36results about How to "Remove toxic side effects" patented technology

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide / glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100 / 0 to 1 / 99.

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide / glycolide) copolymer having a molar composition of lactide / glycolide from 90 / 10 to 40 / 60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100 / 0 to 1 / 99.

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide / glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100 / 0 to 1 / 99.

The invention relates inter alia to a method of treating tumorous disease in a human patient by administering to the patient a human immunoglobulin specifically binding to the human EpCAM antigen, the immunoglobulin exhibiting a serum half-life of at least 15 days, the method comprising the step of administering the immunoglobulin no more frequently than once every week, preferably no more frequently than once every two weeks.

A wound-healing and hemostatic sponge of squid ink polysaccharide / chitosan, a preparation method and use thereof are provided. The sponge comprises squid ink polysaccharide and chitosan as carriers and calcium chloride as an initiator for blood coagulation, and the wound-healing and hemostatic sponge of squid ink polysaccharide / chitosan is achieved via a lyophilization technology. Particularly, the preparation method comprises slowly adding a squid ink polysaccharide solution to a chitosan solution to form a uniformly mixed solution, adding a calcium chloride solution to the uniformly mixed solution, forming a gel followed by the gel being frozen and then lyophilized, and achieving the product. The wound-healing and hemostatic sponge has a good absorbing-errhysis effect, a good pro-coagulant effect, fast hemostasis and a complete hemostatic effect, without secondary re-hemorrhage. Moreover, the wound-healing and hemostatic sponge can promote wound healing, re-epithelialization and repair of epidermis and dermis, with strong wound-healing ability, good biocompatibility, weak toxic side effects and irritation, belonging to a novel wound-healing and hemostatic material. Moreover, the preparation method is reliable, fast, and low cost.

A class of compounds commonly containing a trialkylammonium group have been synthesized and characterized as anticancer compounds. A representative of this class, N,N-diethyl-N-methyl-2-[(9-oxo-9H-thioxanthen-2-yl)methoxy]ethanaminium iodide (CCDTHT) was shown in various tumor models to decrease tumor volume, enhance the effects of other chemotherapeutic agents including cisplatin, reduce chemotherapy-induced loss of body weight, and increase survival of animals co-treated with toxic amounts of cisplatin. CCDTHT had even greater effects on tumor volume, body weight, and survival when administered to animals together with the human protein placental alkaline phosphatase. These trialkylammonium group-containing compounds and alkaline phosphatases, particularly in combination with each other and other therapies, may be used to treat cancer and other cell proliferative diseases.

The present invention belongs to the field of natural medicines and discloses a compound medicine composition with anti lymphoma activity containing piperlongumine and houttugnin and use thereof. Active ingredients of the compound medicine composition comprise the piperlongumine and the houttugnin in a molar ratio of 1:1 to 1:20. Through combination of the piperlongumine and the houttugnin, the compound medicine composition has a strong synergistic treatment effect on lymphoma.

The invention discloses a formula of an anticancer Chinese medicine and a process for preparing products of the anticancer Chinese medicine. The process comprises the following steps of: decocting centipede, eupolyphaga, wall lizard, scorpio, leech, gadfly, toad skin, American ginseng, notoginseng root, ligusticum wallichii, Chinese honeylocust spine and angelica dahurica, filtering, adding Zygosaccharomyces bailii into obtained filtrate and decoction dregs, and statically culturing for 192 to 240 hours at corresponding temperature and humidity to obtain oral liquid, oral tablets or capsules of the anticancer Chinese medicine. The products are used for treating gastric cancer, liver cancer, esophagus cancer, intestinal cancer, lung cancer and other cancers, are directly and orally taken, have quick response and high therapeutic effect and sweet taste, and can be quickly adsorbed, the cancer is not relapsed, and a user does not have sequela or complications after taking the anticancer Chinese medicine; two special processes, namely solid and liquid fermentation processes are realized by applying microorganisms to the Chinese medicine, so that the toxic or side effect of a raw medicine is eliminated, the products are convenient to store and take, and waste decoction dregs are not produced; and the source of raw materials is rich, the medicine is easy to prepare, the cost is low, and the products can be used for both treatment and health protection.

The invention belongs to the field of natural medicine, and discloses a compound medicine composition with a lung cancer resistant effect and application of the compound medicine composition. Active ingredients of the compound medicine composition consist of piperlongumine and rheum emodin in a molar ratio of (1:1) to (1:10). By combining the piperlongumine and rheum emodin, a synergic effect for treating the lung cancer is relatively good.

The invention belongs to the technical field of pharmaceutical preparation, and in particular to a potassium ion competitive acid blocker Vonoprazan fumarate injection with the effect of treating gastric acid-related diseases, and a preparation method thereof. The invention overcomes the defect of poor solubility of the main drug Vonoprazan fumarate, uses an inclusion form of sulfobutylether-beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin for solution increase. The prepared injection has the advantages of good stability, high safety and no precipitation during long-term placement, and can meet the medication requirement for the patients who are not convenient for oral administration.

The invention provides a traditional Chinese medicine composition capable of moistening the intestines and relaxing the bowels, belonging to the field of Chinese herbal compounds. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 15 to 20 parts of senna leaf, 10 to 16 parts of fruit of ford manglietia, 6 to 12 parts of Chinese angelica, 6 to 12 parts of cistanche, 6 to 10 parts of licorice root and 6 to 10 parts of honey. The traditional Chinese medicine composition provided by the invention is capable of benefiting lung qi, clearing away deficiency fire and dredging the intestinal tracts. The invention also discloses a preparation method for the traditional Chinese medicine composition. The preparation method comprises the following steps: crushing the Chinese angelica into powder; separately extracting the senna leaf, cistanche, fruit of ford manglietia and licorice root so as to obtain liquid extracts, combining the liquid extracts to obtain a liquid extract mixture and concentrating the liquid extract mixture so as to obtain extract paste; and mixing the powder, the extract paste and the honey so as to obtain the traditional Chinese medicine composition. The method can effectively extract active components in the raw materials.

The invention provides a yew anti-cancer paste, which is an extract of more than ten rare traditional Chinese medicines including taxol, dragon's blood, oldenlandia diffusa and Chinese actinidia root. The external anti-cancer paste is prepared by ultrasonically crushing cytoplasm and coordinating with azone and magnetic chips. The paste has high drug loading capacity, drug factors of quantum particle peptides activate the magnetic memory of the drug factors due to the strong magnetic field function of the magnetic chips, the drug factors rapidly penetrate through the skin and enter the focus and penetrate through the cancer cells in a targeting mode, and the DNA protein chain polymerization is locked and is not depolymerized, so that the cancer cells atrophy, suicide and generate apoptosis. The paste is rapid in effect, high in air permeability, convenient and comfortable, has no toxic or side effect and constant-speed slow release, and has an extremely obvious treatment effect on cancers such as gastrointestinal carcinoma, lung cancer, breast cancer, skin cancer, nasopharynx cancer, laryngeal carcinoma, lymph gland cancer, superficial skin tumor and pancreatic cancer. The anti-cancer paste is simple in process, easy to operate, high in medicine activity and outstanding in antalgic anti-cancer effect.

The invention discloses a phosphogypsum forest conditioner. The phosphogypsum forest conditioner comprises, by weight, 80-90 parts of phosphogypsum, 1-3 parts of berberis soulieana, 1-3 parts of herbaartemisiae annuae powder and 1-3 parts of brown sugar. A method for preparing the phosphogypsum forest conditioner includes steps of (1), drying and smashing the phosphogypsum and then sieving the phosphogypsum via mesh sieves to obtain phosphogypsum powder for standby application; (2), dissolving the brown sugar in 2-5 parts of water to obtain brown sugar water for standby application; (3), proportioning other components, drying and smashing the other components, sieving the other components via mesh sieves, then adding the brown sugar water and the phosphogypsum powder into the other components, mixing and stirring the brown sugar water, the phosphogypsum powder and the other components with one another to obtain mixtures and fermenting the mixtures for the fermentation time of 40-60 hours under the control; (4), taking out fermentation broth after the mixtures are completely fermented, and carrying out drying and smashing treatment on the fermentation broth to obtain the phosphogypsum forest conditioner. The phosphogypsum forest conditioner and the method have the advantages that the problem of incapability of utilizing the phosphogypsum as a main raw material for conditionerson a large scale in the prior art can be solved by the aid of the phosphogypsum forest conditioner and the method; the toxicity and side effects of phosphogypsum can be removed, required nutrient elements can be provided to protected vegetation, and the phosphogypsum forest conditioner can assist the vegetation to grow.

The invention discloses a processing production technology for polygonum multiflorum. Conventional processing technologies for polygonum multiflorum are long in processing period and waste manpower and material resources. The processing production technology for polygonum multiflorum comprises: selecting polygonum multiflorum dry sheets immersed by black soybean juice, putting a bamboo or wood container loaded with polygonum multiflorum dry sheets in a circulated steam kettle for high-temperature boiling for 12 h. The content of the component stilbenes with liver-protecting effect is relatively high after 12 h boiling; and combined anthraquinones contained in raw polygonum multiflorum sheets has purgation effect and light hepatotoxicity, and is converted into free anthraquinones which has no purgation effect after polygonum multiflorum is processed. Therefore, processed polygonum multiflorum is reduced in toxicity and helps to increase hepatic glycogen; the boiling time is controlled at 12 h, so that not only the processing time is saved and the manpower and the materials resources are saved, but also the relatively high beneficial component content of the product is guaranteed, the toxic and side effects of the product are furthest reduced, and thus the quality of the product is guaranteed; and the processing production method is widely applicable to process and produce polygonum multiflorum.

The invention relates to a medicament for treating hysteromyoma, which comprises (by weight portions) cinnamon twig 20-40g, poria cocos wolf 20-40g, gen-seng 45-75g, Chinese angelica root 20-40g, Sichuan fritillary bulb 20-40g, Eupolyphaga Sinensis Walker 20-40g, pangolin scales 20-40g, pseudostellaria root 45-75g, trogopterus dung 20-40g, leeches 10-20g, evodia rutaecarpa 20-40g, Cinnamomum cassia 10-20g, centipede 4-10g, bupleurum root 10-20g, cyathula root 20-40g and asarum herb 10-20g.

The invention discloses targeted nano magnetic donkey-hide gelatine as well as a preparation method and application thereof. The targeted nano magnetic donkey-hide gelatine is composed of 1% of chitosan-folic acid-surfactant modified nano magnetic particles and the balance of flagged donkey-hide gelatine in percentage by mass, wherein the chitosan-folic acid-surfactant modified nano magnetic particles is composed of nano magnetic iron oxide, chiston or chiston derivative, folic acid, polyethylene glycol and surfactant. The preparation method comprises that firstly the chitosan-folic acid-surfactant modified nano magnetic particles are added into donkey-hide gelatine about to be flagged, uniform mixing is carried out, and then flagging is carried out, so that the targeted nano magnetic donkey-hide gelatine is obtained. The targeted nano magnetic donkey-hide gelatine can be used for reducing chemoradiotherapy reaction in tumour therapy, reducing toxic and side effects of chemotherapeutic drugs, improving tolerance and living quality of patients, prolonging meso-position survival time and the total survival time of the patients and improving immunity of people.

The invention belongs to the field of natural medicines and discloses a compound medicine containing conjugated linoleic acid and luteolin and application thereof. The active ingredient of the compound medicine is composed of linoleic acid and luteolin at the mole ratio of (1:1) to (1:20). The medicine combining with linoleic acid and luteolin has a strong function of cooperatively treating lymphoma.

The present invention discloses a dual-drug co-delivery system, a preparation method therefor and use thereof, the dual-drug co-delivery system being prepared from raw materials comprising a block copolymer, Homoharringtonine and Doxorubicin hydrochloride. The dual-drug co-delivery system provided by the present invention has a stronger killing effect on various hematologic tumors and solid tumor cells, can provide a feasible drug delivery system for inhibiting tumor growth and leukemia treatment, and has broad prospects.

The invention belongs to the technical field of pharmaceutical preparation, and in particular to a potassium ion competitive acid blocker Vonoprazan fumarate injection with the effect of treating gastric acid-related diseases, and a preparation method thereof. The invention overcomes the defect of poor solubility of the main drug Vonoprazan fumarate, uses an inclusion form of sulfobutylether-beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin for solution increase. The prepared injection has the advantages of good stability, high safety and no precipitation during long-term placement, and can meet the medication requirement for the patients who are not convenient for oral administration.

The invention belongs to the field of natural drugs and discloses an adenosine and andrographolide compound drug composition and application thereof. An active ingredient of the compound drug composition consists of adenosine and andrographolide with a molar ratio of 1:1-1:20. The combination of the two drugs has a strong application to the synergistic treatment of lymphoma.

The invention discloses a preparation method of an aprepitant micelle intravenous injection, and belongs to the field of pharmacy. The aprepitant micelle intravenous injection comprises the followingcomponents in percentage by mass: 2-10% of aprepitant and 90-98% of a surfactant. The micelle provided by the invention is used for clinically treating nausea and vomiting of tumor patients after chemotherapy, reducing nausea and vomiting in the early and middle stages of tumor chemotherapy, improving the immunity of tumor patients and improving the nutritional support of patients; and the acute and delayed nausea and vomiting caused by high-dose cisplatin combined high-dose sensitization cancer chemotherapy are reduced, and the rehabilitation of tumor patients is facilitated.

The invention discloses a method for detecting expected curative effects of docetaxel and cis-platinum and efficient typing of gene loci related to toxic and negative effects and application of the method. The efficient typing method comprises the following steps of constructing a detection site table, determining a to-be-detected SNP site, synthesizing an amplification primer, preparing a solvent, carrying out an amplification reaction, carrying out an SAP reaction, carrying out a single base extension reaction, desalting and purifying, and analyzing data to obtain a result. According to the method, expected curative effects of docetaxel and cis-platinum and gene loci related to toxic and negative effects can be rapidly and accurately detected, the operation process is simple, the detection accuracy is high, the detection flux is high, and the detection cost is low; data are judged and read through an instrument, the result analysis is convenient, the interpretation standard is clear, and the consumed time is short; and the operation is convenient, and market practical applicability is achieved.

The invention belongs to the field of natural medicines and discloses a composites medicine composition and the application thereof. The composite medicine composition comprises active components, namely ursolic acid and an aldose reductase inhibitor epalrestat in a mole ratio of 1-1 to 1-8. With the combination of the two components, the composites medicine composition has good application in synergetic treatment on leukemia.

The invention relates to a gene biological preparation as well as a preparation method and application thereof, a section of IN044 sequence is knocked into a protein gene of the gene biological preparation by using a gene editing technology, so that a target gene in the protein gene is silenced, and a gene knockout effect is achieved. After the target gene is edited by using the method disclosed by the invention, on one hand, the frame-shift mutation target gene cannot be translated into the protein, and on the other hand, the generated protein can be quickly degraded, so that the toxicity generated by the translated protein with unknown characters is completely eradicated. The method is wide in application prospect and can be applied to various aspects such as gene editing, disease diagnosis and treatment and the like.