30 results about "Chronic arthritis" patented technology

The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula:

or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R¹ to R¹¹ are as defined herein.

The invention belongs to the technical field of nutrient health-care foods, and particularly relates to a marine polypeptide special dietary food for patients suffering from chronic arthritis to eat.The special dietary food comprises the following raw material components in parts by weight: 4.5-6.5 parts of marine oligopeptide, 1.0-2.0 parts of marine ogranism activity polysaccharide, 1.0-1.5 parts of dried marine algae powder, 0.5-1.5 parts of olive oil, 0.5-1.0 part of an antioxidant, 0.1-0.5 part of a nutrient, 0.1-0.5 part of royal jelly and 0.1-0.5 part of curcumin. The raw materials arehigh in safety, so that after the special dietary food is eaten for a long term, no side effects are generated, and the special dietary food can be eaten by the patients suffering from the chronic arthritis for a long term to supplement nutrition and relieve a pain.

A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell. Depending on the choice of activator sequence and active substance, the following can be treated by administering the DNA sequence: defective formation of blood cells autoimmune diseases and allergies and, in addition, rejection reactions against transplanted organs chronic arthritis viral and parasitic infections and, in addition, prophylaxis of viral, bacterial and parasitic infections, and leukaemias.

The invention discloses application of a salt formed by combining tri(hydroxymethyl)aminomethane and acid radicals or an aqueous solution of the salt to preparing of a medicine for treating hyperuricemia, gout, acute and chronic arthritis, urinary calculus diseases and related diseases. The treatment action mechanism is as follows: tri(hydroxymethyl)aminomethane and uric acid are combined throughhydrogen bonds to generate a uric acid-tri(hydroxymethyl)aminomethane conjugate, uric acid crystallization is prevented, and uric acid crystals (calculi) are dissolved; meanwhile, the combination of uric acid with macromolecular substances such as blood fat and blood sugar is reduced, and the influence of uric acid on blood fat and blood sugar is reduced. Compared with existing three action mechanisms of 1, intake reduction, 2, endogenous synthesis inhibition and 3, kidney excretion promotion for treating hyperuricemia, the action mechanism of the invention can be called as a fourth action mechanism. The invention can also be referred to as a fourth treatment method for hyperuricemia. And the problems of uric acid crystallization and influence of uric acid on blood fat and blood sugar aresolved in a targeted manner. The action mechanism is clear; the curative effect is good; and the side effect is small.

The invention belongs to the technical fields of plasters and preparation thereof. The invention discloses an externally applied plaster for treating arthralgia and arthritis, and a preparation method of the externally applied plaster. The plaster is prepared from the following raw materials: capsicum annuum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, a coating agent, gasoline, and the like. The preparation method comprises the steps of preparing the raw materials, carrying out medicine preparation, refining rubber, coating, mashing, gluing, drying, carrying out aftertreatment, and the like. The externally applied plaster for treating the arthralgia and the arthritis has the effects of expelling wind and removing cold, relaxing tendons and activating collaterals, relieving swelling and pain, and the like, can be used for treating the arthralgia, backache and sprain bruise as well as diseases such as chronic arthritis and chilblain being not broken; furthermore, the externally applied plaster has good air permeability and is long in drug onset time; the externally applied plaster for treating the arthralgia and the arthritis is simple in preparation method and can be easily realized on the existing equipment.

The present invention relates to the composition according to the present invention, which has not only the effect of suppressing inflammation and pain, which are the common symptoms of acute and chronic arthritis, but also the effect of alleviating movement disorders, which are the symptoms of chronic arthritis.

The invention discloses health care medicated bath powder for treating eczema and arthritis and a preparation method thereof. The powder is prepared from the following components in parts by weight: 1 to 10 parts of cacumen biotae, 1 to 10 parts of myricaria bracteata, 1 to 10 parts of herba artemisiae scopariae, and 1 to 10 parts of ilex pubescens. The preparation method comprises the following steps: firstly, cleaning and sorting; secondly, drying; thirdly, crushing; fourthly, sieving to obtain finished powder. The powder has the efficacies of reducing fever, eliminating damp, treating exterior cold syndrome, and promoting eruption; the powder is applied to measles without adequate eruption, treats fever and cough, has the effects of sterilization and detoxification, and treats symptoms of arthralgia, beriberi, scalp itch, dermatitis, ringworm sores and jaudice due to wetness-heat evil, and has good effects for treating eczema and acute and chronic arthritis; when the powder is matched with a medicated bath method, the preparation steps of boiling for oral agentia is canceled, the powder is convenient to use and carry, the application cost is low, meanwhile the effect range of the powder can be expanded when the medicated bath method is adopted, so that the powder is more direct, the transdermal effect of the powder is good, and the curative effect is brought into full play.

The invention provides a carbon fiber or resistance wire heating electrode phototherapy instrument which comprises a phototherapy instrument body. The phototherapy instrument body is provided with anirradiation light source, a carbon fiber or resistance wire heating layer and electrode slices. The carbon fiber or resistance wire heating electrode phototherapy instrument further comprises a circuit controller or a Bluetooth circuit controller. The Bluetooth circuit controller is controlled through a mobile phone APP. The irradiation light source irradiates infrared ray or red light. The carbonfiber or resistance wire heating layer comprises a carbon fiber or resistance wire electric heating heat insulating layer and heat insulating cloth. The circuit controller or the Bluetooth circuit controller performs controlling on the carbon fiber or resistance wire heating layer, the irradiation light source and the electrode slices. The carbon fiber or resistance wire heating layer and the irradiation light source are arranged at the middle part, and the electrode slices are arranged at two sides. The carbon fiber or resistance wire heating electrode phototherapy instrument is particularlyeffective for treating symptoms such as arthritis, rheumatoid arthritis, acute arthritis and chronic arthritis, nervous pain and muscle ache.

The invention provides an external traditional Chinese medicine composition and powder for treating acute and chronic arthritis and application of the external traditional Chinese medicine compositionand powder. The traditional Chinese medicine composition is prepared from, by weight, 70-90 parts of radix trichosanthis, 35-50 parts of lignum dalbergiae odoriferae, 35-45 parts of radix et rhizomarhei, 30-50 parts of cortex phellodendri chinensis, 35-45 parts of rhizoma curcumae longae, 30-50 parts of radix angelicae, 10-25 parts of rhizoma arisaematis, 10-25 parts of garden balsam stem, 10-20parts of peach kernels, 10-20 parts of flos carthami and 10-25 parts of chinaroot greenbrier rhizome. The external traditional Chinese medicine composition and powder for treating the acute and chronic arthritis and the application of the external traditional Chinese medicine composition and powder have the advantages that all the components are scientific in compatibility and have a mutually synergistic effect, and the external traditional Chinese medicine composition and powder nourish blood and activate collaterals, dredge paralysis and remove blood stasis, relieve swelling and pain, relaxthe muscles and activate blood circulation and smooth joints, and a therapeutic effect on treating the acute and chronic arthritis is significant.

The invention discloses a Tongbi pill and a preparation method thereof. The Tongbi pill comprises safflower, pilose antler, gastrodia elata, toad, lucid ganoderma, centipede, scorpion, agkistrodon, raw astragalus membranaceus, roasted rhizoma atractylodis macrocephalae, codonopsis pilosula, angelica sinensis, radix stephaniae tetrandrae, salvia miltiorrhiza, radix paeoniae alba, frankincense, myrrh, cassia twigs, rheum officinale, pawpaw, eucommia ulmoides, berba aristolochiae mollissimae, rhizoma drynariae, rhizoma cibotii, rhizoma corydalis and radix achyranthis bidentatae. The Tongbi pill has the beneficial effects that the Tongbi pill can relieve the acute or continuous joint swelling and pain symptoms of various chronic arthritis such as rheumatism, rheumatoid arthritis, gouty arthritis, osteoarthritis, spinal arthropathy and the like, can also relieve various soft tissue rheumatic pains and acute light and moderate pains, and has no side effects.

The invention provides a novel polypeptide with an amino acid sequence as shown in SEQ ID NO:2 or obtained by adding, deleting and/or substituting one or more amino acid residues on the sequence as shown in SEQ ID NO:2. The invention further provides a pharmaceutical composition comprising the polypeptide, preferably a phlogenzym tablet which is used for relieving edema after trauma or operation, shortening blood clot coagulation time, relieving pains caused by swelling and inflammation, treating thrombophlebitis, inflammation of genitourinary tract, arthritis (for example chronic arthritis) or soft tissue rheumatism.

The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R<1> to R<8> and X are as defined herein.

The invention discloses lotus seed powder for relieving and conditioning chronic arthritis and a preparation method thereof. The lotus seed powder is prepared from pseudo-ginseng powder, pollen, lotus seed powder, prepared rehmannia roots, garden burnet, radix geutianae, herba ephedra, safflowers, tylophora mollissima, common leafflower herb with roots, semen strychni, limacia sagittata, adder tongue herb, roots or leaves of cochinchina raspberry, apocynum venetum, rhizoma alismatis, herba centellae, alpine cladonia, radix polygni multiflori, tuber fleeceflower stems, globe amaranth flowers and roughhaired holly roots. All the traditional Chinese medicine is mixed in proportion, water is added for decocting, medicine liquid is obtained, then pseudo-ginseng powder, pollen and lotus seed powder are added, the mixture is stirred to be uniform, the mixture is subjected to vacuum concentration till paste is obtained, drying under reduced pressure is carried out, and the mixture is smashed into powder; the powder is mixed with flour or rice flour, and biscuits or bread or steamed sponge cakes are made. The traditional Chinese medicine and food are combined, the good dietary therapy function of food is achieved, the treatment and conditioning function of the traditional Chinese medicine is achieved, and the lotus seed powder has a good treatment effect on chronic arthritis and is free of toxic and side effects, safe and effective.

The invention discloses a blood-activating and stasis-removing paste as well as a preparation method and an application thereof, which belong to the technical field of traditional Chinese medicines. The blood-activating and stasis-removing paste comprises sesame oil, a traditional Chinese medicine composition and yellow lead, the traditional Chinese medicine composition is prepared from the following components: angelica dahurica, rhizoma sparganii, curcuma zedoary, angelica sinensis, pawpaw, ligusticum wallichii, teasel root, rheum officinale, lycopodium clavatum, garden balsam stem, dioscorea nipponica makino, schizonepeta, divaricate saposhnikovia root, flos rhododendri mollis, radix angelicae pubescentis, radix clematidis, Zoumajin, cynanchum paniculatum, geranium wilfordii, achyranthes bidentata, notopterygium root, akebia stem, stephania tetrandra, eupolyphaga, safflower, monkshood, radix aconiti agrestis, nux vomica, rhizoma arisaematis, dragon's blood, frankincense, myrrh, garter snake, scorpion, rosin, camphor, leech, garden balsam, borneol, menthol, pseudo-ginseng and gadfly. The paste capable of promoting blood circulation to remove blood stasis provided by the embodiment of the invention is convenient to use, is suitable for people and diseases, has the effects of promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, and can be usedfor effectively treating diseases such as bone diseases, pain toxin, chronic arthritis, lumbago, heel spur and the like.

The invention discloses application of a miRNA-C compound in preparing a clinical diagnosis marker of chronic pain diseases and a medicine for treating the chronic pain diseases. Upon a great deal of experimental screening, experimental results show that the expression of miRNA-C in a chronic arthritis pain model and in blood of patients of chronic pain drops; the occurrence and formation of the chronic pain can be remarkably inhibited by increasing the miRNA-C; and furthermore, through quantitative analysis on clinical blood samples of the patients of chronic pain, the miRNA-C can serve as a marker of the occurrence of the chronic pain.