9 results about "Postherpetic neuralgia" patented technology

The invention relates to the technical field of traditional Chinese medicine, in particular to an oral traditional Chinese medicine composition and an external traditional Chinese medicine composition for treating postherpetic neuralgia, a preparation method and a combined medication method. The oral traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of scutellaria baicalensis, 3-9 parts of rheum officinale, 9-15 parts of rhizoma anemarrhenae, 12-18 parts of lalang grass rhizome, 9-15 parts of asparagus cochinchinensis, 9-15 parts of honeysuckle, 12-18 parts of rhizoma phragmitis, 9-15 parts of burdock, 6-12 parts of cicada slough, 6-12 parts of gastrodia elata, 6-12 parts of moutan bark, 12-18 parts of kudzu vine root, 12-18 parts of dried rehmannia root and 12-18 parts of tortoise shell. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of gypsum, 10-20 parts of gypsum rubrum, 0.1-0.3 part of borneol, 4-8 parts of mint, 3-7 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni and 1-3 parts of indigo naturalis. The traditional Chinese medicine composition achieves the aims of quickly and thoroughly relieving pain and regulating and improving the whole body.

This invention belongs to the field of biomedical technology, specifically relating to an ointment and its application. The toad oil used in this invention differs significantly in composition from toad venom, and its ointment is effective for various acute and chronic pain conditions. Animal experiments have confirmed that the toad oil ointment significantly reduces the frequency and delays the onset of acetic acid-induced writhing responses, demonstrating a clear analgesic effect. Clinical studies have shown that this ointment is rapidly effective and has a definite therapeutic effect on acute gout attacks, postherpetic neuralgia, and arthritis-related pain and swelling. The formulation effectively improves drug retention and user comfort, and no skin irritation has been observed. This development achieves comprehensive utilization of toad resources, providing an example for the sustainable development of traditional Chinese medicine and the efficient utilization of biological resources.

This invention provides the application of deoxycholic acid in the treatment of postherpetic neuralgia. This invention is the first to discover that deoxycholic acid is effective in treating postherpetic neuralgia, and that inhibiting the nucleus tractus solitarius-paraventricular nucleus circuit of the thalamus is also effective in treating postherpetic neuralgia. A synergistic therapeutic effect was achieved when deoxycholic acid was combined with an inhibitor of the nucleus tractus solitarius-paraventricular nucleus circuit. This invention provides a new strategy for the treatment of postherpetic neuralgia.

This invention relates to the field of assistive devices for shingles, and more particularly to a hot compress device for relieving postherpetic neuralgia, comprising: a hot compress component. Specifically, the hot compress component includes a heat insulation layer and a covering layer. The covering layer is connected to and separated from the heat insulation layer to form a liquid cavity. The surface of the heat insulation layer has several mounting grooves communicating with the liquid cavity. A phase change heat storage component is embedded inside the mounting grooves. The surface of the covering layer has a water inlet communicating with the liquid cavity. This invention uses a phase change heat storage component to store the heat of hot water injected into the liquid cavity, forming thermal radiation, thereby creating a hot compress effect on the human body surface. Unlike traditional chemical heating and ordinary hot towels or hot water bottles, the phase change heat storage component can maintain the temperature at a relatively mild state and retain heat for a longer period. It provides a good hot compress effect and has the function of long-term use and multiple reuses.

This invention discloses a magnetic nanoprobe and kit for assessing postherpetic neuralgia. The magnetic nanoprobe is a complex formed by thiolized carbonized polymer dots, a chelating agent, superparamagnetic molecules, and 2-phospho-D-glyceric acid. 2-phospho-D-glyceric acid specifically reacts with NSE, dehydrating to generate phosphoenolpyruvate and releasing water molecules. The magnetic nanoprobe is specific for NSE and can be used for assessing postherpetic neuralgia. The kit includes the magnetic nanoprobe and instructions, and can determine the NSE marker content in a single sample, with a detection limit better than 1 pg / mL, thereby achieving effective assessment of postherpetic neuralgia.

This disclosure describes a cannabinoid-based nanoplatform for treating shingles, designed to enhance bioavailability and controlled release of active ingredients. The composition includes cannabinoids like cannabidiol (CBD) and cannabigerol (CBG), alongside flavonoids, polyphenols, and alkaloids, in oral and topical formulations. The oral capsule combines cannabinoids with polyphenols and flavonoids to provide systemic anti-inflammatory, antiviral, and neuroprotective effects, particularly for nerve pain and inflammation, including postherpetic neuralgia. The topical cream includes cannabinoids, capsaicin, and aloe vera, offering localized relief from pain, itching, and rash. The method targets both systemic and localized symptoms during the acute phase of shingles, aiming to inhibit varicella-zoster virus replication, disrupt viral assembly, and prevent viral release, while also providing immune modulation and anti-inflammatory benefits. The nanoplatform uses nano-emulsification techniques, producing particles smaller than 200 nm to ensure optimal delivery and therapeutic efficacy, offering comprehensive relief for shingles symptoms.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological conditions including grade IV glioblastoma, grade 3 glioma, embryonal tumor, pituitary tumor, meningioma, hemangiopericytoma, hemangioblastoma, mesothelioma, cholangiocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urinary tract cancer, bladder adenocarcinoma, and esophageal cancer, as well as for use in the treatment of peripheral diabetic neuropathy, spinal cord injury, postherpetic neuralgia, chemotherapeutic agents, antitumor agents, cancer, fibromyalgia, or neuropathic pain caused by hepatitis. The present invention also relates to pharmaceutical compositions comprising 2-hydroxy-octadecene-9-cis-oate.

The invention discloses a traditional Chinese medicine formula for treating herpes zoster sequelae, and belongs to the technical field of traditional Chinese medicine formulas for herpes zoster, the traditional Chinese medicine formula comprises the following raw materials by weight: 47-52 parts of phellodendron, 47-52 parts of rheum officinale, 47-52 parts of goldthread root, 47-52 parts of white spirit, 47-52 parts of galactophyllite, 47-52 parts of talc, 47-52 parts of pseudosciaena crocea, 3-8 parts of borneol, 47-52 parts of gypsum rubrum, and 3-8 parts of mirabilite. According to the traditional Chinese medicine composition, the cortex phellodendri, the radix et rhizoma rhei, the rhizoma coptidis, the alumen, the galactophyllite, the talc, the pseudosciaena crocea, the gypsum rubrum and the like which are used for clearing away heat and toxic materials, eliminating dampness and healing sores are used as main materials, and the borneol and the mirabilite are used as auxiliary materials for enhancing the effects of relieving swelling and pain and transdermal absorption; the traditional Chinese medicine composition is especially suitable for symptoms such as postherpetic neuralgia and skin scorching hot stabbing pain, and is high in pertinence and remarkable in curative effect.

This invention relates to the field of biomedical technology, specifically to the role, implementation method, and application of a Prmt6 inhibitor for the prevention and treatment of postherpetic neuralgia. This invention reveals a novel function of Prmt6 and its coding sequence: inhibiting the body's antiviral immune response to herpesviruses during the pathological process of herpes zoster. Targeting and inhibiting the expression and function of Prmt6 can effectively prevent and treat pain abnormalities in postherpetic neuralgia, improving patients' quality of life.