Targeted nano magnetic donkey-hide gelatin as well as preparation method and application thereof

A technology of nano-magnetic and nano-magnetic particles, which is applied in the fields of targeted nano-magnetic donkey-hide gelatin and its preparation and application, can solve problems such as large solubility, and achieve the effects of reducing toxic and negative effects, strong anti-fatigue effect, and easy absorption.

Inactive Publication Date: 2014-09-10
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chitosan also faces the problem of greater solubility in the upper digestive tract

Method used

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  • Targeted nano magnetic donkey-hide gelatin as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0050] A targeted nano-magnetic donkey-hide gelatin, calculated by mass percentage, composed of 1% chitosan-folate-surfactant-modified nano-magnetic particles and the rest of donkey-hide gelatin with flags;

[0051] Described chitosan-folic acid-surfactant modified nano-magnetic particle, calculated by mass percentage, its composition and content are as follows:

[0052] Nano Magnetic Iron Oxide 6%

[0053] Chitosan 26%

[0054] Folic Acid 22%

[0055] Polyethylene glycol 38%

[0056] Surfactant 8%;

[0057] The nano-magnetic iron oxide has a particle size of 30-80nm;

[0058] The chitosan has a molecular weight of 3000-18000;

[0059] The molecular weight of polyethylene glycol is 400-5000;

[0060] Surfactants are alkyl polyglycosides, Tween-80 and sodium lauryl sulfate calculated by mass ratio, that is, alkyl polyglycosides: Tween-80: sodium lauryl sulfate is 0.7:1:0.3;

[0061] Described chitosan-folate-surfactant-modified nano-magnetic particle is prepared by the m...

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Abstract

The invention discloses targeted nano magnetic donkey-hide gelatine as well as a preparation method and application thereof. The targeted nano magnetic donkey-hide gelatine is composed of 1% of chitosan-folic acid-surfactant modified nano magnetic particles and the balance of flagged donkey-hide gelatine in percentage by mass, wherein the chitosan-folic acid-surfactant modified nano magnetic particles is composed of nano magnetic iron oxide, chiston or chiston derivative, folic acid, polyethylene glycol and surfactant. The preparation method comprises that firstly the chitosan-folic acid-surfactant modified nano magnetic particles are added into donkey-hide gelatine about to be flagged, uniform mixing is carried out, and then flagging is carried out, so that the targeted nano magnetic donkey-hide gelatine is obtained. The targeted nano magnetic donkey-hide gelatine can be used for reducing chemoradiotherapy reaction in tumour therapy, reducing toxic and side effects of chemotherapeutic drugs, improving tolerance and living quality of patients, prolonging meso-position survival time and the total survival time of the patients and improving immunity of people.

Description

technical field [0001] The invention relates to a preparation method and clinical application of targeted nano-magnetic donkey-hide gelatin for treating and preventing tumors, regulating immune function of tumor patients, and regulating sleep of neurasthenia patients. Background technique [0002] At present, most cancer patients are diagnosed at an advanced stage, losing the opportunity for surgery, and radiotherapy, chemotherapy and targeted therapy have become the main methods. Chemotherapy (chemotherapy) is the method of treating diseases with chemically synthesized drugs. It is one of the main means of treating tumors at present, but it has great toxic and side effects and is poorly tolerated by patients. Since the beginning of the 21st century, the development of modern Chinese medicine and the application of nanotechnology have made molecular targeting possible. The ultimate goal of targeted drug delivery and controlled-release drug delivery is to maximize the effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61K47/36A61K9/14A61P35/00A61P37/02A61P25/20
Inventor 叶斌董桂云
Owner SHANGHAI INST OF TECH
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