The invention discloses a fundus image focus segmentation and quantitative analysis method based on data enhancement, and the method comprises the steps: P1, obtaining medical image data, and carryingout the preprocessing; P2, extracting the preprocessed image data to obtain a fundus focus image; P3, establishing a calculation model based on the focus image; P4, predicting a focus area on the medical image data based on the calculation model; P5, counting the boundary of the lesion area of each parallel layer, calculating the lesion area, and combining to obtain the lesion volume; P6, substituting the focus volume into the fundus image, inputting the fundus image into the training model, and training to obtain a focus segmentation model; P7, performing manual segmentation on the segmentation model, and meanwhile, performing automatic segmentation through a model contour to obtain two true value tags; and P8, performing quantitative analysis through true value label comparison results,boundary deviation is avoided, side effects are reduced, cross validation is carried out finally, safety and accuracy are guaranteed, operation stability is improved, and application and popularization are facilitated.