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A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and / or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.

A reaction chamber apparatus includes a vertically movable heater-susceptor with an attached annular attached flow ring that performs as a gas conduit. The outlet port of the flow ring extends below the bottom of a wafer transport slot valve when the susceptor is in its process (higher) position, while the gas conduit formed by the flow ring has an external surface at its edge that isolates the outer space of the reactor above the wafer from the confined reaction space. In some cases, the outer edge of the gas conduit is in proximity to a ring attached to the reactor lid and, together, the ring and conduit act as a tongue-in-groove (TIG) configuration. In some cases, the TIG design may have a staircase contour, thereby limiting diffusion-backflow of downstream gases to the outer space of the reactor.

A ridesharing system and method involving selected negotiated participation of riders and ride providers. The ridesharing system in a specific implementation involves a computer-implemented capability for computational matching of potential participants in a ridesharing arrangement, wherein such system is adapted for prioritized ranking of target ridesharing attributes by such potential participants, involving allocation by potential participants of quantitative weight within a quantitative total budget of allocatable value to predetermined selection criteria, with such system having an input capability for inputting the allocations of potential participants, and the system being constructed and arranged for effecting the computational matching based on the allocations, with communication capability for outputting results of the computational matching to the potential participants.

A system and method for creation, distribution and tracking of advertising via electronic networks, enabling creation of advertisements using licensed third party content and placement of said ads at desired network locations, utilizing an auction of ad spaces based on bids placed by advertisers to have their ads displayed at such locations. When a network user / ad viewer requests an ad by clicking or other action, an auction algorithm executes to select the ad to be displayed from those that bid for display at such ad space location and then the ad is composed and delivered to the ad space location by accessing a relational database storing commands that retrieve, assemble and dispatch the licensed ad content. Usage and display of licensed content on designated ad space is tracked to enable cost-per-use charging for both use of licensed content and ad display at the designated ad space.

A communication system architecture (SA) for a vehicle which may be integrated into the vehicle's multiplexed electronic component communication system, and a process for communicating with the vehicle to provide information for and about the vehicle's operational status and coordinating the vehicle's activities. The communication system will include a multi-functional antenna system for the vehicle that will have the capability to receive AM / FM radio and television signals, and transmit and receive citizens band (CB) radio signals, satellite and microwave and cellular phone communications. The antenna may be installed as original equipment or as a back-fit part in the after-market. In either case the multi-functional antenna will be integrated with the vehicle's multiplexed electronic component communication system. The process for communicating with the vehicle will involve a communication service for which the vehicle's driver will enroll for and service will continue so long as maintenance fees are paid. The service will be capable of providing various levels of information transfer and coordination. The levels may include vehicle information such as (1) the need for servicing and location of the nearest service center with the necessary parts in stock, (2) routing, and (3) load brokering and coordination. The modular design of the system architecture (SA) will allow it to be employed with the vehicle platform that does not possess a full multiplexed electronic component communications system. The resulting vehicle, using an after-market application package, will be able to participate in some of the services.

A cardiac stimulation device and method detect myocardial ischemia and provide a response for alleviating the ischemia. Myocardial ischemia is detected by identifying changes in the ST-segment of the intracardiac electrogram (EGM) sensed using large sensing electrode surfaces created by electrically coupling one or more cardiac electrodes or by using larger surface area shocking coils. Myocardial ischemia monitoring is performed when stimulation parameters are adjusted for increasing cardiac output, causing an increased metabolic demand to be placed on the myocardium itself. When myocardial ischemia is detected, stimulation parameters are re-adjusted to reduce the demand placed on the myocardium and thereby alleviate the ischemia.

A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and / or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.

A method and apparatus for providing an adjustable length surgical implant is provided, wherein the surgical implant is readily adjustable by a surgeon using a surgical tool sized for use with the surgical implant. Adjustment of the surgical implant further requires a small incision through the skin prior to the adjustment of the length of the implant, such that the potential for infection is greatly reduces and the associated trauma of surgery is lessened for the patient.

A vapor sensing device that is sufficiently small and lightweight to be handheld, and also modular so as to allow the device to be conveniently adapted for use in sensing the presence and concentration of a wide variety of specified vapors. The device provides these benefits using a sensor module that incorporates a sample chamber and a plurality of sensors located on a chip releasably carried within or adjacent to the sample chamber. Optionally, the sensor module can be configured to be releasably plugged into a receptacle formed in the device. Vapors are directed to pass through the sample chamber, whereupon the sensors provide a distinct combination of electrical signals in response to each. The sensors of the sensor module can take the form of chemically sensitive resistors having resistances that vary according to the identity and concentration of an adjacent vapor. These chemically sensitive resistors can each be connected in series with a reference resistor, between a reference voltage and ground, such that an analog signal is established for each chemically sensitive resistor. The resulting analog signals are supplied to an analog-to-digital converter, to produce corresponding digital signals. These digital signals are appropriately analyzed for vapor identification. The device can then subsequently transmit the digital signals over a computer network, such as the Internet, for analysis at a remote location.

An e-commerce outsourcing system and method provides hosts with transparent, context-sensitive e-commerce supported pages. The look and feel of a target host is captured for future use. The host is provided with one or more links for inclusion within a page on the host website that correlates with a selected commerce object, which may be contextually related to material in the page. The commerce object can be a product, a product category, or a dynamic selection indicator. Upon activation of the provided link, a visitor computer is served with a page with the look and feel of the host website and with content based upon the associated commerce object. Where the commerce object is a dynamic selection indicator, the content is selected at the time of activation based upon an analysis of the page containing the activated link.

An improved radio frequency identification (RFID) tag and related reader system and process are provided, wherein the RFID tag includes an on-board battery for enhanced signal transmission range, relatively rapid signal transmission speed, and optimized completion of a data transaction between the tag and a reader. The RFID tag further includes a power management system for activating the tag battery on an as-needed basis, and for thereupon enabling limited portions of the tag circuitry as required for a specific communication protocol, thereby conserving battery power and prolonging battery service life. In one preferred form, the battery is integrated with an antenna structure of single or dual mode with respect to frequency or type. This combination battery-antenna may be designed for recharging from a source of ambient energy.

A method and apparatus for providing an adjustable length surgical implant is provided, wherein the surgical implant is readily adjustable by a surgeon using a surgical tool sized for use with the surgical implant. Adjustment of the surgical implant further requires a small incision through the skin prior to the adjustment of the length of the implant, such that the potential for infection is greatly reduces and the associated trauma of surgery is lessened for the patient.

The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplification and detection of one or more specific nucleic acid sequences, the use of internal controls, reduced potential for contamination caused by the manual manipulation of reagents, and improved reagent compositions to better control assay performance and provide for further protection against contamination.

The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

A method and apparatus for optimizing cardiac resynchronization therapy are provided. An iterative optimization procedure is performed to test the systolic hemodynamic effects of varying A-V-V timing schemes. The hemodynamic effect is assessed based on a surrogate of stroke volume. The stroke volume surrogate is derived from a sensor signal proportional to the blood pressure in the aorta or a major artery. The A-V-V timing scheme corresponding to the greatest stroke volume, as indicated by the stroke volume surrogate, is identified and automatically programmed to maintain optimal A-V-V settings acutely and chronically.

Chewing gums and methods of making same that have improved flavor duration by stimulating a trigeminal nerve of a consumer of the chewing gum are provided. The chewing gums of the present invention includes a trigeminal stimulant. The trigeminal stimulant stimulates the trigeminal nerve of the consumer to provide longer lasting flavor duration.

A medical treatment device comprising an elongate probe member having proximal and distal extremities. The elongate probe member has a longitudinal axis and at least one passageway extending from the proximal extremity to the distal extremity. A guide is mounted in the at least one passage of the elongate probe member and has proximal and distal extremities with the distal extremity of the guide being in the vicinity of the distal extremity of the elongate probe member. The guide has an opening in the distal extremity and a lumen extending from the proximal extremity to the opening in the distal extremity. A needle is slidably disposed in the lumen of the guide. The needle is in the form of a tube having an axial lumen extending therethrough. A control mechanism is coupled to the proximal extremity of the elongate probe member and is secured to the needle for advancing and retracting the needle relative to the guide.

Compositions are disclosed comprising a conventional surfactant, a cationic or amphoteric gemini surfactant and a polymeric soil release agent. The conventional surfactant comprises a hydrophilic group and a hydrophobic group. The gemini surfactant comprises two surfactant moieties attached to each other by a spacer moiety. Each surfactant moiety having at least one hydrophilic group and at least one hydrophobic group. Novel trimeric and tetrameric cationic gemini surfactants are also disclosed along with their use in combination with soil release polymer compositions that exhibit superior cleaning efficacies when incorporated in laundry and other cleaning detergent systems. Novel surfactant / soil release polymer compositions are also disclosed employing known cationic gemini surfactants. The polymeric soil release agent can be any conventional polymeric soil release agent, but preferably comprising PET-POET copolymer. The compositions are useful as surfactant additive packages, detergents and fabric softeners.

Methods and system for managing demand for an object includes capturing information about the object through a mobile device associated with a user. The mobile device is configured to capture information about the object that include one or more of a spatial, temporal, topical and social attributes of the object. The identity of the object is verified and validated using this metadata captured by the user through the device from the real world object or its proxy. Upon successful verification and validation, the object and its metadata are automatically added to a wish list of the user. An aggregate list is generated using the attributes and metadata of the object from a plurality of users. The aggregate list defines a source of demand for the object. The object is tracked as it progresses through various phases of ownership cycle using dynamic demand calculations based on the information associated with the objects, the users and the aggregate lists.

A multiple display apparatus includes a hub capable of supporting a variable number of display support members and at least two support members coupled to the support hub. The apparatus is expandable to provide a plurality of displays and support members on the hub. Mounting brackets are respectively associated with the members to secure flat panel displays to the apparatus.

In various embodiments, the present invention provides a means for improving gas turbine engine performance by applying fluid flow control to the inter-turbine duct joining a high-pressure turbine spool and an associated low-pressure turbine spool, allowing the low-pressure turbine spool to have a relatively larger diameter than the high-pressure turbine spool. One or more unobstructed fluid flow paths between one or more boundary layer suction ports disposed within the upstream end of the outer-body surface of the inter-turbine duct and the suction side of the associated low-pressure turbine nozzle are provided. Advantageously, the natural static pressure difference between these points results in a self-aspirating assembly. The fluid flow control provided by the respective suction and blowing forces generated allows for a relatively larger diameter low-pressure turbine spool and / or relatively fewer low-pressure turbine nozzles to be used than is possible with conventional systems, assemblies, and methods. Thus, a gas turbine engine weight savings and optimized performance may be achieved.

A wagering monitoring system configured to detect player wagers at a roulette table is disclosed. A table having antennas associated with the various wagering areas is provided for player. A reader connects to the antenna to thereby communicate via the antenna with token equipped with identification element. By monitoring wagers, game play is monitored and processing may occur to track each player wager and the amount wagered by a player. To facilitate play at a roulette table, the identification element associated with the token includes a token color identification code which identifies the color of the token. The token color identification code is associated with a player which in turn provides means to associated each wager and a total amount wagered with a player.

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and / or sensitizing cells to additional agent(s).

The present invention relates to pharmaceutical compositions and dietary supplement comprising yeast cells that can produce a healthful benefit in a subject inflicted with lymphoma. The biological compositions can be used to retard the growth of lymphoma cells and / or prolonging the time of survival of the subject. The invention also relates to methods for manufacturing the biological compositions.

The present invention provides improved processes for recovering components of distillers' grain, such as, the components of distillers' dried grain (DDG), for use in various applications, including in the production of ethanol.

Compositions, kits, and methods for repairing bonds, for example, disulfide bonds, in hair or on the skin are disclosed. The compositions provide improved conditioning benefit for dry hair or moisturize the skin. The compositions also provide a long lasting moisturized feel and smooth feel to the skin or hair, without feeling greasy. The compositions contain one or more compounds that covalently bind at least two thiol groups in the hair or on the skin. Use of the binding compositions prevents reversion of the repaired bonds to their free thiol state, for at least one week or one month, or more, after a single application of the composition. Improved methods of styling hair, for example permanent hair waving, hair curling, hair coloring or highlighting, and hair straightening, are also provided.