead or other probe can be advanced to a potential implantation site and used to identify the precise location of an implanted medical device, such as an electrode, a small lead, a lead, or an intracardiac device. Some methods may include locating a potential implantation site in the Koch triangle in the right atrium of the patient's heart; attaching a retaining sheath to the right atrial endocardium of the potential implantation site; and implanting the medical device via a guidewire at the potential implantation site. An implantable medical device may include an intracardiac housing and a small lead that can be delivered by these methods.

An aorta intervention catheter device for heart failure comprises a catheter and a bag body arranged at one end of the catheter, an elastic diaphragm is arranged in the bag body, an inner cavity of the bag body is divided into a blood chamber and an air chamber by the elastic diaphragm, the blood chamber is communicated with the catheter, an exhaust assembly is arranged on the bag body, and the air chamber is connected with an air source connector arranged on the bag body; the other end of the catheter is a proximal end, first guide films which are staggered at intervals and inclined towards one side of the proximal end and second guide films which are inclined towards a distal end are arranged on the inner wall of the catheter, and first guide holes and second guide holes which correspond to the first guide films and the second guide films and are communicated with an inner cavity of the catheter are respectively formed in the outer wall of the catheter; the proximal side of the second guide film is provided with at least one set of third guide films which are fixed to the inner wall of the catheter, incline towards the distal end and are tightly attached to each other to be closed. The aorta is directly intervened to enter the heart, and coronary artery blood perfusion is increased in the diastolic period; the left ventricular post-load is reduced in the systolic period, and the heart failure can be more directly treated.

An device for treating a native valve includes a sealing element and an anchoring element. The sealing element is made from a braided mesh material. The sealing element is dimensioned to be deployed in an annulus of a native valve of a heart at a position between native valve leaflets to contact the native valve leaflets during ventricular systole to create a seal to prevent regurgitation of blood from the left ventricle to the left atrium. The sealing element is configured to both be radially expanded and radially reduced while at the position between the native valve leaflets. The anchoring element is adapted for deployment in the heart, the anchoring element coupled to the sealing element and configured to support the sealing element at the desired position between native valve leaflets.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

The exemplified methods and systems facilitate the quantification of cardiac cycle-variability as a metric of signal quality of an acquired signal data set and the rejection, based on that quantification, of said acquired signal data set from one or more subsequent analyses that can predict and / or estimate a metric associated with the presence, non-presence, severity, and / or localization of abnormal cardiovascular conditions or disease, including, for example, but not limited to, coronary artery disease, abnormal left ventricular end-diastolic pressure disease (LVEDP), pulmonary hypertension and subcategories thereof, heart failure (HF), among others as discussed herein. The quantification of levels of cycle-variability assessed noise such as skeletal-muscle-related-signal contamination and muscle-artifact-noise contamination, and other asynchronous-noise contamination in an acquired signal can be subsequently used for the automated rejection of such asynchronous noise from measurements of biophysical signals.

Systems and methods for delivering a device for regulating blood pressure across a patient's atrial septum are provided. The delivery apparatus may include a first catheter, a hub having one or more engagers disposed thereon, the one or more engagers configured to releasably engage with a first expandable end of the shunt in a contracted delivery state within a lumen of a sheath, and an second catheter extending through a center lumen of the first catheter and the hub, wherein the first catheter, the hub, and the second catheter are independently moveable relative to the sheath. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices also may be used to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.

A system to treat heart failure with preserved ejection fraction (HFpEF) is described. The system comprises a blood pumping device (120) configured for implantation in a left ventricle (31) of a heart of a subject, in which the blood pumping device is configured to draw blood from a left atrium (30) into the left ventricle (31) of the heart through a mitral valve (34) upon activation, an anchoring assembly (122) for anchoring the blood pumping device to the heart, and a connector (125) rigidly connecting the anchoring assembly (122) to the blood pumping device (120) in a spaced-apart relationship to allow the blood pumping device to be positioned in the left ventricle and the anchoring assembly to be anchored at an anatomical location in or adjacent to the heart and distant to the left ventricle, wherein the system is configured for percutaneous delivery to the heart.