915 results about "Lung" patented technology

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.

Systems and methods herein generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. The systems and methods herein can include an electronic pump that pumps gas into an organ and a mechanical pressure regulator to release gas based on organ pressure.

The systems and methods relate to cyclically inflating and deflating a lung. The lung can be stored and transported while pumping a gas into the lung and removing another gas from the lung. The cyclical inflation and deflation of the lung can be performed at a rate enhanced or optimized for lung performance.

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.

A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.

The invention relates to the technical field of radiotherapy, in particular to a space-time compensation method and system for radiotherapy of pancreas respiratory movement variability, and the method comprises the steps: setting an infrared reflective mark point on the body surface of a patient, and obtaining a body surface three-dimensional CT image and an infrared camera real-time image under respiratory movement; establishing a pancreas three-dimensional model, a CTV target region model and a respiratory movement model; predicting body surface mark point displacement by adopting a long-short-term memory network algorithm and generating a respiration curve; determining a pancreas three-dimensional coordinate motion state; predicting lung motion by using optical flow motion estimation, and reversely solving a pancreas motion trail; determining the opening and closing states of the blades of the multi-blade collimator; according to the method, the mapping relation between lung movement and pancreatic movement is established through reverse mapping, an improved optical flow movement estimation algorithm and an LSTM network are adopted to predict respiratory movement, and the CTV leakage volume can be remarkably reduced to 0.4 cm from 2.1 cm of a traditional gating technology.

The invention belongs to the technical field of medical imaging and digital twinning, and discloses a thoracic cavity whole organ system level lung four-dimensional EIT detection digital motif and a library building method, and the method comprises the following steps: S1) segmenting multiple organs such as double lungs, heart, sternum, rib and thoracic vertebra central axis skeleton, main bronchus and esophagus based on an individual CT image, and building a three-dimensional geometric model integrated with an EIT electrode array; s2) simulating breathing dynamic deformation by using a solid mechanical model; s3) establishing a coupling relationship between deformation and conductivity, and generating dynamic three-dimensional conductivity distribution; s4) solving an electromagnetic field positive problem, and generating a virtual EIT voltage database synchronous with respiration; the invention also covers pathological model integration and data enhancement strategies. According to the method, a high-fidelity, large-scale and diversified EIT virtual data set can be generated, core data support is provided for training and verifying an AI intelligent reconstruction algorithm, and a model foundation is laid for developing a lung function dynamic digital twinning system.

The invention relates to the technical field of lung demonstration models, and particularly discloses a lung demonstration model for breathing machine teaching, which comprises a storage bottle, a lung model and a trachea model, and is characterized in that the trachea model is connected with the lung model; the air pressure simulation mechanism is located in the base; the switching mechanism is located in the base; according to the lung demonstration model for breathing machine teaching, students control the air pressure simulation mechanism to simulate different states of air pressure of the lung through the switching mechanism, and the air passage blocking mechanism synchronously adjusts the size of the inner diameter of the trachea model. Therefore, data conditions monitored by the breathing machine in different pathological states of a patient in an actual scene are simulated, students are helped to practice preliminary judgment of lung and airway conditions of the patient according to data changes such as the tidal volume of the breathing machine, the learning effect of the students is enhanced, and various emergencies when the patient wears the breathing machine are simulated. And the actual strain capability of students is exercised.

The present disclosure provides methods of treating pulmonary fibrosis, the methods comprising administering taladegib to a subject in need thereof.

The invention belongs to the technical field of intelligent rehabilitation equipment control, and relates to a multi-parameter feedback regulation and control method for postoperative lung function rehabilitation training, which comprises the following steps: acquiring an electrocardiosignal, a respiration signal and a limb movement signal of a patient; identifying a heart rate fluctuation form of the electrocardiosignal to generate an abnormal fluctuation time period, and analyzing a time difference between an inspiration phase and an expiration phase of the respiratory signal to generate a starting point of respiratory rhythm disorder; judging a cardiopulmonary risk level; the exercise intensity of rehabilitation training equipment is automatically adjusted based on the cardiopulmonary risk level, and meanwhile a regulation and control mode is dynamically selected according to the proportion change of the chest fluctuation amplitude and the abdomen fluctuation amplitude; when the heart rate recovery rate is lower than a preset reference and the respiratory rhythm stabilization time exceeds a critical value, gradually improving the exercise intensity; calculating a motion intensity correction coefficient and triggering a motion posture correction instruction; and generating a rating report containing the cardiopulmonary function fitness. According to the invention, the problem of lack of comprehensive quantitative evaluation of rehabilitation efficiency in the prior art is solved.

The invention discloses a respiration monitoring system based on a flexible strain sensor and a monitoring analysis method, and belongs to the technical field of sensors and respiration monitoring equipment. The respiration monitoring system comprises a flexible strain sensor, a connecting line, a data acquisition card and an upper computer; the flexible strain sensor is a band-aid type flexible strain sensor and can be directly adhered to the skin surface of a human body, and the deformation of muscles related to respiration is monitored and converted into the change of a resistance signal. And the flexible strain sensor is connected with the data acquisition card through a connecting line. And the data acquisition card is connected with the upper computer and is used for transmitting the acquired resistance signals to the upper computer. The quantitative breathing mode judgment standard is provided through dynamic measurement of the respiratory muscle group, and the defect that judgment is mainly conducted through naked eyes of doctors for a long time can be overcome; the relation between the respiratory muscle group deformation and the lung function parameters is associated, and the problem that the actual respiration condition of part of patients does not conform to the detection condition in conventional lung function detection can be solved.

The invention relates to the technical field of intelligent monitoring, and particularly discloses a lung function evaluation method and device, electronic equipment and a storage medium, and the method comprises the following steps: obtaining a universal dynamic threshold range of respiratory rate and respiratory amplitude; continuously collecting breathing data output by the MEMS breathing sensor, and obtaining and updating the moving average value and the moving standard deviation of the breathing frequency and the breathing amplitude in real time so as to calculate the change rate of the breathing frequency and the breathing amplitude in real time; according to the updated moving average value and the moving standard deviation, dynamically adjusting the dynamic threshold range of the breathing frequency and the breathing amplitude; comprehensively considering the adjusted dynamic threshold range and the change rate to carry out breathing abnormity judgment so as to carry out lung function evaluation; according to the method, finally, the adjusted dynamic threshold range and the breathing parameter change rate are comprehensively considered, breathing abnormity judgment is conducted, the lung function evaluation result is generated, breathing abnormity can be recognized more accurately, and the accuracy and reliability of lung function evaluation are improved.

The present disclosure provides methods of treating pulmonary fibrosis, the methods comprising administering taladegib to a subject in need thereof.

The present disclosure provides methods of treating pulmonary fibrosis, the methods comprising administering taladegib monotherapy as the main component to a subject in need thereof, as well as diagnostic criteria and markers establishing the progress of therapy.

The invention relates to the technical field of atomization rate control, in particular to an intelligent atomization compliance monitoring method and system for children. The method comprises the following steps: firstly, acquiring expiration flow velocity, inspiration flow velocity and multi-direction motion acceleration time sequence data of a child in a historical monitoring period, and reflecting breathing and behavior action conditions; dynamically analyzing the numerical characteristics of the expiration flow velocity and the inspiration flow velocity to divide a respiratory cycle, and analyzing the cycle length, the inspiration flow velocity cumulant and the like to construct a respiratory characteristic vector; screening a target monitoring period based on the breathing feature vector and the period number similarity; further analyzing the motion acceleration change and accumulation characteristics in the target monitoring period, and quantifying the behavior compliance expression degree; the behavior compliance expression degree and the breathing feature vector are deeply fused, a'breathing state-behavior cooperation 'joint evaluation model is established, the breathing and behavior states of children are dynamically recognized, the medicine atomization rate is accurately adjusted, and effective deposition of lung medicine is improved.

A lung fluid monitor monitors a fluid level in a lung and includes: a radiation source disposable on a first body surface and that produces nascent radiation, the nascent radiation: being received by the first body surface, communicated from the first body surface to a lung, attenuated proportionately to an amount of fluid in the lung, and communicated from the lung to a second body surface as attenuated radiation; a radiation detector disposable on the second body surface opposing the first body surface and in electromagnetic communication with the radiation source via the lung and that: receives the attenuated radiation from the lung and produces a detector signal from the attenuated radiation in response to receiving the attenuated radiation.

The utility model relates to the technical field of equipment testing, in particular to a passive following type respirator testing device and system.The device comprises a respiration simulation assembly provided with a passive following type respirator; the muscle simulation assembly is connected with the respiration simulation assembly and used for driving the respiration simulation assembly to move and simulating the expiration and inspiration exchange process of the human body based on the movement of the respiration simulation assembly; and the upper computer is communicated with the muscle simulation assembly and is used for inputting a test instruction to enable the muscle simulation assembly to move and outputting a test result of the passive following type respirator according to the test data of the passive following type respirator. Therefore, the problem that the test accuracy is low due to the fact that the simulated lung lacks a power source and the spontaneous respiration state of human muscles cannot be simulated in the prior art is solved.

The present invention discloses an intelligent respiratory support and airway clearance auxiliary system, method, device and storage medium, which relates to the field of medical data processing technology. The data acquisition module is used to obtain real-time parameter data; the respiratory analysis unit analyzes the blood oxygen saturation, oxygen partial pressure and carbon dioxide partial pressure data; the lung image data analysis unit intelligently analyzes the lung auscultation image data to identify the lung sputum blockage; the ventilator waveform analysis unit identifies abnormal waveform data based on the waveform data of the ventilator; the airway clearance module is used to determine whether it is necessary to start the Ilohen expectoration breathing mode according to the intelligent analysis results. The present invention uses advanced data processing technology and algorithms to monitor the patient's breathing in real time, and promptly discover and deal with airway problems. Through systematic data collection and analysis, the efficiency and accuracy of airway clearance are improved, the patient's treatment effect is improved, and the patient can actively expectorate while using a ventilator.

The invention provides a lung function compensation mechanism dynamic quantitative analysis method combining partition impedance measurement and a machine learning algorithm, and the method comprises the steps: obtaining a corresponding relation between a ventilation dynamic sequence and a blood flow characteristic value, and enabling the ventilation dynamic sequence and the blood flow characteristic value to be aligned in a time dimension through a multi-dimensional data fusion technology, constructing a joint feature matrix reflecting the breathing process change and the blood flow state to obtain a time-space synchronization feature set; expanding the three-dimensional dynamic model according to a time axis by adopting a data visualization technology through a compensation state quantification result, extracting a key frame from linkage change of a ventilation state value and a blood flow characteristic value, and generating a dynamic representation sequence reflecting a lung function compensation process; and obtaining a dynamic representation sequence, carrying out grouping analysis on individual differences in the sequence by utilizing a clustering algorithm, extracting a characteristic mode related to disease dynamics from a grouping result, and obtaining final lung function compensation quantitative representation data.

The invention belongs to the technical field of lung function nursing, and discloses a nursing device for improving lung function after thoracic surgery, comprising: a back plate, two sides of the lower end of the back plate are respectively provided with an air filter box and a waste liquid inbox; an outlet of the air filter box is connected with a breathing mask through a hose; a mouthpiece is fixedly arranged on the breathing mask; a suction pump is arranged on the waste liquid inbox, the input end of the suction pump is communicated with a sputum suction pipe, and the sputum suction pipe is in sliding connection with the breathing mask; elastic ropes are fixedly arranged on the two sides of the lower end of the back plate, handles are fixedly arranged at the outer ends of the elastic ropes, and a monitoring mechanism is fixedly arranged on the back plate. The device can be conveniently used when a patient lies in bed, the device can be fixed to the back through the shoulder buckle belt and the waist buckle belt, the patient can hold the handles with two hands to stretch the elastic rope to conduct chest expanding training, the comprehensive evaluation module comprehensively evaluates the physical condition and the lung function condition of the patient, the drainage monitoring module monitors the drainage condition, and the risk prediction module conducts risk prediction.

The invention relates to the technical field of phase change heat storage, in particular to a simulation method for enhancing a lung groove imitating blood vessel fin phase change heat storage system through nanofluid. The method comprises the following steps: firstly, establishing a three-dimensional physical model of the phase change heat storage enhanced heat transfer system simulating lung groove blood vessel fins, performing simulation analysis on the three-dimensional model, comparing a simulation result with an experimental result, and adjusting parameters of the simulation model to improve the accuracy of the simulation result; different nano-fluids are selected through the optimized simulation analysis platform to carry out enhanced heat transfer research on the TES, and the influence of the volume fraction of the nano-particles, the variety of the nano-particles, the temperature of the heat transfer fluid (HTF) and the initial speed on liquid phase distribution, temperature distribution, melting characteristics and kinetic energy consumption of the TES is analyzed. And finally, performing three-objective optimization on the kinetic energy, the TES heat storage amount and the melting time to obtain an objective function and an optimal value, and providing a certain reference basis for TES multi-objective optimization under the condition that the working medium is the nanofluid.

The invention relates to the technical field of medical data mining, in particular to a postoperative pulmonary infection prediction method and system.The postoperative pulmonary infection prediction method comprises the following steps that a continuous data set is formed by collecting breathing parameters and conducting alignment completion, tidal volume and blood oxygen response delay characteristics are extracted through sliding analysis, and a functional abnormal pulmonary segment is located through local anomaly recognition; and fusing physiological and anatomical features to establish a spatial probability map, extracting a respiratory variation coefficient and a risk feature regression analysis confidence index, and outputting an infection risk early warning list with anatomical positioning. According to the method, data faults are eliminated through timestamp alignment to improve the reliability of time sequence association, the breathing compensation capability is quantified through multi-scale window analysis dynamic coupling, lesion avoidance feature masking is accurately positioned through local anomaly detection, and the result interpretability is enhanced through combination of multi-modal feature fusion and space mapping. The three-stage progressive mechanism improves the prediction precision and timeliness, and provides a decision basis with both time sensitivity and anatomical orientation for clinic.

The invention relates to the technical field of rehabilitation assistance, in particular to an intelligent breathing assistance system for lung rehabilitation, comprising: a breathing part, the breathing part comprising a breathing cylinder, the breathing cylinder comprising a fixed cylinder and a folding cylinder, the fixed cylinder being internally provided with an auxiliary assembly; the wearing part comprises a chest cover and an abdomen cover, a connecting channel and a vibration channel are formed in the chest cover, an air bag is embedded in the abdomen cover, and a vibration phlegm eliminating assembly is arranged in the vibration channel; the thoracico-abdominal movement mode recognition unit is used for detecting a breathing mode of a user; the lung function detection unit is used for calculating and detecting the tidal volume of a user; the personalized training control unit is used for adjusting breathing resistance according to the tidal volume and breathing modes, according to different breathing modes of users, the breathing assisting force is adjusted through kinetic energy of gas exhaled by the users, key parameters such as the tidal volume and the recovery condition are monitored in real time, the lung rehabilitation effect is further improved, and the lung rehabilitation effect is improved. And more accurate and effective breathing adjuvant therapy is realized.

A method of assessing airway clearance therapy efficacy includes generating a pressure pulse in a respiratory device being used by a patient. The patient's lung impedance is measured during the pressure pulse and the patient's lung condition is assessed based on the patient's lung impedance. The patient's lung condition is then assessed after airway clearance therapy.

The subject of the invention is a method of electroacoustic heart-lung dynamics that includes the steps of: A) recording a three-dimensional ECG; B) recording three-dimensional impedance rheometry of the chest; C) recording of chest sounds resulting from internal organs in the frequency range up to 20 kHz; D) recording ultrasound from the chest resulting from the movement of internal organs in the frequency range above 20 kHz; E) determination of characteristic events in the data from steps A), B), C), and D) associated with a given organ in particular detection of the breathing phase, breathing rhythm, and breathing rate, and in particular detection of the heart contraction phase using the data from steps A) and B), and detection of sounds from the lungs; F) determining the temporal and / or phase correlation of events in the data from steps A), B), C) and D); G) comparing the temporal and / or phase correlation of events from steps A), B), C), and D) with the benchmark data; H) determination of the relationship between the determined temporal and / or phase correlation of events and the benchmark temporal and / or phase correlation of events. The object of the invention is also a device for implementing this method. (15 claims)

The application belongs to the technical field of animal models for basic scientific research, and particularly relates to a method for establishing an acute lung injury animal model, which comprises the following steps: sending a podophyllotoxin or a podophyllotoxin reagent into a rat body through oral administration or intragastric perfusion to obtain the acute lung injury animal model. The method for establishing the acute lung injury animal model provided by the application uses the podophyllotoxin as an inducer for establishing a mouse acute lung injury model, and the mouse can orally take or intragastrically perfuse the podophyllotoxin to achieve the method, without needing a special medicine injection device, so that the method is simple in medicine taking, few in experimental steps, and does not need complex surgical operations.

The utility model discloses a respiratory nursing lung function rehabilitation training device, and relates to the technical field of medical equipment. The device comprises a base, a connecting cylinder is fixedly connected to the upper surface of the base, a connecting plate is fixedly connected to the top end of the connecting cylinder, a connecting block is fixedly connected to the top of the connecting plate, a ventilation groove is formed in the connecting block, a breathing hose is fixedly connected to the position, close to the bottom, of the outer surface of the connecting cylinder, and a bottom plate is placed in the connecting cylinder; a top plate is arranged on the upper surface of the bottom plate, and two ends of a spring are fixedly connected between the bottom plate and the top plate. According to the breathing training device, through the installed air filter element, when a patient exhales into the training device, air can be blown into the connecting cylinder from one side of the spring, then enters the air filter element from one circle of the edge to be filtered, and then comes out of the middle of the air filter element to flow into the ventilation groove, so that the exhaled air is filtered; furthermore, the quantity of germs in exhaled air is greatly reduced, and the sanitary condition of the device in use is optimized.

The disclosure provides systems and methods for treating obstructive sleep apnea using an acoustic sensor configured to detect acoustic sounds generated by the heart and lungs. Sensory data from the acoustic sensor is used by an implanted stimulation system to determine when to deliver electrical stimulation to a nerve which innervates an upper airway muscle, such as the hypoglossal nerve, to treat sleep apnea.

A lung exercise measurement device and method that utilizes one or more lift timers, rest timers and / or set counters to accurately display valuable metrics and goals for tracking and improving respiratory development using a lung trainer breathing technique device, with particular advantages for instructive, competitive, self-learning, and group training environments.