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Immunosuppressive medicament

A technology of immunosuppression and medicine, applied in the field of 1′-O-β-D--4′-O-caffeoyl-glucoside, which can solve the problems of undetermined use and pharmacological activity not yet grasped by people

Inactive Publication Date: 2010-09-01
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the pharmacological activity of CalceolariosideA has not yet been grasped, so its use has not yet been determined.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] Extraction: Extracted from Fraxinus mandshurica.

[0026] Spectral detection:

[0027] Using 500M, the 1H-NMR, 13C-NMR and HMBC nuclear magnetic resonance spectral data of the extracted material were determined in DMSO-d6 as shown in the following table:

[0028]

[0029] From the above-mentioned spectral identification results, it can be known that the extracted substance is Calceolarioside A.

[0030] experiment:

[0031] 1. TNF-α immunoassay

[0032] THP-1 cells were plated at 5 × 10 5 The density of / ml was inoculated into a 24-well culture plate, and different concentrations of drugs were added respectively. After culturing for 1 h, LPS was added to induce in 5% CO. 2 3. Incubate at 37°C for 4 h, collect cell culture supernatant by centrifugation at 3000 r / min, and operate according to the instructions of HumanTNF-α / TNFSF1A Immunoassay (R&D Systems). At the same time, Coomassie brilliant blue method (Bradford method) was used to determine the protein conten...

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Abstract

The invention relates to an immunosuppressive medicament, which belongs to the technical field of immunosuppressive medicaments. In the conventional chemical preparation and fungal metabolite, cell sub-selectivity is high, the side effect of hormone is serious, and the dosage of Chinese medicament such as tripterygium glycosides is large. The immunosuppressive medicament is characterized in that: an active substance is 1'-O-beta-D-(3, 4-dihydroxyl phenethyl)-4'-O-caffeoyl-glucoside; and the active substance is used for immunosuppression.

Description

technical field [0001] The invention relates to a 1'-O-β-D-(3,4-dihydroxyphenethyl)-4'-O-caffeoyl-glucoside for immunosuppression. The compound is also called Calceolarioside A, which belongs to The technical field of immunosuppressive drugs. Background technique [0002] There are four main classes of drugs currently used for immunosuppressive therapy. 1. Chemical preparations. There are two main categories of alkylating agents and antimetabolites, which are used for antitumor. 2. Hormones. For the treatment of anti-inflammatory and various types of hypersensitivity diseases. 3. Fungal metabolites. There are mainly cyclosporine A and FK-506. These drugs have a good selective inhibitory effect on T cells, especially TH cells, while the inhibitory effect on other immune cells is relatively weak. 4. Chinese medicine. For example, tripterygium glycosides are used to treat nephritis, lupus erythematosus, rheumatoid arthritis, etc. [0003] Calceolarioside A is a compound...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P37/06A61P35/00
Inventor 王会堂陈玉娟王维
Owner CHANGCHUN UNIV OF SCI & TECH
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