83 results about "Acute gouty arthritis" patented technology

A URAT1 activity inhibitor containing a nitrogen-containing fused ring compound represented by the following formula [1]:

wherein each symbol is as defined in the description. The present invention is useful for the prophylaxis or treatment of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like.

[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like.

[Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained.

wherein each symbol is as defined in the description.

Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like.

A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient:

wherein each symbol is as defined in the specification.

The invention relates to the field of a drug formula, in particular to composite traditional Chinese medical decoction for treatment of acute gouty arthritis, which consists of angelica polyclada, radix angelicae pubescentis, radices sileris, fried rhizoma atractylodis, ligusticum wallichii, mulberry twig, asarum, Tuckahoe, pawpaw, jujube paste, angelica sinensis, cassia twig, raw licorice, radix clematidis, macrophylla, stephania terandra, semen coicis, rhizoma corydalis, prepared olibanum, prepared myrrh and cinnamon. The cost is low, the efficacy is high, no toxic or side effects can be caused, the decoction has anti-inflammatory and analgesic effects and functions of invigorating qi and blood, eliminating dampness and dredging channels, the total efficiency is 95 percent, the curing rate is 80 percent, the improvement rate is 15 percent, and the rate of ineffectiveness is 5 percent.

The invention discloses a medicine for treating gouty arthritis and hyperuricemia. The medicine is prepared by the following bulk drugs by weight percentage: 10 to 60 parts of gypsum, 5 to 20 parts of anemarrhena, 10 to 40 parts of Japanese honeysuckle stem, 10 to 40 parts of plantago, 15 to 40 parts of Smilax glabra, 5 to 20 parts of radix paeoniae rubrathe, 3 to 15 parts of licorice, 1 to 15 parts of scorpion and 5 to 60 parts of coix seeds. The medicine provided in the invention has obvious therapeutical effects on gouty arthritis and hyperuricemia and no toxic and side effects, and is safe and effective. The invention also discloses the preparation method for granules of the medicine, and the granules have the characteristics of convenient administration, good mouthfeel and rapid effect.

Traditional Chinese medicine composition for treating acute gouty arthritis. The traditional Chinese medicine composition is prepared from Artemisia eriopoda, Passiflora wilsonii Hemsl., stephania, root of bidentate achyranthes, radix clematidis, Radix Celastri Orbiculati, Platycodon grandiflorum, folium orthosiphoni, honeysuckle stem, coix seed, pawpaw and horseradish.

The invention relates to the technical field of molecular biology, and in particular relates to a recombinant protein, a protein compound containing the recombinant protein and application. The recombinant protein disclosed by the invention is composed of a human interleukin 1 receptor antagonist protein and a protein containing a VPGKG repetitive unit, can be used for adjuvant therapy of rheumatoid arthritis, acute gouty arthritis and other rheumatic immune diseases, hereditary diseases and tumours with increased interleukin 1 (interleukin, IL-1), and has a remarkable curative effect.

A Chinese medicine for treating acute gouty arthritis is prepared from 6 Chinese-medicinal materials including coptis root, scutellaria root, rhubarb, China root, etc through extracting in water and/or alcohol, concentrating and preparing any form.

The invention discloses a traditional Chinese medicine composition for treating acute gouty arthritis and a preparation method and application thereof; the traditional Chinese medicine composition is made from, by weight, 15-25 parts of Rhizoma Atractylodis, 10-20 parts of Cortex Phellodendri, 15-25 parts of Radix Achyranthis Bidentatae, 25-35 parts of Semen Coicis, 25-35 parts of Rhizoma Smilacis Glabrae, 15-25 parts of Rhizoma Dioscoreae Colletii, 5-15 parts of Lumbricus, 5-15 parts of Eupolyphaga seu Steleophaga, 25-35 parts of Radix Clematidis, 10-20 parts of Rhizoma Alismatis, 10-20 parts of Herba Lycopi, 10-20 parts of Radix Paeoniae Rubra, 5-15 parts of Semen Persicae, 10-20 parts of Radix Gentianae Macrophyllae, 15-25 parts of Radix Salviae Miltiorrhizae, 15-25 parts of Herba Plantaginis, 10-20 parts of Fructus Forsythiae, 5-15 parts of Rhizoma Acori Graminei, 15-25 parts of Rhizoma Atractylodis Macrocephalae, and 15-25 parts of Poria, 25-35 parts of Rhizoma Corydalis, and 4-10 parts of Scorpio. Scientific compatibility is made based on traditional syndrome differentiation in traditional Chinese medicine in conjunction with clinical practice, optimal doses of Chinese herbs are determined by repeated experiments, and the traditional Chinese medicine composition is significantly effective in treating acute gouty arthritis.

The invention discloses external applied heat-reducing medicinal liquor, which is prepared by soaking 10 to 40 grams of jasmine, 5 to 30 grams of scutellaria baicalensis, 3 to 10 grams of as arum, 1 to 6 grams of menthol and 1 to 6 grams of borneol in white liquor or alcohol. The external applied heat-reducing medicinal liquor has the effects of clearing heat, detoxifying, cooling blood, relieving restlessness and relieving cough and pain, and has functions of clearing heat, resisting inflammation, resisting viruses, relieving pain and itching and relieving allergy and can be used for treating heat and fever caused by various of reasons, particularly heat, fever, cough and headache caused by infection of the upper respiratory tract, pneumonia, cold, sphagitis, tonsillitis, mumps and acutebronchitis. The external applied heat-reducing medicinal liquor also can be used for treating protopathy and is particularly suitable for treating high fever and convulsion in infants, children. The external applied heat-reducing medicinal liquor can increase immunity and resistance. The external applied heat-reducing medicinal liquor also can be used for treating closed soft tissue injury, acutemastitis, acute gouty arthritis, herpes zoster and burn and scalding. The external applied heat-reducing medicinal liquor can be accepted easily and address both the symptoms and root causes, and is convenient to use and quick in effectiveness.

The invention relates to a medicine for resisting acute gouty arthritis and a preparation method and application thereof. The effective components of the medicine are a lagotis brachystachya total extract extractum and a lagotis brachystachya polar part extractum, wherein the medicine is dried whole herb of a scrophulariaceae plant Lagotid brachystachya Maxim. The preparation process of the lagotis brachystachya polar part extractum comprises the following steps: carrying out ethanol heating reflux extraction on lagotis brachystachya herb, and carrying out vacuum concentration to obtain the lagotis brachystachya total extract extractum; and adsorbing the lagotis brachystachya total extract extractum through macroporous adsorption resin column D101 chromatography, then carrying out gradientelution with distilled water and ethanol with different volume fractions, performing collecting to obtain corresponding eluent, and carrying out reduced-pressure recovery to obtain the lagotis brachystachya polar part lagotis brachystachya. The medicine for resisting acute gouty arthritis provided by the invention can well treat gouty arthritis and has a wide application prospect.

The invention discloses an extract of the effective fractions of two Chinese herbal medicines (smilax macrophylla Ver. and smilax trinervula Miq.) in smilax for treatment of acute gouty arthritis, and extraction methods thereof. The extract of effective fractions are prepared by the following methods of: crushing the smilax macrophylla Ver. or the smilax trinervula Miq., extracting by decocting in water, collecting the water decoction, and filtering to obtain the extract; or crushing the smilax macrophylla Ver. or the smilax trinervula Miq., extracting by using 10-90% ethanol, collecting the ethanol extract, and recovery the ethanol to obtain the extract. The effective fractions not only can release the inflammation response of redness, swelling, heat, and aching of joints in acute phase, but also can reduce the uric acid level in blood aiming at the pathogenesis; and because the effective fractions has the effect of simultaneous treatment of principal and subordinate symptoms of gout, safe and reliable medicines with good curative effect for treatment of acute gouty arthritis can be prepared by using the effective fractions. The extraction technology for the effective fractions of the invention is simple, safe, easy to operate and low in cost, without the need of high temperature, high pressure or special equipment.

The invention provides an application of salidroside in preparation of a medicine for resisting gouty arthritis, and particularly relates to prevention and curing functions of salidroside on acute gouty arthritis. The salidroside has the benefits as follows: the salidroside has prevention and curing functions on gouty arthritis, especially acute gouty arthritis. The animal experiment proves that sodium urate induced acute gouty arthritis can really be relieved by the salidroside. Therefore, when the salidroside is applied to preparation of the medicine for resisting gouty arthritis, one natural or natural-like medicine can be provided for treatment of gouty arthritis, and adverse effects caused by the medicine for treating gouty arthritis are reduced.

The invention belongs to the technical field of pharmacy, and in particular relates to novel application of (2E,6E)-2-(3,5-dimethoxy phenylidene)-6-(4-chlorphenyl methylene)cyclohexanone and a derivative thereof. With a moderate/high dose, the (2E,6E)-2-(3,5-dimethoxy phenylidene)-6-(4-chlorphenyl methylene)cyclohexanone and the derivative thereof provided by the invention can remarkably reduce the acute gouty arthritis mouse ankle joint swelling degree and the serum uric acid level, meanwhile have very good NLRP3 and TLR4 dual inhibition activity, have effects better than that of a positive control dexamethasone, can be used for preparing medicines for treating hyperuricemia or acute gouty arthritis, and is small in side effect and high in safety.

The invention discloses external-application traditional Chinese medicine powder for treating acute gouty arthritis and a preparation method of the external-application traditional Chinese medicine powder, belonging to the technical field of traditional Chinese medicines. The external-application traditional Chinese medicine powder contains the following 26 traditional Chinese medicines: chinese redbud bark, negundo chastetree fruit, angelica, radix paeoniae rubra, radix cyathulae, zedoary, cortex acanthopanacis, pawpaw, notopterygium root, radix angelicae tuhuo,radix angelicae dahuricae, radix clematidis, radix saposhnikoviae, radix stephaniae tetrandrae, radices trichosanthis, rhizoma chuanxiong, radix gentianae macrophyllae, fructus forsythia, liquorice, poisonvine, achyranthes aspera, rhizoma smilacis glabrae, caulis spatholobi, rhizoma polygoni cuspidate, cacumen platycladi and radix sophorae flavescentis. The invention also discloses a preparation method and a use method of the external-application traditional Chinese medicine powder. The external-application traditional Chinese medicine powder takes multiple traditional Chinese medicines as raw materials, has the efficacies of clearing away heat, removing dampness, promoting blood circulation, removing blood stasis, relieving swelling and pain, setting fracture and benefiting joints, is mainly used for treating thermal arthritis mainly presenting red, swelling, heat and pain, particularly the acute gouty arthritis, and can be further used for treating purplish swelling and pain caused by the injury of bones and muscles as well as old trauma.

The invention relates to a composition with an anti-gout effect and a preparation method and application thereof, and belongs to the technical field of natural active products. The active ingredient of the composition is prepared from, by weight, 1-2 parts of edible amaranth, 1-2 parts of frankincense, 1-2 parts of myrrh and 1-2 parts of safflower. According to the composition, edible amaranth has the effects of easing and relieving pain, achieving astringing, clearing away heat and toxic materials and dispelling wind-evil, frankincense has the effect of promoting blood circulation to arrest pain, myrrh has the effect of dispersing blood stasis to arrest pain, frankincense and myrrh both can achieve the effects of eliminating swelling and promoting granulation when externally used, safflower has the effects of activating blood circulation, moistening dryness, relieving pain, eliminating swelling and promoting menstruation, therefore, the raw materials jointly achieve the synergistic effect, and the very good anti-gout effect is achieved; in addition, the composition is prepared by taking natural Chinese herbs as the raw materials, has the advantages of having few side effects and being high in safety and can be widely applied to treatment of gout, especially acute gouty arthritis.

The invention discloses a six ingredients gout powder prescription, relating to a prescription of six ingredients gout powder for treating acute gouty arthritis. The prescription consists of 30g of polygonum cuspidatum, 12g of ash bark, 30g of sargent gloryvine, 30g of rhizoma smilacis glabrae, 15g of radix curcumae and 6g of rhubarb. The preparation method thereof comprises the following steps of: evenly mixing each drug, decocting to be 2.2g/ml of crude drug-containing solution by adding water, sterilizing by means of high temperature, sealing bottle, and putting the prepared medicine liquid into a refrigeratory at 4 DEG C for later use. The six ingredients gout powder prescription has the function of anti-inflammatory, detumescence and analgesia, can release arthroncus and pain, changes pathological change of tissue surrounding joint, inhibits inflammatory cytokine (MMP-3, IFN-Gamma), can reduce lithic acid, inhibits the activity of xanthine oxidase, not only can be used for treating the acute exacerbation of the acute gouty arthritis, but also can be used for reducing the lithic acid in gout intermission and hyperuricemia.

The invention discloses a medicine composition for treating gout, which is a preparation prepared from bulk pharmaceutical medicines in weight proportion: 1-10 parts of thlaspi arvense and 1-10 parts of ash bark. The invention also provides a preparation method and application of the medicine composition. According to the invention, the thlaspi arvense and the ash bark are compounded by adopting a specific proportion, thus a cooperative synergistic effect is developed, and the medicine effect of a mixture of the thlaspi arvense and the ash bark is remarkably superior to that of the thlaspi arvense or ash bark under the same dosage. The medicine composition can remarkably reduce blood uric acid, is better in anti-inflammatory effect, has better treatment functions for gout and acute gouty arthritis, and provides a new selection for clinical medication.

A traditional Chinese medicine agent for treatment of acute gouty arthritis is prepared from plantain herb, glabrous greenbrier rhizome, twotooth achyranthes root, salvia miltiorrhiza, clematis root, radix gentianae macrophyllae, radix platycodi, folium orthosiphoni, cortex phellodendri, honeysuckle stem, coix seed and edible tulip, and can be use for clinical treatment of the acute gouty arthritis.

The invention discloses a pharmaceutical composition of etimicin sulfate and application of the pharmaceutical composition in biomedicine. The pharmaceutical composition comprises the etimicin sulfate and a natural product compound (I) novel in structure; when in single action, the etimicin sulfate and the compound (I) have therapeutical effect in acute gouty arthritis; when the etimicin sulfate and the compound (I) are in combined action, therapeutical effect in acute gouty arthritis is further improved, so that the pharmaceutical composition can be developed into drugs for treating acute gouty arthritis; compared with the prior art, the pharmaceutical composition has outstanding substantive features and significant improvement.

The invention relates to a Chinese herb composition for treating the acute gouty arthritis. The Chinese herb composition is prepared from, by mass, 2-8 parts of rhizoma smilacis glabrae, 2-8 parts ofamur cork tree bark, 2-8 parts of Chinese atractylode rhizomes, 2-8 parts of radix cyathulae, 1-6 parts of coix seeds, 1-6 parts of fructus chaenomelis lagenariae, 1-6 parts of gentiana macrophylla, 1-6 parts of radix stephaniae tetrandrae, 1-6 parts of honeysuckle stems, 1-3 parts of sojae semen germinatum, 1-3 parts of earthworms and 1-3 parts of clematis roots. With the rhizoma smilacis glabrae, the Chinese atractylode rhizomes, the coix seeds, the amur cork tree bark and the radix cyathulae being sovereign drugs, the functions of clearing heart, expelling dampness, dredging collaterals andeliminating stagnations are realized under the joint effect; other components have the functions of clearing heat, promoting diuresis, promoting blood circulation to remove blood stases, relieving swelling and pains and reducing blood uric acid to help to rapidly treat joint pains caused by uric acid crystals, and the problems which are unresolved even after long treatment with Chinese medicine and western medicine are solved.

The invention provides a traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine preparation formulae: 12g of notopterygium roots, 12g of radix angelicae tuhuo, 10g of carthamus tinctorius, 15g of akebiaquinata, 10g of lycopodium clavatum, 15g of rhizoma corydalis, 10g of radix angelicae, 6g of asarum, 10g of rhizoma sparganii and 10g of curcuma zedoary. A making method comprises the following steps: preparing materials; cleaning, and crushing; making medicine bags; soaking with cold water; carrying out primary decoction; carrying out secondary decoction; mixing decoctions; smashing medicine dregs; mixing, and boiling; molding the traditional Chinese medicine preparation. The traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis, which is provided by the invention, has the effects of eliminating swelling and reliving pain and activating blood and removing stasis for swelling pain and hydrarthrosis caused by orthopedic diseases such as acute gouty arthritis, acute sprain, scapulohumeral periarthritis degenerative arthritis, tenosynovitis and synovitis.

The invention relates to traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 2-10 parts of amur corktree bark, 5-8 parts of swordlike atractylodes rhizomes, 7-20 parts of glabrous greenbrier rhizomes, 4-9 parts of plantain herbs, 3-10 parts of oriental waterplantain rhizomes, 5-12 parts of dandelion, 6-10 parts of honeysuckle, 3-14 parts of indigowoad roots, 10-20 parts of scandent schefflera stems and leaves, 4-20 parts of weeping forsythiae capsule, 6-8 parts of dwarf lilyturf tubers, 3-6 parts of cape jasmines, 2-7 parts of chicken's gizzard-membranes, 8-10 parts of cherokee rose fruits, 2-5 parts of fragrant solomonseal rhizomes, 7-10 parts of tortoise plastron, 3-6 parts of sharpleaf galangal fruits, 1-8 parts of clematis roots, 4-7 parts of cassia seeds, 3-6 parts of herbs of spicate clerodendranthus, 4-9 parts of fineleaf schizonepeta herbs and 10-20 parts of snake gallbladder. Granules prepared with a preparation method are convenient to take, taste good, take effect quickly and have a certain treatment effect on obesity complicated with acute gouty arthritis, diabetes, hypertension, hyperlipemia and the like.