543results about How to "Good treatment effect" patented technology

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

The invention belongs to the technical field of brain-computer interfaces, and particularly relates to a post-stroke dysphagia rehabilitation recognition system, feedback stimulation equipment and a storage medium. The system comprises a signal acquisition module, an electroencephalogram signal preprocessing module, a neural network feature extraction module, a statistical feature extraction module and a swallowing intention recognition module, and can recognize whether a patient has a swallowing intention or not through a Mama deep learning model based on space-time statistical features. The invention also constructs brain-computer interface equipment for rehabilitation of dysphagia after stroke in combination with electroencephalogram signal acquisition equipment and electrical stimulation equipment. The technical scheme of the invention has the advantages of being accurate in recognition, good in rehabilitation treatment effect and capable of forming center-periphery closed loop feedback, and has a very good application prospect.

The invention discloses an ROS-responsive prostate cancer targeting prodrug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The prodrug is formed by covalently linking a prostate cancer targeting peptide SYEELR, a ROS (reactive oxygen species) response type ketal thiol (TK) connexon and an active molecule Devimistat. The preparation method comprises the following two steps: firstly, coupling Devimistat with a TK linker to obtain an intermediate Dev-TK, and then coupling the intermediate Dev-TK with an SYEELR peptide fragment to obtain a target product. The prodrug can specifically break and release Devimistat in a tumor high active oxygen microenvironment, and active targeting delivery is realized by virtue of the SYEELR peptide. The invention provides a novel prostatic cancer treatment strategy with accurate targeting, controllable release, enhanced curative effect and toxicity reduction potential.

This invention belongs to the field of medical device technology and discloses a foot pressure relief device for diabetic foot. It includes a base, a pressure relief plate and a motor connected to the base, and a foot pedal and a transmission assembly connected to the pressure relief plate. The transmission assembly includes a crank, a first connecting rod, and a sliding seat. The crank is fixedly connected to the output shaft of the motor, and the sliding seat is connected to the pressure relief plate. The two ends of the first connecting rod are respectively connected to the crank and the sliding seat. The sliding seat is connected to a foot rolling shaft and a second connecting rod, and the second connecting rod is connected to a foot massage roller. A buffer spring is provided between the pressure relief plate and the base. The foot pedal has a through groove, and the foot rolling shaft is connected to a foot massage roller. This invention utilizes the foot rolling shaft / foot massage roller and the foot massage roller to simultaneously perform rolling massage on the sole and instep of the foot. The periodic oscillation of the pressure relief plate causes the heel and toes to alternately rise, resulting in good pressure relief for the foot.

The application discloses a controllable breathing machine atomization processing circuit, which comprises a main control module, a display module, a carbon dioxide concentration detection module, a pressure detection module, a judgment module, an atomization output control module and an oscillation driving module; wherein the main control module is connected with the display module, the judgment module, the carbon dioxide concentration detection module and the pressure detection module respectively; the display module, the carbon dioxide concentration detection module and the pressure detection module are connected with the judgment module respectively; the judgment module is connected with the atomization output control module; and the atomization output control module is connected with the oscillation driving module. Through the cooperation of the main control module, the carbon dioxide detection module and the pressure detection module, the breathing frequency data of a patient can be accurately collected and fed back in real time; and through the atomization output control module and the input oscillation driving module, the vibration frequency of the atomization screen is regulated and controlled, so that the atomization screen can better adapt to the breathing frequency of the patient.

The application discloses a method for preparing cell-derived exosomes and products and applications thereof, and the method comprises the following steps: co-culturing immune-activated programmable cells with a stimulating agent with immune-activation effect, and collecting the cell-derived exosomes with immune activity by a natural secretion collection method or an artificial extrusion collection method. The application has safe and controllable local immune activation, and the immune activation strategy based on the exosomes fully overcomes the safety bottleneck of traditional live bacterial preparations in tumor treatment. By replacing live bacteria with engineered exosomes, not only potential risks such as systemic inflammatory response and infection are effectively avoided, but also the local controllability of immune stimulation signals is ensured, the precise activation and directional regulation of tumor region immune cells are realized, the tumor microenvironment is reshaped, the anti-tumor effect is strengthened, and the broad-spectrum cross-tumor potential is verified across models.

The application relates to the technical field of medical devices, in particular to a balloon for vascular access intervention, which comprises an outer catheter, a cleaning pipe and a telescopic hose, one end of the outer catheter is provided with a guide wire connecting port, the cleaning pipe is arranged on the guide wire connecting port, and a guide head is fixedly connected to the end of the outer catheter far from the guide wire connecting port; medicine is smeared into a medicine applying groove, the medicine in the medicine applying groove will be attached to the inner wall of the blood vessel of a patient after the balloon body is inflated, covers the wound, avoids the elution of the medicine when the balloon body moves, and improves the use rate of the medicine.

The utility model discloses a medicine application nursing appliance, which belongs to the technical field of medical instruments and comprises a substrate layer, a medicine bag cavity, an anti-seepage ring, a heating component and a displaceable pressing component. When the medicine applying nursing appliance is used, the medicine applying nursing appliance is stably adhered to the umbilical region of a user through the adhering edge on the base layer, the medicine bag in the medicine bag cavity acts on the umbilical region for treatment, and the movable pressing assembly can be moved to the umbilical region or near the Tianshu point for intermittent pressing during the period. In addition, the heating assembly can be started to conduct low-temperature heat conduction on the application area, integration of medicine, hot compress and acupoint pressing is achieved, and the treatment effect is improved. The medicine bag is arranged in the medicine bag cavity, replacement is convenient, medicine liquid leakage can be prevented, and use convenience is improved.

The invention discloses application of a palmitoylation inhibitor in prevention and treatment of gastric cancer. The chromatin remodeling protein SNF2 derived from S.anginosus EVs can be combined with a transcription factor TEAD1, so that the transcription of the palmitoyl transferase ZDHHC11 is promoted together. Then, the stability of the ZDHHC11 is enhanced by catalyzing palmitoylation of PD-L1, and finally immune escape is induced. In addition, SNF2 also can activate AXL, CTGF, CYR61 and other carcinogenic targets at the downstream of TEAD1, thereby further accelerating the malignant progression of gastric cancer. In an in-vivo experiment, the intragastric administration of the S.anginosus EVs not only promotes the tumor growth of mice, but also significantly inhibits the infiltration of CD8 + T cells. Blocking of ZDHHC11 can effectively reverse immune escape, and has a synergistic effect with an anti-PD-1 therapy, so that the treatment effect is remarkably improved.

The invention discloses an electrode pad and a non-invasive high-frequency output device, and relates to the technical field of skin improvement through electric energy, the electrode pad is used for being electrically connected with a radio frequency energy output device so as to convey radio frequency energy to skin tissue, and the electrode pad comprises a plurality of radio frequency energy areas which are electrically connected with at least one radio frequency energy output device; the electrode pad is provided with a treatment surface, the multiple radio frequency energy areas are arranged on the treatment surface, the treatment surface is provided with a central part and an edge part, and the multiple radio frequency energy areas surround the central part in an annular path mode and are sequentially arranged in the direction from the central part to the edge part; wherein the impedances of the plurality of radio frequency energy regions are sequentially increased along the direction from the central part to the edge part; the invention aims to solve the problem that the energy of the noninvasive high-frequency output equipment is concentrated at the edge part of the electrode pad due to the influence of the edge part effect.

The utility model relates to the clinical technical field of dermatology, in particular to a sensitive skin care instrument which comprises a fixing frame, a first fixing ring is installed at the top end of the fixing frame, a cold compress treatment assembly is installed on the inner wall of the first fixing ring, and a second fixing ring is fixedly connected to the top end of the fixing frame and located on one side of the first fixing ring. And a fixing plate is mounted on the inner wall of the second fixing ring. According to the sensitive skin care instrument, through the arrangement of the fixing frame, the first fixing ring and the cold compress treatment assembly, when the sensitive skin care instrument is used, the fixing frame is used for fixing the first fixing ring, the face of a patient is placed in the first fixing ring, after hot compress treatment is conducted on the patient, facial pores of the patient can be shrunk through the cold compress treatment assembly, and dust and bacteria are prevented from entering the pores; by combining hot compress, the treatment effect of a patient can be improved, red, swollen and itching of sensitive skin are relieved, and the device is integrated, does not occupy the use space and reduces the trouble of carrying a machine.

The application belongs to the technical field of biological medicine, and discloses an oncolytic virus M1 synergistic composition and application thereof, and specifically discloses application of low molecular heparin or a pharmaceutically acceptable salt thereof in preparation of a product for enhancing the antitumor effect of an oncolytic virus. The application first proposes a technical scheme for increasing the therapeutic effect of oncolytic virus M1 in tumor treatment by using low molecular heparin, the low molecular heparin can affect the replication process of the oncolytic virus in cancer cells, and the combined use of the two shows a positive effect, opening up a new direction for optimization of oncolytic virus therapy and providing a new possibility for improving the therapeutic effect.

This utility model relates to the field of atomization spray technology, specifically an atomization spray precision control device. The device includes an atomizer with a side-hollow structure. A baffle plate is located inside the atomizer, and a transmission groove is formed within the atomizer. A connecting rod is fixedly connected to the top of the baffle plate. The top of the connecting rod extends into the transmission groove and is fixedly connected to a gear. A threaded rod is rotatably connected inside the transmission groove. A sliding block is threadedly connected to the external thread of the threaded rod, and another sliding block is threadedly connected to its external thread. A rack is fixedly connected to the bottom of the sliding block. A limit rail is fixedly connected to the top of the inner wall of the transmission groove. The advantages of this utility model are that it ensures uniform drug particle size, enabling precise deposition in the respiratory tract and lungs, improving drug absorption efficiency, optimizing drug distribution, avoiding excessively high or low local drug concentrations, enhancing therapeutic effects, and reducing side effects. Compared to traditional devices, it significantly improves operational quality and efficiency.

The present application relates to a kind of operating nutrient metal ion modified anaerobic probiotics and its preparation method and application, and the surface of anaerobic probiotics is sequentially deposited with polyphenols and sodium alginate Nutrient metal ion is obtained.The present application can supplement nutrient element while improving the oxygen tolerance and gastrointestinal environment tolerance of anaerobic probiotics, increase the intestinal adhesion retention capacity of probiotics;Modified probiotics can repair intestinal barrier, regulate intestinal mucosal immune balance, reshape intestinal flora structure, and improve systemic inflammatory response through intestine-multiple organ interaction axis, and has significant therapeutic effect on extraintestinal immune-mediated inflammatory diseases.

The invention belongs to the technical field of moxibustion cabins, and discloses a full-automatic intelligent moxibustion cabin with a smoke purifying function, which comprises a moxibustion cabin body, a box body is fixedly mounted in the moxibustion cabin body, a supporting round block is fixedly mounted at the top of the box body, a threaded sleeve I is fixedly mounted at the bottom of the supporting round block, and a smoke purifying device is fixedly mounted at the bottom of the threaded sleeve I; a first threaded rod is movably mounted in the first threaded sleeve. Compared with a traditional moxibustion cabin, the moxibustion cabin has the advantages that the first teeth and the second teeth are matched, the height of the moxibustion box and the height of the moxibustion plate can be reasonably adjusted according to the internal temperature of the moxibustion cabin body, in this way, it can be ensured that the moxibustion temperature is appropriate, and irritation or discomfort caused by too high or too low temperature to the skin is avoided; by accurately adjusting the heights of the moxibustion box and the moxibustion plate, the moxibustion device can be better aligned to acupuncture points or treatment parts, the treatment effect is improved, and meanwhile the moxibustion box and the moxibustion plate can be flexibly adjusted in a matched mode.

The application relates to the technical field of biological medicine, in particular to a medicine for combined treatment of tumors by using a recombinant oncolytic virus and a small-molecule anticancer drug. The method comprises the following steps: combined treatment of tumors by using a recombinant oncolytic virus and a small-molecule anticancer drug; the small-molecule anticancer drug is a small-molecule anticancer drug targeting Parp; the recombinant oncolytic virus comprises M protein, G protein, N protein, P protein and L protein after site-directed mutagenesis. The application can kill tumor cells by using a recombinant oncolytic virus and a small-molecule anticancer drug, and the curative effect is 1+1>2.

This invention belongs to the field of medical device technology, specifically relating to a nebulized inhalation device for treating pediatric pneumonia. The device includes a main body connected to a spray tube; an oxygen supply section including an oxygen cylinder, the outlet of which is connected to the spray tube; a spray section including a compressor, the outlet of which is connected to a mixing tank, which is connected to the spray tube; a feeding section including a medication cartridge connected to a delivery tube, which is connected to the mixing tank; and an adjustment section including a guide rod with a sealing plug at its lower end, a lifting rod inside the guide rod, and a U-shaped plug fixedly connected to its lower end, positioned above the delivery tube. This invention enables rapid mixing of medication and oxygen with the medication mist, allows for quick assembly and disassembly of the medication cartridge, and allows for flexible control of the dynamic and directional release of a specific medication during treatment, ensuring the comfort of the child during treatment.

The utility model provides a radiofrequency ablation instrument which comprises an electrode base body, a first electrode, a second electrode, a third electrode and a fourth electrode. The handle is connected with the electrode base body, and the handle can rotate; the bending control assembly is arranged on the handle and is connected with the deformation part; when the handle rotates, the bending control assembly can be driven to rotate, and the bending control assembly drives the deformation part to bend. According to the radiofrequency ablation instrument, the bending amplitude of the deformation part can be controlled by rotating the handle, so that the position of the deformation part can be adjusted according to different patients, the matching degree of different patients is improved, the treatment effect is improved, and the operation risk is reduced.

The application discloses an inhibitor for inhibiting KRAS phase separation to play an anti-tumor role and application, and relates to the fields of tumor molecular biology and targeted therapy.The application aims at solving the problems of limited effect, strong drug resistance and limited application range of KRAS tumor treatment methods, and the inhibitor is a statin.The KRAS protein can form a liquid condensate in cells, and the application discloses the mechanism of the KRAS protein in promoting KRAS protein processing, transportation and downstream signal activation, and further provides a technical scheme for inhibiting tumor growth and enhancing the therapeutic effect of a KRAS inhibitor by inhibiting the formation of KRAS condensates, so as to provide a new target and intervention approach for tumor treatment.

The present invention relates to the use of beta-hydroxy-beta-methylbutyric acid (HMB) or a pharmaceutically acceptable salt thereof as an inhibitor of Gasdermin D (GSDMD) in the manufacture of a medicament for the treatment of pyroptosis. HMB modulates pyroptosis in macrophages by blocking palmitoylation of GSDMD and has the potential to be a novel therapeutic agent for the treatment of inflammatory diseases driven by pyroptosis disorders.

The application relates to the field of medical instruments, and provides an appendix orifice supporting device for endoscopic retrograde appendix treatment, which comprises a support head, a support base, an unfolding piece, a first direction line, a second direction line and an opening and closing piece. A channel is arranged on a colonoscope. The support base is arranged around the front end of the colonoscope. The unfolding piece is arranged in at least three groups and is arranged in sequence along the support base. The opening and closing piece is located in the channel and is divided into a pushing end and a connecting end. The pushing end is located outside the colonoscope. When the pushing end is pushed, the connecting end moves along the channel and extends out of the channel. The support head is an elastic structure with expansion characteristics, and the bottom is connected with the connecting end and the unfolding piece. The application has the advantages of conveniently providing support for the appendix orifice and providing the effect of extending a sub-scope into the appendix cavity for shooting, exploration and treatment on the basis of facilitating colonoscope treatment.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

This invention discloses 5α-reductase degrading molecules, their preparation methods, and applications. Four 5α-reductase degrading molecules can induce proteasome-dependent degradation of 5α-reductase, achieving complete clearance of the enzyme protein rather than merely inhibiting its activity, thus obtaining a more durable therapeutic effect. Under equal-dose conditions, the 5α-reductase degrading molecules are more effective than the traditional inhibitor finasteride in treating benign prostatic hyperplasia (BPH). These four 5α-reductase degrading molecules can effectively degrade 5α-reductase protein and significantly inhibit the development of BPH, exhibiting good biocompatibility. This provides a new strategy and candidate drugs for the treatment of BPH, prostate cancer, androgenetic alopecia, acne, and other diseases related to 5α-reductase.

The utility model relates to the technical field of acupuncture equipment, and provides an acupuncture needle with sticking and pricking performance, which comprises an acupuncture needle handle, an acupuncture needle body, a fixer, kinesio and isolation paper, the isolation paper is stuck below the kinesio, the kinesio and the kinesio are arranged on the kinesio in a penetrating manner, and the acupuncture needle handle is connected with the fixer. The filiform needle handle and the filiform needle body are integrally formed, the fixator is arranged at the combined part of the filiform needle handle and the filiform needle body, the size of the filiform needle body is 0.25 * 40mm, and the fixator is a soft fixing band piece with a changeable shape. After acupuncture acupoint selection and needle insertion of a fixed filiform needle body are performed, a fixator and isolation paper are removed, kinesio tape is downwards fixed to acupoint skin along the needle body, then the kinesio tape is properly pulled, and local tissue is fixed in an attached and pricked mode, so that the acupoint stimulation effect is achieved, the local tissue is fixed, and the acupoint stimulation effect is achieved. Lymphatic reflux is improved, so that swelling and pain are relieved, and the treatment effect is improved.

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

This invention relates to a traditional Chinese medicine combination for treating intrahepatic cholestasis, which is made from the following raw materials in parts by weight: Artemisia capillaris and Glycyrrhiza uralensis 5:1 and 3:1. This invention also provides the preparation of the above-mentioned medicine and its use in treating intrahepatic cholestasis. Its advantages are: the traditional Chinese medicine composition of this invention (Artemisia capillaris and Glycyrrhiza uralensis decoction) has a significant ameliorative effect on intrahepatic cholestasis (non-obstructive type) induced by a 1% CA-containing diet in mice. Artemisia capillaris and Glycyrrhiza uralensis decoction can alleviate weight loss in mice and improve liver necrosis; significantly reduce serum ALT and ALP levels in mice; reduce the content of total bile acids in the liver and decrease the proportion of toxic bile acid taurine deoxycholic acid (TDCA) in the bile acid pool; upregulate liver BSEP protein expression to promote bile acid efflux; and downregulate liver NLRP3 protein expression to alleviate liver necrosis.

The present application provides a kind of complex probiotic paste, which combines Enterococcus faecalis, Saccharomyces cerevisiae and vitamin B 12 Producing lactic acid bacteria of canine source, adds prebiotics, flavoring substances and auxiliary substances such as paste matrix preparation.In the paste, the viable count of Enterococcus faecalis, Saccharomyces cerevisiae and lactic acid bacteria is 1-2:1-2:1-8;Paste matrix includes fructooligosaccharide 0.5-3%, psyllium husk powder 0.1-2%, goat milk powder 2-8%, chicken liver powder 1-5%, potassium sorbate 0.5-2%, xanthan gum 1-4%, and the balance is water.The above-mentioned complex probiotic paste can be stably stored for 56 days at 4 DEG C and normal temperature dry place, has good storage stability, good safety, and can adjust intestinal flora and increase the content of intestinal lactic acid bacteria.The above-mentioned complex probiotic paste has good palatability and oral tolerance for pets such as dogs and cats, and has good therapeutic effect on DSS-induced chronic enteritis diarrhea and vitamin B 12 Deficiency.

The application relates to the technical field of cell culture, in particular to application of Gremlin1 protein in promoting proliferation of adipose-derived cells. The application also provides a culture medium containing the Gremlin1 protein, which is used for culturing the adipose-derived cells, can significantly promote proliferation of the adipose-derived cells, and is significantly superior to a commercial special culture medium.

The present invention relates to a bioactive conjugate, a preparation method therefor, and use thereof. In particular, the present invention relates to a novel type of bioactive molecular conjugates obtained by improving the coupling of a drug to a targeted moiety in ADC or SMDC, a preparation method therefor, and use thereof in the preparation of drugs for treating diseases associated with abnormal cellular activity.

This utility model relates to the field of traditional Chinese medicine plaster technology, and discloses a leak-proof, visible joint and acupoint traditional Chinese medicine plaster, including a skin-friendly layer, which is a circular medical-grade transparent silicone film with a diameter of 40mm; a leak-proof layer, which is a TPU waterproof and breathable film covering the back of the skin-friendly layer; elastic fixing wings; and a four-petal flower-shaped elastic non-woven fabric surrounding the skin-friendly layer. In this utility model, the composite design of the transparent skin-friendly layer and the leak-proof layer achieves both visualization of the treatment process and leak-proof functionality: the transparent skin-friendly material allows direct observation of whether redness, swelling, or allergic reactions occur on the skin; the middle waterproof and breathable film prevents the medicinal liquid from seeping out while allowing moisture to pass through, avoiding staining of clothing and causing stuffiness and discomfort on the skin.