The invention provides an
expression data preprocessing method, device and
system and a storage medium, and relates to the technical field of space-time
omics. The
expression data preprocessing method comprises the following steps: obtaining
sequencing data based on a space-time
group technology, and obtaining a
gene expression matrix according to the
sequencing data; carrying out dimension reduction
processing to obtain a
cell population; determining a differential
gene list among the
cell populations, and constructing a
gene set expression matrix; and converting the gene set expression matrix into contribution degrees, and constructing a gene contribution
degree matrix. According to the method,
cell grouping and
gene screening technologies are applied, a gene set expression matrix is accurately converted, matrix
dimensionality reduction is remarkably achieved, similar feature
gene sets are more aggregated, some potential valuable features are reserved as far as possible, the analysis accuracy is improved, the use efficiency of computing resources is optimized, and the method is suitable for large-scale popularization and application. And a more reliable and efficient research way is provided for scientific researchers.