The present invention provides a design method of a distributed water cycle model based on a multi-source mutual aid water supply model, including: step S1, nested HRU division; step S2, HRU attribute design; step S3, multi-source mutual aid water supply module design; Step S4, SWAT model improvement. Based on the SWAT model, the present invention develops a distributed natural-artificial water cycle dynamic mutual-feedback simulation model, which enables it to have the dynamic mutual-feedback of natural water cycle and artificial side branch water cycle, and the integrated simulation functions of water resources development, utilization and regulation, and can Completed the simulation of the natural-artificial water cycle process in the basin based on the urban multi-source water supply and multi-source irrigation water supply model, which not only reflects the impact of the water cycle process on artificial water intake, but also reflects the real-time intervention of water resource development, utilization and regulation on the water cycle process, thereby It provides a scientific reference for in-depth understanding of the basin water cycle mechanism under the influence of strong human activities, and rational development and utilization of water resources.