7 results about "Acute gout" patented technology

This invention discloses a natural plant extract anti-gout product, its preparation method, and its application. The natural plant extract anti-gout product comprises the following raw material components in parts by weight: acerola cherry powder: 10-30 parts, bellflower powder: 10-30 parts, celery seed powder: 10-30 parts, peppermint leaf extract: 1-10 parts, and vitamin C: 3-15 parts. The peppermint leaf extract is concentrated at a ratio of 10:1 to 20:1 and prepared using a low-temperature extraction process. Its efficacy is clear and comprehensive: breaking through the limitations of existing single-component supplements, it constructs a three-dimensional efficacy system of "uric acid regulation - anti-inflammatory and analgesic - blood pressure auxiliary regulation." The components work synergistically to quickly relieve acute gout pain, balance blood uric acid levels in the long term, and assist in regulating blood pressure, meeting the dual needs of people with gout and hypertension. This solves the problems of limited efficacy and insufficient consideration of comorbidities in existing technologies.

The invention discloses a traditional Chinese medicine composition for treating acute gout, an external gel and a preparation method thereof, and the traditional Chinese medicine composition comprises the following raw material components in parts by mass: 5-20 parts of radix clematidis, 5-20 parts of polygonum cuspidatum, 5-20 parts of honeysuckle stem, 5-15 parts of radix aconiti preparata, 5-15 parts of pine nodular branch, 1-5 parts of corydalis tuber and 1-3 parts of asarum. The gel disclosed by the invention is an external gel prepared by researching through a traditional Chinese medicine composition intermediate extraction process and a preparation forming process, has the effective effects of directly reaching an affected part, taking effect quickly, being good in patient compliance and the like, and can realize industrial production through pilot scale-up experiment verification. Animal experiment research results show that the radix clematidis pain-relieving gel has remarkable anti-inflammatory and pain-relieving effects.

The invention belongs to the technical field of pharmaceutical preparations, particularly discloses a colchicine and lidocaine eutectic mixture as well as a preparation method and application thereof, and aims to solve the problems that colchicine is poor in transdermal effect, large in gastrointestinal tract side effect after oral administration and insufficient to meet the anti-inflammatory and analgesic requirements of acute gout in time. According to the invention, colchicine and lidocaine are mixed according to a molar ratio of 0.1: 0.9-0.9: 0.1 to prepare a eutectic mixture with a melting point of 46.1-64.7 DEG C through a solvent-assisted grinding method, and the eutectic mixture is also prepared into an external pharmaceutical composition. The solubility and transdermal effect of the mixture are remarkably improved, colchicine and lidocaine can be locally and efficiently delivered to lesion joints, the complementary and synergistic effects of the two drugs on anti-inflammatory and analgesic mechanisms are fully played, meanwhile, the gastrointestinal toxic and side effects of oral administration are avoided, the safety is good, the skin tolerance is good, and the application prospect is wide. The medicine is suitable for treating acute gouty arthritis.

This invention belongs to the field of biomedical technology, specifically relating to an ointment and its application. The toad oil used in this invention differs significantly in composition from toad venom, and its ointment is effective for various acute and chronic pain conditions. Animal experiments have confirmed that the toad oil ointment significantly reduces the frequency and delays the onset of acetic acid-induced writhing responses, demonstrating a clear analgesic effect. Clinical studies have shown that this ointment is rapidly effective and has a definite therapeutic effect on acute gout attacks, postherpetic neuralgia, and arthritis-related pain and swelling. The formulation effectively improves drug retention and user comfort, and no skin irritation has been observed. This development achieves comprehensive utilization of toad resources, providing an example for the sustainable development of traditional Chinese medicine and the efficient utilization of biological resources.

The application provides a chlorogenic acid amide derivative, a preparation method and application thereof. The chlorogenic acid amide derivative has a structure shown in general formula I, the active carboxylic acid part in the chlorogenic acid structure is chemically modified, different alkyl / aromatic amine groups and the like are connected, and the anti-inflammatory activity of the chlorogenic acid derivative is enhanced. Meanwhile, in order to improve the fat solubility of the chlorogenic acid derivative, the phenolic hydroxyl and alcoholic hydroxyl parts and the like in the structure are protected by etherification or acylation, and the fat solubility of the chlorogenic acid derivative is improved. The chlorogenic acid amide derivative has good anti-inflammatory activity in an acute inflammatory cell model in vitro and an acute gout rat model, and is an anti-inflammatory preparation with good development potential. The synthesis method of the chlorogenic acid amide derivative is simple and efficient, and compared with original drugs, has the characteristics of increasing fat solubility and stability, improving absorption performance, improving drug efficacy and reducing toxicity and the like.

The invention aims at providing an acute gouty arthritis diagnosis and treatment preparation based on natural antioxidants and a preparation method and application thereof, and belongs to the technical field of nano biomedical materials.The acute gouty arthritis diagnosis and treatment preparation is self-assembled with spheroidic tea polyphenol and acidified rutin as sources and comprises a polyphenol hydroxyl structure of the natural antioxidants, and the natural antioxidants are added into the polyphenol hydroxyl structure of the natural antioxidants; the nano-probe is formed by coating maleoyl bovine serum albumin (MBSA) and then coupling a NOX2 antibody through an antibody drug coupling technology, and the nano-probe with integrated diagnosis and treatment of acute gouty arthritis is constructed. The nano probe can be used for positioning an acute gouty arthritis part in real time under the guidance of near-infrared region imaging; the probe can directionally remove macrophages and microenvironment high-expression reactive oxygen species (ROS), and the preparation method of the probe is simple and easy to implement.

The invention relates to the technical field of traditional Chinese medicine compound preparations, and discloses a pharmaceutical composition and application thereof in preparation of drugs for preventing and treating hyperuricemia and gout, the pharmaceutical composition takes gentiana macrophylla as a monarch material, and focuses on expelling wind-damp, clearing damp-heat, relieving arthralgia, inhibiting uric acid generation, and promoting kidney excretion to reduce blood uric acid. Gastrodia elata and radix cyathulae serve as ministerial drugs, and gastrodia elata dispels wind, dredges collaterals The radix cyathulae has the effects of easing joint movement, guiding the medicine to move downwards and inducing And the raw lalang grass rhizome is used for reducing fever and causing diuresis, and guiding turbidity to go out. Ligusticum wallichii is used as a guide to activate blood and qi, dispel wind and relieve pain. Through targeted adjustment of the ratio of the raw materials and scientific compatibility, the effects of reducing the level of serum uric acid, remarkably improving the activity of liver uricase, synchronously improving renal function indexes, relieving hepatic and nephropathy damage, resisting acute gout and the like are achieved, and the medicine effect is remarkable.