The invention discloses a regional energy comprehensive coordination management and control system. The system comprises a regional operation monitoring subsystem, a distributed power forecasting subsystem, a load cluster prediction response analysis subsystem, a fault fast processing subsystem, an energy analysis and management subsystem, an electric vehicle optimal scheduling subsystem and a regional multi-level energy comprehensive coordination control subsystem. The regional energy comprehensive coordination management and control system achieves comprehensive operation monitoring of power sources, power grids and user loads in a region and forecasting, analysis and scheduling of a variety distributed energy resources on the basis of multi-source information integration, achieves rapid fault diagnosis and processing of the power grid, achieves load forecasting, energy consumption analysis, energy saving management and electric vehicle intelligent scheduling of users and achieves reasonable distribution and pluralistic complementary of regional energy through comprehensive coordination of energy interaction among the power sources, the power grids and the user loads, thereby greatly increasing the energy efficiency and enabling the power grids to be in economical and efficient operation.