32 results about "Ethylparaben" patented technology

Compared with the prior art, the traditional Chinese medicine compound oral liquid is mainly used for invigorating qi and blood, regulating yin and yang, nourishing liver and kidney, strengthening spleen and stomach, strengthening muscles and bones and the like, a plurality of traditional Chinese medicine components are compounded and decocted to obtain liquid medicine, and finally specific modified polysaccharide, steviosin, sodium benzoate and ethylparaben are added, so that the traditional Chinese medicine compound oral liquid is prepared. The modified polysaccharide is screened and optimized and is added into the compound oral liquid, and the problems of serious wall hanging and high liquid medicine waste rate in the prior art are solved by reducing the low-temperature storage wall hanging rate and the hydrolysis rate in storage stability on the premise of not influencing the medicine effect and safety.

The invention relates to a plaster with large drug loading capacity and strong permeability and a preparation method thereof, belongs to the technical field of pharmaceutical preparations, and solves the problems of low drug loading capacity and poor drug transdermal efficiency of the traditional plaster. The plaster comprises the following components in parts by weight: 10-20 parts of gelatin, 5-15 parts of sodium polyacrylate, 1-3 parts of carbomer 9401 and 150-260 parts of glycerol. 0.1 to 0.5 part of a volatile oil compound and 0.2 to 0.4 part of azone; 5 to 15 parts of silicon dioxide, 0.1 to 0.5 part of ethylparaben and 3 to 5 parts of deionized water. The plaster provided by the invention is high in drug loading capacity, the drug loading capacity reaches 80% or above, the permeability is strong, and the preparation process of the plaster is stable.

The invention discloses a preparation method and application of an endothelium corneum gigeriae galli and angelica sinensis ointment, and relates to the technical field of traditional Chinese medicine, the endothelium corneum gigeriae galli and angelica sinensis ointment comprises the following raw materials in parts by weight: a medicine solution: 1-3g of angelica sinensis extract and 30-35 parts of endothelium corneum gigeriae An oil phase: 1-5 g of white vaseline, 1-5 g of glycerin monostearate, 10-14 g of stearic acid, 5-8 g of liquid paraffin and 3-6 g of wool fat; a water phase: 0.2 to 0.5 g of triethanolamine, 0.5 to 1 g of glycerin, and 0.1 to 0.5 g of ethylparaben; according to the endothelium corneum gigeriae galli and angelica sinensis ointment, endothelium corneum gigeriae galli and angelica sinensis materials are adopted, endothelium corneum gigeriae galli has the effects of healing sore, promoting tissue regeneration, removing blood stasis and the like, angelica sinensis has the effects of replenishing qi, enriching blood and promoting blood circulation to remove blood stasis, and skin wound healing and capillary regeneration can be effectively promoted, local blood circulation is improved, and inflammatory response is inhibited; meanwhile, the ointment is soft in texture and can absorb percolate and inhibit microbial infection; the method is convenient, economical, practical, good in stability and suitable for application and popularization.

This invention belongs to the field of pharmaceutical chemistry, and specifically relates to a compound antifungal cream containing the traditional Chinese medicine ingredient tryptamine ketone and its application. The invention comprises the following components, with the following percentage content: stearic acid 10%~16%, glyceryl monostearate 3%~7%, liquid paraffin 5%~9%, tryptamine 0.1%~0.01%, terbinafine hydrochloride 0.00625%~0.000625%, glycerin 4%, triethanolamine 2%~6%, ethylparaben 0.5%, and the balance being purified water or distilled water. This invention is highly effective, low in toxicity, and exhibits low drug resistance.

The invention discloses a preparation for treating psoriasis and application. The preparation is prepared from the following raw materials: propylene glycol, halcinonide, fluocinonide acetate, salicylic acid, dimethyl sulfoxide, polyethylene glycol 400, glycerol, borneol, edetate disodium, ethylparaben and ethylparaben. The traditional Chinese medicine composition is reasonable in composition, the treatment effect on psoriasis can be remarkably improved, the problem of pigmentation after treatment can be effectively improved or avoided, and particularly, due to the use of salicylic acid and edetate disodium, it is verified that the traditional Chinese medicine composition has a remarkable curative effect on psoriasis. Salicylic acid and edetate disodium have a synergistic effect on psoriasis treatment effect and pigmentation improvement of the whole medicine system.

The invention relates to the technical field of medical supplies, and particularly provides an NMN-containing circulation promoting and skin aging resisting repair patch which comprises a repair liquid and a non-woven fabric, the repairing liquid is prepared from the following raw materials in percentage by weight: 0.2 to 0.5 percent of sodium hyaluronate, 0.01 to 0.2 percent of beta-nicotinamide mononucleotide (NMN), 2 to 4 percent of glycerol, 0.5 to 1.5 percent of propylene glycol, 0.005 to 0.015 percent of ethylene diamine tetraacetic acid disodium salt, 0.015 to 0.03 percent of ethylparaben, 1 to 2 percent of sodium carboxymethyl cellulose, 0.05 to 2.0 percent of triethanolamine and the balance of purified water. The repair patch has good moisture retention, stability and oxygen permeability, and is small in irritation.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses an external liquid containing lime and alum for astringing sores and a preparation method of the external liquid. The external liquid containing lime and alum for healing sores is prepared from the following raw materials: lime, alum, water, a thickening agent, a cortex phellodendri extract, carbonized sanguisorba root powder, borneol and a pH regulator. The preparation method comprises the following steps: S1, preparing lime milk; s2, preparing an alum solution; s3, mixing reaction; s4, performing curing treatment; s5, blending; s6, refining: filtering the mixture obtained in S5, adding borneol and ethylparaben into the filtrate before filtering, and uniformly stirring to obtain the external liquid for healing sore. The external liquid containing lime and alum for healing sores can be used for treating various skin injuries such as skin ulcers, wounds, burns, eczema and postoperative wounds, and has the advantages of efficient astringency and hemostasis, antisepsis and anti-inflammation, promotion of wound healing, good system stability, comfort in use and high safety.

This invention discloses a skin cream for chapped hands and feet and its preparation process, belonging to the field of skin cream preparation technology. The skin cream is composed of ginseng leaf and stem extract, royal jelly, glycerin, octadecanol, glyceryl stearate, liquid paraffin, sodium lauryl sulfate, ethylparaben, fragrance, and purified water in a specific mass ratio. Its preparation process includes steps such as heating and melting the oil and water phases separately, emulsifying and stirring, cooling and adding active ingredients, and aging. This product, through the synergistic effect of moisturizing and active repairing ingredients, can effectively relieve dry and cracked skin, promote healing, and has the advantages of stable formula, gentle skin feel, and high safety.

The invention discloses a preparation method of panda-derived exosome gel. The preparation method comprises the following steps: step 1, culturing panda umbilical cord-derived mesenchymal stem cells by using a culture medium; 2, culturing in an air-permeable culture bottle, and then collecting cell supernate; 3, centrifuging for five times, and continuing to resuspend with the PBS buffer solution to obtain an exosome solution; and 4, adding carbomer into a proper amount of distilled water, continuously stirring, sterilizing after the carbomer is swelled into a semitransparent solution, then adding the exosome solution and triethanolamine, uniformly stirring, gradually adding the ethylparaben solution, triethanolamine and glycerol, then adding distilled water, uniformly stirring, and storing to obtain the exosome gel. The invention further provides panda-derived exosome gel and an effect of the panda-derived exosome gel in promoting wound healing of pandas. The invention provides a panda-derived new medicine which can be used for promoting wound healing of pandas and has a relatively good anti-inflammatory effect.

The invention relates to amitriptyline gel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides amitriptyline gel. The amitriptyline gel is prepared from the following components in parts by mass: 2 to 8 parts of amitriptyline hydrochloride, 16 to 24 parts of glycerol, 2 to 8 parts of hydroxypropyl methylcellulose, 16 to 24 parts of 70 to 80 percent ethanol solution, 0.05 to 0.15 part of ethylparaben, 0.2 to 0.8 part of laurocapram and 36 to 64 parts of water. The amitriptyline gel plaster prepared from the amitriptyline gel can effectively relieve postherpetic neuralgia, and compared with traditional oral tablets, the amitriptyline gel plaster can effectively reduce side effects.

The invention discloses a feed for larvae of spodoptera frugiperda and a preparation method of the feed. Comprising the following components in parts by weight: 100-200 parts of corn flour, 20-60 parts of yeast powder, 10-30 parts of agar, 3-5 parts of lecithin, 0.1-0.3 part of cholesterol, 0.5-1.5 parts of trehalose, 1-4 parts of vitamins, 2-8 parts of a bacillus cereus fermentation product, 5-10 parts of corn leaf powder, 5-10 parts of a preservative and 800-1200 parts of water. The prepared feed is used for feeding spodoptera frugiperda, the pupation rate and eclosion rate are high, the malformation rate is low, and the shelf life of the feed is long. Cholesterol and trehalose in the components of the feed are combined for use, the pupation rate and eclosion rate of the spodoptera frugiperda are increased, a bacillus cereus fermentation product and corn leaf powder are combined for use, the malformation rate is reduced, monomethyl fumarate and ethyl p-hydroxybenzoate are combined for use, the corrosion resistance of the feed is improved, and the shelf life is prolonged.

The invention relates to the technical field of medical supplies, and particularly provides a female gel composition containing NMN. The composition is prepared from the following raw materials in percentage by weight: 0.8 to 1.5 percent of carbomer (940), 0.5 to 1.5 percent of isomaltooligosacharide, 2 to 4 percent of glycerol, 0.005 to 0.02 percent of beta-nicotinamide mononucleotide (NMN), 0.001 to 0.01 percent of ethylene diamine tetraacetic acid, 0.01 to 0.03 percent of ethylparaben, 0.5 to 1 percent of propylene glycol, 0.5 to 2 percent of triethanolamine and the balance of purified water. The composition is good in moisturizing performance, safe and free of irritation.

The present invention relates to an amitriptyline spray, a preparation method thereof and an application thereof, belonging to the technical field of medicine. The amitriptyline spray of the present invention uses water as a solvent and comprises components with the following concentrations: 30-100 g / L of amitriptyline hydrochloride, 0.5-4 g / L of disodium ethylenediaminetetraacetate, 40-60 mL / L of dimethyl sulfoxide, and 5-15 mL / L of ethylparaben solution. The amitriptyline spray prepared by the present invention can relieve and treat neuropathic pain, and has the advantages of stable properties, good skin absorbability, fast analgesic speed, high analgesic strength, long-lasting analgesic effect, no toxic and side effects, and convenient use.

The invention provides a Chinese pulsatilla root oral liquid preparation and a preparation method thereof.The Chinese pulsatilla root oral liquid preparation per liter comprises 300 g of Chinese pulsatilla roots, 150 g of rhizoma coptidis, 300 g of cortex fraxini, 225 g of cortex phellodendri, 50 ml of PEG-400, 20 g of xanthan gum, 20 g of hydrophilic colloidal silicon dioxide, 5 g of neotame, 1.5 g of ethylparaben and the balance auxiliary materials. The palatability is better, and the clinical effect is obviously improved compared with that of other similar products.

This application relates to the technical field of daily cosmetics, specifically disclosing a hair-repairing and conditioning wheat composition, a cosmetic containing the composition, and a preparation method thereof. The hair-repairing and conditioning composition comprises the following components in parts by weight: 0.003-0.006 parts of a mixture of hydrolyzed wheat protein / phenoxyethanol / methylparaben / ethylparaben / ethylhexylglycerin / propylene glycol / water; 0.03-0.05 parts of a mixture of wheat germ oil glycerides / glyceryl stearate; and 2.4-2.6 parts of a mixture of cationic surfactant / ethanol. The wheat germ oil glycerides selected in this application are rich in linoleic acid and vitamin E, exhibiting a stronger affinity for cationic surfactants, enabling the formation of a stable "cationic-oil complex" for efficient deposition. Simultaneously, the wheat germ oil glycerides are homologous to hydrolyzed wheat protein, forming a synergistic repair mechanism of first penetrating and filling, then sealing and locking in moisture, thus improving the hair-repairing and conditioning effect.

The present invention discloses a triamcinolone acetonide and econazole nitrate cream, which comprises an aqueous phase and an oil phase. The aqueous phase matrix is one or more of polyoxyethylene castor oil, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene oleyl alcohol, polyoxyethylene fatty alcohol, and polyoxyethylene methyl stearate; the oil phase matrix is one or more of isooctyl palmitate, isooctyl stearate, isopropyl palmitate, and dimethyl polysiloxane; it also contains an antibacterial agent, which is one or more of methylparaben and ethylparaben. The present invention also discloses a preparation method thereof. Experimental studies have proved that the quality of the present invention is stable.

This invention, entitled "A Method for Preparing an Antiepileptic Carbon Dot Suspension," belongs to the field of pharmaceutical technology. It relates to a method for preparing a nanoparticle suspension and provides a carbon dot suspension for treating epilepsy. The raw materials and excipients of the suspension include: carbon dots from human hair, stabilizers, flavoring agents, and preservatives. The suspension of this invention exhibits stable properties, simple excipient composition and preparation process, and excellent taste. The most preferred formulation is: 5g of carbon dots from human hair, 0.125% CMC-Na, 0.05% ethylparaben, and 2.5% sucrose.

The invention discloses a chemical detection method for oculent.The chemical detection method relates to the technical field of chemical analysis, the oculentcomprises ganciclovir, yellow vaseline, lanolin, liquid paraffin, white vaseline, glycerin, ethylparaben and vitamin E. The method comprises the following steps that (a) the content of ganciclovir in the oculent.The content of ganciclovir in the oculent.The content of ganciclovir in the oculentis is measured through a high performance liquid chromatography; (b) carrying out quality control on the lanolin raw material, namely measuring an acid value, a saponification value and a peroxide value; (c) carrying out wool fat related quality monitoring on the oculentum finished product, wherein the wool fat related quality monitoring comprises determination of a peroxide value; according to the method, chromatographic conditions are optimized, an exclusive impurity detection method is established, and raw materials are associated with finished product detection, so that the quality control problem of ganciclovir oculentum is solved.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to lamiophlomis rotata gel and application thereof. The lamiophlomis rotata gel is an external preparation prepared from the following raw and auxiliary materials in parts by weight: 1.25 to 5 parts of lamiophlomis rotata extract, 0.5 to 1 part of carbomer 940, 0.01 to 0.05 part of ethylparaben, 0.5 to 1 part of triethanolamine, 1 to 2 parts of glycerol and 1.5 to 2 parts of 1, 2-propylene glycol. The curative effect of the lamiophlomis rotata gel is equivalent to that of the lamiophlomis rotata extract with the same dosage when the lamiophlomis rotata gel is used for repairing acute wounds; however, when the composition is used for repairing infectious wounds, the curative effect of the composition is obviously superior to that of the same dosage of lamiophlomis rotata extract, and is also superior to that of fusidic acid cream and compound cortex phellodendri liquid which are commonly used clinically at present, so that the composition has practical popularization and application values.

The invention discloses a litsea cubeba essential oil oral spray and a preparation method, and relates to the technical field of oral sprays.The litsea cubeba essential oil oral spray is characterized by being prepared from, by mass volume, 1-2% of litsea cubeba essential oil, 7.5-12.5% of xylitol, 2-3% of Tween-80, 0.3% of ethylparaben and the balance water. The prepared oral spray is clear and transparent in appearance, fresh and fragrant in smell, mild and comfortable in taste, capable of effectively caring oral health and wide in market prospect.

The invention discloses atomized eye liquid for treating diabetic retinopathy as well as a preparation method and a use method thereof, and aims at solving the problem that medicines are externally applied to eyes of a patient, quickly relieving blurred vision and dry and uncomfortable eyes and achieving the treatment purposes of clearing heat, activating blood, improving eyesight and removing nebula. The traditional Chinese medicine formula comprises 0.5 to 1.5 Kg of pipewort, 0.9 to 1.5 Kg of semen celosiae and 1 to 2 Kg of red sage root. The preparation method comprises the following steps: step 1, primary water extraction; step 2, secondary water extraction; and step 3, combining extracting solutions, filtering and concentrating the extracting solutions. And step 4, combining the extracting solutions, adding ethylparaben, boiling, and filtering to obtain atomized liquid. The use method comprises the following steps: atomizing or boiling atomized liquid oxygen, and fumigating and washing eyes. The traditional Chinese medicine has the beneficial effects that the treatment effect on a large number of 60-70-year-old patients proves that the vision blurring is relieved, the eye dryness symptom is improved, the microhemangioma exudation area is reduced, the vision is lightly recovered, and the OSDI dry eye score is obviously reduced.

The invention provides a method for determining the content of ethylparaben in urea vitamin E cream. According to the method, HPLC (High Performance Liquid Chromatography) is adopted to detect a test solution, a chromatographic column takes octadecylsilane chemically bonded silica as a filling agent, a solution of acetonitrile and 0.5% acetic acid in a volume ratio of (18: 82)-(30: 70) is taken as a mobile phase, and good separation of an ethylparaben peak, an auxiliary material peak and vitamin E can be realized. The determination method disclosed by the invention is high in accuracy, good in precision, strong in specificity and good in stability.

This invention belongs to the field of pharmaceutical preparations, and particularly relates to a dimethicone emulsion and its preparation method. The preparation method provided by this invention includes the following steps: a) grinding and mixing dimethicone and silica at 100-140°C to obtain an oil phase mixture; b) mixing sodium saccharin, ethylparaben, and water, and then mixing with sodium carboxymethyl cellulose to obtain an aqueous phase mixture; c) mixing the oil phase mixture, polysorbate 80, and sorbitan oleate, and then mixing with a portion of the aqueous phase mixture, followed by homogenization to obtain a primary emulsion; d) mixing the remaining aqueous phase mixture, an ethanol solution of butylated hydroxytoluene, and a fragrance, and then mixing with the primary emulsion, finally adding water to make up to a fixed volume and mixing to obtain the dimethicone emulsion. The preparation method provided by this invention has a short production cycle and high production efficiency, and the resulting dimethicone emulsion product has excellent defoaming ability and quality stability.

The invention discloses a preparation method and a quality detection method of a Jianer food retention removing patch, and belongs to the technical field of traditional Chinese medicine preparations, the preparation method comprises the following steps: crushing clove and pepper accounting for about 1 / 3 of the total amount of pepper into finest powder, and mixing to obtain a fine powder mixture; crushing fructus gardeniae, semen armeniacae amarae and the remaining pepper into coarsest powder, cutting fresh fistular onion stalks into sections, and mixing the sections with the coarsest powder to obtain a coarse powder mixture; carrying out reflux extraction on the coarse powder mixture by using 90% ethanol, and combining filtrates; recovering ethanol in the filtrate, and concentrating to obtain clear paste with the relative density of 1.16-1.20; and adding ethylparaben into the clear paste, uniformly stirring, adding the fine powder mixture, and uniformly stirring again to prepare the lozenge with specified weight. According to the invention, a preparation process and a quality control method are combined to form a complete technical scheme, so that the problem of unstable product quality possibly existing in the prior art is solved, and a product with more reliable curative effect and higher safety is provided for clinic.

The present invention discloses a method for extracting and separating vitex compounds and their applications. The extraction and separation method includes: (1) crude extraction and separation of medicinal materials: refluxing and extracting the crude powder of medicinal materials with ethanol, and extracting with petroleum ether, dichloromethane, ethyl acetate, and n-butanol; (2) separation and purification of the dichloromethane fraction; (3) separation and purification of the ethyl acetate fraction; (4) fine separation and purification of the active fraction: separating and purifying the extract of the active fraction by methods such as column chromatography, semi-preparative liquid phase, and recrystallization to finally obtain the compounds vitexdoin A and ethylparaben. The two compounds have significant inhibitory effects on Escherichia coli, Staphylococcus aureus, and Candida albicans, and are potential antifungal drugs and potential antibacterial drugs, providing a scientific basis for the further development and utilization of vitex resources.

The invention provides a preparation method of a veterinary drug preparation for clearing away heat and toxic materials and a drug composition. Wherein each liter of the liquid preparation contains 150g of radix rehmanniae, 200g of fructus gardeniae, 200g of radix scutellariae, 200g of herba violae, 150g of radix scrophulariae, 200g of radix isatidis, 100g of liquorice root, 50g of taurine, 50g of vitamin C, 50g of bile acid, 50g of PEG-400, 50g of Tween-80 or span-80, 50g of alcohol, 2.5 g of sodium benzoate and 1.5 g of ethylparaben. Compared with other similar products, the veterinary drug preparation prepared by the method has the advantages that the clinical effect is obviously improved, and the cost is low.

To provide a grape sap which can stably be formulated in cosmetics and quasi-drugs by a prescription for suppressing the amount of a preservative to the minimum unlike a combination of an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol with a preservative, and to provide cosmetics and quasi-drugs formulated with the grape sap.SOLUTION: Without using an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol, the preservability of the grape sap can be enhanced by the baked powder of the scallop and the plant extract having the antiseptic auxiliary action, and the grape sap can further stably be formulated with cosmetics and quasi-drugs.SELECTED DRAWING: None

The invention discloses an enzyme response hydrogel for treating inflammatory bowel disease as well as a preparation method and application thereof, and the enzyme response hydrogel comprises the following components in percentage by weight: 13-18% of an effective part of pediatric stolonifera, 75-85% of an enzyme response gel matrix, 0.5-1% of purified water, 2-4% of a transdermal absorption enhancer, 0.5-1% of a solubilizer and 0-0.1% of a preservative. The enzyme response gel matrix is tripolyglycerol monostearate, the transdermal absorption enhancer is at least one of azone, oleic acid and propylene glycol, the solubilizer is at least one of tween-80, propylene glycol, polyethylene glycol and span, and the preservative is at least one of ethylparaben, phenoxyethanol and hexanediol. The enzyme response hydrogel prepared by the invention can release drugs in the presence of a specific enzyme, and due to the characteristic, the enzyme response hydrogel can act on diseased regions more accurately in treatment of inflammatory bowel diseases, so that the side effects of the whole body are reduced, and the safety and effectiveness of treatment are improved.

The invention provides amitriptyline hydrochloride emulsifiable paste as well as a preparation method and application thereof, and belongs to the technical field of medicines. The amitriptyline hydrochloride emulsion is prepared from the following components in parts by mass: 3 to 8 parts of amitriptyline hydrochloride, 5 to 10 parts of glycerol, 3 to 8 parts of octadecanol, 3 to 8 parts of hexadecanol, 0.5 to 2 parts of ethylparaben, 2 to 5 parts of white vaseline, 0.5 to 2 parts of lauryl sodium sulfate, 12 to 20 parts of dimeticone, 0.5 to 2 parts of laurocapram, 1 to 5 parts of OP-10 and 40 to 67.5 parts of water. When a neuropathic pain model mouse is smeared with the amitriptyline hydrochloride emulsifiable paste, the symptom of the neuropathic pain of the mouse can be improved, the amitriptyline hydrochloride emulsifiable paste can quickly play a role in easing pain, and repair of injured nerves can be promoted through long-term administration.

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis and ointment thereof, and belongs to the technical field of traditional Chinese medicine preparations. The ointment comprises a traditional Chinese medicine composition and auxiliary materials, wherein the traditional Chinese medicine composition consists of divaricate saposhnikovia root, ligusticum wallichii, fried cocklebur fruit, biond magnolia flower, radix angelicae, menthol and borneol; the auxiliary materials comprise PEG400 (polyethylene glycol 400), PEG4000 (polyethylene glycol 4000), vaseline, azone, dithiothreitol, violet leaf alcohol, propyl gallate and ethylparaben. The invention further provides a preparation method of the ointment. The preparation method comprises the steps of traditional Chinese medicine extraction and ointment preparation. The traditional Chinese medicine composition is simple in formula and has the synergistic effects of expelling wind, removing cold, opening orifices and relieving pain; through matching of specific auxiliary materials, the ointment can promote transdermal absorption of drugs, can effectively improve symptoms such as nasal obstruction, rhinocnesmus, sneezing and clear nasal discharge of allergic rhinitis patients, and has good clinical application value.