294 results about "Chemical preparation" patented technology

The invention provides a method for efficiently synthesizing basic nickel carbonate, and belongs to the technical field of chemical preparation. Comprising the following steps: (1) preparing a mixed solution of sodium carbonate and sodium hydroxide; (2) under low-temperature and high-speed stirring conditions, dropwise adding a nickel salt solution into the mixed solution, adding a competitive adsorbent, adjusting the pH value of the solution, then heating, continuing stirring reaction, separating the competitive adsorbent by a magnet, centrifuging, washing and collecting prepared primary basic nickel carbonate; and (3) recrystallizing the primary basic nickel carbonate in an ethanol water solution, and drying to obtain the basic nickel carbonate. According to the preparation method disclosed by the invention, the content of impurity ions in the product is reduced, so that the high-purity basic nickel carbonate can be prepared, the synthesis efficiency is high, the production cost is relatively low, the method is green and environment-friendly, the competitive adsorbent can also be repeatedly utilized and recycled, the production cost is reduced, and the method has a wide application prospect.

The invention discloses gold-titanium alloy nanoparticles as well as a wet chemical preparation method and application thereof. The preparation method comprises the following steps: in a water-free and oxygen-free environment, uniformly dissolving a gold salt, a titanium salt and a support carrier in an ether solvent, mixing with lithium triethylborohydride, transferring into a high-pressure reaction kettle, stirring and heating to 180-220 DEG C under the inert gas pressure of 0.5-1 MPa, and keeping the temperature for 1-4 hours; and after the mixture is cooled to the room temperature, the product solution is diluted with normal hexane, cleaning and drying are conducted, and the gold-titanium alloy nanoparticles are obtained. According to the invention, gold salt and titanium salt adsorbed on a support carrier are reduced by using a strong reducing agent under the conditions of high temperature and high pressure, and highly dispersed nanoparticles with uniform particle size are prepared; by introducing the supporting carrier, the problem that the particle size is increased due to agglomeration of alloy nanoparticles at high temperature is avoided, the catalytic performance and the anti-sintering performance of the catalyst are enhanced through strong interaction with the carrier, and the catalyst has wide application prospects in the fields of CO thermal oxidation and CO electrochemical oxidation.

The invention discloses a eutectic solvent for promoting ultrahigh dissolution of curcumin and a preparation method of the eutectic solvent, relates to the technical field of chemical preparations, and aims to solve the technical problem of relatively low solubility of curcumin in a solvent in the prior art. The preparation method of the eutecticevaporate solvent for promoting ultrahigh dissolution of curcumin comprises the following steps: mixing a hydrogen bond donor, a hydrogen bond acceptor and other components, and heating to a first preset temperature to obtain a clear and transparent eutecticevaporate solvent; and heating the eutectic solvent to a second preset temperature, adding curcumin powder, carrying out rapid vortex dissolution, centrifuging, and collecting a supernatant to obtain a clear and transparent high-solubility curcumin solution. According to the method, the green solvent is adopted as a medium, no additional substance needs to be added, operation is easy and convenient, the solubility of the curcumin is remarkably improved, and therefore the application range of the curcumin in the fields of cosmetics, food and pharmacy is expanded.

The utility model belongs to the technical field of ball valves, and particularly relates to a ball body of a ball valve, which comprises a ball body, a flow channel hole for fluid to pass through is arranged in the center of the ball body, one end of the flow channel hole is an inlet end, the other end of the flow channel hole is an outlet end, and a plurality of spiral rifling grooves are arranged on the inner wall of the flow channel hole in an annular array mode. A plurality of groups of defoaming channels are formed in the spiral rifling groove, one end, close to the direction of the inlet end, of each defoaming channel is an inlet, the other end of each defoaming channel is an outlet, the hole diameter of each outlet is smaller than that of each inlet, and the hole diameters of the inlets and the outlets in the groups of defoaming channels from the inlet end to the outlet end tend to be gradually reduced. The shape and the layout of the spiral rifling groove can improve the flowing stability of the fluid, and the defoaming channel shrinks and crushes large bubbles in the fluid step by step to enable the large bubbles to be dissolved in the liquid, so that the detection precision of the metering equipment on the fluid flow is improved, and the quality of subsequent chemical preparations or liquid blending is guaranteed.

The invention relates to composition and preparation of a thick-film copper conductor sintered at different temperatures and different atmospheres, and belongs to the field of chemical preparation. Comprising the following steps: mixing 65-85% of copper powder, 3.0%-15.0% of glass, 15.0%-35.0% of an organic adhesive and 0.1-1.5% of an additive which is one or more of titanium trioxide or stannous oxide, cuprous oxide and copper oxide, rolling into slurry, and sintering at 850-950 DEG C under the protection of nitrogen or ammonia gas to obtain a copper conductor. The medium-temperature copper paste is prepared by the following steps: mixing 60.0-85.0% of copper powder, 3.0-13.0% of glass, 8.0-25.0% of an organic adhesive and 0.2-1.6% of an additive which is one or more of titanium sesquioxide or stannous oxide, cuprous oxide and copper oxide, rolling into paste, and sintering at 450-650 DEG C under the protection of nitrogen or ammonia gas to obtain a copper conductor. The low-temperature copper paste is prepared by mixing 60.0-85.0% of copper powder, 3.0-13.0% of glass, 8.0-25.0% of an organic binder and 0.1-2.0% of an additive which can be one or more of elemental elements of magnesium, zinc, boron and phosphorus or one or more of nickel phosphide, nickel boride, copper phosphide and copper oxide, rolling the mixture into paste, and sintering the paste in air at 250-350 DEG C to obtain a copper conductor.

The invention relates to the technical field of chemical preparations, in particular to a sodium hypochlorite stabilizer, a preparation method and a use method thereof and a stable sodium hypochlorite solution. The sodium hypochlorite stabilizer is prepared from the following components in percentage by mass: 2.5 to 3.5 percent of sodium diethylenetriamine pentaacetate, 2.5 to 3.5 percent of disodium ethylene diamine tetraacetate, 1.0 to 1.25 percent of sodium silicate, 3.5 to 5.0 percent of sodium bicarbonate, 2.5 to 3.0 percent of sodium chloride and the balance of water. The stable sodium hypochlorite solution prepared by adopting the sodium hypochlorite stabilizer disclosed by the invention is higher in stability and longer in validity period.

The invention relates to a preparation method of biphase hard nanoparticle reinforced nodular cast iron applied to lost foam casting. The preparation method comprises the following steps: (1) a synchronous chemical preparation process of TiC-TiB2 biphase hard nanoparticles; and (2) preparing the reinforced nodular cast iron containing the double-phase hard nanoparticles by using an evanescent mode casting process. The preparation method has the advantages that the preparation process is simple, casting equipment and the process are not changed, nano-particles are uniformly dispersed and the like, and the mechanical property and the wear resistance of the obtained nano-particle reinforced nodular cast iron are obviously improved; tiC-TiB2 double-phase hard nanoparticles are added into an evanescent mode model, in the casting process, the nanoparticles gradually enter molten iron along with melting of the model, the nucleation rate of a primary structure of nodular cast iron is effectively increased, grains are refined, and the obdurability of a matrix is improved; the nano-particle reinforced nodular cast iron can be widely applied to the fields of automobiles, mining equipment, ships, infrastructure construction and the like.

The invention relates to the technical field of chemical preparation, in particular to a preparation method of phosphorus trifluoride, which comprises the following steps: step 1, preparing reactants: preparing phosphorus pentoxide and pure fluorine gas; 2, mixing reactants: in a proper reaction container, mixing phosphorus pentoxide with pure fluorine gas; step 3, controlling the reaction conditions of reactants: ensuring that the reaction is carried out at proper temperature and pressure so as to promote the smooth proceeding of the reaction; and 4, separating the product to obtain phosphorus trifluoride. The method comprises the following steps: putting phosphorus pentoxide into a dry container, preparing a storage tank filled with fluorine gas, putting the prepared phosphorus pentoxide into a reaction container, introducing the dry fluorine gas from the storage tank, carrying out a reaction at high temperature and high pressure, and after the reaction is completed, adding the fluorine gas into the reaction container, phosphorus trifluoride and a byproduct oxyfluoride are separated through a physical method (distillation or condensation), so that the process is simple, and the reaction conversion rate is high.

The invention relates to the technical field of chemical preparation, in particular to a chemical reaction kettle. Comprising a reaction shell; the material storage shell is fixedly connected to the reaction shell, the material storage shell rotates and is communicated with a rotating pipe, and the rotating pipe is located in the reaction shell; the rotating ring is fixedly connected and communicated with the other end of the rotating pipe; the multiple connectors are in ball joint with the rotating ring and communicate with the rotating ring; the number of the discharging pipes is the same as that of the connectors, the discharging pipes are in ball joint with the adjacent connectors and communicate with the adjacent connectors, and each discharging pipe is provided with a plurality of discharging holes; and the oscillator is arranged in the reaction shell and is used for pushing the connector to oscillate and adjusting the blanking position of the blanking pipe. According to the manganese solution feeding device, feeding is conducted in a manganese solution, it is guaranteed that a methyl solution can make direct contact with the manganese solution, meanwhile, the swing device drives the discharging pipe to swing, the methyl solution in the discharging pipe is more dispersed when entering the manganese solution, and the methyl solution can make full contact with the manganese solution.

The invention belongs to the technical field of preparation of low-dimensional nano composite materials, and discloses a simple and rapid preparation method of an MXene-noble metal composite nano material. The method is based on the principle of mild chemical reduction, meanwhile, the reduction capacity of lone pair electrons of MXene is utilized, and mild preparation of the MXene-precious metal composite nanomaterial can be achieved. Controllable preparation of different MXene-noble metal composite nanomaterials can be realized by flexibly adjusting the components of the noble metal precursor. Meanwhile, the used chemicals are few in variety and environment-friendly, and the principle of green chemical synthesis is combined.

The invention discloses a hexamethyldisiloxane preparation method capable of purifying a raw material, and relates to the technical field of chemical preparation, the hexamethyldisiloxane preparation method capable of purifying the raw material comprises the following steps: S1, raw material preparation: cooling deionized water through a cooling system, and maintaining the temperature to be less than or equal to 10 DEG C, then injecting part of the cooled deionized water into a tubular reactor, pumping trimethylchlorosilane and methylbenzene into a premixing tank according to a proportion, and uniformly stirring and mixing; s2, catalytic promotion: injecting diluted hydrochloric acid into the tubular reactor, uniformly mixing the diluted hydrochloric acid with deionized water, and maintaining the pH value to 2-3; according to the hexamethyldisiloxane preparation method capable of purifying the raw materials, redundant steps such as catalyst recovery and repeated washing can be omitted through the hydrolysis reaction, the method is suitable for continuous production, meanwhile, the process of the hydrolysis reaction is optimized by changing the use steps and the input method of the deionized water, and the stability in the preparation process is further maintained.

The invention discloses a molten salt dielectric heat conduction chemical preparation method of a flat wood carbon electrode substrate material, a wood carbon electrode precursor is covered with molten salt, the molten salt dielectric heat conduction chemical synthesis is carried out according to the heating-heat preservation-cooling process, and the molten salt is a mixture formed by mixing inert molten salt and active molten salt; and removing condensed fused salt on the surface of the synthetic product, polishing the surface, and drying to obtain the wood carbon electrode substrate material. According to the preparation method, the problems of high cost, high energy consumption, narrow application range and the like in preparation of a high-performance plate electrode substrate carbon material aiming at integral wood with a specific size are solved, and the self-supporting electrode material substrate which is low in cost, has a hierarchical pore structure and has comprehensive performance is obtained. The obtained wood carbon electrode substrate material can be used as a plate electrode substrate carbon material; alternatively, a high surface capacitance plate electrode is directly used for capacitive deionization or supercapacitors.

The embodiment of the invention discloses a wet chemical preparation method of an electrolyte material. The wet chemical preparation method comprises the following steps: providing a halide mother solution and a lithium source solution; slowly adding the lithium source solution into the halide mother solution for coprecipitation to generate a coprecipitation product; evaporating the halide mother liquor and the lithium source solution which do not participate in coprecipitation to crystallize and separate out a coprecipitation product; and carrying out low-temperature sintering on a co-precipitation product separated by crystallization to obtain the electrolyte material. According to the wet chemical preparation method of the electrolyte material, the lithium source solution is slowly added into the halide mother solution, evaporative crystallization and coprecipitation are combined, uniform crystallization of all components can be achieved, and segregation is avoided; and the lithium source solution is slowly added, so that the solution state in the evaporation process can be changed, and the crystal granularity of the product is controllable.

The invention belongs to the technical field of chemical preparation of nano-porous materials, and relates to core-shell type porous silicon dioxide microspheres, a preparation method thereof and application of the core-shell type porous silicon dioxide microspheres in structural color. The preparation method comprises the following steps: (1) mixing absolute ethyl alcohol, ammonia water and deionized water to obtain alkaline hydrolysate; (2) mixing tetraethyl orthosilicate with organosilane to obtain a silane mixed solution; (3) simultaneously and respectively dropwise adding the alkaline hydrolysate and the silane mixed liquid into the silicon dioxide microsphere dispersion liquid under stirring, and reacting to obtain an intermediate; and (4) calcining the obtained intermediate at 550-650 DEG C to obtain the core-shell type porous silicon dioxide microspheres. The preparation method of the core-shell type porous silicon dioxide microspheres is simple, easy to operate and mild in condition. The raw materials are simple, easy to obtain, non-toxic and harmless, a surfactant and a template agent are not needed, and the cost is greatly reduced.

The invention discloses a porous catalytic membrane, a membrane electrode assembly and a water electrolysis device, and relates to the technical field of new energy. The porous catalytic membrane provided by the invention comprises a porous polymeric membrane formed by interweaving randomly arranged nanofibers, and a catalyst covering the surfaces of the nanofibers, the porous polymeric membrane has a self-supporting structure and a large specific surface area, and provides a large number of loading sites for the catalyst; the catalyst can be directly anchored on the nanofiber of the porous polymeric membrane through a physical or chemical preparation method, uniform dispersion is realized, and no ionomer is needed for coating, so that the problems of high cost and performance reduction caused by use of the ionomer are avoided, the exposure degree of catalytic active sites is remarkably improved, and the catalytic activity of the catalyst is improved. Therefore, the utilization efficiency of the catalyst is improved and the dosage of the noble metal catalyst can be reduced; in addition, the porous catalytic membrane and the ion exchange membrane have excellent interface contact characteristics, and integrated combination of the porous catalytic membrane and the ion exchange membrane is facilitated.

The invention discloses a silicon dioxide anti-blocking agent and a preparation method thereof, and relates to the technical field of chemical preparation. Comprising the following steps: taking a water glass solution and a dilute sulphuric acid solution as raw materials, and carrying out parallel flow mixing reaction to prepare silica gel; the method comprises the following steps: crushing silica gel, transferring the crushed silica gel into a reaction kettle, adding an aprotic organic solvent, adding a pH buffer solution and organic alkali into the reaction kettle to adjust the pH value of the solution, carrying out heating reflux to carry out an aging reaction, stopping heating after the reaction is completed, opening a filter valve, and filtering the liquid into an alkaline recovery tank; continuously adding an aprotic organic solvent and an organic acid acidification system into the reaction kettle to adjust the pH value of the solution, aging, opening a filter valve to filter the liquid into an acidic recovery tank, washing gel to be neutral, and filtering washing water into a water recovery tank; and adding high-purity water into the reaction kettle, homogenizing and emulsifying to prepare slurry, drying and crushing to obtain the silicon dioxide anti-blocking agent product. The preparation cost is reasonable, the treatment method is simple, and the obtained product is fine and smooth in hand feeling, high in transparency and high in yield.

The invention belongs to the technical field of chemical preparation of nano-porous materials, and relates to core-shell type porous silicon dioxide microspheres, a preparation method thereof and application of the core-shell type porous silicon dioxide microspheres in structural color. The preparation method comprises the following steps: (1) mixing absolute ethyl alcohol, ammonia water and deionized water to obtain alkaline hydrolysate; (2) mixing tetraethyl orthosilicate with organosilane to obtain a silane mixed solution; (3) simultaneously and respectively dropwise adding the alkaline hydrolysate and the silane mixed liquid into the silicon dioxide microsphere dispersion liquid under stirring, and reacting to obtain an intermediate; and (4) calcining the obtained intermediate at 550-650 DEG C to obtain the core-shell type porous silicon dioxide microspheres. The preparation method of the core-shell type porous silicon dioxide microspheres is simple, easy to operate and mild in condition. The raw materials are simple, easy to obtain, non-toxic and harmless, a surfactant and a template agent are not needed, and the cost is greatly reduced.

The invention provides a zinc negative electrode with a composite interface structure and an ultrasonic chemical preparation method and application thereof, and belongs to the technical field of zinc-based batteries. According to the sonochemical preparation method of the zinc negative electrode with the composite interface structure, the zinc substrate is placed in the oxidizing solution to be subjected to the oxidation-reduction reaction under the ultrasonic condition, the cavitation effect generated by ultrasound can greatly activate electrolyte salt, the mass transfer process is enhanced, and the electrochemical performance of the zinc negative electrode is improved. And a chemical reaction which is difficult to occur or is slowly carried out under a conventional condition is excited, and a composite interface structure consisting of two or more metal elementary substances and / or compounds is formed on the surface of the zinc matrix, so that the interface stability of the zinc negative electrode is improved, and the cycle life of the zinc-based battery is prolonged.

The present invention discloses a puerarin microcapsule for intestinal targeted release and its preparation method and application in the field of puerarin microcapsule embedding technology. The preparation method is as follows: using yeast β-glucan as an embedding carrier, in a solution environment, puerarin is embedded in yeast β-glucan under ultrasound to form a core material to obtain a first mixed solution; then sodium alginate powder is added to the first mixed solution under stirring to coat the surface of the core material with sodium alginate to form a layer of wall material to obtain a second mixed solution; using a sharp hole method, the second mixed solution is added dropwise to a coagulation bath for solidification, washed, and freeze-dried after solid-liquid separation to obtain puerarin microcapsules. The preparation method of the present invention is simple and easy to operate, selects medicine and food homologous substances as raw materials, does not introduce toxic and harmful chemical preparations such as cross-linking agents, avoids chemical pollution and potential health risks, and the puerarin microcapsules of the present invention have good intestinal sustained release and antioxidant properties.

The invention discloses an intelligent self-adaptive chemical preparation batching method and batching system, and relates to the technical field of chemical preparation production. The method comprises the following steps: monitoring the properties of various raw materials in real time, and generating multi-source data marked with timestamps; s2, performing space-time alignment on the multi-source data generated in the step S1 by adopting Kalman filtering and wavelet transform, and fusing and outputting comprehensive property parameters of the raw materials through a BP (Back Propagation) neural network; based on a reinforcement learning DQN algorithm, taking the raw material property parameters as a state space, taking the flow adjustment amount as an action space, and dynamically generating a correction ratio; and executing the proportioning instruction to detect the product quality on line and generate a quality report. The system comprises a raw material monitoring module, a data fusion processing unit, a dynamic formula engine module, an execution control module and an online quality detection module. Raw material properties are monitored in real time through various sensors, the proportion is dynamically corrected, online quality detection is integrated, and batch consistency control is achieved.

The invention discloses a synthesis method of an organosilicon polyurethane fluoride-free waterproof agent, which belongs to the technical field of chemical preparation, and is prepared by adopting organosilicon as a main body to react with diisocyanate and acrylate monomers, carrying out chain extension by using a special double-bond chain extender and then adding various assistants. Organic silicon is a low-surface-energy substance and has a good water-repellent effect, a large number of siloxane bonds exist in the organic silicon, bond angles of the siloxane bonds are large, and methyl connected to silicon atoms can freely rotate. After use, the fabric has a good waterproof effect and a soft hand feeling; after the fluorine-free waterproof agent with the branched structure is used, a certain rough texture can be formed on the fabric, the surface roughness can influence the contact angle of liquid drops on the fabric, the nano lotus effect is realized, and the fabric has an excellent waterproof effect; the cationic waterborne polyurethane can be well combined with fabrics with negative charges, so that the waterproof agent is better in washability.

The invention discloses a preparation method of an electronic-grade hydroxylamine aqueous solution, and relates to the field of chemical preparation. The preparation method comprises the following steps: reacting electronic-grade ammonia water or organic alkali with electronic-grade hydroxylamine salt to generate a hydroxylamine aqueous solution; and after the reaction, separating through a POSS (Polyhedral Oligomeric Silsesquioxane) nano blending modified membrane, and removing salt, impurities and unreacted raw materials to obtain a high-purity hydroxylamine aqueous solution. And concentrating the solution into a 50% hydroxylamine aqueous solution by adopting a low-temperature vacuum concentration technology. The method can effectively remove metal ions and inorganic impurities, and ensures that the final product is high in purity and meets the electronic grade requirement.

The application relates to the technical field of chemical preparation, and particularly relates to a liquid monoammonium phosphate and iron phosphate production system. The system comprises a mother liquor treatment device, a pH adjusting tank, a purified phosphoric acid storage tank, a liquid monoammonium phosphate storage tank and an iron phosphate production device; the output end of the mother liquor treatment device is connected with the first input end of the pH adjusting tank, the output end of the purified phosphoric acid storage tank is connected with the second input end of the pH adjusting tank, and the purified phosphoric acid and the mother liquor to be adjusted are injected into the pH adjusting tank; the mixed reaction area of the pH adjusting tank is configured to neutralize the mother liquor to be adjusted and the purified phosphoric acid according to a preset ratio to generate liquid monoammonium phosphate; the input end of the liquid monoammonium phosphate storage tank is connected with the output end of the pH adjusting tank, the output end of the liquid monoammonium phosphate storage tank is connected with the raw material inlet of the iron phosphate production device, and the iron phosphate production device is configured to synthesize iron phosphate by taking the liquid monoammonium phosphate as a raw material. The application has the beneficial effects of simplifying a production process and reducing energy consumption.

The utility model discloses a layering device for preparing a solid active compound preparation, and belongs to the technical field of chemical preparation preparation devices. The utility model discloses a layering device for preparing a preparation from a solid active compound. The partition plate is fixedly connected in the cylinder body; the first air inlet pipe is fixedly connected to the top of the barrel; the second air inlet pipe is fixedly connected to the side wall of the barrel; the first feeding pipe is fixedly connected to the cylinder body; the second feeding pipe is fixedly connected to the cylinder body; the discharging pipe is fixedly connected to the partition plate; the discharging pipe is fixedly connected to the bottom of the cylinder body; the barrel is divided into the temporary storage area and the sedimentation area through the partition plate in the device, a transfer tank does not need to be used for transfer, the production cost is reduced, meanwhile, through the observation window formed in the barrel, the sedimentation condition of mixed liquid does not need to be observed through multiple times of sampling, supernate can be taken out after direct observation, the operation difficulty is reduced, and the operation efficiency is improved. And the production efficiency is improved.

The utility model discloses a kind of purification equipment of self-cleaning type sedimentation treatment, belong to chemical preparation technical field, including shunting discharge shell, further including self-cleaning type washing device and multifunctional discharge device, self-cleaning type washing device and multifunctional discharge device for washing purification of sediment are installed on the shunting discharge shell, multifunctional discharge device upper end is connected with self-cleaning type washing device;The multifunctional discharge device includes rotatable discharge component for cooperating self-cleaning type washing device changes discharge path and driving component for providing drive, rotatable discharge component is connected with shunting discharge shell, driving component and self-cleaning type washing device, driving component is connected with shunting discharge shell.By the above-mentioned mode, rotatable discharge component is rotated and adjusted by driving component drive, so that filtered wastewater, sediment and self-cleaning wastewater effectively shunt, improve the purification effect, reduce the influence of sediment impurity on filtration effect.

The utility model provides a reaction tower for preparing polyether polyol with low energy consumption, which belongs to the technical field of chemical preparation reaction and comprises a preparation reaction tower body, a limiting top plate is fixedly connected to the surface of the preparation reaction tower body, a first opening is formed in the top of the preparation reaction tower body, and a second opening is formed in the top of the preparation reaction tower body. According to the low-energy-consumption reaction tower for preparing the polyether polyol, reaction raw materials are put into the mixing assembly from the filler box, meanwhile, the mixing assembly is started to conduct sufficient stirring reaction on the reaction raw materials, meanwhile, in order to prevent filler from sinking to the bottom, the vibration assembly is used for further conducting vibration reaction on the filler at the bottom of the mixing assembly, and therefore the reaction efficiency is improved. The raw materials are fully utilized and prevented from being wasted, meanwhile, the circulating pump inputs the reacted raw materials into the polyether polyol flash sieve plate furnace, and the raw materials are fully reacted, so that the circulating pump can convey the raw materials in a large quantity and in a small number of times, the service life of the circulating pump is prolonged, and the overall economic value of the device is further increased.

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a glucolactone crystal with controllable product granularity, which comprises the following steps: carrying out ultrasonic induced nucleation on a gluconic acid concentrated solution to generate a seed crystal, then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h, stirring by adopting a Taylor flow stirrer while cooling, and then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h to obtain the glucolactone crystal with controllable product granularity. A 45-degree four-blade axial Taylor flow stirring paddle is assembled below the Taylor flow stirrer, the rotating speed is 200-400 rpm, the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer is 0.4-0.8, after the cooling procedure is completed, solid-liquid separation is conducted, crystals are collected, and a glucolactone crystal product is obtained after drying treatment. The number of fine grains is controlled by changing the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer and the stirring speed, glucolactone crystal products with different granularities are obtained, the process is stable, the granularity of the glucolactone crystals can be effectively controlled, and the granularity of the crystal products can be finely adjusted according to actual product requirements.

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a phthalimide compound, which comprises the following steps: S1, raw material mixing: sequentially adding phthalic anhydride, a primary amine compound, p-toluenesulfonic acid and phosphorus pentoxide into a reaction container with a stirring device and a temperature control module, and stirring for 1-2 hours; adding ethanol as a solvent, and carrying out a stirring reaction; s2, curing: cooling the reaction liquid to 20-25 DEG C, slowly adding deionized water into the reaction liquid while stirring, standing, and separating out a solid product; a traditional dehydrating agent is changed into a low-cost green dehydrating agent combination, so that the cost loss is reduced, the stimulation effect is reduced, the catalytic activity is equivalent to that of p-toluenesulfonic acid by adding a new sulfonic group functional polymer, but the problems of volatility of liquid acid and equipment corrosion are avoided, a low-toxicity and low-cost solvent of ethanol is added, the toxicity is reduced, and the environment-friendly dehydrating agent is prepared. The preparation is safer, the cost is lower, and the applicability is wider.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

This invention discloses a chemical preparation method for pharmaceutical-grade dexborneol. The method employs Noyori asymmetric hydrogenation, asymmetric reduction of camphor, and the use of ruthenium as a catalyst. Under the action of phosphine ligands, dexborneol and a small amount of its isomer, isoborneol, are prepared. Then, under the action of trimethylchlorosilane, dexborneol, due to its spatial configuration, can form a silicon-oxygen bond with TMS, while isoborneol cannot. Isoborneol is removed by recrystallization to obtain a silyl ether protected compound of dexborneol. Dexborneol is then prepared under hydrochloric acid conditions and purified by recrystallization to obtain highly purified dexborneol. This route features mild reaction conditions, does not use highly toxic materials, and has a high yield, meeting the requirements for pharmaceutical-grade dexborneol.