1118 results about "Phenylboronic acid" patented technology

The invention provides temperature and pH responsive hydrogel entrapped with chlorogenic acid lipidosome as well as a preparation method and application of the temperature and pH responsive hydrogel, and relates to the technical field of biology. The temperature and pH responsive hydrogel entrapping chlorogenic acid lipidosome contains chlorogenic acid lipidosome, phenylboronic acid grafted modified gelatin and dopamine grafted oxidized hyaluronic acid, the concentration of the phenylboronic acid grafted modified gelatin is 3-10 wt%, the concentration of the dopamine grafted oxidized hyaluronic acid is 3-10 wt%, and the concentration of chlorogenic acid is 1-20 [mu] M. The temperature and pH responsive hydrogel can effectively promote wound healing independently or in combination with blue light.

The invention discloses a preparation method of injectable nano composite hydrogel for relieving osteoarthritis, which comprises the following steps: firstly, synthesizing nano rod-like hydroxyapatite with the length of 150-300 nm and the diameter of 10-15 nm, and the hydroxyapatite is hydrophilic hydroxyapatite doped with strontium and europium ions; the preparation method comprises the following steps: by taking Ca (NO3) 2, Sr (NO3) 2, Eu (NO3) 3 and soluble phosphate as main raw materials, carrying out hydrothermal reaction to prepare strontium and europium ion co-doped hydrophobic hydroxyapatite, dispersing the strontium and europium ion co-doped hydrophobic hydroxyapatite in a Tris-HCl buffer solution, adding tannic acid, stirring, centrifugally collecting precipitate, and drying to obtain strontium and europium ion doped hydrophilic hydroxyapatite; the preparation method comprises the following steps: taking chondroitin sulfate and adipic dihydrazide as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the chondroitin sulfate solution grafted with the hydrazide group; the preparation method comprises the following steps: taking hyaluronic acid, 3-aminophenylboronic acid and sodium periodate as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the phenylboronic acid group grafted oxidized hyaluronic acid solution; the preparation method comprises the following steps: blending hydrophilic hydroxyapatite doped with strontium and europium ions, a chondroitin sulfate solution grafted with a hydrazide group, an oxidized hyaluronic acid solution grafted with a phenylboronic acid group and a recombinant collagen solution, and stirring to obtain the injectable nano composite hydrogel. The injectable nano composite hydrogel obtained by the invention has good biocompatibility, and a favorable local immune microenvironment can be created to immunomodulate macrophages so as to relieve osteoarthritis and promote subchondral bone repair.

The invention belongs to the technical field of flame-retardant materials, and particularly relates to a phenylboronic acid-based P / N / B-containing halogen-free flame retardant, a preparation method thereof and application of the phenylboronic acid-based P / N / B-containing halogen-free flame retardant in epoxy resin. The preparation method comprises the following steps: by taking diphenyl hypophosphorous chloride as a basis, preparing a flame-retardant intermediate through nucleophilic substitution reaction between diphenyl hypophosphorous chloride and an aldehyde group-containing phenolic compound, then reacting a phenylboronic acid structure with 3-amino-1, 2-propylene glycol to obtain an amino group-containing phenylboronic acid compound, and finally reacting the phenylboronic acid compound with 3-amino-1, 2-propylene glycol to obtain the amino group-containing phenylboronic acid compound. And finally, carrying out a Schiff base reaction on the flame-retardant intermediate and an amino-containing phenylboronic acid compound to obtain the halogen-free flame retardant containing phosphorus, nitrogen and boron elements. The flame retardant provided by the invention can significantly improve the flame retardant property and mechanical property of epoxy resin. A flame-retardant epoxy resin prepared based on the flame retardant; the influence on Tg of an epoxy resin cured product is small, the smoke suppression and char formation performance and the mechanical performance of the cured product can be remarkably improved, and meanwhile, the flame retardant has excellent flame retardant efficiency; the limit oxygen index of the flame-retardant epoxy resin can reach 31%; the vertical combustion grade is V-0 or above, and the carbon residue amount can reach 18% or above.

The invention relates to a dynamic-covalent hybrid cross-linked hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a component A-phenylboronic acid modified polymer derivative in a biocompatible medium to obtain a solution A; dissolving a component B, namely a macromolecular derivative containing a vicinal diol group, into a biocompatible medium to obtain a solution B; dissolving a component C-double bond group modified polymer derivative in a biocompatible medium to obtain a solution C; and mixing the solution A, the solution B and the solution C with certain concentrations for a certain time, and performing illumination under a photoinitiator for a certain time to obtain the dynamic-covalent hybrid cross-linked hydrogel material. Compared with single dynamic bond crosslinking or covalent bond crosslinking, the prepared hydrogel material has machinability and mechanical stability; the hydrogel material has plasticity, shear thinning, self-repairing property and the like in the early stage of crosslinking; enough mechanical strength and long-term stability are realized in the later stage of crosslinking.

The invention relates to the technical field of pharmaceutical chemicals, and discloses sequential drug release liposome hydrogel and a preparation method and application thereof, and the preparation method of the liposome hydrogel comprises the following steps: step 1, preparation of drug-loaded positive charge liposome; step 2, preparing phenylboronic acid modified polysaccharide; and step 3, carrying out vortex mixing on the drug-loaded positive charge liposome solution, the phenylboronic acid modified polysaccharide hydrogel precursor powder and the spermidine solution to obtain the liposome hydrogel. According to the sequential drug release liposome hydrogel as well as the preparation method and the application thereof, the liposome hydrogel is prepared by taking high-molecular hyaluronic acid and phenylboronic acid as main raw materials, and the liposome hydrogel has microenvironment responsiveness and time-space characteristics of drug release, and can be used for treating osteoarthritis in an environment with active oxygen increase, so that the drug release effect is good, and the drug release effect is good. The functions of early-stage anti-inflammation and continuous cartilage regeneration are achieved by sequentially releasing double drugs, synovitis can be effectively relieved, cartilage regeneration can be promoted, and the compound can be used for preparing drugs for treating osteoarthritis.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses preparation and application of a block cationic copolymer / quaternary ammonium salt chitosan-based composite hydrogel. The preparation method comprises the following steps: reacting a sodium alginate solution with a NaIO4 solution at room temperature in a dark place to obtain an oxidized sodium alginate solution; adding ethylene glycol into the oxidized sodium alginate solution, reacting, concentrating, dialyzing and drying to obtain oxidized sodium alginate; the preparation method comprises the following steps: mixing acrylamide, 1-butyl-3-vinyl imidazole ammonium bromide, 3-acrylamide phenylboronic acid and quaternary ammonium salt chitosan, dissolving in water, adding ammonium persulfate and N, N-methylene bisacrylamide, heating for reaction, and cooling to obtain a cooling liquid; adding the oxidized sodium alginate solution into the cooling liquid, continuously adding polymerized N, N, N ', N'-tetramethylethylenediamine, reacting and curing to obtain composite hydrogel; and soaking the composite hydrogel in a glycerin / water mixed solution to obtain the composite hydrogel. When the composite hydrogel is used as a wound dressing, the composite hydrogel has the characteristics of good antibacterial activity, high sterilization efficiency, good anti-freezing and anti-drying performance and difficulty in generating drug resistance.

The invention discloses a lithium battery diaphragm with a self-repairing function and a preparation method thereof, and belongs to the field of lithium battery diaphragms. The lithium battery diaphragm comprises a polymer base membrane and a ceramic coating, the ceramic coating is coated on one side surface, facing the negative electrode, of the polymer base membrane or two side surfaces of the polymer base membrane; the ceramic coating comprises the following raw materials in parts by mass: 40-50 parts of modified ceramic particles, 4-8 parts of self-repairing microcapsules, 0.5-3 parts of a dispersing agent and 50-60 parts of water; the surfaces of the modified ceramic particles are grafted with amino-phenylboronic acid difunctional silane; chitosan / polyurethane is used as a wall material of the self-repairing microcapsule, and polyisocyanate is used as a core material of the self-repairing microcapsule. When the lithium ion diaphragm is stressed or punctured by dendritic crystals, the polyisocyanate can be released to react and crosslink, the generated cracks are closed, and an ion channel is reconstructed. Through the physical barrier of the ceramic coating and the self-repairing effect of the self-repairing microcapsule, the mechanical strength and the ion transmission performance of the lithium battery diaphragm can be effectively maintained.

The invention discloses a polyvinyl alcohol composite film as well as a preparation method and application thereof in food coloring detection. The polyvinyl alcohol composite film is prepared from raw materials including phenylboronic acid modified carbon dots and polyvinyl alcohol through a thermocuring reaction, a phenylboronic acid group on the surface of the phenylboronic acid modified carbon dot and polyvinyl alcohol form a reversible covalent bond crosslinking point based on boric acid ester so as to form a dynamic three-dimensional network, and the structural formula of the phenylboronic acid modified carbon dot is # imgabs 1 #. The phenylboronic acid modified carbon dot is simple in process, easy to process and form and simple and convenient to use; compared with the prior art, the carbon dots modified by phenylboronic acid groups and the polyvinyl alcohol are added, the crosslinking effect between the carbon dots modified by the phenylboronic acid groups and the polyvinyl alcohol is remarkably enhanced, the mechanical strength and water resistance of the composite film are improved, the food coloring detection capacity of the composite film is improved, and in addition, the composite film further has the characteristic of being capable of being reprocessed, so that the composite film has wide application value.

The invention relates to a protein-based phenylboronic acid ester dynamic crosslinking hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a component A, namely a phenylboronic acid modified protein polymer derivative, in a biocompatible medium to obtain a solution A; dissolving a component B, namely a macromolecular derivative containing a vicinal diol group, into a biocompatible medium to obtain a solution B; and mixing the solution A and the solution B with a certain concentration for a certain time to obtain the protein-based phenylboronic acid ester dynamic crosslinking hydrogel material. The boric acid ester dynamic cross-linking bond belongs to reversible chemical cross-linking reaction, and the prepared protein-based hydrogel material has enough mechanical strength and cheap operability. The protein-based hydrogel material disclosed by the invention can provide the effects of cell adhesion, proliferation and differentiation promotion, tissue regeneration and the like, can load and slowly release beneficial components for promoting tissue repair, is an ideal tissue engineering scaffold material, and can be applied to defect regeneration and repair of soft tissues, cartilages, bones and the like.

The invention relates to the technical field of biological adhesives, in particular to a pH response type chitosan medical biological adhesive and a preparation and application method thereof.The preparation method includes the steps that phenylboronic acid modified chitosan, polyphenol compounds, cross-linking agents with different functional groups and polyethylene glycol with different molecular weights are evenly mixed in a PBS buffer solution with the pH equal to 7-8; and adjusting the pH value of the system to 7.5-8 by using a KOH aqueous solution, and standing at room temperature until the pH-responsive chitosan medical biological adhesive is formed. The chitosan biological adhesive disclosed by the invention still keeps excellent adhesive power in a moist environment, is rapid in adhesion, is non-toxic and biodegradable in material, has good biocompatibility, and effectively avoids secondary stitch removal pain caused by non-degradable materials. Due to the charge characteristic of the chitosan, the chitosan has good affinity with human tissues, is suitable for adhesion of various tissues, and has wide clinical application potential.

The invention discloses a preparation method of an organosilicon anticorrosive coating, and relates to the technical field of coatings. When the organic silicon anticorrosive coating is prepared, firstly, heptamethylcyclotetrasiloxane, N, N-dimethyl vinylamine and 4-(chloromethyl) phenylboronic acid pinacol ester are subjected to a reaction to prepare quaternized cyclotetrasiloxane, then the quaternized cyclotetrasiloxane, octamethylcyclotetrasiloxane and 1, 3-bis (3-aminopropyl) tetramethyldisiloxane are subjected to a reaction to prepare functionalized polysiloxane, and then the functionalized polysiloxane is subjected to a reaction to prepare the organic silicon anticorrosive coating. The preparation method comprises the following steps: reacting titanium dioxide nanosheets, aniline and (3-aminophenyl) phosphonic acid to prepare modified nano titanium dioxide, and finally mixing epoxy resin, functionalized polysiloxane, xylene, the modified nano titanium dioxide and a polyamide curing agent to prepare the organic silicon anticorrosive paint. The prepared organic silicon anticorrosive paint has excellent corrosion resistance, self-repairing performance, flame retardance and antibacterial performance.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention discloses a cellulose coated diaphragm and a preparation method thereof in the field of lithium ion batteries, the diaphragm comprises alpha-cellulose pulp, a cellulose grafted phenylboronic acid-co-oligomeric ethylene oxide copolymer, a thermal response star zwitterionic polymer and nano aluminum oxide, and an N-methylmorpholine-N-oxide aqueous solution is adopted as a solvent system. The preparation method comprises the following steps: firstly synthesizing a cellulose grafted copolymer with dynamic borate bonds through atom transfer radical polymerization, then preparing a star polymer with thermal response arms and zwitter-ion terminals by taking cyclodextrin as a core, and finally mixing all the components to prepare coating slurry. And the composite diaphragm is prepared through the processes of coating, phase conversion, ultraviolet curing and drying. The diaphragm combines the thermal stability and lyophilic property of cellulose, forms a dynamic self-adaptive interface layer through the synergistic effect of two functional compounds, has the advantages of active safety protection, dendritic crystal inhibition, long cycle life and the like, and remarkably improves the comprehensive performance of the lithium ion battery.

The invention discloses a boron-silicon-containing phenolic resin heat prevention and insulation integrated composite material and a preparation method thereof. The method comprises the following steps: step 1, weighing phenol, formaldehyde, 4-hydroxyphenylboronic acid, a reaction solvent and a reaction catalyst according to a ratio, adding the weighed materials into a reaction container, and carrying out reaction polymerization to prepare linear boron-containing phenolic resin; 2, silicon resin is added into the linear boron phenolic resin prepared in the step 1, and boron silicon phenolic resin is prepared through chemical polymerization; and step 3, compounding the boron-silicon phenolic resin prepared in the step 2 with a three-dimensional fiber braided fabric, adding a certain curing catalyst, and performing curing molding to obtain the boron-silicon phenolic resin-containing heat-proof and heat-insulating integrated composite material. The preparation method provided by the invention solves the problem that the boron-silicon phenolic resin and the silicon resin are easy to disperse during co-curing, the prepared boron-silicon phenolic resin has outstanding heat resistance and wide process applicability, and the prepared heat prevention and insulation integrated composite material integrates light weight, high strength and heat prevention and insulation integration, and has obvious advantages in a high-temperature use scene.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention discloses a baicalin and boric acid antibacterial peptide assembly and a preparation method and application thereof, belongs to the technical field of biological medicine, and provides a baicalin and boric acid antibacterial peptide assembly which comprises baicalin and boric acid antibacterial peptide. The amino acid sequence of the boric acid antibacterial peptide is one of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6. According to the baicalin and boric acid antibacterial peptide assembly, phenylboronic acid molecules introduced to the C end of boric acid antibacterial peptide polypeptide can form boric acid ester bonds with the baicalin, the water solubility and membrane permeability of the baicalin can be improved, the baicalin can enter bacterial cells more easily to play a role, and the baicalin and the boric acid antibacterial peptide can form a multi-target synergistic antibacterial effect; therefore, the antibacterial effect is obviously improved.

The invention provides a battery positive plate and a battery. The battery positive plate comprises a positive active material and a binder, and the binder is a product obtained by crosslinking a phenylboronic acid compound modified polyacrylic acid compound and a hydroxylated carbon nanotube. According to the battery positive plate, a three-dimensional conductive network binder based on crosslinking of a phenylboronic acid compound modified polyacrylic acid compound and a hydroxylated carbon nanotube is adopted, and the binder utilizes a multi-crosslinking mechanism between a phenylboronic acid group and the hydroxylated carbon nanotube (OHCNT) and between the phenylboronic acid group and positive active particles; a boroxane structure is formed through self-crosslinking of the boron oxide and the phenylboronic acid, and a special three-dimensional conductive network structure is formed, so that the mechanical strength and the conductivity of the binder and the cycle performance and the stability of the battery are improved; the discharge performance and the rapid charge-discharge capability of the battery can be improved, and the consumption of electrolyte can be reduced, so that the cycle life of the battery is prolonged.

The invention discloses a carrier-free nano-particle with pH / ROS dual response as well as a preparation method and application of the carrier-free nano-particle. The preparation method comprises the following steps: enabling quinolizidine alkaloid and flavonol to be subjected to self-assembly, so as to prepare quinolizidine alkaloid-flavonol carrier-free nano particles; modifying the quinolizidine alkaloid-flavonol carrier-free nano particles by adopting a phenylboronic acid-hyaluronic acid conjugate, so as to prepare nano particles modified by the phenylboronic acid-hyaluronic acid conjugate; and coating the surfaces of the nano-particles modified by the phenylboronic acid-hyaluronic acid conjugate with a pH sensitive polymer to prepare the pH / ROS dual-response carrier-free nano-particles. The sophocarpidine-kaempferol carrier-free nanoparticles with pH / ROS dual response, prepared by the invention, have the advantages of good targeting property, high biocompatibility, small toxicity and adverse reaction and the like, meanwhile, the nanoparticles have a good anti-inflammatory effect, and a new choice is provided for the treatment of ulcerative colitis.

The invention belongs to the technical field of court ground materials, and particularly relates to a ground material of a ground throw court and a preparation method thereof. The ground material of the ground throwing field comprises the anti-skid surface layer, the elastic buffer layer and the sound insulation layer from top to bottom, and has excellent sound insulation, impact resistance and wear resistance. The polyvinyl butyral bonded acrylic sound insulation felt and the jute fiber board are used as a sound insulation felt composite material to be laid on the surface of the base layer, so that the sound insulation effect of the ground of the ground throwing field is enhanced, boric acid and phenylboronic acid are compounded to react with siloxane, and reinforced gel prepared by adding a reinforcing material has excellent shear hardening and thermal stability, so that the sound insulation effect of the ground of the ground throwing field is improved. An elastic reinforcing material is prepared by compounding alkali-treated straw fibers and a reinforcing body prepared by compounding the alkali-treated straw fibers and a hydrophobically modified sponge framework, and has remarkable creep resistance and excellent impact hardenability, and the esterified straw fibers prepared by reacting the alkali-treated straw fibers with citric acid are used as a toughening agent to be added into wear-resistant elastic microspheres prepared by rubber, so that the wear-resistant performance of the wear-resistant elastic microspheres is greatly improved. The material has excellent wear resistance, light weight and aging resistance.

The invention discloses an antibacterial material rich in a bismuth metal organic framework and a preparation method thereof, the method comprises the following steps: adding an indole monomer and an alcohol monomer into a solvent, and then adding nitrosalicylaldehyde into the solvent to obtain a spiropyran compound; the preparation method comprises the following steps: adding humic acid into a binary solvent consisting of dioxane and butanol to obtain a mixed solution; the ratio of the mass of the humic acid to the volume of the binary solvent is (2-3): (20-40) g / ml; sequentially adding a bismuth source, 2-bromo-5-(trifluoromethyl) pyridine and 4-(trifluoromethyl) phenylboronic acid into the mixed solution to obtain a bismuth metal organic framework; and adding the spiropyran compound into the bismuth metal organic framework to obtain the antibacterial material rich in the bismuth metal organic framework. The antibacterial capability of the antibacterial material is improved.

The invention discloses a preparation method of recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria, which comprises the following steps: binding copper porphyrin pi-pi on titanium carbide nanosheets to form MXene coated CuTCPP nanoparticles, and carrying out amidation reaction on 3-aminophenylboronic acid and recombinant collagen to obtain the recombinant collagen nano-composite hydrogel for repairing wounds infected by multiple drug-resistant bacteria. MXene coated CuTCPP is doped into a modified recombinant collagen system and mixed with a polyvinyl alcohol solution, and the recombinant collagen nano-composite hydrogel is prepared. The self-healing property endowed by the dynamic cross-linking characteristic of the phenylboronic acid ester bond in the composite hydrogel disclosed by the invention can be highly adapted to irregular wounds; the nano particles with the heterojunction structure can be combined with photothermal therapy and photodynamic therapy to efficiently sterilize wounds; the hydrogel has the antibacterial property and the property of promoting wound healing, and can comprehensively and efficiently treat wounds infected by multiple drug-resistant bacteria.

The invention provides a nanoparticle capable of releasing EGCG (epigallocatechin gallate) in response to ROS (reactive oxygen species) as well as a preparation method and application of the nanoparticle. The nanoparticles comprise a carrier and EGCG (epigallocatechin gallate) loaded on the carrier; the carrier is Prussian blue nanoparticles of which the surfaces are modified with polyethyleneimine and phenylboronic acid compounds. The preparation method of the nanoparticles is simple and easy to operate, the nanoparticles are good in dispersity, and through research, the nanoparticles have CAT-like, SOD-like and other multi-enzyme activities, can remove. OH, have a high EGCG drug loading rate and release EGCG in the presence of ROS. Besides, the nanoparticles show a good effect of improving myocardial ischemia reperfusion injury in cell level and rat in-vivo experiments, through comparison of EGCG and PB NPs single-drug treatment, synergistic treatment in the composite material achieves an effect of '1 + 1 > 2', and the composite material has good biological safety.

The invention discloses a self-crosslinking hydrogel with a tertiary amine group and preparation and application thereof, and belongs to the field of biomedical polymer materials, the self-crosslinking hydrogel comprises aminophenylboronic acid modified oxidized glucan, tertiary amine compound modified oxidized glucan and a solvent medium; the preparation method comprises the following steps: dissolving amino phenylboronic acid modified oxidized dextran and tertiary amine compound modified oxidized dextran in a solvent medium, mixing, standing for a certain time, and carrying out self-crosslinking to obtain the self-crosslinking hydrogel with tertiary amine groups. A cross-linking point (phenylboronic acid) of the gel network is a response unit of glucose. In addition, the hydrogel can effectively avoid uncontrollable drug release caused by non-responsive factors, and the response release efficiency of the drug is improved; by loading the hypoglycemic drug insulin to be applied to the treatment research process of diabetes, the occurrence of hypoglycemia can be avoided, and meanwhile, the possibility is provided for realizing intelligent controlled release of insulin through blood glucose response.

Amphotericin B (AmB) is the gold standard for treatment of life-threatening systemic fungal infections. To develop cost-effective AmB formulations with reduced toxicity, embodiments disclosed introduce controlled number of phenylboronic acid (PBA) moieties into telodendrimer (TD) nanoplatform for optimizing AmB conjugation via reversible boronate ester strategy. This multivalent flexible boronate TD nanoplatform can also be applied in developing prodrugs for different cis-diol containing or α- or β- hydroxyl ketone-containing drug molecules.

The invention relates to the technical field of biomedical materials, and discloses a thrombectomy stent support material and a preparation process thereof, the thrombectomy stent support material comprises the following components by mass: 60-70% of a polysebacic diglyceride prepolymer; 25-35% of a dynamic covalent bond cross-linking agent; 5%-10% of carboxylated nano-diamond; 3 to 5 percent of temperature-sensitive and photo-thermal dual-response microspheres; the dynamic covalent bond cross-linking agent is composed of 4-formyl phenylboronic acid and hexamethylenediamine according to a molar ratio of 1: (1-3); the microsphere is prepared from poly (N-isopropylacrylamide), a gold nanorod and a recombinant tissue type plasminogen activating agent, and by combining a low-temperature 3D printing technology, the material can form a complex bionic structure, the mechanical strength is dynamically adjusted along with the physiological environment after implantation, and the material is safely degraded after functions are completed. The material is suitable for the scenes of cardiovascular and cerebrovascular stents, bone repair instruments and the like, has treatment accuracy, manufacturing suitability and clinical safety, and solves the problems of non-degradability, sudden drug release, mechanical mismatch and the like of traditional implants.

The invention relates to a preparation method of an active oxygen responsive microneedle with a separable base, which comprises the following steps: mixing 3-(acrylamide) phenylboronic acid, epigallocatechin gallate and N-vinyl pyrrolidone, and standing to obtain an E-A compound solution; dissolving cyclosporine and an initiator in the E-A compound solution to obtain a microneedle precursor solution; placing the microneedle precursor solution on the surface of a microneedle mold, and performing in-situ polymerization to form a microneedle body; paving a mixed aqueous solution of poly (N-isopropylacrylamide-n-butyl acrylate) and polyvinyl alcohol on the microneedle mold substrate forming the microneedle body, and drying to form a microneedle substrate; and stripping the microneedle body with the microneedle substrate from the microneedle mold to obtain the active oxygen responsive microneedle with the separable base. According to the product prepared by the preparation method, drug release can be adjusted by sensing ROS of an inflammation part, deep penetration of the drug is realized, controllable separation between a backing layer and a needle head can be realized, and discomfort of a patient is reduced.

The invention discloses an extracellular matrix-imitated anti-inflammatory nerve repair-promoting conductive hydrogel as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The preparation method of the conductive hydrogel comprises the following steps: preparing an MXene nanosheet dispersion liquid, and sequentially adding polyphenol and magnesium ions into the MXene nanosheet dispersion liquid to obtain a modified nanosheet solution; mixing the modified chitosan with polyvinyl alcohol to obtain a solution A; mixing and reacting the modified nanosheet solution with phenylboronic acid modified gelatin to obtain a solution B; mixing the solution A and the solution B for reaction, refrigerating at low temperature, and unfreezing to obtain the conductive hydrogel. The hydrogel prepared by the invention has excellent conductivity, and the obtained conductive hydrogel has the functions of resisting inflammation and promoting nerve repair. The bionics method not only improves the diversity and functionality of biological materials, but also provides new possibility for future tissue engineering and regenerative medicine.

The invention discloses preparation of a nitrogen-containing seven-membered fluorine-boron compound and application of the nitrogen-containing seven-membered fluorine-boron compound to a fluorescent anti-counterfeiting film, the structure of the compound is as follows: # imgabs0, the dye takes 2, 3, 3-trimethylindole and dibromo-2-pyrrolecarboxaldehyde as raw materials, under the action of acetic acid, piperidine and methylbenzene, a Knoevenagel condensation reaction is carried out, and the dibromo seven-membered fluorine-boron fluorescent dye is generated. The dibromo seven-membered fluorine boron fluorescent dye respectively reacts with phenylboronic acid, 4-cyanophenylboronic acid, p-methoxyphenylboronic acid and triphenylamine phenylboronic acid to obtain a final compound. The compound can act with acrylic resin to form a film on a thin film, and can be colored under natural light, and clear fluorescence can be seen under an ultraviolet lamp (365nm). The fluorescent dye is simple, easy to obtain, low in manufacturing cost, high in film forming speed with acrylic resin or a polyvinyl alcohol solution on a thin film, high in anti-counterfeiting coefficient, large in counterfeiting difficulty and huge in potential in the aspects of fluorescent anti-counterfeiting packaging films, OLDE and the like.