26 results about "Upper digestive tract" patented technology

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The utility model discloses an intracavity negative pressure device for treating upper digestive tract fistula, which comprises a drainage catheter, and two ends of the drainage catheter are respectively a suction end and a negative pressure end connected with the negative pressure device; a liquid suction hole adjacent to the suction end is formed in the side wall of the drainage catheter, and a sponge body wrapping the liquid suction hole is arranged on the outer wall of the drainage catheter. The sponge body comprises a first sponge body and a second sponge body with the aperture larger than that of the first sponge body, the first sponge body wraps the suction end, and the second sponge body is arranged between the first sponge body and the negative pressure end. The two cavernous bodies with different pore diameters are arranged in a partitioned mode, the first cavernous body with the small pore diameter absorbs effusion at the wound of the upper digestive tract fistula in time, granulation tissue hyperplasia is promoted, recovery of a patient is facilitated, and the treatment period is shortened; the second sponge body with the large hole diameter enables secretions with large viscidity to be adsorbed in time, the sponge body and the drainage catheter are not prone to being blocked, the service life of the negative pressure device is prolonged, and the replacement frequency of the device is reduced.

The invention discloses a method and a device for solving direction perception disorder caused by a rotating mirror, and solves the problem that an adjacent tissue structure outside a part is difficult to determine after endoscopic examination rotation in a similar upper digestive tract wall internal lesion. The method comprises the following steps: acquiring pose information of an endoscope in an electromagnetic navigation system of a lumen target position and a corresponding image in the lumen as a reference pose; obtaining a track pose of the endoscope after the view field is adjusted in the electromagnetic navigation system and a corresponding intraluminal image, and determining an Euler angle of each track point according to the track pose; obtaining a track pose of the endoscope after the view field is adjusted in the electromagnetic navigation system and a corresponding intraluminal image, and determining an Euler angle of each track point according to the track pose; performing three-dimensional reconstruction on the lumen and the adjacent tissue thereof according to the lumen image map, and performing corresponding rotation according to the rotating mirror angle and the corresponding image in the lumen to obtain the rotated lumen and the adjacent tissue thereof; according to the invention, after the endoscope rotates to the optimal visual field, the adjacent tissues outside the endoscope can be clearly known.

The invention belongs to the field of microorganisms and medicine health care, and relates to an ackermania muciniphila strain and application thereof, the preservation number of the ackermania muciniphila strain is CGMCC (China General Microbiological Culture Collection Center) No.34370, and a 16SrDNA (Deoxyribose Nucleic Acid) sequence of the ackermania muciniphila strain has 93% similarity with a sequence shown as SEQ ID NO: 1. The new ackermania muciniphila strain (AKKBC300) is separated from a healthy human body and has good safety; good tolerance to low pH value and bile salt is shown in vitro, and it is indicated that the compound can reach the intestinal tract through the upper digestive tract and play a role; according to the present invention, genomics analysis results prove that the bacterial strain contains the gene Akkermansia BC00573 with high homology with the known probiotic functional protein Amuc1100, such that the molecular basis is provided;

The protective cover is of a multi-section structure, the multi-section structure comprises a protective section located at the front end, a visual expansion section located in the middle and a gastroscope fixing section located at the rear end, and when a gastroscope is fixed to the gastroscope fixing section, the protective section reversely wraps the gastroscope; and the protection section is made of a medical elastomer material. According to the technical scheme, when foreign bodies in the digestive tract are taken out, mucous membranes of the whole esophagus, the junction of the esophagus and the stomach and the esophagus inlet can be protected, long foreign bodies and sharp foreign bodies can be conveniently taken out under an endoscope, the occurrence rate of complications of the upper digestive tract foreign body taking-out operation is reduced, and the safety and effectiveness of treatment are improved.

The present invention relates to a single cell cylindrical battery, such as a button cell or a button battery, that can be regarded to have the shape of a slice of a cylinder, and to a method preventing upper digestive and upper respiratory tract injury after accidental ingestion of the single cell cylindrical battery. It is noted that in some case ingestion has even led to the death in particular of children or small size adults, or people with a mental limitation, or people with a prior narrowing of structures in which the battery can be lodged. The structures in which the battery can be lodged are both the pharyngeal, upper digestive and upper respiratory tracts. As ingestion itself can not always be prevented, a relatively safe battery has been developed, which mitigates problems associated with ingestion.

The utility model relates to a gastroscope treatment operating cap, and relates to the technical field of medical instruments. Comprising a cap body and a first water absorption part. The first water absorption piece is arranged on the brim of the cap body and is attached to the side face and the ears of the patient. The pressure of the head of the patient causes a recess in the contact place of the head of the patient. At the moment, secretions or blood generated by the patient can flow into the sunken part. Due to the arrangement of the first water absorption piece, the first water absorption piece can be attached to the side face of the patient and wrap the ears, secretions or blood of the patient can flow into the first water absorption piece along the mouth, and the secretions or the blood can be absorbed by the first water absorption piece in the flowing process of the secretions or the blood, so that the face or the ears are prevented from being stained by the secretions or the blood; the problem that secretions or blood of a patient can contaminate the side face and ears of the patient in the third-level and fourth-level minimally invasive surgery process of the upper digestive tract is solved.

This invention relates to a device for electric field therapy of the human digestive tract, comprising: an inner guide rod, an outer sleeve, a rotating ring, and a supporting component, with an electrode array membrane spirally wound around the supporting component. When the supporting component is in a radially contracted state, the invention can be placed within the surgical instrument channel of a commonly used gastroscopy. When the supporting component is in a radially expanded state, it supports the electrode array membrane, enabling accurate electric field therapy of the upper digestive tract, particularly the inner wall of the duodenum.

The present application relates to a kind of electric field treatment device for digestive tract, it includes: slender rod, sleeve, expandable component, the expandable component includes: multiple groups of support framework, multiple groups of electrode array film;When the sleeve is slid forward to first position relative to the slender rod, the expandable component is in first expansion working state;When the sleeve is slid forward again to second position relative to the slender rod, the expandable component is in second expansion working state;The present application can accurately carry out electric field treatment to the inner wall of upper digestive tract, especially duodenum.

The invention discloses a colon-targeted slow-release PLA-Eudragit S100 nanofiber membrane as well as a preparation method and application thereof, and belongs to the technical field of nano medical materials. The nanofiber membrane comprises a pharmaceutical active component and a fiber matrix, wherein the pharmaceutical active component is dispersed in the fiber matrix formed by blending PLA (Polylactic Acid) and Eudragit S100; the nanofiber membrane has colon pH environment response, and multistage pore channels are formed through corrosion of the fiber matrix in a colon pH environment. Unique pore channels in the nanofiber membrane form a synergistic mechanism with skeleton slow release, precise control of the medicine from intelligent triggering to programmed slow release is achieved, the stability of the medicine in the upper digestive tract can be effectively protected, the local concentration and bioavailability of the medicine in the colon part are remarkably improved, the preparation process is simple, and large-scale production is easy.

The invention relates to a high-simulation upper digestive tract endoscope training simulator based on clinical data, and belongs to the technical field of medical training simulation.The high-simulation upper digestive tract endoscope training simulator comprises an outer frame, a fixed model, an upper digestive tract model, a simulated oral cavity inlet and an external power source, the head outer frame and the chest and abdomen outer frame are integrally manufactured. The training simulator can provide a highly-simulated endoscope operation environment, adopts high-precision 3D modeling and printing, performs three-dimensional reconstruction based on inflatable CT image data, realizes high-precision manufacturing of a model through a 3D printing technology, can precisely restore an anatomical structure of an upper digestive tract, provides real visual and tactile feedback, and is high in practicability. The system supports the simulation of various lesions, meets the training requirements of doctors at different levels, remarkably improves the endoscope operation skills, reduces the medical risk, and has an important clinical application value.

Tubular prostheses are provided for use in the airways, upper digestive tract, and urinary tract. Each of these uses has its own set of biological specifications, based on what it must contain and discharge, as well as the physical and chemical pressures and loads to which it is subjected. The prostheses can be fabricated from allogeneic cells. Therefore, they can be fabricated and stored before an individual's personal need arises.

The invention discloses an upper digestive tract ultrasonic image processing method and device, equipment and a medium, and relates to the technical field of image processing, and the method comprises the steps: positioning the position of an initial contour line corresponding to an ultrasonic probe from an upper digestive tract ultrasonic image; acquiring the position of a lesion image area contained in the upper digestive tract ultrasonic image; expanding outwards based on the position of the initial contour line, and positioning the position of each layer of anatomical structure boundary contour line of the upper digestive tract tube wall from the upper digestive tract ultrasonic image; and outputting a position relationship between the lesion image region and the boundary contour line of each layer of anatomical structure. According to the method, the initial contour line corresponding to the ultrasonic probe is expanded outwards, so that the position of each layer of anatomical structure boundary contour line of the upper digestive tract tube wall can be automatically positioned from the upper digestive tract ultrasonic image, and the position relationship between the lesion image area and each layer of anatomical structure boundary contour line is obtained; and the lesion occurrence level can be quickly and accurately positioned from the upper digestive tract ultrasonic image.

This invention relates to the fields of biomedicine and functional food technology, and discloses an intestinal immune regulation system based on the microenvironmental release of black goji berry polysaccharides (LBPs). The system includes a microenvironment-responsive delivery unit for delivering and releasing LBPs. The delivery unit comprises a LBP core and a responsive layer encapsulating the core. The responsive layer contains at least one responsive material capable of responding to microenvironmental signals at the intestinal target site, enabling the delivery unit to undergo structural changes in response to these signals upon reaching the intestinal target site, thereby achieving the targeted release of the LBPs. This intestinal immune regulation system based on the microenvironmental release of LBPs constructs a physical barrier by encapsulating the active core of LBPs with a "responsive layer" composed of responsive materials. This system can effectively resist the damage to the LBP structure caused by the harsh environment of the upper digestive tract.

The present invention discloses a protective sleeve for removing sharp foreign bodies from the upper digestive tract through endoscopy, comprising: a fixed sleeve, a mounting surface is formed at the front end of the fixed sleeve, the mounting surface is used to cover a water outlet, a limit block is provided at the fixed sleeve corresponding to the mounting surface, when the fixed sleeve is sleeved with the endoscope, a gap is formed between the mounting surface and the front end of the endoscope through the limit block; a soft sleeve, the soft sleeve is trumpet-shaped, one end of the soft sleeve is connected to the mounting surface, a protective space is formed inside the soft sleeve, a support channel is provided on the soft sleeve corresponding to the mounting surface, the support channel extends along the length direction of the soft sleeve, one end of the support channel corresponds to the mounting surface to form an opening, the opening is used for water flow to enter so as to keep the support channel in an open state, the soft sleeve can be automatically deformed to the end of the endoscope when the endoscope enters, so as to reduce interference with the entry of the endoscope, and can naturally deform to the front end of the endoscope when the clamp is withdrawn, so as to complete the wrapping of the sharp foreign body, thereby avoiding possible damage when the sharp foreign body is removed.

The application provides a prebiotic composition based on in-vitro simulation and artificial intelligence collaborative optimization, and an optimization method and system thereof, which comprises the following steps: determining a target physiological function to be adjusted, identifying microbial functional characteristics and genera related to the target physiological function, and then deducing candidate prebiotics; constructing an in-vitro multi-chamber intestinal simulation system to simulate the physiological environment from the upper digestive tract to the colon and inoculate intestinal flora samples; establishing a machine learning model to predict the influence of different prebiotic combinations on the abundance of target genera and the activity of metabolic pathways, thereby selecting candidate prebiotic combinations; introducing the candidate prebiotic combinations predicted by the machine learning model into the simulation system, detecting changes in flora composition and metabolic product distribution, and verifying the actual effect of the candidate prebiotic combinations; based on the actual effect verified in step S4, optimizing the parameters of the machine learning model in step S3 to form a closed-loop iterative screening process.

The invention provides a preparation method of fermented polygonatum kingianum polysaccharide and polygonatum kingianum hepta-oligosaccharide, which comprises the following steps: preparing fermented polygonatum kingianum by virtue of fermentation of pediococcus ethanolidurans, extracting the fermented polygonatum kingianum polysaccharide, and extracting and purifying the fermented polygonatum kingianum polysaccharide to obtain brand-new polygonatum kingianum hepta-oligosaccharide with the structural formula of alpha-D-Glcp-1-(2-beta-D-Fruf-1) 5-2-beta-D-Fruf, the enterococcus faecium has excellent tolerance to an upper digestive tract environment, can be selectively utilized by intestinal microflora at cecum and colon parts, specifically increases relative abundance of beneficial intestinal flora, remarkably promotes proliferation of enterococcus and lactobacillus, also can reduce the pH value of colon, optimizes intestinal microecological balance, stimulates biosynthesis of short-chain fatty acid, and has a good application prospect. The prebiotic tea has an excellent prebiotic effect and a wide application prospect.

The invention is suitable for the technical field of health-care food, and provides an edible mushroom composition with an intestinal flora regulating function and a preparation method of the edible mushroom composition. The edible mushroom composition comprises grifola frondosa polysaccharide, cordyceps militaris polysaccharide, ganoderma sinensis extract, hericium erinaceus polysaccharide, agaricus blazei polysaccharide, lentinan, pleurotus nebrodensis polysaccharide, auricularia polytricha polysaccharide, agaricus bisporus polysaccharide and pachymaran, and the ratio of the materials is optimized based on the theory of monarch, minister, assistant and guide. The preparation method comprises the following steps: carrying out all-component stepped extraction on ganoderma sinensis, carrying out function-oriented graded extraction on other mushrooms, and carrying out a key gradient self-assembly process. According to the method, composite particles with time sequence release characteristics are constructed through a gradient self-assembly process, functional division of rapid release of adjuvant drugs in the upper digestive tract and slow release of monarch drugs in the intestinal tract is achieved, time sequence control of active ingredients is achieved, and the effects of regulating immunity, improving intestinal flora and improving yang deficiency symptoms are achieved.

This invention relates to the field of medical device technology, and discloses a device for collecting early gastrointestinal cancer cells, comprising a silicone-coated polyester thread; a sponge ball fixedly mounted on the surface of the silicone-coated polyester thread; and a capsule disposed outside the sponge ball for wrapping the sponge ball. One end of the silicone-coated polyester thread passes through the capsule and extends to the outside of the capsule. Compared with traditional endoscopes, this device for collecting early gastrointestinal cancer cells adopts a capsule shape, allowing the patient to complete the insertion of the collection device by swallowing the capsule, significantly reducing discomfort in the throat. The capsule contains a compressed spherical sponge ball with a diameter of 30mm, which is small in size and causes less irritation to the digestive tract, making it easier for patients to accept. Since the patient can move freely after swallowing the capsule, the collection process is not limited to a specific environment and can be performed in any environment, which increases the flexibility of collection, improves the effectiveness of the device, and meets practical needs.

The present invention relates to a single cell cylindrical battery, such as a button cell or a button battery, that can be regarded to have the shape of a slice of a cylinder, and to a method preventing upper digestive and upper respiratory tract injury after accidental ingestion of the single cell cylindrical battery. It is noted that in some case ingestion has even led to the death in particular of children or small size adults, or people with a mental limitation, or people with a prior narrowing of structures in which the battery can be lodged. The structures in which the battery can be lodged are both the pharyngeal, upper digestive and upper respiratory tracts. As ingestion itself can not always be prevented, a relatively safe battery has been developed, which mitigates problems associated with ingestion.

The invention discloses upper digestive tract radiography simulation equipment, and relates to the technical field of medical instruments, the upper digestive tract radiography simulation equipment comprises a fixing plate and a supporting structure, a state simulation assembly is arranged between the fixing plate and the supporting structure, the fixing plate is lifted by hand, and an upper digestive tract model on the fixing plate can be adjusted back and forth between the vertical direction and the horizontal direction through a connecting rod; the upper digestive tract model on the fixing plate is in a side-lying state through the rotating rod by rotating the fixing plate, the angle of the upper digestive tract model on the fixing plate can be adjusted in any small range by moving the fixing plate through the ball, the adjusting assembly is arranged on the fixing plate, the oral cavity model can stretch and retract up and down on the sliding plate through the sliding block, and one side of the sliding plate is poked by hand. Through the state simulation assembly, various postures such as standing, lying and side lying of a human body can be accurately simulated, and the characteristic greatly enriches the simulation effect of flowing and distribution states of radiography liquid in an upper digestive tract.

The invention discloses a simple suction tube for removing blood clots for upper gastrointestinal hemorrhage, and belongs to the technical field of medical instruments, the simple suction tube comprises a tube body which is driven by an external negative pressure source to suck and remove the blood clots at the gastrointestinal hemorrhage position; the tip is located at the inlet of the tube body, and the tip comprises a conical section and a cylindrical section; the suction holes are obliquely formed in the tip end in a circumferential array mode, and feeding ports of the suction holes are located in the connecting position of the conical section and the cylindrical section. By means of the elastic film and the cutting edges, periodic negative pressure is generated through negative pressure nodes, so that the elastic film is driven to deform periodically, the cutting edges are driven to vibrate in the radial direction in the suction holes, and compared with static cutting, the probability of the blocking phenomenon is effectively reduced; the breaking efficiency of the blood clots and the clearing efficiency of the blood clots in the upper digestive tract are effectively improved.

The present disclosure relates to the field of medical instruments, and provides a digestive tract stent retrieval apparatus and a sleeve for an endoscope. The digestive tract stent retrieval apparatus comprises a detachable handle, a tube body, a trumpet-shaped protective sleeve, and an endoscope retrieval cap configured to be mounted on a distal end of an endoscope. Two ends of the tube body are a first connection end and a second connection end, respectively. The first connection end is connected to the detachable handle, and the second connection end is connected to the trumpet-shaped protective sleeve. The inner diameter of the second connection end is greater than the inner diameter of the tube body. The endoscope retrieval cap is trumpet-shaped. The endoscope retrieval cap extends out of the tube body and, under a pulling force, carries a digestive tract stent into the tube body. The present disclosure can reduce the risk of upper digestive tract injury during stent removal, improve treatment safety, and allow separation of the stent and the retrieval apparatus using the detachable handle after stent removal.

The invention discloses a preparation method of mesalazine sustained-release granules and the sustained-release granules. The sustained-release granule comprises a mesalazine drug-containing granule core and a sustained-release coating layer wrapping the mesalazine drug-containing granule core, and the sustained-release coating layer is made of an azobenzene methacrylate copolymer. After oral administration, the coating layer can completely pass through the upper digestive tract and reach the colon, azo bonds in the structure of the coating layer can be specifically degraded by special azo reductase in the colon, so that the coating layer is gradually damaged to form a diffusion channel, and mesalazine can be slowly and continuously released at the colon part along with the expansion of the channel; and accurate colon targeted drug delivery is realized. According to the invention, premature release of the medicine in the stomach and the small intestine and possible burst release risk are effectively avoided, and the concentration and curative effect of the medicine in the diseased region are remarkably improved. In addition, the granule dosage is convenient for dose adjustment, the production process is simple, and the granule has a good clinical application prospect.

The invention discloses a contrastive learning-based indigo carmine staining simulation method for an upper digestive tract, and relates to the technical field of medical image processing. The invention discloses an upper digestive tract simulated indigo carmine staining method based on comparative learning. The method comprises the steps of image processing, calculation of difference hash codes among continuous N frames of images, calculation of Hamming distances among adjacent N frames of images, judgment of a video motion state, recognition of lesions by using a lesion detection model, starting of a simulated indigo carmine staining model for staining, and outputting of simulated stained images. Based on the multi-frame difference hash and deep learning target detection technology, automatic judgment of suspected lesions observed by endoscopic doctors is achieved, based on the comparative learning and generative adversarial network technology, the lesions simulate indigo carmine staining effect, virtual staining images can be provided for the endoscopic doctors in time, and the efficiency of the endoscopic doctors is improved. And the method has the advantages of clear image, low model complexity, short training time, low memory consumption, short image generation time and the like.