1141 results about "Synergy" patented technology

A scalable platform for orchestrating networks of specialized AI multi-agent networks that enables secure collaboration through token-based protocols and real-time result streaming with advanced dynamic chain-of-thought pruning. The central orchestration engine manages domain-specific agents, implementing sophisticated multi-branch reasoning with contribution-estimation layers that evaluate each agent's utility using Shapley value-inspired metrics. The system employs information-theoretic and gradient-based surprise metric to guide memory updates and dynamic reasoning expansion, preventing local minima stagnation while preserving valuable insights through adaptive forgetting mechanisms. The platform unifies Monte Carlo tree search with contribution-aware estimation to detect high-synergy expert combinations while maintaining privacy through partial data approaches. It scales across distributed computing environments, enabling complex collaborative tasks like materials discovery, product engineering and manufacturing process design, biomedical research, and drug development. The system supports multi-party economic rewards through systematic contribution effort, cost and importance tracking, while standardized interfaces manage security, privacy, and policy constraints across heterogeneous agents.

The invention provides a bacillus subtilis LU5 and a lignocellulose degrading flora as well as a culture method and application thereof, and belongs to the technical field of microorganisms. According to the invention, a strain is screened from surface soil of composted straws and identified as bacillus subtilis, the strain is combined with bacillus velezensis SS6 and trichoderma longibrachiatum according to a specific proportion, co-culture is carried out in a specific culture medium, a flora capable of degrading lignocellulose is obtained, all microorganisms of the flora are in synergistic symbiosis, and the effect of degrading lignocellulose is achieved. The produced various cellulases have a synergistic effect, so that the aim of degrading lignocellulose is fulfilled. And by adopting the flora provided by the invention, the efficiency and the stability of the lignocellulose degradation process are remarkably improved.

A multidrug linker, an antibody-drug conjugate comprising the multidrug linker, a preparation method for the antibody-drug conjugate, and uses of the multidrug linker and the antibody-drug conjugate in disease treatment. A specific structure can effectively reduce the aggregation of a multi-payload drug-antibody conjugate, thereby facilitating process scale-up. In addition, payload drugs can achieve a significant synergistic effect, thereby achieving a synergistic anti-tumor effect, effectively overcoming the resistance to drugs, and improving the therapeutic window of drugs.

The invention relates to a drug target affinity prediction method based on multi-mode collaborative generation, which comprises the following steps: respectively preprocessing a drug and a protein to obtain preset characterization data of the drug and the protein; performing feature extraction on the preset characterization data of the medicine and the protein to obtain feature extraction results of the preset characterization data of the medicine and the protein; fusing the feature extraction result of the drug and the feature extraction result of the protein to obtain drug fusion features and protein fusion features; performing interactive processing on the drug fusion features and the protein fusion features by adopting a joint attention mechanism to obtain interactive features; and based on the interaction characteristics, predicting the binding affinity between the drug and the protein.

The invention discloses a nano system for tumor radioimmunotherapy and a preparation method and application thereof, and belongs to the technical field of biological medicines.The system modifies bacteria outer membrane vesicles (OMVs) through engineering to enable the bacteria outer membrane vesicles to carry magnetite nanoparticles (Fe3O4NPs) and an ATR inhibitor VE822, the Fenton reaction activity of the Fe3O4NPs and the synergistic effect of the ATR inhibitor for inhibiting DNA damage repair are utilized, and the tumor radioimmunotherapy effect is improved. DNA damage is amplified, DNA damage reaction (DDR) is inhibited, generation of hydroxyl radicals (. OH) under radiation is enhanced, radiation resistance of tumor cells is reduced, immune reaction is reactivated, infiltration of effector T cells to tumors is improved, growth of mice tumors is remarkably inhibited, and an effective strategy is provided for tumor radioimmunotherapy.

The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.

The present disclosure provides a vaccine composition wherein the antigen components comprise a factor H binding protein (fHbp), a recombinant outer membrane vesicle (OMV) carrying porin A (PorA protein), and optionally a heparin binding protein (NHBA protein). The antigen components in the vaccine composition disclosed by the invention have a good synergistic effect, so that the vaccine composition has extremely high vaccine forming potential, is used for preventing epidemic of group B meningococcus, and plays a role in protecting infection of group B meningococcus.

The invention belongs to the technical field of genetic engineering and biological medicine, and particularly discloses a cascade response type nano-particle with a microenvironment remodeling function and a preparation method and application of the cascade response type nano-particle. The nanoparticle provided by the invention adopts a bionic hybrid membrane engineering strategy: an inner core is formed by loading an exosome inhibitor on a nano material, and the surface is covalently coupled with M2 type macrophage specific targeting peptide; the outer layer coats a macrophage membrane and active oxygen response type liposome composite membrane layer through a co-extrusion technology, and is loaded with a TLR agonist. Animal experiments show that after being injected through caudal vein, the nano-particles are enriched at a tumor site in a targeted manner through homing receptors such as membrane surface integrin alpha4beta1 and the like, and outer membrane cracking is triggered in a high-ROS tumor microenvironment, so that space-time controlled release of a TLR agonist and targeted phagocytosis of an exosome inhibitor by macrophages guided by a targeted peptide are realized. The anti-tumor synergistic effect is achieved through multiple regulation and control mechanisms, and an effective treatment strategy is provided for tumor immunotherapy.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention provides a drug screening and curative effect evaluation method and system based on a glioma organ-like model, and relates to the technical field of biological material analys.The method includes the steps that a three-dimensional fluorescence image of the glioma organ-like model is collected, signal intensity analysis and compensation processing are carried out, a growth feature mapping model is constructed, and the three-dimensional fluorescence image of the glioma organ-like model is obtained; and phenotypic characteristics for representing the glioma organoid heterogeneity are obtained. Inputting the phenotypic characteristics into a drug response evaluation network, and calculating a drug sensitivity score; the drug molecular feature library and the drug collaborative analysis model are combined, the synergistic interaction index of different drug combinations is calculated, the optimal drug combination is screened, the drug administration dosage and the drug administration time sequence are determined in combination with phenotypic features, and finally an individualized treatment scheme is generated. According to the invention, the curative effect of the drug on the glioma organs can be effectively evaluated, and the optimal drug combination and administration scheme can be screened out, so that the accuracy and effectiveness of glioma treatment are improved.

The invention provides a whole-process targeting polypeptide, a drug compound thereof, a drug delivery system and application of the whole-process targeting polypeptide. The whole-process targeting polypeptide comprises pHA and VAP which are covalently connected through a bridging structure; the VAP is LVAP, a reverse sequence polypeptide of the LVAP, DVAP or SVAP; wherein the amino acid sequence of the LVAP is as shown in SEQ ID NO: 1; the SVAP is a D-configuration polypeptide of the LVAP; the DVAP is a D-configuration polypeptide of the LVAP inverted sequence polypeptide; the bridging structure is amino-monoethylene glycol-carboxylic acid or a derivative thereof. The whole-process targeting polypeptide not only can cross a blood-brain barrier, target tumor neovascularization, cross a blood-tumor barrier, target tumor mimicry vessels, tumor cells and stem cells thereof, but also has better tumor cell affinity, anti-tumor treatment and in-vivo safety effects. Meanwhile, the drug compound or the drug delivery system has a synergistic effect after being combined with a chemotherapeutic drug, and the anti-tumor drug effect can be remarkably improved.

The invention discloses an anesthesia strategy generation system fusing time sequence data and a knowledge graph, and relates to the technical field of medical information processing. The method specifically comprises the steps that five types of vital sign data including arterial blood pressure, electrocardio and electroencephalogram are collected, correction is conducted in combination with traction marks and electrotome interference characteristics, and an analysis result is output; the inference analysis module executes double-track processing based on the analysis value, one track evaluates cortical suppression, shock and ventilation risks and generates a risk report, and the other track performs reverse arbitration when the blood oxygen data is abnormal; constructing a knowledge graph fusing the efficacy nonlinear cooperation equation, the age sensitive parameters and the drug administration sequence influence; and the strategy generation module integrates the multi-source data to generate a drug execution track, and executes fast and slow closed-loop regulation and control based on a risk report and an arbitration result. According to the invention, the adaptation capability of the system to individual differences, the abnormal signal identification and processing capability and the intelligent response level of the anesthesia strategy are improved, and the accuracy and safety of clinical anesthesia are significantly enhanced.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention provides recombinant ensifer adhesion as well as a construction method and application thereof. The recombinant ensifer adhesion provided by the invention is applied to preparation of 1, 3-propylene glycol through mixed fermentation with recombinant escherichia coli, and glycerol can be converted into 1, 3-propylene glycol without adding expensive coenzyme vitamin B12 in the fermentation process. And the ensifer adhesion and recombinant escherichia coli mixed bacterium system has good synergy, the growth of the recombinant ensifer adhesion does not generate obvious interference on the escherichia coli in the mixed bacterium system, and the normal growth and metabolism state of the escherichia coli can be basically kept. Experiments prove that after the recombinant ensifer adhesion and the recombinant microorganism escherichia coli are subjected to mixed fermentation, the product yield can be higher than that of fermentation of single-strain recombinant escherichia coli.

The invention relates to preparation of a medicinal and edible active ingredient composition with an immune regulation function. According to the composition, main effective components in medicinal and edible plants including fructus arctii and codonopsis pilosula are adopted, and arctigenin and codonopsis pilosula polysaccharide are combined, so that an immune regulation function is realized. Each experimental index of the composition is superior to that of the single action of the effective components, and the comprehensive effect of the synergistic effect is embodied. The composition is derived from effective components of traditional Chinese medicines with homology of medicine and food, can be applied to susceptible people with immune imbalance, can improve inflammatory response of swollen sore throat and the like, and has wide health-care function development and application prospects.

A synergistic insecticidal composition comprising of (A) Isocycloseram; (B) an insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; and (C) one or more insecticides selected from the given list thereof. The present invention further relates to process for preparing the said compositions in specific amount. The present invention further relates to the process for preparing the said composition along with at least one formulation excipient; and formulations thereof. The present invention further relates to the synergistic compositions, wherein active ingredient present in fixed amount shows synergy in an insecticidal activity.

The invention provides a whole cortical action compound peptide, which comprises acetyl tetrapeptide-11, hexapeptide-9, palmitoyl hexapeptide-12, palmitoyl hexapeptide-14 and / or acetyl hexapeptide-1, and is characterized in that the whole cortical action compound peptide comprises acetyl tetrapeptide-11, hexapeptide-9, palmitoyl hexapeptide-12, palmitoyl hexapeptide-14 and / or acetyl hexapeptide-1; the compound peptide acts on epidermal basal layer keratinocytes, true epidermal junction (DEJ) structural proteins and / or dermal layer fibroblasts, and synergistically exerts a whole-cortex skin anti-aging effect on epidermal layer, basement membrane, dermal layer and / or nerve fibers. The compound peptide has the advantages of full-cortex three-dimensional anti-aging, layered precise targeting, multi-peptide scientific compounding, matrix synergy, clear action mechanism, efficient growth promotion of seven key proteins, remodeling of a true epidermis structure, low-concentration effect, mildness, no stimulation and the like, and is an advanced anti-aging scheme under a precise skin care trend.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention provides a microneedle preparation for co-delivering photo-thermal nano-enzyme and elemene as well as a preparation method and application of the microneedle preparation. The preparation method comprises the following steps: firstly, preparing a novel photo-thermal nano enzyme Au (at) MoS2 through a two-step water phase synthesis strategy; benefited from the synergistic effect of the hybrid material, the nano-enzyme shows significantly enhanced near-infrared (NIR) photothermal effect, peroxidase-like (POD) activity and glutathione-like peroxidase (GSHOx) activity, and can effectively remodel the tumor microenvironment and destroy the redox steady state. Furthermore, photo-thermal nano enzyme, beta-ELE and hyaluronic acid are used as raw materials, and a novel soluble microneedle preparation is successfully prepared through a template method. The novel composite microneedle is in a sharp rectangular pyramid shape, growth of melanoma can be effectively inhibited through percutaneous delivery of photo-thermal nano-enzyme and beta-ELE, remarkable systemic toxicity is avoided, and an innovative strategy is provided for non-invasive, efficient and safe melanoma combined treatment.

The invention belongs to the technical field of biological medicines, and particularly relates to a pharmaceutical composition for preventing / treating Alzheimer's disease. According to the pharmaceutical composition based on the NPAFP protein provided by the invention, the synergistic effect of natural and artificially synthesized compounds is utilized, so that the pharmaceutical composition can play a role in a plurality of pathological levels, and the AD symptom is remarkably improved. The composition has the remarkable effects of resisting oxidation, resisting inflammation, promoting A beta removal, improving mitochondrial quality, reducing A beta 42 secretion and pathological states caused by Tau PFF and the like, and can protect neurons by adjusting the metabolic process. By screening and optimizing the compound with synergistic effect, the action mechanism of the compound is further defined, a novel safe and efficient potential solution is provided for AD treatment, and the compound has wide clinical application prospect. The medicine is high in safety, strong in specificity, simple and convenient in preparation method and suitable for mass production.

The invention belongs to the technical field of composite plant extracts, and discloses a composite plant extract and a preparation method and application thereof.The composite plant extract comprises wheat germ peptide and swertiamarin, and the mass ratio of the wheat germ peptide to the swertiamarin is 1: (0.8-1.2); the types and quantity of amino acids in the wheat germ peptide meet the following conditions: (1) Glu + Lys + Pro + Val + His + Gly is greater than 32%, and (2) Gly + Ala + Val + Ile + Pro + Thr + Lys + His is greater than 62%. The stability of swertiamarin in the active component of the composite plant extract provided by the invention is high. In order to repair and relieve problem skin, the wheat germ peptide and the swertiamarin can increase target expression of different pathways and can also synergistically promote target expression on the same pathway, and the wheat germ peptide and the swertiamarin can also promote mutual expression of targets among the pathways, so that the effect of repairing and relieving the problem skin is achieved. And the soothing and repairing effects on the skin are improved through multi-dimensional synergy.

The present invention primarily relates to a mixture comprising or consisting of one or more compound(s) of formula (I) or (II) as defined herein and one or more further antimicrobial agent(s) and it relates to a product comprising a mixture as defined herein. Moreover, the present invention relates to the use of one or more compound(s) of formula (I) or (II) as defined herein to improve the antimicrobial effect of one or more further antimicrobial agent(s) and to the use of one or more further antimicrobial agent(s) to improve the antimicrobial effect of one or more compound(s) of formula (I) or (II) as defined herein. The present invention further relates to the use of a mixture as defined herein as an antimicrobial agent and to a process as defined herein for improving the antimicrobial effect of one or more compound(s) as defined in step (a) and / or of one or more compound(s) as defined in step (b) of the process. Moreover, the present invention relates to a process for inhibiting or preventing the growth of one or more microorganisms in a product or semi-finished product and to a process for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa and / or for inhibiting or preventing the growth of one or more microorganisms on / in a surface. Moreover, the present invention relates to a mixture or compound as defined herein for use as an antimicrobial agent for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa. Finally, the present invention relates to the use of one or more compound(s) as defined herein as antimicrobial agent(s) and to a process as defined herein for inhibiting or preventing the growth of one or more microorganisms on a mammal's skin or mucosa, and / or for inhibiting or preventing the growth of one or more microorganisms in a product or semi-finished product, and / or for inhibiting or preventing the growth of one or more microorganisms on / in a surface.

The invention provides an additive composition for promoting itraconazole absorption, and the additive composition is prepared from the following components in parts by mass: 20 to 40 parts of modified hydroxypropyl methylcellulose acetic acid succinate, 10 to 25 parts of copovidone, 5 to 15 parts of N-capryloyl sodium salicylate, 2 to 8 parts of nano silicon dioxide and 3 to 10 parts of polyoxyethylene-polyoxypropylene segmented copolymer. According to the additive composition disclosed by the invention, the problems of dissolution rate, bioavailability and stability of the itraconazole oral preparation are comprehensively solved through polymer modification, compounding synergy and parameter optimization, and the process cost is remarkably lower than that of the prior art.

The invention relates to a compound microorganism deodorization fungicide as well as a preparation method and application thereof, and belongs to the technical field of microorganism application. The invention provides a compound microorganism deodorization bacterium agent. The compound microorganism deodorization bacterium agent is prepared from bacillus cereus GXMU-Q5.3, streptomyces beihaiensis GXMU-J15 and lactobacillus paracasei GXMU-G1, the viable count ratio of the bacillus cereus GXMU-Q5.3 to the streptomyces beihaiensis GXMU-J15 to the lactobacillus paracasei GXMU-G1 is (1 to 2): (1 to 2): (1 to 2). The strain of the composite microbial deodorant agent is screened from soil and water at the stacking place of the marine product processing waste, the decomposition and deodorization effects on the marine product processing waste are obvious, the bacteria have a synergistic effect, and the deodorization effect of the composite microbial agent is improved by 40% or above compared with that of a single strain; the cost is low, the efficiency is high, the application range is wide, the deodorization period is short, and the safety is high.

The invention belongs to the technical field of biomedicine, and particularly relates to application of Ackermania muciniphila in improvement and treatment of cerebral malaria caused by Plasmodium berghei. The invention tries to evaluate the effect of the AKK bacterium on improving and treating the cerebral malaria of a mouse under the condition that the AKK bacterium or auxiliary medicines (dihydroartemisinin, rapamycin and atorvastatin) are independently used on a cerebral malaria model of the mouse. Results indicate that the strain can effectively improve behavioristics of mice and immune pathological injuries of all organs, reduce protozoemia and prolong the lifetime of the mice whether the strain is independently used or combined with the drugs, and compared with the strain which is independently used with the drugs, the strain can effectively treat cerebral malaria of the mice. As ackermania muciniphila is common probiotics in human intestinal tracts, the three drugs (dihydroartemisinin, rapamycin and atorvastatin) used in the invention are all clinically used drugs, and if the drugs are clinically transformed to treat human brain malaria caused by plasmodium falciparum, the feasibility is high, and meanwhile, the transformation time can be shortened. According to the invention, a bacterium-medicine synergistic concept is provided for the first time, that is, probiotics can assist medicines in treating diseases, and a solution is provided for treating human cerebral malaria under the guidance of the concept.

The invention belongs to the technical field of biological medicine, and relates to a composite polypeptide composition as well as a preparation method and application thereof. According to the technical scheme, pH responsive polymer loaded oligopeptide-1, acetyl heptapeptide-4 and palmitoyl tripeptide-1 are adopted as a core, hyaluronic acid is adopted for wrapping, a hyaluronic acid layer adsorbs palmitoyl tripeptide-8, heptapeptide-6 and decapeptide-4, and the composite polypeptide with a core-shell structure is prepared and used for treating inflammatory skin diseases. In the acute stage of inflammation, the active ingredients on the outer layer quickly inhibit the activation of proinflammatory factors and immune cells and relieve red, swollen and heat pain, and the gel outer layer formed by hyaluronic acid realizes continuous release, prolongs the action time and supplements moisture to the skin; the pH-responsive polymer of the inner layer releases active ingredients at the inflammation part, so that relapse is prevented, and the skin barrier function is repaired. The composition plays a role from multiple dimensions of inflammation regulation, barrier repair, oxidation resistance and the like through a multi-layer structure design and a multi-component synergistic effect.

The invention discloses a method and system for analyzing the synergy degree and participation degree of multiple pelvic floor muscles, and relates to the technical field of pelvic floor multiple muscle data analys.The method comprises the following steps that S100, electromyographic signals of the pelvic floor, rectus abdominis, gluteus and hip adductor are collected, and normalization processing is conducted on the collected signals; step S200, carrying out synergy analysis on the plurality of muscles by adopting the normalized electromyographic signals; step S300, performing independent muscle participation degree analysis according to a collaborative analysis result; step S400, evaluating the similarity between the rectus abdominis, the hip adductor and the gluteus and the pelvic floor muscle activity in different contraction stages by calculating the Pearson correlation coefficient of each muscle in different time windows; and step S500, calculating the reference total work amount of the muscles and combining the window similarity to obtain the participation degree of each muscle in different time windows.

The invention relates to a high-throughput screening system for bacteriostatic active components of rhizoma polygonati. Firstly, polygonatum kingianum multi-component extraction and sample pretreatment are performed; performing component separation and preliminary screening based on high performance liquid chromatography; then, quickly mixing the separated components with target bacteria by utilizing a micro-fluidic chip technology to form a micro-droplet reaction unit; through a digital micro-fluidic platform, each micro-droplet represents a bacteriostatic test unit of one component, and real-time bacteriostatic effect monitoring is carried out in a micron-sized environment; after the preliminary bacteriostatic activity test is completed, high-throughput data processing and component activity analysis are carried out; through construction of a high-throughput screening platform and high-throughput screening of synergistic effects of antibacterial components, a component activity prediction model based on artificial intelligence is finally obtained.

The invention relates to the technical field of medical chemistry, in particular to a bridge oxygen site regulatively modified rhodamine anti-cancer fluorescent compound as well as a preparation method and application thereof. The invention develops the rhodamine anti-cancer fluorescent compound of which the meso site is functionalized by tetraarylethene and the bridge oxygen site can be regulated and modified, the fluorescent compound has adjustable red light-near infrared fluorescence emission and excellent fluorescence quantum yield, and the quantum yield can be as high as 99%; the fluorescent compound specifically targets mitochondria, and mainly inhibits growth of tumor cells by inducing para-apoptosis; under irradiation of 655 nm near-infrared laser, ferroptosis is further triggered, efficient treatment of tumor cells is achieved through chemical-photodynamic synergistic effect, and a new treatment thought is provided for overcoming tumor drug resistance.

The invention is applicable to the field of blue-green algae detection, and particularly provides a blue-green algae detection method based on multi-task deep learning and adaptive background removal, in the detection method, a MAGAN model is constructed, local features are extracted through a graph convolutional network, global context perception is enhanced by using a self-attention mechanism, and the detection accuracy is improved. And finally, the foreground and background distinguishing is optimized through a background removing module, so that the self-adaptive background removing task is realized. Then, a multi-task deep learning framework is adopted; the targets of the multiple tasks are learned in the same model at the same time, so that the model can share knowledge from the multiple tasks; the blue-green algae detection task and the background removal task share part of features and are cooperatively optimized, background removal is achieved, support is provided for blue-green algae recognition, the blue-green algae recognition provides reference information for background removal, the cooperative effect between the tasks is enhanced, the model can more accurately distinguish blue-green algae from other water substances, and false detection and missing detection are reduced.