36 results about "Upper digestive tract" patented technology

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The utility model discloses an intracavity negative pressure device for treating upper digestive tract fistula, which comprises a drainage catheter, and two ends of the drainage catheter are respectively a suction end and a negative pressure end connected with the negative pressure device; a liquid suction hole adjacent to the suction end is formed in the side wall of the drainage catheter, and a sponge body wrapping the liquid suction hole is arranged on the outer wall of the drainage catheter. The sponge body comprises a first sponge body and a second sponge body with the aperture larger than that of the first sponge body, the first sponge body wraps the suction end, and the second sponge body is arranged between the first sponge body and the negative pressure end. The two cavernous bodies with different pore diameters are arranged in a partitioned mode, the first cavernous body with the small pore diameter absorbs effusion at the wound of the upper digestive tract fistula in time, granulation tissue hyperplasia is promoted, recovery of a patient is facilitated, and the treatment period is shortened; the second sponge body with the large hole diameter enables secretions with large viscidity to be adsorbed in time, the sponge body and the drainage catheter are not prone to being blocked, the service life of the negative pressure device is prolonged, and the replacement frequency of the device is reduced.

The invention discloses a throat and upper digestive tract foreign matter taking-out device and a foreign matter taking-out method.The throat and upper digestive tract foreign matter taking-out device comprises an outer shell, an inner shell is nested in the outer shell, the inner shell is in sliding fit with the outer shell, a moving assembly used for pushing the inner shell to slide is arranged on the surface of the outer shell, an operating rod is arranged in the inner shell, and a clamping assembly is hinged to the operating rod; a plurality of supporting petals are hinged to the surface of the outer shell, first connecting rods are hinged to the inner walls of the supporting petals, first hinge bases are hinged to the middles of the first connecting rods, second connecting rods are hinged to the first connecting rods, and the second connecting rods are hinged to the inner shell. Through opening and closing of the multiple supporting petals, expansion of the throat or the upper digestive tract and wrapping operation during taking out of the foreign matter are completed, the foreign matter clamping efficiency is improved, and meanwhile the possibility of secondary damage to the throat or the upper digestive tract caused by the foreign matter in the process of taking out the foreign matter from the throat or the upper digestive tract after the foreign matter is clamped is reduced; and the safety and efficiency of the foreign matter extraction process are improved.

The protective sleeve comprises a fixing sleeve, a mounting surface is formed at the front end of the fixing sleeve and used for covering a water outlet, a limiting block is arranged on the portion, corresponding to the mounting surface, of the fixing sleeve, and after the fixing sleeve is connected with an endoscope in a sleeved mode, a gap is formed between the mounting surface and the front end of the endoscope through the limiting block; the soft sleeve is trumpet-shaped, one end of the soft sleeve is connected with the mounting surface, a protection space is formed in the soft sleeve, the soft sleeve is provided with a supporting channel corresponding to the mounting surface, the supporting channel extends in the length direction of the soft sleeve, an opening is formed in one end of the supporting channel corresponding to the mounting surface, and the opening is used for water flow to enter so as to keep the supporting channel in an open state; the flexible sleeve can be automatically deformed to the tail end of the endoscope when the endoscope enters so as to reduce interference to the endoscope entering, and meanwhile, the flexible sleeve can be naturally deformed to the front end of the endoscope when the flexible sleeve is clamped and withdrawn so as to complete wrapping of sharp foreign matters, so that damage possibly caused when the sharp foreign matters are moved out is avoided.

The invention discloses a method and a device for solving direction perception disorder caused by a rotating mirror, and solves the problem that an adjacent tissue structure outside a part is difficult to determine after endoscopic examination rotation in a similar upper digestive tract wall internal lesion. The method comprises the following steps: acquiring pose information of an endoscope in an electromagnetic navigation system of a lumen target position and a corresponding image in the lumen as a reference pose; obtaining a track pose of the endoscope after the view field is adjusted in the electromagnetic navigation system and a corresponding intraluminal image, and determining an Euler angle of each track point according to the track pose; obtaining a track pose of the endoscope after the view field is adjusted in the electromagnetic navigation system and a corresponding intraluminal image, and determining an Euler angle of each track point according to the track pose; performing three-dimensional reconstruction on the lumen and the adjacent tissue thereof according to the lumen image map, and performing corresponding rotation according to the rotating mirror angle and the corresponding image in the lumen to obtain the rotated lumen and the adjacent tissue thereof; according to the invention, after the endoscope rotates to the optimal visual field, the adjacent tissues outside the endoscope can be clearly known.

The invention belongs to the field of microorganisms and medicine health care, and relates to an ackermania muciniphila strain and application thereof, the preservation number of the ackermania muciniphila strain is CGMCC (China General Microbiological Culture Collection Center) No.34370, and a 16SrDNA (Deoxyribose Nucleic Acid) sequence of the ackermania muciniphila strain has 93% similarity with a sequence shown as SEQ ID NO: 1. The new ackermania muciniphila strain (AKKBC300) is separated from a healthy human body and has good safety; good tolerance to low pH value and bile salt is shown in vitro, and it is indicated that the compound can reach the intestinal tract through the upper digestive tract and play a role; according to the present invention, genomics analysis results prove that the bacterial strain contains the gene Akkermansia BC00573 with high homology with the known probiotic functional protein Amuc1100, such that the molecular basis is provided;

The protective cover is of a multi-section structure, the multi-section structure comprises a protective section located at the front end, a visual expansion section located in the middle and a gastroscope fixing section located at the rear end, and when a gastroscope is fixed to the gastroscope fixing section, the protective section reversely wraps the gastroscope; and the protection section is made of a medical elastomer material. According to the technical scheme, when foreign bodies in the digestive tract are taken out, mucous membranes of the whole esophagus, the junction of the esophagus and the stomach and the esophagus inlet can be protected, long foreign bodies and sharp foreign bodies can be conveniently taken out under an endoscope, the occurrence rate of complications of the upper digestive tract foreign body taking-out operation is reduced, and the safety and effectiveness of treatment are improved.

The present invention relates to a single cell cylindrical battery, such as a button cell or a button battery, that can be regarded to have the shape of a slice of a cylinder, and to a method preventing upper digestive and upper respiratory tract injury after accidental ingestion of the single cell cylindrical battery. It is noted that in some case ingestion has even led to the death in particular of children or small size adults, or people with a mental limitation, or people with a prior narrowing of structures in which the battery can be lodged. The structures in which the battery can be lodged are both the pharyngeal, upper digestive and upper respiratory tracts. As ingestion itself can not always be prevented, a relatively safe battery has been developed, which mitigates problems associated with ingestion.

The utility model relates to a gastroscope treatment operating cap, and relates to the technical field of medical instruments. Comprising a cap body and a first water absorption part. The first water absorption piece is arranged on the brim of the cap body and is attached to the side face and the ears of the patient. The pressure of the head of the patient causes a recess in the contact place of the head of the patient. At the moment, secretions or blood generated by the patient can flow into the sunken part. Due to the arrangement of the first water absorption piece, the first water absorption piece can be attached to the side face of the patient and wrap the ears, secretions or blood of the patient can flow into the first water absorption piece along the mouth, and the secretions or the blood can be absorbed by the first water absorption piece in the flowing process of the secretions or the blood, so that the face or the ears are prevented from being stained by the secretions or the blood; the problem that secretions or blood of a patient can contaminate the side face and ears of the patient in the third-level and fourth-level minimally invasive surgery process of the upper digestive tract is solved.

The present invention discloses a nano-microsphere loaded with lactic acid bacteria and its preparation method and application. ROS-responsive blank nano-microspheres PEG2000-TK-PlGA2000 and polydopamine-modified lactic acid bacteria are mixed in a volume ratio of 1:2, incubated at 25°C for 30 minutes, and washed with PBS to obtain nano-microspheres loaded with lactic acid bacteria. When administered orally, the nano-microspheres can protect lactic acid bacteria from the harsh digestive environment of the upper digestive tract. Due to the high ROS content in the inflamed intestine, the microspheres loaded with lactic acid bacteria will be degraded and release lactic acid bacteria. Polydopamine-modified lactic acid bacteria can prolong the residence time of lactic acid bacteria in the inflammatory area, further produce antimicrobial peptides to destroy harmful bacteria in the inflammatory tissue, and restore intestinal stability. At the same time, it only stays in the inflammatory area of ​​the lesion without affecting the flora in other normal areas.

This invention relates to a device for electric field therapy of the human digestive tract, comprising: an inner guide rod, an outer sleeve, a rotating ring, and a supporting component, with an electrode array membrane spirally wound around the supporting component. When the supporting component is in a radially contracted state, the invention can be placed within the surgical instrument channel of a commonly used gastroscopy. When the supporting component is in a radially expanded state, it supports the electrode array membrane, enabling accurate electric field therapy of the upper digestive tract, particularly the inner wall of the duodenum.

1. The name of the product of this design: diseased cell collector. 2. The purpose of this product design: to remove mucus, exfoliated cells and microenvironmental factors in the upper digestive tract. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present application relates to a kind of electric field treatment device for digestive tract, it includes: slender rod, sleeve, expandable component, the expandable component includes: multiple groups of support framework, multiple groups of electrode array film;When the sleeve is slid forward to first position relative to the slender rod, the expandable component is in first expansion working state;When the sleeve is slid forward again to second position relative to the slender rod, the expandable component is in second expansion working state;The present application can accurately carry out electric field treatment to the inner wall of upper digestive tract, especially duodenum.

The invention belongs to the field of immunodetection, and particularly relates to a digestive tract tumor fecal protein biomarker detection reagent and application thereof. The marker is specifically hemoglobin, antitrypsin or a fragment thereof; according to the invention, the fecal protein biomarker combination is detected by using an antibody through a single epitope detection method or a mass spectrum mode; the detection result is used for screening or auxiliary diagnosis of digestive tract tumors. It is found for the first time that the hemoglobin fragment can significantly improve the detection rate of upper gastrointestinal tumors and precancerous lesions; the joint detection of the fecal hemoglobin and the antitrypsin fragment can be used for screening the gastrointestinal tumors, the sensitivity of screening the upper gastrointestinal tumors can be remarkably improved by detecting the hemoglobin and the antitrypsin fragment, the detection time is short, the price is easily received by the public, and the method has wide application value.

The invention discloses a colon-targeted slow-release PLA-Eudragit S100 nanofiber membrane as well as a preparation method and application thereof, and belongs to the technical field of nano medical materials. The nanofiber membrane comprises a pharmaceutical active component and a fiber matrix, wherein the pharmaceutical active component is dispersed in the fiber matrix formed by blending PLA (Polylactic Acid) and Eudragit S100; the nanofiber membrane has colon pH environment response, and multistage pore channels are formed through corrosion of the fiber matrix in a colon pH environment. Unique pore channels in the nanofiber membrane form a synergistic mechanism with skeleton slow release, precise control of the medicine from intelligent triggering to programmed slow release is achieved, the stability of the medicine in the upper digestive tract can be effectively protected, the local concentration and bioavailability of the medicine in the colon part are remarkably improved, the preparation process is simple, and large-scale production is easy.

The invention relates to a high-simulation upper digestive tract endoscope training simulator based on clinical data, and belongs to the technical field of medical training simulation.The high-simulation upper digestive tract endoscope training simulator comprises an outer frame, a fixed model, an upper digestive tract model, a simulated oral cavity inlet and an external power source, the head outer frame and the chest and abdomen outer frame are integrally manufactured. The training simulator can provide a highly-simulated endoscope operation environment, adopts high-precision 3D modeling and printing, performs three-dimensional reconstruction based on inflatable CT image data, realizes high-precision manufacturing of a model through a 3D printing technology, can precisely restore an anatomical structure of an upper digestive tract, provides real visual and tactile feedback, and is high in practicability. The system supports the simulation of various lesions, meets the training requirements of doctors at different levels, remarkably improves the endoscope operation skills, reduces the medical risk, and has an important clinical application value.

Tubular prostheses are provided for use in the airways, upper digestive tract, and urinary tract. Each of these uses has its own set of biological specifications, based on what it must contain and discharge, as well as the physical and chemical pressures and loads to which it is subjected. The prostheses can be fabricated from allogeneic cells. Therefore, they can be fabricated and stored before an individual's personal need arises.

The invention discloses an upper digestive tract ultrasonic image processing method and device, equipment and a medium, and relates to the technical field of image processing, and the method comprises the steps: positioning the position of an initial contour line corresponding to an ultrasonic probe from an upper digestive tract ultrasonic image; acquiring the position of a lesion image area contained in the upper digestive tract ultrasonic image; expanding outwards based on the position of the initial contour line, and positioning the position of each layer of anatomical structure boundary contour line of the upper digestive tract tube wall from the upper digestive tract ultrasonic image; and outputting a position relationship between the lesion image region and the boundary contour line of each layer of anatomical structure. According to the method, the initial contour line corresponding to the ultrasonic probe is expanded outwards, so that the position of each layer of anatomical structure boundary contour line of the upper digestive tract tube wall can be automatically positioned from the upper digestive tract ultrasonic image, and the position relationship between the lesion image area and each layer of anatomical structure boundary contour line is obtained; and the lesion occurrence level can be quickly and accurately positioned from the upper digestive tract ultrasonic image.

This invention relates to the fields of biomedicine and functional food technology, and discloses an intestinal immune regulation system based on the microenvironmental release of black goji berry polysaccharides (LBPs). The system includes a microenvironment-responsive delivery unit for delivering and releasing LBPs. The delivery unit comprises a LBP core and a responsive layer encapsulating the core. The responsive layer contains at least one responsive material capable of responding to microenvironmental signals at the intestinal target site, enabling the delivery unit to undergo structural changes in response to these signals upon reaching the intestinal target site, thereby achieving the targeted release of the LBPs. This intestinal immune regulation system based on the microenvironmental release of LBPs constructs a physical barrier by encapsulating the active core of LBPs with a "responsive layer" composed of responsive materials. This system can effectively resist the damage to the LBP structure caused by the harsh environment of the upper digestive tract.

The present invention discloses a protective sleeve for removing sharp foreign bodies from the upper digestive tract through endoscopy, comprising: a fixed sleeve, a mounting surface is formed at the front end of the fixed sleeve, the mounting surface is used to cover a water outlet, a limit block is provided at the fixed sleeve corresponding to the mounting surface, when the fixed sleeve is sleeved with the endoscope, a gap is formed between the mounting surface and the front end of the endoscope through the limit block; a soft sleeve, the soft sleeve is trumpet-shaped, one end of the soft sleeve is connected to the mounting surface, a protective space is formed inside the soft sleeve, a support channel is provided on the soft sleeve corresponding to the mounting surface, the support channel extends along the length direction of the soft sleeve, one end of the support channel corresponds to the mounting surface to form an opening, the opening is used for water flow to enter so as to keep the support channel in an open state, the soft sleeve can be automatically deformed to the end of the endoscope when the endoscope enters, so as to reduce interference with the entry of the endoscope, and can naturally deform to the front end of the endoscope when the clamp is withdrawn, so as to complete the wrapping of the sharp foreign body, thereby avoiding possible damage when the sharp foreign body is removed.

The preparation method comprises the following steps: mixing blank nano microspheres PEG2000-TK-PlGA2000 responded by ROS (reactive oxygen species) and lactic acid bacteria modified by polydopamine according to a volume ratio of 1: 2, incubating at 25 DEG C for 30 minutes, and washing with PBS (phosphate buffer solution) to obtain the nano microspheres loaded with the lactic acid bacteria. When oral administration is carried out, the nano microspheres can protect lactic acid bacteria from being affected by the severe digestion environment of the upper digestive tract, and due to the fact that the ROS content of the inflammatory intestinal tract is high, the microspheres loaded with the lactic acid bacteria can be degraded to release the lactic acid bacteria. The polydopamine-modified lactic acid bacteria can prolong the residence time of the lactic acid bacteria in an inflammation region, and antibacterial peptides are further generated to destroy harmful bacteria in inflammation tissues and restore intestinal stability. And meanwhile, the strain only stays in a lesion inflammation area, and flora in other normal areas cannot be influenced.

The application provides a prebiotic composition based on in-vitro simulation and artificial intelligence collaborative optimization, and an optimization method and system thereof, which comprises the following steps: determining a target physiological function to be adjusted, identifying microbial functional characteristics and genera related to the target physiological function, and then deducing candidate prebiotics; constructing an in-vitro multi-chamber intestinal simulation system to simulate the physiological environment from the upper digestive tract to the colon and inoculate intestinal flora samples; establishing a machine learning model to predict the influence of different prebiotic combinations on the abundance of target genera and the activity of metabolic pathways, thereby selecting candidate prebiotic combinations; introducing the candidate prebiotic combinations predicted by the machine learning model into the simulation system, detecting changes in flora composition and metabolic product distribution, and verifying the actual effect of the candidate prebiotic combinations; based on the actual effect verified in step S4, optimizing the parameters of the machine learning model in step S3 to form a closed-loop iterative screening process.

The invention provides a preparation method of fermented polygonatum kingianum polysaccharide and polygonatum kingianum hepta-oligosaccharide, which comprises the following steps: preparing fermented polygonatum kingianum by virtue of fermentation of pediococcus ethanolidurans, extracting the fermented polygonatum kingianum polysaccharide, and extracting and purifying the fermented polygonatum kingianum polysaccharide to obtain brand-new polygonatum kingianum hepta-oligosaccharide with the structural formula of alpha-D-Glcp-1-(2-beta-D-Fruf-1) 5-2-beta-D-Fruf, the enterococcus faecium has excellent tolerance to an upper digestive tract environment, can be selectively utilized by intestinal microflora at cecum and colon parts, specifically increases relative abundance of beneficial intestinal flora, remarkably promotes proliferation of enterococcus and lactobacillus, also can reduce the pH value of colon, optimizes intestinal microecological balance, stimulates biosynthesis of short-chain fatty acid, and has a good application prospect. The prebiotic tea has an excellent prebiotic effect and a wide application prospect.

An applicator (26) as part of a system for accepting chyme from the stomach and for bypass-type conducting the chyme through the pylorus in or through the duodenum of a patient, the system comprising: a transpyloric and, if applicable, transduodenal bypass device (1), comprising: a tubular, preferably radially collapsible and self-erecting transpyloric conducting element (4,7), which is or has to be placed in a patient in such a way that it penetrates the pylorus of the patient and is provided with a central conducting lumen for the chyme, fixing elements for anchoring the transpyloric conducting element (4,7) on the pylorus in the form of a gastric anchor element, and / or in the form of a duodenal anchor element, an upstream mouth to be placed antegrade of the pylorus, and a downstream mouth to be placed retrograde of the pylorus, in order to (i) accept the chyme from the stomach, to (ii) bypass-type conduct the chyme through the pylorus and, if applicable, through the duodenum or a part of the duodenum, and to (iii) release the chyme in or beyond the duodenum of the patient; an endoscope or a catheter or a similar positioning device, comprising: an elongated shaft (28), and a proximal end extending extracorporeally; the applicator (26) for releasably coupling the transpyloric and, if applicable, transduodenal bypass device (1) to the external surface of the shaft (28) of the endoscope or catheter or similar positioning device, in order to insert the bypass device (1) under direct guidance of the endoscope or catheter or similar positioning device from the outside of the patient's body in an antegrade way through the upper digestive tract into the stomach, or in order to remove it in a retrograde way through the upper digestive tract, characterized in that the applicator (26) comprises a coupling element (27), which is or can be slid onto or along the external surface of the shaft (28), and which entirely or partially penetrates the central conducting lumen of the transpyloric conducting element (4,7) of the bypass device (1), thereby at least partially bridging a gap between the external surface of the shaft (28) and an internal surface of the central conducting lumen of the bypass device (1), wherein the coupling element (27) of the applicator (26) acts as a releasable fixation mechanism between the bypass device (1) and the shaft (28).

The invention is suitable for the technical field of health-care food, and provides an edible mushroom composition with an intestinal flora regulating function and a preparation method of the edible mushroom composition. The edible mushroom composition comprises grifola frondosa polysaccharide, cordyceps militaris polysaccharide, ganoderma sinensis extract, hericium erinaceus polysaccharide, agaricus blazei polysaccharide, lentinan, pleurotus nebrodensis polysaccharide, auricularia polytricha polysaccharide, agaricus bisporus polysaccharide and pachymaran, and the ratio of the materials is optimized based on the theory of monarch, minister, assistant and guide. The preparation method comprises the following steps: carrying out all-component stepped extraction on ganoderma sinensis, carrying out function-oriented graded extraction on other mushrooms, and carrying out a key gradient self-assembly process. According to the method, composite particles with time sequence release characteristics are constructed through a gradient self-assembly process, functional division of rapid release of adjuvant drugs in the upper digestive tract and slow release of monarch drugs in the intestinal tract is achieved, time sequence control of active ingredients is achieved, and the effects of regulating immunity, improving intestinal flora and improving yang deficiency symptoms are achieved.

This invention relates to the field of medical device technology, and discloses a device for collecting early gastrointestinal cancer cells, comprising a silicone-coated polyester thread; a sponge ball fixedly mounted on the surface of the silicone-coated polyester thread; and a capsule disposed outside the sponge ball for wrapping the sponge ball. One end of the silicone-coated polyester thread passes through the capsule and extends to the outside of the capsule. Compared with traditional endoscopes, this device for collecting early gastrointestinal cancer cells adopts a capsule shape, allowing the patient to complete the insertion of the collection device by swallowing the capsule, significantly reducing discomfort in the throat. The capsule contains a compressed spherical sponge ball with a diameter of 30mm, which is small in size and causes less irritation to the digestive tract, making it easier for patients to accept. Since the patient can move freely after swallowing the capsule, the collection process is not limited to a specific environment and can be performed in any environment, which increases the flexibility of collection, improves the effectiveness of the device, and meets practical needs.

The invention relates to a short enteroscope simulation model, and relates to the field of medical training models, the short enteroscope simulation model comprises a base and a simulation model installed on the base, the simulation model comprises a head model and a digestive tract model, the head model is fixed on the base, and the digestive tract model is detachably fixed on the base; the alimentary canal model comprises a throat which is detachably placed in the throat area of the head model. According to the invention, the training requirements of medical personnel on the operation of the short enteroscope can be effectively met.

The utility model discloses an upper digestive tract diet device, and relates to the field of health medicine. The device comprises a cylinder, the end portion of the cylinder is fixedly communicated with a fixed cylinder, a feeding mechanism used for feeding is arranged in the cylinder, a food adding mechanism used for supplying liquid food into the fixed cylinder is arranged on the outer wall of the fixed cylinder, and the other end of the fixed cylinder is communicated with a food taking pipe in a threaded mode. And the other end of the feeding pipe is fixedly communicated with a conical feeding head. Through the arrangement of the food adding mechanism, liquid food can be supplied into the fixed cylinder, medical staff can conveniently add and replace the liquid food, and meanwhile pollution and bacterium breeding are avoided; and through the feeding mechanism, the conveying amount and speed of liquid food can be accurately controlled, so that the personalized nutritional requirements of patients are met, and uncomfortable reactions such as excessive feeding or sudden cough are avoided.

The invention relates to a method for assisting in the identification of gastrointestinal pathology from endoscopic images, comprising the steps of: a) retrieving at least one endoscopic image of a surface of the digestive tract wall; b) retrieving position information for the surface of the digestive tract wall present on the image; c) retrieving information on the dimensions of the surface present on the image; d) displaying the endoscopic image to a user with an indication of the surface's position and dimensions; e) prompting the user to select a pathology from a list of predefined pathologies; f) storing the user's selection; g) displaying the user's selection to another user. Figure to be published with the abstract: Fig. 1