Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of
hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange
catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the
catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-
usable control units. The control units include a heater / cooler device, a
user input device, and a processor connected to receive input from various sensors around the body and the
system. The heater / cooler device may be thermoelectric to enable both heating and cooling based on polarity. A
temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral
pump head that engages with a pump drive mechanism within the re-
usable control unit. More than one
control unit may be provided to receive the same heat exchange cassette so that a
large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.