The invention provides an ROI mark point matching method based on an intravascular unltrasound image, and relates to the field of computer medical image analysis. The method is characterized by including the steps of firstly, conducting background suppression on the area, except the ROI, of an IVUS image, extracting an ROI image, and setting even mark points of an original image; secondly, setting a search window on a to-be-matched image according to the limitation of blood vessel wall deformation and the fact that no rotation conversion can happen between collected images, wherein the size of the search window is set according to the maximum deformation amount of endangium; thirdly, finding a matched point in the search window through a traversing method, and using the central position of a search sub-image as the matched point, wherein the search sub-image and a neighborhood sub-image of the mark points have the maximum mutual correlation similarity measure. Compared with an ordinary matching algorithm, the method is short in matching time and high in accuracy. By means of the method, the displacement situations of blood vessels before and after deformation can be provided, conditions are provided for elastic computing, and the good foundation is provided for the lesion analysis.