671 results about "Phenylboronic acid" patented technology

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a lithium battery diaphragm with a self-repairing function and a preparation method thereof, and belongs to the field of lithium battery diaphragms. The lithium battery diaphragm comprises a polymer base membrane and a ceramic coating, the ceramic coating is coated on one side surface, facing the negative electrode, of the polymer base membrane or two side surfaces of the polymer base membrane; the ceramic coating comprises the following raw materials in parts by mass: 40-50 parts of modified ceramic particles, 4-8 parts of self-repairing microcapsules, 0.5-3 parts of a dispersing agent and 50-60 parts of water; the surfaces of the modified ceramic particles are grafted with amino-phenylboronic acid difunctional silane; chitosan / polyurethane is used as a wall material of the self-repairing microcapsule, and polyisocyanate is used as a core material of the self-repairing microcapsule. When the lithium ion diaphragm is stressed or punctured by dendritic crystals, the polyisocyanate can be released to react and crosslink, the generated cracks are closed, and an ion channel is reconstructed. Through the physical barrier of the ceramic coating and the self-repairing effect of the self-repairing microcapsule, the mechanical strength and the ion transmission performance of the lithium battery diaphragm can be effectively maintained.

The invention discloses an antibacterial drug delivery system based on a dynamic response type microneedle patch and a preparation method, and belongs to the field of biomedical materials.The antibacterial drug delivery system comprises a substrate layer and a needle point layer arranged on the surface of the substrate layer, the substrate layer is a mixed matrix of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), and the needle point layer is made of nano-silver; the needle tip layer is a phenylboronic acid modified oxidized hyaluronic acid and polyvinyl alcohol composite system. The antibacterial drug delivery system based on the dynamic response type microneedle patch, namely the microneedle patch with the pH response drug release function, is suitable for antibacterial treatment of infectious wounds, the mechanical strength of the needle point layer is improved, it can be better guaranteed that a microneedle completely penetrates into the skin, and the delivery efficiency is improved; meanwhile, drug release can be responded according to the pH of a bacterial infection part, and the antibacterial effect is good.

Aiming at the challenge of osteochondral defect repair, the invention provides a preparation method of a fiber-reinforced self-repairing hydrogel scaffold (SBPS). According to the method, phenylboronic acid modified sodium alginate, polyvinyl alcohol and fibroin nanofibers rich in beta-Sheet are utilized to form the hydrogel through dynamic boric acid ester bonds and hydrogen bonds. The SBPS hydrogel loaded with PDGF-BB is combined with the nanosheet containing LDH / ChS / TGF-beta3, so that multi-dimensional synergy of mechanical strengthening, sequential drug release (PDGF-BB is released in an early stage and TGF-beta3 / Mg < 2 + > is released in a later stage), ROS removal and endogenous repair is realized. The Mg < 2 + > concentration gradient effect further assists staged regulation (vascularized bone regeneration-cartilage matrix synthesis), and breaks through the limitation of a single factor. Experiments prove that the scaffold can effectively drive angiogenesis, stem cell recruitment and cartilage / bone differentiation in vivo and in vitro, and finally osteochondral regeneration with structure-function matching is achieved.

The invention discloses a cellulose coated diaphragm and a preparation method thereof in the field of lithium ion batteries, the diaphragm comprises alpha-cellulose pulp, a cellulose grafted phenylboronic acid-co-oligomeric ethylene oxide copolymer, a thermal response star zwitterionic polymer and nano aluminum oxide, and an N-methylmorpholine-N-oxide aqueous solution is adopted as a solvent system. The preparation method comprises the following steps: firstly synthesizing a cellulose grafted copolymer with dynamic borate bonds through atom transfer radical polymerization, then preparing a star polymer with thermal response arms and zwitter-ion terminals by taking cyclodextrin as a core, and finally mixing all the components to prepare coating slurry. And the composite diaphragm is prepared through the processes of coating, phase conversion, ultraviolet curing and drying. The diaphragm combines the thermal stability and lyophilic property of cellulose, forms a dynamic self-adaptive interface layer through the synergistic effect of two functional compounds, has the advantages of active safety protection, dendritic crystal inhibition, long cycle life and the like, and remarkably improves the comprehensive performance of the lithium ion battery.

The invention discloses a hydrogel wound dressing with a synergistic healing promoting function as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, dissolving oxidized methacrylated hyaluronic acid and dopamine in deionized water to obtain a solution A; the preparation method comprises the following steps: dissolving N-isopropylacrylamide, a photoinitiator 2-hydroxy-2-methyl-1-(4-(2-hydroxyethoxy) phenyl)-1-acetone and a cross-linking agent N, N '-methylene bisacrylamide in deionized water to obtain a solution B; 2, mixing the solution A and the solution B to obtain a pre-gel solution; or dissolving polyphenylboronic acid ester nanoparticles or polyphenylboronic acid ester-kaempferol with deionized water to obtain a solution C, and mixing the solution C with the solution A and the solution B to obtain a pre-gel solution; and 3, injecting the pre-gel liquid into a mold, and illuminating to obtain the hydrogel wound dressing loaded with the nanoparticles. The hydrogel disclosed by the invention can be used for effectively solving various problems in a wound healing process and promoting rapid and high-quality healing of a wound.

The invention discloses a baicalin and boric acid antibacterial peptide assembly and a preparation method and application thereof, belongs to the technical field of biological medicine, and provides a baicalin and boric acid antibacterial peptide assembly which comprises baicalin and boric acid antibacterial peptide. The amino acid sequence of the boric acid antibacterial peptide is one of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6. According to the baicalin and boric acid antibacterial peptide assembly, phenylboronic acid molecules introduced to the C end of boric acid antibacterial peptide polypeptide can form boric acid ester bonds with the baicalin, the water solubility and membrane permeability of the baicalin can be improved, the baicalin can enter bacterial cells more easily to play a role, and the baicalin and the boric acid antibacterial peptide can form a multi-target synergistic antibacterial effect; therefore, the antibacterial effect is obviously improved.

The invention discloses a carrier-free nano-particle with pH / ROS dual response as well as a preparation method and application of the carrier-free nano-particle. The preparation method comprises the following steps: enabling quinolizidine alkaloid and flavonol to be subjected to self-assembly, so as to prepare quinolizidine alkaloid-flavonol carrier-free nano particles; modifying the quinolizidine alkaloid-flavonol carrier-free nano particles by adopting a phenylboronic acid-hyaluronic acid conjugate, so as to prepare nano particles modified by the phenylboronic acid-hyaluronic acid conjugate; and coating the surfaces of the nano-particles modified by the phenylboronic acid-hyaluronic acid conjugate with a pH sensitive polymer to prepare the pH / ROS dual-response carrier-free nano-particles. The sophocarpidine-kaempferol carrier-free nanoparticles with pH / ROS dual response, prepared by the invention, have the advantages of good targeting property, high biocompatibility, small toxicity and adverse reaction and the like, meanwhile, the nanoparticles have a good anti-inflammatory effect, and a new choice is provided for the treatment of ulcerative colitis.

The invention discloses an antibacterial material rich in a bismuth metal organic framework and a preparation method thereof, the method comprises the following steps: adding an indole monomer and an alcohol monomer into a solvent, and then adding nitrosalicylaldehyde into the solvent to obtain a spiropyran compound; the preparation method comprises the following steps: adding humic acid into a binary solvent consisting of dioxane and butanol to obtain a mixed solution; the ratio of the mass of the humic acid to the volume of the binary solvent is (2-3): (20-40) g / ml; sequentially adding a bismuth source, 2-bromo-5-(trifluoromethyl) pyridine and 4-(trifluoromethyl) phenylboronic acid into the mixed solution to obtain a bismuth metal organic framework; and adding the spiropyran compound into the bismuth metal organic framework to obtain the antibacterial material rich in the bismuth metal organic framework. The antibacterial capability of the antibacterial material is improved.

The invention provides a pharmaceutical wastewater treatment process. The pharmaceutical wastewater treatment process comprises the following steps: A1, pretreatment, A2, adsorption treatment, A3, oxidation treatment and A4, filtration treatment. In the step A2, a composite adsorbent comprising the following raw materials: attapulgite, activated carbon, carbon nanotubes, 4-carboxyphenylboronic acid, polyethyleneimine, sodium dithiocarbamate, epoxy resin E-44, deionized water and modified nano zero-valent iron is used, and self-repairing is realized through dynamic chemical bonds such as boric acid ester bonds, imine bonds and thiol-disulfide bonds; the adsorbent can be self-repaired during microscopic damage, so that the service life is prolonged, and relatively high adsorption capacity is kept. In the step A3, a gel microsphere oxidant comprising the following raw materials: hydrogen peroxide, potassium persulfate, copper-iron sulfide, nitrogen-doped carbon quantum dots, sodium alginate powder, sodium polyacrylate and a phosphate buffer solution is used, and efficient degradation is realized through a synergistic mechanism of free radical oxidation, non-free radical oxidation and photocatalysis.

The invention provides a preparation method of a shape-adaptive hydrogel material for tissue repair. The method comprises the following steps: S1, preparing HPC (Hydroxypropyl Chitosan); s2, preparation of phenylboronic acid functional chitosan PHPC (Polyhydroxyalkanoate); s3, preparing a PHPC solution; s4, preparing a polyvinyl alcohol (PVA) solution; and S5, preparing the dynamic covalent bond hydrogel. According to the invention, a dynamic covalent bond-boric acid ester bond with stimulation response capability is introduced on the basis of common dual-network CS-PVA hydrogel; on the premise of not changing the biocompatibility and biodegradability of the original dual-network hydrogel, the hydrogel is endowed with response capability under physical and chemical stimulation, and the diversity of application scenes is expanded; the dynamic mechanical behavior changes of the PCA hydrogel at four different strain rates of 0.05 mm / s, 0.5 mm / s, 5 mm / s and 50 mm / s are explored, and the passive shape adaptability of the PCA hydrogel along with tissue growth is studied; meanwhile, changes of hydrogel creep deformation and stress relaxation caused by addition of dynamic covalent bonds are researched.

The invention is applicable to the technical field of hydrogel, and provides dynamic cross-linked hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: cross-linking oxidized dextran and carboxymethyl chitosan containing phenylboronic acid modification groups; glucanase is added before the hydrogel is formed, and calcium peroxide nanoparticles coated with polydopamine are introduced; wherein the mass concentration of the oxidized dextran is 2-10% w / v, the mass concentration of the carboxymethyl chitosan containing the phenylboronic acid modified group is 2% w / v, the concentration of the glucanase is 10-100 U, and the concentration of the calcium peroxide nanoparticles coated with the polydopamine is 0.1-1% w / v. The hydrogel disclosed by the invention shows good cell compatibility, angiogenesis promoting capability and bioactivity for promoting dental pulp regeneration in multiple in-vitro and in-vivo experiments, is suitable for tissue engineering fields such as dental pulp injury repair and the like, and effectively solves the technical problem that conventional hydrogel is insufficient in cell survival support in three-dimensional culture and the like.

The invention discloses a high-temperature and high-pressure electrolyte additive, an electrolyte containing the high-temperature and high-pressure electrolyte additive and a lithium ion battery. The electrolyte additive is selected from at least one of cyclic borate compounds. According to the invention, after the cyclic borate compound (such as bis (pinacol) diboron or 3-(trifluoromethyl) phenylboronic acid pinacol ester compound) is applied to the high-nickel lithium ion battery as the electrolyte additive, the battery can still maintain the capacity greater than or equal to 88% at the working voltage of 2.8-4.5 V (55 DEG C, and 300 cycles), meanwhile, the rate capability of the battery is improved, and the service life of the battery is prolonged. Compared with a battery without the cyclic borate compound additive, the cyclic borate compound additive is greatly improved under the same battery test condition. The cyclic borate additive is added into the electrolyte, so that the cycle performance of the lithium ion battery at high temperature and high voltage can be improved, and the rate capability of the battery can be improved.

This invention discloses a method for preparing a pH / glucose dual-responsive chronic wound dressing containing frankincense essential oil, comprising: (1) using 4-formaldehyde phenylboronic acid as a crosslinking agent to form Schiff base and borate ester bonds with carboxymethyl chitosan and two different molecular weight hyaluronic acids, respectively, to prepare a hydrogel capable of filling skin surface wounds and performing dual dynamic covalent crosslinking adhesion, and freeze-drying for later use; (2) preparing frankincense essential oil into microcapsules by emulsification coagulation method, and freeze-drying for later use; (3) mixing the hydrogel with the freeze-dried powder of frankincense essential oil microcapsules, adding deionized water or PBS and stirring to reconstitute to form a pH / glucose dual-responsive hybrid hydrogel dressing coated with frankincense essential oil microcapsules. The composite dressing prepared by this invention has anti-inflammatory, antioxidant, antibacterial, and healing-promoting effects, is quick and easy to prepare, and has the ability to respond to the acidic / high-glucose microenvironment of diabetic wounds, and has important practical application value.

The invention discloses a manganese-enriched albumin boron-containing nano preparation as well as a preparation method and application thereof, and belongs to the field of medicines and nano biological materials. According to the manganese-enriched albumin boron-containing nano preparation, albumin serves as a core carrier, phenylboronic acid derivatives are loaded through covalent or electrostatic interaction, then a manganese oxide layer is deposited on the surface in situ, and the prepared manganese-enriched albumin boron-containing nano preparation can remarkably increase the boron accumulation amount in tumor tissue; local and systemic immune response of tumors is promoted through the immune activation effect of manganese ions, so that the treatment effect of boron neutron capture therapy (BNCT) is remarkably improved. According to the invention, a phenylboronic acid derivative with tumor targeting is compounded with albumin, and manganese oxide is deposited in situ on the surface of the phenylboronic acid derivative, so that a multifunctional nano preparation with high boron delivery efficiency, immunological enhancement and magnetic resonance imaging functions is formed.

The invention relates to a polymer solid electrolyte, a preparation method thereof and a solid-state battery, the polymer solid electrolyte comprises a polymer, a metal sodium salt and an additive, and the additive is phenylboronic acid functionalized nano silicon dioxide. The invention also provides a solid-state battery comprising the polymer solid-state electrolyte. The MSN-CFPBA is prepared through grafting modification, so that silicon dioxide is functionalized, and the comprehensive performance of the polymer electrolyte is improved. B atoms in a CFBBA molecular structure have Lewis acidity and can be coordinated and interacted with salt anions (such as TFSI-, PF6-and the like), the acting force between the anions and sodium ions is weakened, dissociation and migration of sodium salt are promoted, and meanwhile, the mechanical strength of the electrolyte can be improved and growth of dendritic crystals can be effectively inhibited in the presence of a proper content of nano silicon dioxide. The polymer electrolyte provided by the invention has high ionic conductivity, excellent interface stability and relatively good mechanical property, and is suitable for a high-energy-density solid metal sodium battery.

The invention belongs to the technical field of nano-medicines and targeted therapy, and particularly relates to a targeted nano-system nano-drug delivery system based on mesoporous polydopamine as well as a preparation method and application thereof, in particular to an N2E4-MPDA-Gem nano-system based on mesoporous polydopamine (MPDA). A targeting nano system based on mesoporous polydopamine comprises mesoporous polydopamine nano particles loaded with pancreatic cancer chemotherapy drugs, targeting molecules N2E4 are combined with the surfaces of the mesoporous polydopamine nano particles, and phenylboronic acid coatings used for controlling drug release are arranged on the surfaces of the mesoporous polydopamine nano particles. The system adopts a modular design, can be compatible with various chemotherapeutic drugs such as oxaliplatin, irinotecan and the like, and can be flexibly coupled with different targeting antibodies such as EGFR (epidermal growth factor receptor), HER2 (human epidermal growth factor receptor) and the like. A standard preparation process and good stability provide reliable guarantee for clinical transformation, and the compound shows an excellent treatment effect in a solid tumor model represented by pancreatic cancer.

The invention discloses a double-recognition colloidal gold detection method for o-dihydroxy octadecenoic acid, which is characterized in that phenylboronic acid probe molecules are introduced on a colloidal gold probe, and a detection line is coated with a quaternary ammonium salt compound, so that double capture and signal amplification of o-dihydroxy octadecenoic acid metabolites in tears are realized; therefore, the o-dihydroxy octadecenoic acid metabolite in the tears can be rapidly and quantitatively analyzed. Complex sample pretreatment steps and expensive equipment requirements are reduced, so that the detection process is more convenient.

The invention provides a bacteriostatic and scale-inhibiting PE material and a preparation method thereof, and belongs to the technical field of high polymer materials, the preparation method comprises the following preparation steps: dissolving polyethylene in xylene, dissolving, adding perfluorohexylethylene and dicumyl peroxide, reacting, precipitating, washing, and drying to obtain perfluoro modified PE; the preparation method comprises the following steps: dissolving four-arm polyethylene glycol amine in a PBS buffer solution, adding 4-carboxyphenylboronic acid, EDC.HCl and NHS, carrying out a stirring reaction in a dark place, carrying out ultrafiltration and freeze drying to obtain PBA-PEG, dissolving the PBA-PEG in a Tris-HCl buffer solution, adding dopamine hydrochloride, and carrying out mixing, oxidation reaction, dialysis purification and drying to obtain a PBA-DA-PEG compound; the preparation method comprises the following steps: pre-mixing perfluorinated modified PE, mixing with an antioxidant and a compatibilizer, injecting the PBA-DA-PEG compound, continuously mixing, extruding, and carrying out water-cooling pelletizing to obtain the antibacterial and scale-inhibiting PE material. According to the PE material obtained by the invention, the antibacterial performance and the scale inhibition performance of the material can be improved at the same time.

The invention provides a binder for a lithium ion battery, a preparation method of the binder, a positive pole piece and the lithium ion battery. The binder for the lithium ion battery is obtained by mixing a Diels-Alder dynamic bond cross-linked polyurethane prepolymer and a phenylboronic acid ester derivative and carrying out a free radical polymerization reaction under the action of an initiator, the Diels-Alder dynamic bond crosslinking type polyurethane prepolymer has a dynamic reversible six-membered ring crosslinking structure, and the crosslinking density of the six-membered ring crosslinking structure is 1.0 to 2.2 moL / m < 3 >. According to the binder for the lithium ion battery based on the dual-dynamic grid synergistic repair effect, a gradient conductive network is constructed by combining the carbon nanotubes, the carbon black and the vapor growth carbon fibers, and is finally applied to the lithium ion battery, so that the battery performance is effectively improved, and the synergistic bottleneck of energy density, cycle life and safety is solved.

The invention discloses injectable hydrogel for alveolar bone repair, the injectable hydrogel comprises a first component and a second component, the first component comprises 4-carboxyl-3-fluorophenylboronic acid modified carboxymethyl chitosan CMCS-FPBA and beta-tricalcium phosphate, and the second component comprises oxidized dextran, PPS-HA nano-micelle and curcumin. The invention also discloses a preparation method and application of the injectable hydrogel. The injectable hydrogel disclosed by the invention has the effects of resisting oxidation, resisting inflammation and promoting bone tissue regeneration, is high in biocompatibility, can be customized in a personalized manner, and can be used for repairing alveolar bones.

The invention discloses HA-PAS hydrogel for enhancing cartilage repair of early osteoarthritis and a preparation method of the HA-PAS hydrogel. According to the hydrogel, formylated hyaluronic acid, hydrazide modified low-methoxyl pectin and phenylboronic acid modified alginate form a ternary polysaccharide skeleton, a double-dynamic cross-linked network is formed through acylhydrazone bonds and boric acid ester bonds, and a triple network structure is formed by combining permanent cross-linking catalyzed by horse radish peroxidase. The hydrogel integrates functional components such as nano-selenium, a pulullan-strontium chelate and a mesenchymal stem cell source exosome, so that multiple effects of resisting oxidation, resisting inflammation, promoting cartilage differentiation and repairing subchondral bones are achieved. The compression modulus of the hydrogel is 0.8-1.5 MPa, and the hydrogel can be injected for in-situ gelling and MMP responsive degradation, shows an excellent cartilage repair effect in animal experiments, and provides a new solution for treatment of early osteoarthritis.

The invention relates to the technical field of biomedical materials, in particular to photo-thermal antibacterial healing-promoting hydrogel as well as a preparation method and application thereof. The preparation method of the hydrogel comprises the following steps: dispersing mesoporous polydopamine (MPDA) into a Tris-HCl solution, and then adding L-arginine to prepare L-MPDA; the preparation method comprises the following steps: fully dissolving 3-(aminomethyl) phenylboronic acid hydrochloride and 4-(4, 6-dimethoxytriazine-2-yl)-4-methylmorpholine hydrochloride into hyaluronic acid (HA), regulating the pH value to 6.5 by using alkali liquor to obtain phenylboronic acid modified hyaluronic acid mixed liquor, and dialyzing and freeze-drying to obtain HA-PBA. The preparation method comprises the following steps: dissolving metformin and purified L-MPDA in deionized water, sequentially adding purified HA-PBA and a polyvinyl alcohol (PVA) solution, and uniformly mixing to obtain the hydrogel. The hydrogel prepared by the invention has excellent hemostasis, antibacterial and adhesion properties. When the hydrogel is used as a hydrogel dressing for treating a diabetic wound surface, the healing speed of the diabetic wound surface can be effectively improved.

The invention discloses fluorine-containing bio-based epoxy resin as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method of the fluorine-containing bio-based epoxy resin comprises the following steps: enabling octafluoropentyloxy glycidyl ether as a fluorine unit to react with dihydric alcohol to obtain fluorine-terminated side chain butanediol, enabling the fluorine-terminated side chain butanediol to react with isocyanate to obtain a polyurethane prepolymer, and performing boric acid end capping on the polyurethane prepolymer by using 3-aminophenylboronic acid to obtain the fluorine-containing bio-based epoxy resin. The fluorine-containing bio-based epoxy resin (FBPU-ER) is prepared by the following steps: adding fluorine-containing polyurethane resin and phenylboronic acid into epoxidized soybean oil to obtain phenylboronic acid modified fluorine-containing polyurethane resin (FBPU), carrying out boric acid treatment on the epoxidized soybean oil by using 3-aminophenylboronic acid to obtain phenylboronic acid modified epoxy resin (BER), and finally, mixing the phenylboronic acid modified fluorine-containing polyurethane resin and the phenylboronic acid modified epoxy resin to obtain the fluorine-containing bio-based epoxy resin (FBPU-ER). The fluorine-containing bio-based epoxy resin prepared through fluorine-containing modification and toughening design has good mechanical properties, stability and self-repairing performance.

The invention relates to the technical field of biomedical materials, in particular to a microneedle patch for diabetes wound healing and a preparation method and application thereof. The microneedle patch comprises a substrate and a microneedle array arranged on the surface of the substrate, the substrate is prepared from a first raw material system comprising polyvinyl alcohol, phenylboronic acid modified oxidized hyaluronic acid, bromothymol blue and first drug micromolecules; the microneedle array is prepared from a second raw material system which comprises methylacryloylated gelatin, 2-(methylacryloyloxy) ethyl choline phosphate and platelet cell membrane wrapped MOF loaded second drug micromolecules. The microneedle patch has the characteristics of promoting angiogenesis, being excellent in antibacterial property and slow release, also has sensitive pH responsiveness and ROS responsiveness at the same time, can adjust the release dose of the medicine according to the wound surface microenvironment change (pH value change and ROS concentration change), can monitor the wound surface state in real time according to the wound surface pH value change indication, and is suitable for being popularized and used clinically.

The invention provides an electrolyte and a lithium iron manganese phosphate battery, and relates to the technical field of lithium batteries. The electrolyte comprises a lithium salt, an organic solvent and an additive, the additive is a phenylboronic acid pinacol ester compound, and the phenylboronic acid pinacol ester compound has a structure as shown in a formula I. The electrolyte provided by the invention is helpful for improving the cycling stability of the lithium manganese iron phosphate battery under a high-temperature condition.

The application belongs to the technical field of dechlorination carrier and specifically provides a preparation method of a dechlorination active carrier, which comprises the following steps: 1) polyoxyethylene-polyoxypropylene block copolymer and modified protein solution are dissolved in deionized water, then cobalt nitrate, aluminum lactate and 2-aldehyde benzene boronic acid are added and stirred uniformly, reaction is carried out at 110-130 DEG C, centrifugation and drying are carried out to obtain a precursor; 2) tetrabutylphosphonium hydroxide and sodium aluminate are added into deionized water, TEOS and the precursor are added after mixing, stirring is carried out, crystallization is carried out at 165-175 DEG C, centrifugation and washing are carried out, and the obtained solid is dried and calcined to obtain the dechlorination active carrier. The carrier prepared by the application has the advantage of good dechlorination effect.

The invention relates to a preparation method and application of dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody, and belongs to the technical field of tumors. According to the invention, the dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody is prepared, and the hydrogel is constructed on the basis of dynamic crosslinking of phenylboronic acid modified hyaluronic acid (HA-PBA) and tannic acid (TA) through a borate bond, and has excellent tissue adhesion and programmed drug release characteristics.

The invention relates to the technical field of high polymer materials, in particular to a corrosion-resistant cable sheath material and a preparation method thereof. The sheath material is prepared by taking an ethylene-octylene copolymer as a matrix and compounding functional fillers such as an aminated magnesium ion exchange A type molecular sieve, dopamine shell silicon dioxide nanoparticles and phenylboronic acid / octadecyl double-grafted silicon dioxide nanoparticles. Wherein the aminated Mg-A molecular sieve is used for efficiently capturing and fixing chloride ions through an ion-dipole effect and a hydrogen bond network; the dopamine shell layer silicon dioxide enhances the interface bonding strength through dual active groups of catechol and amido; phenylboronic acid / octadecyl double-grafted silicon dioxide constructs a dynamic boric acid ester cross-linked network and a hydrophobic barrier, and synergistic protection of crack self-healing and moisture barrier is achieved. The sheath material remarkably improves the long-term corrosion resistance and mechanical stability of the cable in a severe environment.

The invention provides a preparation method of pH / ROS double-response drug-loaded microspheres, a microneedle system and a method for optimizing the microneedle system, and belongs to the technical field of crossing of biomedical engineering and intelligent materials. The preparation method of the pH / ROS double-response drug-loading microspheres comprises the following steps: mixing chitosan, 4-hydroxyphenylboronic acid pinacol ester, polyethylene glycol diacrylate and dialdehyde polyethylene glycol, emulsifying, and carrying out chemical crosslinking, so as to obtain the pH / ROS double-response drug-loading microspheres. According to the pH / ROS dual-response drug-loading microsphere provided by the invention, targeted precise drug release of an inflammation site can be realized; the core-shell structure layered microneedle system has a shell layer-transition layer-core layer three-dimensional structure, so that sequential controlled release can be realized; according to the method for optimizing the microneedle system, reverse optimization of the preparation process can be achieved, and an individualized treatment scheme can be predicted.