109 results about "Rheumatoid arteritis" patented technology

Disclosed are compositions and methods for the treatment and / or prevention of rheumatoid arthritis, comprising administering to a subject an effective amount of anti-IL-1β antibody or fragment thereof.

A composite medicine for treating the umatoid arthritis and autoimmune disease contains the sweet worm wood herb's extract (dihydroarteannuin, artesumate, artemether, etc).

The present invention is based in part on the identification of a signature marker profile of immune variables to diagnose an immune mediated disease or for prediction of response to an immune mediated disease therapeutic agent. Additionally, the present invention provides methods for the prediction of response to an immune mediated disease therapeutic agent.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

A mark substance of specificity - anti-genicity for atrophic arthritis is carbamyl ornithine fibre connexin existied in blood plasma and joint synovium tissue of atrophic arthritis patient. The invented mark substance has excellent application value in preparing reagent and medicine for diagnosing and curing disease of atrophic arthritis.

The Chinese medicine composition for curing rheumatic and rheumatoid arthritis comprises 17 Chinese medicinal materials of Chinese angelica root, black-striped snake, scorpion, gastrodia tuber, chaenomeles fruit, achyranthes root and others as raw material.

The invention features methods and compositions for preventing or treating rheumatoid arthritis and osteoporosis by administering an antagonist of IL-20. The IL-20 antagonist may be an anti-IL-20 antibody, such as mAB 7E, that is capable of binding human IL-20 and blocking IL-20 interaction with its receptors.

The invention relates to the use of gelsolin to treat inflammatory diseases (e.g., rheumatoid arthritis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of inflammatory diseases (e.g., rheumatoid arthritis).

Provided are methods of diagnosing rheumatoid arthritis in a patient by detecting the presence and / or amount of a biomarker of rheumatoid arthritis in a sample from the patient. The methods and biomarkers may be used to develop an accurate prognosis for a patient having rheumatoid arthritis or suspected of having rheumatoid arthritis, or to accurately diagnose a patient having, or suspected of having rheumatoid arthritis. The methods and biomarkers may be used to identify and / or classify a patient as a candidate for a rheumatoid arthritis therapy.

The invention provides a Chinese patent medicine for treating rheumatoid arthritis, which is characterized in that the medicine comprises the following components by weight: 8-12 parts of ephedra sinica, 8-12 parts of Chinese mugwort leaves, 12-18 parts of zaocys dhumnades, 12-18 parts of agkistrodon acutus, 8-12 parts of frankincense, 8-12 parts of angelica dahurica, 45-55 parts of clematis roots, 8-12 parts of rhizoma homalomena, 8-12 parts of root-bark of Chinese hydrangeavine, 27-33 parts of common clubmoss herb, 27-33 parts of millettia dielsiana, 12-18 parts of notopterygium incisum, 12-18 parts of pubescent angelica, 12-18 parts of achyranthes, 9-15 parts of angelica, 9-15 parts of menispermaceae, 12-18 parts of cassia twig, 9-15 parts of pawpaw, 12-18 parts of kudzu roots, 12-18 parts of pangolin, 45-55 parts of ants, 18-22 parts of radix astragali, 12-18 parts of bighead atractylodes rhizome, 75-85 parts of fructus eucalypti robustae, 12-18 parts of cherokee roses, and 12-18 parts of licorice. The Chinese patent medicine of the present invention has the efficacy of dispelling wind and dissipating binds, freeing channels and promoting qi, activating blood and dissolving stasis, dispersing blood stasis and detumescence; the plurality of traditional Chinese medicine components can complement each other, dredge circulatory disturbance, and repair damaged joints. The invention can regulate body endocrine, and maintain internal hormone balance. The invention has significant curative effect, and has no toxic or side effect.

The Chinese medicine for curing rheumatoid arthritis is made up by using 11 Chinese medicinal materials of red poria, Chinese angelica root, kochia fruit, acanthopanax root bark, erythrina bark and others. Said Chinese medicine can be made into decoction, pill, soluble granules or capsule preparation. Its therapeutic effect is obvious, and its effectual rate is above 95%, and its cure rate is above 90%.

A drug for curing rheumatoid arthritis belongs to the technical field of traditional Chinese medicine preparation and is mainly composed of 24 crude drugs of radix paeoniae alba, ligusticum wallichii, radices sileris, eucommia ulmoides, radix cyathulae, fraxinus bungeana, radix aconiti agrestis, nux vomica, pangolin, antler glue, rare giraldii and the like. The drug has the functions of tonifying kidneys, reinforcing waists, dispelling wind, scattering cold, facilitating urine, promoting blood circulation, removing obstruction, detoxifying and strengthening tendon and bones. Clinical application shows that the drug is accurate in treatment on rheumatoid arthritis, free of side effects and convenient to take.

The invention discloses a traditional Chinese medicine smoking lotion for treating rheumatoid arthritis. According to traditional Chinese medical science, the rheumatoid arthritis belongs to the scope of 'arthralgia', the primary asthenia is debility in vital energy and blood, yin and yang as well as viscera, the secondary sthenia syndrome is about receiving coldness, dampness and heat externally, and generating phlegm and extravasated blood internally. The traditional Chinese medicine smoking lotion is prepared from the following components: Cantonese speranskia, littleleaf indianmulberry herb, subcalvous yam roots, Chinese holly roots, radix achyranthis bidentatae, marsdenia longipes, common exbucklandia stem, acuteleaf caper roots and teasel root. According to the clinical observation, the total effective rate reaches 96.2%, the efficacy is obviously better than that of a matched group, the side effect is small and the therapy is convenient.

The invention provides a dendropanax dentiger(Harms)Merr. extract, a preparation method and application in medicine for treating rheumatoid arthritis. According to an extraction method of the dendropanax dentiger(Harms)Merr. extract, dendropanax dentiger(Harms)Merr. plant branches are used as raw materials, water is used as an extractant, and the water extraction process is adopted; and the method includes the steps that firstly, the dendropanax dentiger(Harms)Merr. plant branches are cut into the shape of traditional Chinese medicine decoction pieces; secondly, dendropanax dentiger(Harms)Merr. filtrate is prepared; and thirdly, the dendropanax dentiger(Harms)Merr. extract is prepared. According to the application of the dendropanax dentiger(Harms)Merr. extract in preparation of medicine preparations for preventing and treating rheumatic arthritis and rheumatoid arthritis, and the preparation is selected from pharmaceutical preparations including but not limited to water aqua, granular preparations, capsules, powder and the like of the dendropanax dentiger(Harms)Merr. extract, or is a biological preparation. Meanwhile, application of the dendropanax dentiger(Harms)Merr. extract to prevention and treatment of rheumatic arthritis and rheumatoid arthritis diseases is disclosed, the dendropanax dentiger(Harms)Merr. extract has a good treatment effect, and the dendropanax dentiger(Harms)Merr. extract has the beneficial effects of being small in side effect, not likely to cause drug resistance, affordable and the like when used for preventing and treating rheumatic arthritis and rheumatoid arthritis.

The invention provides a traditional Chinese medicine preparation for treating rheumatoid arthritis, which is characterized in that, in parts by weight, it comprises the following components: Astragalus 28-32, Ginseng 8-12, Atractylodes Rhizoma 9-15, Angelica 8-12, Xian Mao 8-12, Cuscuta 28-32, Epimedium 8-12, Paeoniae Alba 12-18, Caulis Spatholobus 28-32, Clematis 12-18, Fangji 9-15, Guizhi 12-18, Zhilicorice 8-12, ginger 8-12, jujube 8-12. The above-mentioned combination nourishes the liver and kidneys, regulates the Qi and blood of the spleen and stomach, and has the functions of dispelling wind and dispelling stagnation, dredging the meridian and promoting qi, promoting blood circulation and removing blood stasis, dispelling blood stasis and reducing swelling. , to repair damaged joints. Regulate the body's endocrine and maintain the balance of hormones in the body. The treatment effect is remarkable, and there is no toxic side effect.

The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out the method of diagnosing.

The invention provides a formula of traditional Chinese medicine for treating rheumatoid arthritis. The formula is characterized by comprising the following components in parts by weight: 9-12 parts of fructus psoraleae, 12-24 parts of prepared rhizome rehmannia, 12-18 parts of teasel, 9-12 parts of epimedium herb, 6-9 parts of roasted armadillo, 9-12 parts of divaricate saposhnikovia root, 6-12 parts of prepared radix aconiti lateralis, 10-20 parts of drynaria rhizome, 9-15 parts of cassia twig, 9-12 parts of red paeony root, 9-12 parts of white paeony root, 9-15 parts of anemarrhena, 10-12 parts of notopterygium root, 10-12 parts of wild celery, 9-12 parts of loose knot, 6-10 parts of Chinese polyphaga, 3-6 parts of Chinese ephedra, 6-10 parts of atractylodes lancea, 9-15 parts of clematis root, 25-35 parts of common clubmoss herb, 9-15 parts of achyranthes bidentata and 9-12 parts of roasted tiger bone. In the formula provided by the invention, principal, assistant and adjuvant ingredients have obvious effects and are synergic, compatibility of medicines is perfect; root causes are addressed, symptoms are treated, disease differentiation is discriminated, whole treatment is realized; after a patient takes the medicine, limb joint swelling pain is alleviated, and the patients has strong physical strength, good face colour is moist, and high mobility, and the formula provided by the invention is superior to any common medicine for treating rheumatism.

The invention discloses a Chinese medicinal fumigant for treating rheumatoid arthritis. The rheumatoid arthritis mainly comprises symptoms of articular cavity arthromeningitis, seepage, cell proliferation, formation of granuloma, cartilage and bone tissue breakage, final ankylosis and dysfunction. At present, Western medicine is short of an ideal treatment method. After many years' clinic testes by the applicant, the Chinese medicinal fumigant is prepared from Chinese medicaments including long-stalked kadsura, root of veined inula, root of Chinese coriaria, pedicularis resupinata, artemisia capillaries, root of saururus sinensis, pika droppings, craspedolobium root, tripterygium hypograucum, lysidice rhodostegia, pungent litsea root and horehound which have effects of dispelling wind to relieve pain, clearing heat and dampness, promoting blood circulation to remove blood stasis and relaxing muscles and tendons to activate the channels. Clinical tests show that the effective rate of the Chinese medicinal fumigant reaches 97.9%, and compared with an orally-taken western medicine, the Chinese medicinal fumigant has few side effects.

The present invention relates to the diagnosis of autoimmune disorders, more specifically to the diagnosis of rheumatoid disorders, chronic autoimmune arthritis and even more specifically to the diagnosis of rheumatoid arthritis. A biomarker panel is provided which can be used to detect if a subject has rheumatoid arthritis. Also described are methods of identification of such biomarkers.

The invention discloses a novel rheumatoid arthritis diagnosing marker-protein CD38. Through flow cytometrical experiments, the applicant of the invention proves that compared with normal subjects, CD38+ cells are highly expressed in peripheral blood lymphocytes of a RA (rheumatoid arthritis) patient, and the expression levels of the CD38+ cells are significantly related to the RF (rheumatoid factor) level. In addition, flow cytometrical results show that the ratio of a CD38+ cell subset to a CD56+ cell subset is also significantly increased and the CD56 is a cell surface marker of a natural killer cell (NK cell), which means that the CD38 plays an important role in autoimmune disorder of the RA and can be used as the rheumatoid arthritis diagnosing marker. A kit for detecting the rheumatoid arthritis consists of CD3 marked by FITC, a CD4 monoclonal antibody, a CD56 monoclonal antibody marked by PE, and a CD38 monoclonal antibody marked by Percp-Cy5.5.

The invention discloses a traditional Chinese medicine for treating chronic infectious arthritis, belonging to the technical field of treatment of orthopedics and traumatology. The traditional Chinese medicine is characterized by being prepared from the Chinese medical herbs in parts by weight: 15-20 parts of Chinese angelica, 15-20 parts of rhizoma rehmannia, 10-15 parts of cocklebur fruit, 20-25 parts of garter snake, 10-15 parts of eupolyphaga, 3-5 parts of scorpio, 10-15 parts of roasted squamamanitis into puffy with sand, 30-35 parts of rhizoma dioscoreae nipponicae, 20-25 parts of epimedium, 25-30 parts of caulis spatholobi, 15-20 parts of cortex erythrinae, 5-8 parts of dung beetle, 2-4 parts of centipede and 15-20 parts of medicinal cyathula root. According to the pathological mechanism principle of the chronic infectious arthritis and the reason causing the chronic infectious arthritis, a pure Chinese medicine formula is adopted, an oral liquid, or powder, or a tablet, or a capsule is prepared through extracting effective components; and an externally applied agent plaster can also be prepared. After the traditional Chinese medicine is orally taken, the chronic infectious arthritis can be effectively treated, and an ideal effect is achieved.

The invention belongs to the technical field of medicines and in particular relates to a pharmaceutical composition for treating rheumatoid arthritis and application thereof. The pharmaceutical composition provided by the invention comprises the following components: notopterygium root, garden balsam stem, codonopsis pilosula, cassia twig, astragalus, divaricate saposhnikovia root, lycopodium clavatum, honeysuckle stem, rhizoma atractylodis and poria cocos. The pharmaceutical composition disclosed by the invention is exact in curative effect of treating rheumatoid arthritis (RA), is safe and reliable and can serve as an effective method for treating RA.

The invention belongs to the field of macromolecule and biomedical materials, and relates to a polymer nanoparticle capable of treating rheumatoid arthritis, in particular to a cationic polymer micelle, a method for preparing the polymer micelle and a pharmaceutical composition containing the polymer micelle. The micelle provided by the invention can bind with cf-DNA, reduce the concentration of cytokines and enzymes related to rheumatoid arthritis, and be used for the treatment of rheumatoid arthritis.

Provided are: a novel test method for rheumatoid arthritis; and a kit for rheumatoid arthritis test, which is used in the novel test method for rheumatoid arthritis. A test method for rheumatoid arthritis according to the present invention is characterized by comprising a step for measuring the amount of talin in the plasma or serum of an animal subject. This measurement is carried out, for example, by an immunological method using an antibody which binds to talin. A kit for rheumatoid arthritis test according to the present invention is used for such a test method and contains, for example, a solid-phase carrier to which an antibody that binds to talin is affixed.

The invention discloses a Chinese medicinal composition for preventing and treating rheumatoid arthritis. The Chinese medicinal composition is prepared from the following Chinese medicines in part by weight: 5 to 20 parts of blast-fried prepared common monkshood daughter root, 5 to 30 parts of cassia twig, 5 to 30 parts of largehead atractylodes rhizome and 5 to 20 parts of honey-fired tamariskoid spikemoss herb. The invention also provides a preparation containing the Chinese medicinal composition and a preparation method for the preparation. Experiments prove that the Chinese medicinal composition has a definite curative effect of treating rheumatoid arthritis.

The invention discloses a medicament for treating chronic nephritis. The medicament is prepared from the following raw materials in parts by weight: 20-200 parts of pilose asiabell roots, 20-50 parts of heterophylly falsestarwort roots, 10-50 parts of largehead atractylodes rhizomes, 15-150 parts of Indian buead, 30-100 parts of cooked rehmannia, 12-100 parts of dogwood fruits, 20-150 parts of south dodder seeds, 15-100 parts of peach seeds, 10-100 parts of safflower, 15-100 parts of danshen roots, 15-100 parts of weeping forsythiae capsule, 15-100 parts of kudzuvine roots, 10-200 parts of golden thread, 15-150 parts of pinellia tubers and 15-100 parts of liquoric roots. The invention also discloses a method for preparing a Chinese medicinal composition for treating the chronic nephritis. According to folk traditional formula, the medicament is prepared by meticulously researching in combination with the theraputic principle of strengthening the body resistance and fostering the root and activating blood and dispersing blood stasis in traditional Chinese medical science. The chronic nephritis is treated by using a combined principle of strengthening the body resistance to eliminate pathogenic factors and using methods of promoting blood circulation to remove blood stasis, strengthening the kidney and tonifying the spleen and clearing away the heat to resolve turbidity by dieresis, so that the advantages of good effect, quick response and the like are realized.

The invention relates to a medical composition for treating rheumatoid arthritis and a preparation method. The composition is prepared from materials in part by weight as follows: 20-80 parts of prepared kusnezoff monkshood root, 20-80 parts of rhizoma dioscoreae nipponicae, and 20-80 parts of liquorice. The medical composition shown by pharmacology experiment has a good effect for treating rheumatoid arthritis. The preparation method is simple.

The invention discloses a diagnostic marker for rheumatoid arthritis and / or osteoarthritis. The diagnostic marker is an SPAST gene or SPAST protein, and the purpose of diagnosis is achieved by detecting the expression level of the SPAST gene. The research proves that the mRNA expression level of the SPAST gene of patients with rheumatoid arthritis and / or osteoarthritis is obviously improved compared with a normal person. According to the correlation between the SPAST gene and the rheumatoid arthritis and / or osteoarthritis, a kit for diagnosing rheumatoid arthritis and / or osteoarthritis can beprepared, and the kit can be widely applied to clinic. In addition, the invention further discloses application of the SPAST gene or the SPAST protein in the aspects of treating rheumatoid arthritis and / or osteoarthritis.

The invention belongs to the medicine field and particularly discloses application of benzoyl aconine in preparation of rheumatoid arthritis therapeutic drugs, the benzoyl aconine is taken as a natural medical material extractive, remarkable multi-acting target, low toxicity and high-efficiency therapeutic effects to the rheumatoid arthritis can be realized through multiple action mechanisms of anti-inflammation and detumescence, ankle pathologic change reduction, immune visceral organ pathologic change reduction and / or serum cell factor reduction, the cure rate of the rheumatoid arthritis patients is increased, the possibility of the medicine kinds and the dosage is reduced, and the benzoyl aconine has a remarkable and advanced meaning in the preparation of the rheumatoid arthritis therapeutic drugs.

[Problem] The topic of the present invention is the elucidation of the biological function of CTRP6 and its application.[Solution] A pharmaceutical composition containing CTRP6 for the prevention or treatment of autoimmune disease. Ideally, a pharmaceutical composition for the prevention or treatment of inflammation associated with autoimmune disease, for example, rheumatoid arthritis or type 1 diabetes, is provided.