565 results about "Sodium hyaluronate" patented technology

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.

The invention relates to a skin care composition for women and children and a preparation method thereof. The composition comprises the following components: tremella fuciformis extract nanocrystals, a calendula extract, an oat extract, dipotassium glycyrrhizinate, panthenol, sodium hyaluronate and the like. By using a nanocrystalline technology and a compound stabilizer, the moisturizing and anti-oxidation effects of the product are remarkably improved, and the product is suitable for various skins, especially sensitive skins. The product is safe and mild, effectively reduces skin irritation and improves the skin barrier function. The problems that an existing skin care product is not lasting in moisturizing effect and insufficient in oxidation resistance are solved, and an efficient and stable skin care solution is provided.

The invention relates to a sodium hyaluronate fermentation filtrate as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Through a two-stage fermentation mode, the fermentation filtrate containing sodium hyaluronate is prepared by recombining bacillus subtilis, and then residual nutrient substances in a culture medium are consumed by inoculating bacillus velezensis, so that the nutrient substances are metabolized into active substances with repairing and strengthening effects on hair; the prepared sodium hyaluronate fermentation filtrate has the effects of repairing scalp and strengthening hair. The sodium hyaluronate filtrate disclosed by the invention can be used for well reducing the content of NO in macrophages (the NO content of cells is increased due to malassezia lysate), can be used for removing active oxygen ROS of HaCaT cells and increasing the total tensile strength of hair, and has the potential effects of relieving scalp, resisting oxidative stress and enhancing the toughness of the hair.

The invention relates to the technical field of skin care products, and discloses an anti-aging and whitening composition and a preparation method thereof.The anti-aging and whitening composition comprises anti-aging and whitening components, whitening synergistic components, moisturizing and repairing components and deionized water, and the anti-aging and whitening components comprise botryine, ergothioneine and Ectoine; wherein the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2 to 2.0) to (0.4 to 0.7) to (1.0 to 1.5); the whitening synergistic component comprises one or more of nicotinamide, glabridin and tranexamic acid; the moisturizing and repairing component is prepared from one or more of sodium hyaluronate, ceramide NP, glycerol and 1, 3-butanediol. Experiments show that the mass ratio of the glassine to the ergothioneine to the ectoine is (1.2-2.0): (0.4-0.7): (1.0-1.5), so that the glassine, the ergothioneine and the ectoine show a remarkable synergistic effect (in some cases, the synergistic index CIlt is 0.85), and the anti-aging and whitening functions of the composition containing the glassine, the ergothioneine and the ectoine are improved.

The invention belongs to the technical field of exosome freeze-dried powder, and discloses exosome freeze-dried powder and a preparation method thereof, the exosome freeze-dried powder contains mesenchymal stem cell exosome, trehalose, sodium hyaluronate, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide. According to the exosome freeze-dried powder, hydroxypropyl-beta-cyclodextrin, glutathione, ceramide and fructo-oligosaccharide are added, the membrane structure integrity of the exosome is effectively protected, the retention rate of active substances in the exosome freeze-dried powder is high, and therefore the effects of resisting inflammation, regulating cell metabolism, promoting tissue repair and the like of the exosome can be fully exerted. In addition, glutathione can directly remove skin free radicals and inhibit oxidative stress injury, and has an anti-oxidation effect; ceramide can also supplement skin lipid barrier, enhance the water locking capacity and enhance the moisturizing effect of sodium hyaluronate; fructo-oligosaccharide can also regulate skin micro-ecological balance, and has anti-inflammatory and bacteriostatic effects.

The invention belongs to the technical field of medical biological materials, and particularly relates to a sodium hyaluronate gel regeneration filler for injection and a preparation method and application thereof.The sodium hyaluronate gel serves as a carrier to disperse acellular matrix particles, the sodium hyaluronate gel forms a micron-sized porous structure in the cross-linking process through a microbubbling technology, and the sodium hyaluronate gel is prepared into the sodium hyaluronate gel regeneration filler for injection and the preparation method and application of the sodium hyaluronate gel regeneration filler. A local cross-linked network is strengthened by combining a secondary cross-linking process, high elastic modulus is realized while the content of sodium hyaluronate is reduced, so that the porous structure has excellent instant filling and shaping capability and controllable degradation behavior, the porous structure can promote permeation of hyaluronidase, the degradation period of the hyaluronidase is matched with the tissue regeneration process, and the tissue regeneration effect is improved. And the acellular matrix particles can continuously induce adhesion, migration, proliferation and differentiation of endogenous cells of tissues, synergistically promote in-situ tissue regeneration, effectively reduce repeated injection requirements and reduce long-term complication risks, and have a good application prospect in soft tissue filling and repairing.

The invention discloses a hyaluronic acid moisturizing and repairing composition and a preparation method thereof, belongs to the field of cosmetics, and specially meets the requirement of dry skin. The composition consists of a core moisturizing component, an auxiliary functional component and the balance of purified water, the core moisturizing component comprises hyaluronic acid components with oligomeric, low, medium and high molecular weights and sodium hyaluronate cross-linked polymer microbeads with gradient particle sizes; the auxiliary functional components comprise bionic liposome, a nonionic emulsifier, polyol, a natural penetration enhancer, a retardant and a preservative. The gradient microbeads and HA with different molecular weights achieve all-around water replenishing and locking from the surface layer to the deep layer of the skin, the bionic lipidosome promotes component permeation and repairs the skin barrier, the composition is good in stability, mild and free of irritation, the problems that the deep layer of the dry skin is dry, water is continuously deficient, and the barrier is fragile can be effectively solved, and the composition has wide cosmetic application prospects.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine spray for treating rhinitis and a preparation method thereof.The traditional Chinese medicine spray is prepared from flos magnoliae liliflorae, fructus xanthii, herba ephedrae, fructus forsythiae, flos lonicerae, radix angelicae, herba asari, menthol, herba centipedae and herba menthae. Refining to obtain a fluid extract; and mixing the fluid extract with a penetration enhancer consisting of aminoketone and menthol, a sodium hyaluronate mucous membrane repairing agent, a pH regulator, an isoosmotic adjusting agent and a preservative to prepare spray liquid medicine, and finally performing sterile filtration and filling. Through efficient extraction and synergism of composite auxiliary materials, the permeability and bioavailability of the medicine are remarkably improved, and the symptoms such as nasal obstruction and running nose can be quickly relieved; meanwhile, the anti-inflammatory function and the function of actively repairing the damaged nasal mucosa are achieved, and the recurrence rate is reduced from the source; the pH and osmotic pressure of the preparation are precisely adjusted, the use is comfortable, and the quality is stable and controllable.

The invention relates to the technical field of biological medicines, in particular to a soluble skin-adhering microneedle for delivering an inactivated enterovirus vaccine as well as a preparation method and application of the soluble skin-adhering microneedle. Sodium hyaluronate is adopted as a film forming material to wrap an enterovirus 71 type (EV71)-coxsackie virus A16 (CA16) type bivalent inactivated vaccine antigen, and a needle body layer of the soluble microneedle is formed; the substrate layer is prepared from a pullulan material, so that the microneedle patch with a stable overall structure is formed. The technology provided by the invention is completed in a clean environment, and the vaccine patch which is qualified through sterility detection is obtained. The soluble microneedle disclosed by the invention has good antigen stability under the condition of 2-8 DEG C. In animal experiments, the microneedle is attached to the skin surface of a mouse for skin-adhering immunization, a strong immune response reaction can be induced, good immunogenicity is shown, and a novel, safe and effective vaccine delivery way is provided for prevention and control of the infantile hand-foot-and-mouth disease.

The invention belongs to the technical field of plant care essential oil extraction, and particularly relates to sanshool delayed care essential oil and a preparation method thereof. The invention discloses a sanshool-enriched lipid composition which is prepared from the following components in parts by weight: 0.05 to 0.1 part of sanshool-enriched fraction, 1 to 2 parts of solid lipid, 1 to 1.5 parts of liquid lipid, 1.5 to 2.5 parts of stable surfactant, 1 to 2 parts of cosurfactant, 3 to 5 parts of glycerol, 0.2 to 0.5 part of soothing anti-irritation component, 0.05 to 0.1 part of sodium hyaluronate, 0.1 to 0.3 part of hydroxypropyl methyl cellulose, 0.05 to 0.1 part of antioxidant and the balance of purified water. According to the invention, sanshool is used as a core functional factor, and through collaborative design of supercritical extraction, molecular distillation purification, NLC carrier encapsulation and a soothing film-forming system, contradictions of effectiveness, mildness and the like in an existing scheme are solved, and mild desensitization, stable controlled release, reduction of stimulation and migration risks and improvement of tolerance and action consistency are realized.

The invention discloses an anti-adhesion biological polysaccharide flushing glue solution for surgical operation and a preparation method of the anti-adhesion biological polysaccharide flushing glue solution. The anti-adhesion biological polysaccharide flushing glue solution is prepared from the following raw materials in parts by mass: 5-30 parts of sodium carboxymethyl cellulose, 0.1-5 parts of polyoxyethylene with the molecular weight of 1,500,000-2,000,000 Daltons, 2-16 parts of sodium hyaluronate with the molecular weight of 1,200,000-2,000,000 Daltons and 80-100 parts of water for injection. The preparation method comprises the steps of alkalization of the natural plant fibers, carboxymethylation modification of the natural plant fibers, dissolution and mixing of prepared anti-adhesion liquid, emulsification treatment and sterilization filling. Natural plant fibers are used as raw materials, high-purity sodium carboxymethyl cellulose is prepared through a modification technology, and the sodium carboxymethyl cellulose is used as a basic framework of a glue solution and can be maintained to be incompletely degraded in an adhesion generation period in vivo, so that the stability of a physical barrier is ensured; sodium hyaluronate with the molecular weight matched with the anti-adhesion effect and polyoxyethylene for improving the strength and adhesiveness of the flushing fluid are screened and form a synergistic system with synchronous degradation and complementary strength with sodium carboxymethyl cellulose.

The application discloses a skin repair dressing and a preparation method thereof, and belongs to the technical field of medical dressings. The skin repair dressing comprises the following raw materials in parts by weight: carboxymethyl chitosan 4-6 parts, sodium alginate 2-4 parts, polyvinyl alcohol 8-10 parts, recombinant human collagen 1-2 parts, sodium hyaluronate 0.5-1 part, a crosslinking agent 1.5-2 parts, nano filler 0.1-0.5 part, an antioxidant 0.5-1 part and deionized water 80-90 parts; the crosslinking agent is prepared by reacting glutathione with dithio-bismaleimidyl ethane to obtain an intermediate 1, and then reacting with 4-formylphenylboronic acid. The skin repair dressing prepared by the application has excellent tensile properties and antibacterial properties.

The invention discloses a PDRNamp and a method for preparing the PDRNamp. The invention discloses EGT eye wash as well as a preparation method and application thereof, and belongs to the technical field of eye care products. The eye wash is prepared from the following active components in percentage by mass: 0.001 to 0.01 percent of PDRN, 0.03 to 0.1 percent of EGT (Ergothioneine), sodium hyaluronate, sodium chloride, taurine and the like, wherein the mass percent of the PDRN is 0.001 to 0.01 percent, and the mass percent of the EGT is 0.03 to 0.1 percent. Through the synergistic effect of PDRN and EGT, the product has excellent cornea repairing capacity and a powerful anti-oxidation function at the same time, and the moisturizing and soothing effects are enhanced by compounding sodium hyaluronate and taurine. The obtained eye washing liquid is an isotonic solution with neutral pH, is mild and non-irritating, does not contain preservatives, can effectively achieve multiple nursing effects of eye cleaning, moisturizing, repairing, anti-inflammatory and anti-oxidation, and is suitable for relieving xerophthalmia, assisting cornea repair and daily anti-oxidation nursing of eyes.

The invention discloses a preparation method of a nano-liposome coated NAD amino acid nutrient solution, and relates to the technical field of liposome amino acid nutrient solution preparation, the preparation method comprises the following steps: S1, preparing raw materials: S1.1, preparing NAD amino acid; s1.2, lecithin: using pure natural lecithin from soybeans and eggs; s1.3, preparing sodium hyaluronate: adopting sodium hyaluronate with low molecular weight; s1.4, preparing an amino acid compound, wherein the amino acid compound contains a plurality of essential amino acids, including glycine, serine and lysine; according to the mask, when the NAD amino acid nutrient solution wrapped by the nano-liposome is applied to the mask, the mask can more effectively permeate into the deep layer of the skin due to the excellent stability and biological activity of the NAD amino acid nutrient solution, and sufficient nutrition and moisture are provided for the skin; meanwhile, due to the strong anti-aging effect, the mask can remarkably improve the skin texture, reduce fine wrinkles and wrinkles, and make the skin more compact, smoother and elastic.

The invention discloses long-acting high-dynamic hydrazone bond hydrogel as well as a preparation method and application thereof, and particularly relates to the technical field of biomedical materials. The preparation method comprises the following steps: taking 1-adamantane acetic acid and adipic dihydrazide modified sodium hyaluronate and benzaldehyde-terminated eight-arm polyethylene glycol as carrier raw materials; the hydrazone bond hydrogel with relatively high stability is prepared through a coupling reaction of an aldehyde group of benzaldehyde-terminated eight-arm polyethylene glycol and a hydrazide group of 1-adamantane acetic acid and adipic dihydrazide modified sodium hyaluronate. The beta-cyclodextrin modified m-phenylenediamine catalyst is dynamically combined into the carrier through reversible host-guest complexation between beta-cyclodextrin and 1-adamantane acetic acid, so that the long-acting high-dynamic hydrazone bond hydrogel is obtained, and the requirement of three-dimensional culture of stem cells on mechanical properties can be met; and network dynamics can be maintained for a long time, so that stem cell spreading is supported, mechanical signal transduction is activated, osteogenesis-related gene expression is promoted, and stem cell osteogenesis differentiation capability is enhanced.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The application provides a medical bacterial cellulose dressing with high water retention capacity and a preparation method and application thereof, and belongs to the technical field of medical supplies. The medical bacterial cellulose dressing with high water retention capacity is prepared by reacting a bacterial cellulose membrane with a sodium hyaluronate solution in the presence of tetramethylphosphonium chloride, and the water retention time of the dressing is not less than 2000 min. The prepared medical bacterial cellulose dressing with high water retention capacity has great advantages in actual medical application. For burn and scald patients, traditional dressings are often difficult to keep the wound moist for a long time, and if they are removed after drying, secondary wound damage will be caused. However, the dressing can provide a persistent and stable moist environment for the wound and accelerate the repair and regeneration of damaged skin cells due to its excellent water retention capacity.

A rinsing solution for photodynamic disinfection, in particular oral disinfection, including, at least one photosensitiser from the group comprising riboflavin 5′-phosphate sodium in a proportion of 0.2 to 0.6 wt. % and a photosensitiser other than riboflavin 5′-phosphate sodium in a proportion of 0.001 to 0.05 wt. %, at least one viscosity modulator from the group comprising glycerol in a proportion of 1.0 to 5.0 wt. % and hyaluronic acid sodium salt in a proportion of 0.01 to 0.3 wt. %, at least one biofilm inhibitor from the group comprising xylitol in a proportion of 7.0 to 25.0 wt. %, L-arginine in a proportion of 0.01 to 0.5 wt. % and urea in a proportion of 0.5 to 3.0 wt. %, with the remainder on a water base.

1. Name of the designed product: packing box (sodium hyaluronate eye drops). 2. Use of the designed product: the designed product is mainly used for packing of medicines. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention relates to compound herba houttuyniae eye drops as well as a preparation method and application of the compound herba houttuyniae eye drops. Comprising the following preparation raw materials in percentage by mass: 1-6% of a herba houttuyniae extracting solution, 1-5% of an aglaia odorata extracting solution, 1-2% of a gelidium amansii extracting solution, 0.1-0.3% of acyclovir, 0.1-0.3% of tobramycin, 0.01-0.1% of dexamethasone sodium phosphate, 0.1-1% of sodium hyaluronate, 0.1-3% of glycerol and 88-93% of purified water. According to the compound herba houttuyniae eye drops prepared by the preparation method disclosed by the invention, the herba houttuyniae extracting solution, the aglaia odorata extracting solution, the gelidium amansii extracting solution, the acyclovir, the tobramycin and the dexamethasone sodium phosphate are combined for use, so that the compound herba houttuyniae eye drops have a relatively good curative effect on pets suffering from bacterium and virus mixed infection type conjunctivitis / keratitis; the compound herba houttuyniae eye drops are good in high-temperature-resistant storage stability and good in curative effect, the problem of frequent administration can be reduced, and the compound herba houttuyniae eye drops are more convenient to use and store.

The invention discloses a method for improving skin attaching performance and strength of membrane cloth and application. The method comprises the steps that the membrane cloth is treated with a modifying solution, and modified membrane cloth is obtained after drying; the modified liquid is obtained by compounding sodium hyaluronates with different molecular weights, and the sodium hyaluronates with different molecular weights comprise macromolecular sodium hyaluronate and hyaluronic acid which are subjected to enzymolysis to obtain micromolecular oligomeric sodium hyaluronate. The sodium hyaluronates with different molecular weights are compounded to modify the membrane cloth, and the macromolecular sodium hyaluronate forms a protective membrane on the skin surface to prevent water evaporation; the hyaluronic acid is subjected to enzymolysis to obtain small-molecular oligomeric sodium hyaluronate, the small-molecular oligomeric sodium hyaluronate plays a role in moisturizing, keeps the skin moist, can permeate into the deep layer of the skin and promotes skin repair and nutrient absorption, and the sodium hyaluronate with different molecular weights has a synergistic effect, so that the multiple effects of moisturizing, repairing, relieving, resisting aging, promoting permeation and the like are achieved.

The present application relates to a nutritional composition, a product comprising the same and use thereof in the preparation of a product for alleviating synaptic plasticity impairment of a body. The nutritional composition comprises: docosahexaenoic acid (DHA) and / or a metabolic precursor thereof, sodium hyaluronate (SH), and lactoferrin (LF). When docosahexaenoic acid (DHA), sodium hyaluronate (SH) and lactoferrin (LF) are used in combination, they can synergistically alleviate synaptic plasticity impairment of a body, in particular, increase nerve growth factor (NGF) content and / or brain-derived neurotrophic factor (BDNF) content in PC12 cells of the body, and / or increase expression of synaptic-related proteins in PC12 cells of the body.

The invention discloses a fish hydrolyzed collagen peptide-based flavor beverage and a preparation method thereof, and relates to the technical field of food beverages. The flavored beverage comprises the following raw materials: fish hydrolyzed collagen peptide, a compound flavor modification stabilizer, a compound sweetening agent, concentrated fruit and vegetable juice, casein phosphopeptides, VC magnesium phosphate, zinc lactate, a low-nucleic-acid yeast extract, sodium hyaluronate, an acidity regulator and purified water. The compound flavor modification stabilizer is matched with the low nucleic acid yeast extract to form synergistic flavor regulation and control, the hydrophobic bitter peptide fragment of the fish hydrolyzed collagen peptide and the fishy smell characteristic group are wrapped from the molecular level, and meanwhile, the soft modification on the sensory level is realized through the gamma-aminobutyric acid; the effect of debitterizing and deodorizing without adding artificial essence and a large amount of cane sugar is achieved, the product flavor is natural and harmonious, the sour and sweet taste is palatable, the beverage completely conforms to the current healthy consumption trend of low sugar and no artificial addition, and the problem that the beverage has flavor defects is solved.

The invention relates to the technical field of biomedical materials, in particular to a sodium hyaluronate composite solution for relieving skin aging and a preparation method thereof, the sodium hyaluronate composite solution comprises sodium hyaluronate, taurine, proline, glutamic acid, glycine and valine; sodium hyaluronate has a specific molecular weight, the composite solution has a specific pH value and osmotic pressure, and all the components have a synergistic effect, so that a moist environment is provided for skin, free radicals are removed, collagen synthesis is promoted, and aging phenomena such as skin laxity and wrinkles are improved. The composition can maintain skin moisture for a long time, scavenge free radicals, resist oxidation and promote collagen synthesis to improve skin aging, the preparation process guarantees stable components, the solution is matched with the physiological environment of the skin, and the composition is non-irritant, safe to use and good in anti-aging effect.

The invention discloses a polyester polymer microsphere containing hyaluronic acid (sodium) and a preparation method of the polyester polymer microsphere, the hyaluronic acid (sodium) is dispersed in a microsphere body, and the hyaluronic acid (sodium) accounts for 2-20% of the weight of the polyester polymer microsphere. The preparation method of the microspheres comprises the following steps: dispersing hyaluronic acid (sodium) in a polyester polymer solution in a non-solution form to obtain a polyester polymer solution in which hyaluronic acid (sodium) is dispersed; the step of dispersing the hyaluronic acid (sodium) in the non-solution form is that the hyaluronic acid (sodium) is dispersed in the form of solid particles or a solid particle suspension; in the polyester polymer solution, the solvent for dissolving the polyester polymer is a volatile solvent. The microspheres provided by the invention can wrap hyaluronic acid (sodium) with higher content, and have better stability.

The application discloses a new application of a JAK inhibitor and a medicine for promoting skin stretch regeneration, and application of the JAK inhibitor in preparation of the medicine for promoting skin stretch regeneration; the medicine for promoting skin stretch regeneration comprises the following components: a JAK inhibitor and a carrier, wherein the carrier comprises sodium hyaluronate and propylene glycol; the application provides a new application of the JAK inhibitor, and the JAK inhibitor can promote skin stretch regeneration, in particular, can promote increase of hair follicle density, increase of epidermis thickness, increase of dermis thickness, reduction of fibrosis degree, reduction of immune infiltration degree and reduction of myofibroblast quantity after skin expansion.

The application provides a preparation method of calcium hyaluronate, which comprises the following steps: adding sodium hyaluronate into an acidic displacement solution containing calcium salt, performing displacement to obtain calcium hyaluronate precipitate; washing the precipitate with an acidic washing solution; dehydrating the washed precipitate with a neutral dehydration solution, and vacuum drying to obtain calcium hyaluronate powder; wherein the organic medium concentration in the displacement solution is 50-90 wt%, preferably 60-80 wt%, the calcium salt concentration is 0.5-4 wt%, preferably 1-3 wt%, the organic medium concentration in the washing solution is 50-90 wt%, preferably 60-80 wt%, and the organic medium concentration in the dehydration solution is greater than or equal to 90 wt%. The application obtains calcium hyaluronate finished product through high-efficiency displacement, and solves the problems of multiple displacement times, long time consumption, large calcium salt consumption, low calcium displacement efficiency and turbidity of calcium hyaluronate solution in the current calcium hyaluronate production process.

The application relates to the field of biological products, in particular to application and application method of glutathione in medical devices or cosmetics, and a medical device / cosmetic containing glutathione, and provides application of glutathione in specific medical devices (such as products for facial superficial dermis injection, products for wound care) and various cosmetics, wherein the amount of glutathione is 0.1-3 wt%, the glutathione is used in combination with sodium hyaluronate at a mass ratio of (0.1-3):(0.6-3), and specific antioxidant components (such as vitamin C, vitamin E, etc.) and chelating agents can be further compounded to form a synergistically stable composite system. The application effectively improves the storage stability of glutathione in the product, and enables the glutathione to be adapted to various application scenes such as injection, wound care and skin care, thereby providing a reliable technical scheme for industrial application of glutathione in the fields of medical devices and cosmetics.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.