Application of salidroside in preparation of medicine for treating gouty arthritis

A technology of salidroside and drugs, which is applied in the field of pharmacy, can solve problems such as the report that salidroside has not yet been found to fight gout, and achieve the effect of reducing adverse reactions

Active Publication Date: 2015-06-03
WUHAN SYNCHALLENGE UNIPHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] So far, the inventor has not fou

Method used

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  • Application of salidroside in preparation of medicine for treating gouty arthritis
  • Application of salidroside in preparation of medicine for treating gouty arthritis
  • Application of salidroside in preparation of medicine for treating gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1 material

[0034] 1.1 Animals

[0035] 40 male SD rats, weighing 150-200g, were provided by the Hubei Provincial Center for Disease Control and Prevention, animal license number: SCXK (E) 2008-0005.

[0036] 1.2 Instruments

[0037] Electronic analytical balance (FA1204B, Shanghai Precision Instrument Co., Ltd.); high-speed refrigerated centrifuge (F45-30, Eppendorf, Germany); microscope (BM4000B, Leica, Germany); paraffin microtome (Sandon, USA).

[0038] 1.3 Reagents and Reagents

[0039] Salidroside was provided by Wuhan Xinjiahecheng Pharmaceutical Chemical Co., Ltd., and the purity of HPLC identification was >99%; colchicine was a product of Xishuangbanna Banna Pharmaceutical Co., Ltd., 0.5 mg / tablet, 20 tablets / box, approved by the National Drug Administration H53021369, Batch number B1420211502; sodium urate was purchased from Sigma, USA.

[0040] 2 methods

[0041] 2.1 Solution configuration: Add 3.0 g of sodium urate to 100 mL of distilled water and boil...

Embodiment 2

[0070] Take 50g of salidroside, 72g of medicinal starch and 20g of microcrystalline cellulose, dry the medicinal starch, pass through a 80-mesh sieve, mix it with salidroside and microcrystalline cellulose, pass through a 80-mesh sieve, and fill in hard In capsules, make 1000 capsules. Each hard capsule contains 50mg of salidroside.

Embodiment 3

[0072] Acute Toxicity Test

[0073] 20 tested SD rats were given oral salidroside 1g / kg prepared in Example 2, and observed for 14 days. During the experiment, none of the tested rats died, and no other acute toxic reactions were observed except for the slight restlessness of the tested rats during the administration. The results showed that the LD50 of salidroside in SD rats was >1g / kg.

[0074] The LD50 of SD rats orally administered with colchicine was 5 mg / kg. Rat oral LD50≤50mg / kg is a highly toxic chemical, indicating that colchicine is a highly toxic chemical. The safety of salidroside is very high, and no acute toxicity was found in this test.

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Abstract

The invention provides an application of salidroside in preparation of a medicine for resisting gouty arthritis, and particularly relates to prevention and curing functions of salidroside on acute gouty arthritis. The salidroside has the benefits as follows: the salidroside has prevention and curing functions on gouty arthritis, especially acute gouty arthritis. The animal experiment proves that sodium urate induced acute gouty arthritis can really be relieved by the salidroside. Therefore, when the salidroside is applied to preparation of the medicine for resisting gouty arthritis, one natural or natural-like medicine can be provided for treatment of gouty arthritis, and adverse effects caused by the medicine for treating gouty arthritis are reduced.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of salidroside in the preparation of medicines for treating gout. Background technique [0002] Gout is caused by abnormal purine metabolism and excessive uric acid in the body. The incidence of gout is increasing year by year, and it has become the second largest metabolic disease in humans after diabetes. According to the report of the 12th National Rheumatology Annual Conference: A survey of 40,197 adults in 5 provinces and cities showed that the prevalence of gout was 0.15% to 1.3%, and there was a clear upward trend in the past 20 years. Another study conducted in Shanghai showed that among 65,320 Shanghainese, the incidence of hyperuricemia was 11.7%, and it was as high as 17.2% in men, and the incidence tended to be younger. [0003] The clinical features of gout are: hyperuricemia, recurrent acute arthritis, gout stones, chronic arthritis and joint distortion, ...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P19/06A61P19/02
Inventor 巨修练王均震杨静汤兴国郑文钺
Owner WUHAN SYNCHALLENGE UNIPHARM INC
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