4913 results about "Sodium hyaluronate" patented technology

Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.)

The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.

The invention discloses whitening and freckle-removing cream and a preparation method thereof. The whitening and freckle-removing cream comprises water, butanediol, caprylic / capric triglyceride, isohexadecane, glycerol, cyclopentasiloxane, butyrspermum parkii butter, trehalose, cetearyl olivate, sorbitan olivate, cetearyl alcohol, cetearyl glucoside, magnolia sieboldii extract, citrus peel extract, hydrogenated lecithin, phytosterol, bisabolol, tocopheryl acetate, glycyrrhiza glabra root extract, thymus serpyllum extract, panthenol, sodium hyaluronate and the like. The whitening and freckle-removing cream disclosed by the invention can be used for inhibiting tautomerase activity of tyrosinase and dopachrome and hindering polymerization of DHI; the formation of melanin in a body is inhibited, the regeneration capability of pigment cells is improved, the pigment deposition is reduced and pigment cell detachment is promoted; the self-immunity of the cells is enhanced, and the skin elasticity and a metabolism function are improved; and the self-protection capability of skins is improved and the safe whitening and freckle-removing effects are realized.

An ophthalmic composition includes oil globules dispersed in an aqueous phase. The globules include a surfactant component, a polar oil component that includes an Omega-3 fatty acid and a viscosity modifying agent. The surfactant to oil ratio produces an average size of globules of about 0.1 microns or less. The viscosity is at least as viscous as 0.25% 800K sodium hyaluronate. The composition can be used for treatment of dry eye. The compositions are stable and can have anti-microbial activity sufficient for use as contact lens disinfecting solutions.

The invention belongs to the technical field of cosmetics, and in particular relates to a moisturizing essence lotion and a preparation method of the moisturizing essence lotion. The moisturizing essence lotion is prepared from the following components in percentage by weight: 0.00003%-25.5% of sodium hyaluronate, 0.00001%-20% of sodium acetylated hyaluronate, 0.00001%-20% of hydrolyzed hyaluronic acid, 0.001%-1% of a thickener, 0.5%-40% of a moisturizer, 0.1%-30% of a skin efficacy agent, and the balance of deionized water. The essence lotion provided by the invention can regulate the cell viability of the skin essentially, so as to achieve the effects of whitening the skin, resisting wrinkles and resisting skin aging, especially, for the inflammatory skin such as pimple and acne, the moisturizing essence lotion can inhibit the activity of bacteria on the surface of the skin, so that the inflammation can be alleviated.

The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.

The invention discloses whitening and freckle-removing cream. The cream is mainly prepared from glycerin, ethylhexyl palmitate, caprylic / capric triglyceride, isononyl isononanoate, polydimethylsiloxane, 1,2-pentanediol, butyrospermum parkii butter, 1,2-hexanediol, caprylyl glycol, cetostearyl alcohol, carbomer, xanthan gum, nicotinamide, arginine, rosa damascena flower oil, citrus medica L. extract, cucumis sativus fruit extract, bearberry leaf extract, rose extract, sodium hyaluronate, methyl glucose sesqui-stearate, PEG-20 methyl glucose sesqui-stearate, glyceryl stearate, phenoxyethanol and water. A natural cosmetic is prepared from whitening components of natural plants and directly acts on the facial skin, so that the effective ingredients permeate into the basal layer of the skin to reduce and decompose existing melanin, activate cells and diminish facial freckles; and the natural cosmetic is reasonable in compatibility, so that the skin is whitened and moistened and has delicate sheen.

Methods of treating osteochondral lesions by the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate are disclosed.

Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and / or rheumatoid arthritis have been found with krill oil and / or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.

The invention discloses an aloe gel and a preparation method thereof. The aloe gel comprises the following components according to the weight percent: 0.10-50.00 of aloe extract, 0.00-10.00 of matricaria recutita extract, 0.00-5.00 of purslane extract, 0.00-5.00 of Alpha-bisaboll, 0.01-0.50 of sodium hyaluronate, 0.05-0.90 of allantoin, 0.05-2.50 of dipotassium glycyrrhizinate, 0.01-5.50 of Beta-hyskon, 0.30-10.00 of jellies, 0.00-5.00 of antisepticize antimicrobial, 1.00-10.00 of polylols, 0.30-3.00 of alkali liquor, 0.00-0.50 of tween-20, 0.00-10.00 of ethanol and 40.00-95.00 of de-ionized water. The aloe gel has better stability and compatibility and has the functions of preserving moisture, resisting inflammation and irritation, promoting the recovery of local slightly damaged skin, reducing the stigmatization after the damaged skin is recovered, and the like.

The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing hyaluronic acid and a dihydrazide with a crosslinker in an aqueous solution, adding a solvent and an emulsifying agent to form an emulsion, and lowering the pH of the emulsion to allow intramolecular and intermolecular crosslinking to occur, are also disclosed. The invention also provides for pharmaceutical or cosmetic formulations based on the microspheres described herein, further containing one or more active or cosmetic agents, and methods of using such formulations.

A lip balm product having a synthetic ceramide, an anti-irritant compound, sodium hyaluronate, cosmetic wax, boswellic acids and / or esters and / or salts thereof, extract of the Portuluca pilosa plant, matrikin-mimetic peptide, dehydrated microspheres of marine collagen and glycosaminoglycans, and mica along with optional lip balm formulation acceptable carriers and / or solvents. Where desired, the lip balm may further contain medicinal agents suitable for the treatment of various conditions of the lip.

The invention discloses multifunctional aloe gel and a preparation method thereof. Formerly conventional aloe gel products cannot maintain good skin quality and cannot reach multiple beauty-maintaining skin-care effects. The multifunctional aloe gel provided by the invention comprises effective active components such as aloe freeze-dried powder, plant extract, compounded sodium hyaluronate, allantoin, D-panthenol, menthol, betaine, beta-glucan and the like, employs methylisothiazolinone combined with iodopropynyl butylcarbamate as an antiseptic, and employs an alkali liquid selected from solutions of potassium hydroxide or sodium hydroxide with the concentration of 5%. The product prepared by employing the preparation method provided by the invention has the good efficacy of retaining moisture, calming, resisting ageing, resisting inflammation and bacteria, alleviating stimulation, compacting skin, promoting healing of damaged skin, and the like, and is mild in properties, safe to use and excellent in moisture-retaining performance. The simultaneous usage of the multiple components not only gives full play to the effective effects of each component, but also helps to guarantee the best beauty-maintaining skin-care effect of the integral product.

The invention relates to a cross bonding sodium hyaluronate gel for injection and a preparation method thereof. The method is characterized in that sodium hyaluronate and glycidyl ether are mixed and react in alkaline solution to form water-insoluble gel, the gel is purified in deionized water and broken into particles of certain sizes; ionic strength of the deionized water is improved to contract the gel particles. The cross bonding sodium hyaluronate gel features asepsis, apyrogeneity and small and uniform particles; therefore the gel can be applied to prepare injection for beauty care and medical treatment.

The present invention provides a process for preparing cross-linked sodium hyaluronate microspheres capable of being adopted as an emboliaztion agent by adopting sodium hyaluronate as a raw material. The process comprises the following steps: preparing a sodium hyaluronate alkaline solution gel with a concentration of 10-30% g / ml; adding the sodium hyaluronate alkaline solution gel to an emulsifier-containing oil phase, and carrying out high speed emulsification through a shearing machine, wherein an emulsification speed is 500-2000 rpm, and a time is 10-20 min; adding a certain amount of a cross-linking agent, stirring for 4-6 h at a room temperature, carrying out a cross-linking reaction, and standing overnight after completing the reaction, wherein a mass percentage of the cross-linking agent in the oil phase is 0.2-2%; and adopting a water-soluble organic solvent to wash to remove the oil phase remained on the surface of the microspheres, and finally drying to obtain the cross-linked sodium hyaluronate microspheres. According to the present invention, the preparation process is simple; and the size of the obtained microspheres is suitable for routine blood vessel emboliaztion, and the obtained microspheres have characteristics of controllable particle size, good microsphere shape, easy screening, elasticity, expandibility, no toxic-side effect on human body, good biocompatibility, good biodegradability, and ensured clinical safety.

The invention discloses a moistening and repairing facial mask (named meitianfu (Chinese character) moistening and repairing facial mask, and hereinafter called moistening and repairing facial mask) and a preparation method thereof. The moistening and repairing facial mask disclosed by the invention contains the following components: water, butanediol, sodium hyaluronate, carbomer, triethanolamine, carboxymethyl beta-sodium glucosan, a witchhazel extract, a tremella fuciformis extract, an arabian jasmine flower, a german chamomile extract, deer bone collagen protein, a rosemary extract, a scoparia dulcis extract, asiaticoside, a silk extract, a sargassum fusiforme setch extract, acetyl tetrapeptide-9, palmitoyl tripeptide-5, pentapeptide-3, acetyl hexapeptide-8, phenoxyethanol and ethylhexylglycerin. The facial mask prepared by the method disclosed by the invention has the characteristics of being safe, effective and free of irritation.

The invention discloses a stem cells preparation for repairing a wound surface and preparation method thereof, wherein the stem cells preparation uses umbilical cords, placentae or mesenchymal stem cells between amniotic membranes as living cells, and is added with high polymer material sodium alginate with excellent biocompatibility, sodium hyaluronate, chitosan and hydroxyethyl starch as cell stabilizer. The stem cells preparation for repairing the wound surface has higher cell viability and is durable in action, and breaks through technical limitations of effectiveness of the mesenchymal stem cells for treating.

The invention provides plant active peptide firming facial mask essence. The essence is prepared from the following components in percentage by weight: 5-20 percent of glycerinum, 0.02-0.06 percent of sodium hyaluronate, 0.01-0.1 percent of allantoin, 0.1-0.5 percent of xanthan gum, 0.1-5 percent of oligopeptide-1, 0.1-5 percent of oligopeptide-6, 0.1-5 percent of centella asiatica extract, 0.1-5 percent of scutellaria baicalensis extract, 0.1-5 percent of astaxanthin, 0.1-5 percent of gingko leaf extract, 0.1-5 percent of houttuynia cordata extract, 0.1-5 percent of licorice root extract, 0.1-5 percent of rhodiola rosea extract, 0.1-5 percent of watermelon pulp extract, 0.1-2 percent of leuconostoc / radish root ferment filtrate and the balance of purified water. The plant active peptide firming facial mask essence has the effect of firming skin and smoothing skin fine lines in a comprehensive regulating manner.

The invention relates to a soluble microneedle patch used for skin whitening and a preparation method thereof. The soluble microneedle patch comprises a needle point and a substrate, the needle point comprises the following raw materials in parts by weight: 1 part of arbutin, 15-30 parts of hyaluronic acid or its salt, and 5-25 parts of a forming material; wherein the hyaluronic acid or its salt is hyaluronic acid or sodium hyaluronate; and the forming material is selected from at least one of fructose, mannose, carboxymethylcellulose sodium and hydroxypropyl methylcellulose. The soluble microneedle patch has good mechanical strength, hardness and dissolvability, avoids the disadvantage that a traditional skin-caring mode cannot perform arbutin advantage, and has obvious effects for lightning color spots and whitening skin.

The invention relates to cosmetics, and particularly relates to a mask fluid for skin-tendering. The mask fluid for skin-tendering disclosed by the invention comprises the following components in percentage by mass: 2.5-3.5% of 1,3-butanediol, 0.15-0.25% of xanthan gum, 0.04-0.06% of disodium edentate, 4-6% of glycerin, 0.05-1.2% of dipotassium glycyrrhizinate, 1.5-3.5% of 1,2-pentanediol, 0.03-0.2% of sodium hyaluronate, 3-35% of aloe barbadensis leaf juice, 1-15% of tremella extract, 0.5-6% of purslane extract, 0.4-7% of beta-glucose, 0.5-6% of chamomile extract, 0.5-6% of honey, and 0.1-0.25% of chlorphenesin. Compared with the prior art, the mask fluid for skin-tendering disclosed by the invention has the advantages of anti-aging, anti-wrinkling and skin-tendering; and the mask fluid also has the advantages of repairing the sunburned skin, soothing sensitivity, and the like.

The invention belongs to a liposome, in particular relates to a compound liposome preparation with high targeting property of tumor tissues and efficient penetrability of tumor cells. The invention is characterized in that hyaluronic acid or sodium hyaluronate, tumor cell selective penetrating peptides and a liposome are used for together constructing a compound liposome. The compound liposome is characterized by utilizing the dual-tumor cell targeting property of the hyaluronic acid and tumor cell selective penetrating peptides to effectively solve the problem that because a conventional liposome and traditional cell penetrating peptides have no selectivity on normal cells and tumor cells, the toxicity is increased when the drug effect is increased in the therapeutic process, thereby fully meeting the clinical requirements of high efficiency and low toxicity when anti-tumor drugs are prepared into preparations for treating diseases.

The invention discloses whitening and freckle-removing cream which comprises water, hydrogenated polydecene, butanediol, glycerol, ethylhexyl palmitate, isopropyl palmitate, ceteareth-25, ceteareth-6,C12-15 alcohol-benzene formic ester, cetostearyl alcohol, polydimethylsiloxane, magnesium ascorbyl phosphate, simmondsia chinensis seed oil, preservatives, tocopheryl acetate, arbutin, xanthan gum, bisabolol, allantoin, essence, EDTA (ethylene diamine tetraacetic acid) disodium, glycyrrhiza glabra root extracts, sodium hyaluronate and citric acid. Whitening active components such as the glycyrrhiza glabra root extracts, the magnesium ascorbyl phosphate and the arbutin are added in a formula, the whitening and freckle-removing cream can penetrate into skin bottoms, melanogenesis is continuously inhibited, melanin decomposition is accelerated, skins are thoroughly whitened from inside to outside, and rapid whitening and freckle-removing effects are achieved. The magnesium ascorbyl phosphateand vitamin E achieve synergistic effects, and the whitening and freckle-removing effects are better.

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.

The invention discloses a cosmetic and a preparation method thereof. The cosmetic is prepared from five components of A, B, C, D and E. The cosmetic is composed of thirty raw materials including deionized water, hydroxyethyl cellulose, allantoin, carbopol U20, propanediol, 1,3-butanediol, sodium hyaluronate, an aloe vera extract, a natto extract, asiaticoside, vitamin C, bisabolol, an amino acid humectant, D-panthenol, VC ethyl ether, nicotinamide, glabridin, tranexamic acid, ceramide, algal polysaccharide, glucan, dipotassium glycyrrhizinate, an epidermal growth factor (EGF), triethanolamine, isothiazolinone, essence, squalane, jojoba oil, vitamin E oil and crystal sparkling pearl powder. The cosmetic has the functions of making skins fine and smooth, brightening the skins, repairing sensitive skins, controlling oil, toning skins and modifying skin blemishes, has no side effect or no dependence, and does not threaten health of a human body.

The invention discloses a compound anti-wrinkle anti-aging essence containing a plurality of small molecular peptides and a preparation method of the essence. The essence comprises the following raw materials in percentage by weight: 0.1-0.2% of sodium hyaluronate; 0.2-0.3% of acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer; 5-7% of glycerol; 4-6% of 1,3-butanediol; 0.3-0.5% ofdipeptide diaminobutyl benzyl amide diacetate; 0.2-0.3% of palmitoyl tetrapeptide-5; 0.3-0.5% of palmitoyl tripeptide-1; 0.3-0.5% of palmitoyl pentapeptide-4; 0.1-0.3% of carnosine; 0.1-0.3% of serine; 0.1-0.3% of arginine; 0.1-0.3% of nicotinamide; 0.2-0.3% of a preservative and the rest of deionized water. The skin of a human body is repaired in an all-round way, so that good and rapid wrinkle removal and aging resistance effects are achieved.

The invention discloses a high-effective moisture-keeping sodium hyaluronate stock solution comprising a sodium hyaluronate, characterized in that the solution is composed of high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton and low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton which are mixed by proportion, wherein, the high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton is of 0. 1 to 0. 5 parts by weight, the low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton is of 0. 5 to 1. 0 parts by weight, the rest is 100 parts of distilled water, the distilled water. especially can be chose for double distilled waters. The high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention can effectively permeate into a corium layer to promote blood microcirculation, be beneficial to nutrient substance absorption of the skin, with beautification anti-wrinkle health care action; the high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention has strong flexibility and wetting property, can be coated on the skin surface to form a layer of moisture-keeping ventilated membrane for keeping the skin nourishing, moistening and glossy.

The invention provides a cosmetic composition which can smooth fine lines and wrinkles, impart firmness and elasticity to the facial skin, and make fine lines and wrinkles less noticeable, all within a short period of time. The cosmetic composition is in a hydrogel form and contains sodium hyaluronate, modified cornstarch, and pullulan, particularly in amounts of 0.1 to 1.0 wt. %, 0.5 to 5.0 wt. %, and 0.1 to 3.0 wt. %, respectively. The composition may further contain a dispersant.

The invention belongs to the technical field of cosmetics, and particularly discloses a matrix with skin barrier repairing and anti-aging effects. The matrix is prepared from, by mass, 3-4% of 1,2-pentanediol, 10-15% of methyl propanediol, 1-2% of sodium hyaluronate, 3-5% of myrothamnus flabellifolia leaf / stem extracts, 10-15% of hydrolysis elastic protein, 10-20% of an anti-aging agent containing 100-200 ppm palmitoyl oligopeptide, 5-10% of tea extracts, 0.2-0.5% of a cell growth factor stock solution, 3-5% of an anti-aging agent containing 45-55 ppm neurotransmitter inhibition signal peptides, 5-10% of algae extracts and the balance water. According to the skin protection matrix, the skin barrier repairing and anti-aging effects are remarkable, the effect can be seen in a short period, and the skin barrier can be repaired when a user uses the matrix for a long time, so that wrinkles are reduced.

The invention discloses a degradable medical hemostatic adhesion-resistant material and a preparation method thereof. The invention uses chitosan or derivatives thereof and transparent sodium hyaluronate as main raw materials, adopts methods, such as spray drying, self lamination assembly, and the like to prepare microspheric and gel-type hemostatic adhesion-resistant materials, and medicines and activated substances capable of stimulating hemostasis and antiphlogosis can be compounded and added in the preparation process. The material has high water absorption rate, can rapidly arrest bleeding to form an aquagel protective layer on a wound surface, has favorable tissue adhesiveness, adhesion resistance and bacterinertness, can suit a wound in an irregular shape, truly fully covers the wound surface to fully take the aims of arrest bleeding, resisting adhesion and stimulating wound surface healing, has remarkable postoperative hemostatic adhesion-resistant effects while being used for ear-nose-throat department operations, is convenient to use and brings little pain to patients.