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1 results about "Tripterygium" patented technology

Tripterygium is a genus of plants in the family Celastraceae. Tripterygium wilfordii is used in Traditional Chinese medicine.

Terpenoid in tripterygium wilfordii as well as preparation, application and medicine of terpenoid

PendingCN122071406Anovel structureSignificant ACLY inhibitory activityNervous disorderMetabolism disorderPharmaceutical SubstancesBush plant
The invention relates to a diterpenes type compound, a triterpenes type compound, a preparation method of the diterpenes type compound and the triterpenes type compound, and an application of the diterpenes type compound and the triterpenes type compound. The compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from a vine shrub plant tripterygium wilfordii Hook.f. Of a winged euonymus tripterygium genus, and the novel diterpene and triterpene compounds are novel in structure, and the compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from the vine shrub plant tripterygium wilfordii Hook.f. Of the winged euonymus tripterygium genus. Bioactivity experiments show that the compound 5 has significant ATP citrate lyase (ACLY) inhibitory activity, and has application potential in research and development of drugs for cancer, hyperlipidemia, atherosclerotic cardiovascular diseases and the like.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES