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2706 results about "Sodium hyaluronate" patented technology

Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans.

Process for preparing cross-linked sodium hyaluronate microspheres capable of being adopted as emboliaztion agent by adopting sodium hyaluronate as raw material

The present invention provides a process for preparing cross-linked sodium hyaluronate microspheres capable of being adopted as an emboliaztion agent by adopting sodium hyaluronate as a raw material. The process comprises the following steps: preparing a sodium hyaluronate alkaline solution gel with a concentration of 10-30% g/ml; adding the sodium hyaluronate alkaline solution gel to an emulsifier-containing oil phase, and carrying out high speed emulsification through a shearing machine, wherein an emulsification speed is 500-2000 rpm, and a time is 10-20 min; adding a certain amount of a cross-linking agent, stirring for 4-6 h at a room temperature, carrying out a cross-linking reaction, and standing overnight after completing the reaction, wherein a mass percentage of the cross-linking agent in the oil phase is 0.2-2%; and adopting a water-soluble organic solvent to wash to remove the oil phase remained on the surface of the microspheres, and finally drying to obtain the cross-linked sodium hyaluronate microspheres. According to the present invention, the preparation process is simple; and the size of the obtained microspheres is suitable for routine blood vessel emboliaztion, and the obtained microspheres have characteristics of controllable particle size, good microsphere shape, easy screening, elasticity, expandibility, no toxic-side effect on human body, good biocompatibility, good biodegradability, and ensured clinical safety.
Owner:HANGZHOU SINGCLEAN MEDICAL PROD

Dressing composition used for inhibiting scars and accelerating wound healing and application thereof

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.
Owner:DALIAN UNIV OF TECH

Efficient moisture-retention sodium hyaluronic acid raw-liquor

The invention discloses a high-effective moisture-keeping sodium hyaluronate stock solution comprising a sodium hyaluronate, characterized in that the solution is composed of high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton and low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton which are mixed by proportion, wherein, the high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton is of 0. 1 to 0. 5 parts by weight, the low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton is of 0. 5 to 1. 0 parts by weight, the rest is 100 parts of distilled water, the distilled water. especially can be chose for double distilled waters. The high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention can effectively permeate into a corium layer to promote blood microcirculation, be beneficial to nutrient substance absorption of the skin, with beautification anti-wrinkle health care action; the high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention has strong flexibility and wetting property, can be coated on the skin surface to form a layer of moisture-keeping ventilated membrane for keeping the skin nourishing, moistening and glossy.
Owner:TONGXIANG HENGJI BIOTECH

Preparation method of dry nano-fiber facial mask

The invention discloses a preparation method of a dry nano-fiber facial mask. The preparation method comprises the following steps: preparing a polyvinyl alcohol water solution, a chitosan water solution, a sodium hyaluronate water solution and a nutrient solution; mixing the water solutions to form a spinning solution, carrying out multi-needle electrostatic spinning, and finally forming a layerof nano-fiber film on a facial mask non-woven fabric base material serving as a receiving screen, so as to obtain a composite fiber film; drying at 70-80 DEG C for 2-5 minutes; and carrying out slitting, formation, sealed packaging and sterilization, so as to obtain the dry nano-fiber facial mask. According to the preparation method, effective components in facial mask liquid are mixed into a polyvinyl alcohol spinning base solution, the nano-fibers are prepared by virtue of an electrostatic spinning technique and fixed on a facial mask non-woven fabric, the facial mask is taken out in use, aproper amount of purified water is sprayed to the front surface of the facial mask to adequately wet the facial mask, and then the facial mask can be applied to the face of a user. The water content is extremely low before use, and natural chitosan type antibacterial components are added, so that the guarantee period is prolonged, and the facial mask is convenient to transport and store.
Owner:上海世领生物科技有限公司

Preparing method of injectable sodium hyaluronate gel containing microballoons

InactiveCN109621003ASolve the problem of local inflammatory nodulesSimple methodPharmaceutical delivery mechanismTissue regenerationMicrosphereColloid
The invention discloses a preparing method of injectable sodium hyaluronate gel containing microballoons. The preparing method comprises the following steps of dissolving sodium hyaluronate into purewater to obtain a solution A; adding a microballoon material into the solution A, and conducting uniform stirring to obtain a homodisperse suspension liquid B; adjusting the PH value of the suspensionliquid B to obtain a suspension liquid C; adding a crosslinking agent into the suspension liquid C, conducting uniform stirring to obtain a homodisperse suspension liquid D, after a reaction is carried out for a certain period of time, crosslinking sodium hyaluronate in the suspension liquid D to form colloid E containing the homodisperse microballoon material; smashing the colloid E to obtain gel particles F, and obtaining gel particles G through screens with different mesh numbers; removing soluble impurities and crosslinking agents in the gel particles G in a repeated soaking or dialytic mode to obtain gel particles H; utilizing a PBS buffering solution for balancing for repeatedly soaking the gel particles H to obtain gel particles I; obtaining the sodium hyaluronate gel through the procedures of semi-dehydration, filling and sterilization. By means of the preparing method, the problem that the microballoon material is deposited and gets caked is effectively solved.
Owner:长春杭盖生物科技有限公司

Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof

The invention relates to the technical field of masks, and particularly relates to a Dendrobium officinale moisturizing and repair sleeping mask and a preparation method thereof. The mask comprises a phase A component and a phase B component, wherein the phase A component comprises moisturizer, emulsifier, sodium hyaluronate A and water; the phase B component comprises Dendrobium officinale extracting solution, Crocus sativus extract, ganoderma lucidum extract, agilawood extract, sodium hyaluronate B and cosolvent. The mask is prepared from Crocus sativus, ganoderma lucidum, agilawood and Dendrobium officinale, wherein the Crocus sativus achieves the main effect of activating blood circulation to dissipate blood stasis; the ganoderma lucidum and the agilawood respectively achieve the auxiliary effects of invigorating qi and calming the nerves, and promoting circulation of qi to relieve pain; the Dendrobium officinale achieves the adjuvant effect of nourishing yin and promoting salivation; and the whole composition achieves the effects of promoting flow of qi and blood circulation, dispersing blood stasis and nourishing the kidney-yin. Besides, since the Dendrobium officinale extracting solution contains abundant colloid, the loss of moisture and collagen in the skin can be supplemented, elastic fibers can be repaired, and cell tissues can be reformed, so that the original elasticity and gloss of the skin are recovered, the remarkable freckle removal effect is achieved; and under the condition of ensuring that the skin is sufficiently moisturized, the mask has a greatly improved skin repair function.
Owner:GUANGDONG GUOFANG MEDICAL TECH
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