The invention relates to a preparation method of a crisaborole impurity A. The preparation method comprises the following steps: S1, taking 2, 5-dihydroxybenzoic acid and p-halobenzonitrile as raw materials to react, and after the reaction is completed, separating reaction liquid to generate a crisaborole impurity II crude product; s2, purifying the crisaborole impurity I crude product by adopting liquid phase preparation to obtain a refined product; and S3, reducing the crude product of the crisaborole impurity II by using sodium borohydride, and after the reaction is completed, separating and purifying the reaction liquid to obtain the crisaborole impurity A. The preparation method has the advantages that 2, 5-dihydroxybenzoic acid and p-halobenzonitrile are used as raw materials, the raw materials react to generate a crisaborole impurity II, the crisaborole impurity II is purified and then reduced by hydroboration, and the crisaborole A is obtained, so that the preparation method is simple, and the obtained impurity A is high in purity and can be used as a standard substance for the quantitative detection process of crisaborole A; the used reagent raw materials are cheap and easy to obtain, and the crisaborole impurity II with high purity can be prepared in the synthesis route.