2136 results about "Sodium hyaluronate" patented technology

The invention discloses a preparation method and application of a multifunctional self-healing hydrogel material with antibacterial, anti-inflammatory and diabetic wound healing promotion functions. The preparation method comprises the following steps: firstly, synthesizing silver-doped carbon quantum dots (AgCD) in one step through a hydrothermal method; the preparation method comprises the following steps: firstly, preparing sodium hyaluronate (HA), secondly, oxidizing the sodium hyaluronate (HA) into oxidized hyaluronic acid (OHA) by taking sodium periodate as an oxidizing agent, and then encapsulating AgCD and metformin (Met) into hydrogel formed by Schiff base reaction between carboxymethyl chitosan (CMCS) and the oxidized hyaluronic acid (OHA). The hydrogel provided by the invention has certain adhesion, suitable capacity of absorbing wound exudate and good biocompatibility, meanwhile, due to the addition of AgCD, the hydrogel has excellent antibacterial property, and the metformin can promote angiogenesis of a wound part, so that the hydrogel can better promote healing of a diabetic wound. The hydrogel is simple and rapid in preparation method, has low biotoxicity and antibacterial property, and provides a strategic choice for promoting healing of diabetic wounds.

The invention discloses injectable sodium hyaluronate-silk fibroin composite hydrogel and a preparation method and application thereof.The injectable sodium hyaluronate-silk fibroin composite hydrogel is composed of sodium hyaluronate composite gel particles and a sodium hyaluronate solution, and the sodium hyaluronate composite gel particles comprise silk fibroin sponge microspheres and sodium hyaluronate gel particles; the silk fibroin sponge microspheres are loaded on the sodium hyaluronate gel particles, the silk fibroin sponge microspheres are physical crosslinking microspheres, the particle size D50 is 10-30 [mu] m, and the particle size D90 is within 100 [mu] m; the sodium hyaluronate gel particles are chemical cross-linked particles, the particle size D50 is 150-300 microns, and the particle size D90 is within 800 microns. After the sodium hyaluronate gel particles are in contact with tissues, sodium hyaluronate is preferentially degraded, and silk fibroin exposed in the degradation process has better degradation resistance and an effect of stimulating generation of collagen fibers, so that in-situ fixation of the composite gel particles is realized, and an instant and lasting filling effect is achieved; the material is a safe and effective medical beauty filling material.

The invention provides a composition for improving bone joint health as well as a preparation method and application thereof, and relates to the technical field of bone joint health products. The composition for improving bone joint health is prepared from the following components in parts by mass: 0.5 to 5 parts of collagen peptide, 5 to 30 parts of mangosteen extract, 0.5 to 3 parts of non-denatured II type collagen peptide, 0.1 to 2 parts of milk mineral salt, 0.3 to 3 parts of bone collagen peptide, 0.1 to 2 parts of cartilage extract, 0.1 to 2 parts of N-acetylglucosamine, 0.1 to 2 parts of sodium hyaluronate and 0.3 to 3 parts of turmeric extract. The composition obtained by repeatedly compounding the mangosteen extract, the turmeric extract, the cartilage extract and the sodium hyaluronate has the advantages of low cost and high safety, and has a better effect on preventing or improving osteoarthrosis.

The invention discloses a scalp essence capable of controlling oil and removing dandruff and a preparation method thereof, and provides the scalp essence capable of controlling oil and removing dandruff. The formula consists of the following raw materials: water, saccharomycetes / rice fermentation product filtrate, butanediol, phenoxyethanol, caprylic acid / capric triglyceride, galactose yeast-like bacterium fermentation product filtrate, allantoin, a saccharomycetes / zinc fermentation product, nicotinamide, arginine, polysorbate-20, hydrogenated lecithin, acrylic acid (ester) / C10-30 and an alkanol acrylate cross-linked polymer. Hydrolyzed sodium hyaluronate and trace components. According to the oil-controlling and dandruff-removing scalp essence disclosed by the invention, through the synergistic interaction among the raw materials, the effects of replenishing water, preserving moisture, controlling oil and removing dandruff are increased, the effects of relieving, recovering oil-water balance, recovering skin elasticity and delaying senescence are also achieved, the effects of preventing hair loss and nourishing hair are also achieved, and meanwhile, the oil-controlling and dandruff-removing scalp essence has the advantage of being stable in storage.

The invention discloses an absorbable suture line for surgical suture and a preparation method thereof, and relates to the technical field of medical materials. The absorbable suture line for surgical suture is prepared from the following raw materials in parts by weight: 50 to 65 parts of polylactic acid, 15 to 20 parts of polyglycolic acid, 3 to 5 parts of sodium carboxymethyl cellulose, 3 to 8 parts of a toughening agent, 3 to 6 parts of an antibacterial agent, 0.3 to 0.8 part of a lubricating agent, 1 to 2 parts of sodium hyaluronate and 5 to 10 parts of polyvinyl alcohol. The toughening agent is obtained by reacting hydroxyethyl acrylate with ethylenediamine to generate a four-arm compound and then reacting with 6-caprolactone and DL-lactide. The absorbable suture line for surgical suture prepared by the invention has excellent tensile property and antibacterial property, and can meet the application requirements of clinical medical treatment.

The invention discloses roe polypeptide essence water, which is prepared from a water phase component, an active component, an oil phase component, a stabilizer and a thickening agent, the water phase component is prepared from the following components in parts by mass: 60 to 150 parts of purified water, 3 to 7 parts of glycerol, 2 to 5 parts of propylene glycol, 1 to 2 parts of panthenol and 0.1 to 0.3 part of sodium hyaluronate; the oil phase component is prepared from the following components in parts by mass: 2 to 4 parts of squalane, 1 to 3 parts of jojoba oil and 0.5 to 2 parts of shea butter; the active components comprise the following components in parts by mass: 2 to 5 parts of roe extract, 0.5 to 2 parts of argireline, 0.1 to 0.5 part of oligopeptide-1, 1 to 3 parts of collagen, 0.5 to 2 parts of elastin and 2 to 5 parts of nicotinamide; 0.1 to 0.3 part of hydroxyethyl cellulose is adopted as the stabilizer; 0.2 to 0.5 part of carbomer is adopted as the thickening agent. The roe extract is rich in proteins, amino acids, fatty acids, vitamins and trace elements, and is helpful for nourishing the skin so as to provide the effects of nourishing, resisting aging, moisturizing, brightening the skin color and repairing the skin.

The present application relates to the technical field of injectable gels, and specifically discloses an injectable cross-linked hyaluronic acid hydroxyapatite gel and a preparation method thereof. An injectable cross-linked hyaluronic acid hydroxyapatite gel comprises a modified sodium hyaluronate hydroxyapatite microsphere gel and a sodium hyaluronate hydroxyapatite microsphere mixed solution, wherein the raw materials of the modified sodium hyaluronate hydroxyapatite microsphere gel comprise the following components in parts by weight: 40 to 70 parts of hydroxyapatite microspheres, 1 to 3 parts of hyaluronic acid, 0.1 to 0.2 parts of a cross-linking agent, and 30 to 40 parts of a lidocaine solution; the raw materials of the sodium hyaluronate hydroxyapatite microsphere mixed solution comprise the following components in parts by weight: 15 to 25 parts of hydroxyapatite microspheres and 0.5 to 1.5 parts of sodium hyaluronate dry powder.

The preparation method comprises the following steps: firstly, uniformly stirring and mixing synthetic fluorophlogopite, silica, polymethylsilsesquioxane, boron nitride, bismuth oxychloride, zinc stearate, aluminum starch octenylsuccinate, mica, aluminum oxide, hydrolyzed sodium hyaluronate and toner in a stirring homogenizer; then uniformly mixing polydimethylsiloxane, octyldodecanol stearoyloxy stearate, isoamyl laurate, diisostearyl malate, phenoxyethanol and caprylyl glycol, and heating to 45 + / -5 DEG C; pouring the mixture into an oil spraying barrel of a stirring homogenizer, uniformly stirring and mixing while spraying oil, crushing, then carrying out airflow crushing, sieving the material, putting the sieved material into a mold plate, and carrying out compression molding, so as to obtain a pressed powder block; and putting the mixture into a packing material powder box to obtain the make-up fixing and brightening pressed powder. The pressed powder is prepared by adding an airflow crushing process, the particle size of the powder is smaller, the powder is dispersed more uniformly, the powder is pressed into the solid pressed powder, and the phenomenon of powder flying is well reduced while makeup fixing and brightening effects are achieved.

The invention discloses herbal oil control essence. A component A comprises deionized water and sodium hyaluronate; the component B comprises methylpropanediol, a hyperforin perforatum flower / leaf / stem extract, cyclodextrin and a rehmannia chinensis root extract; the component C is prepared from water, butanediol, amur corktree bark extract, coptis root extract, radix sophorae flavescentis extract, rhus chinensis insect gall extract, cnidium monnieri fruit extract, zanthoxylum bungeanum fruit extract and camphor tree leaf extract; and the component D comprises 1, 2-hexanediol. The preparation method of the herbal oil-control essence comprises the following steps: S1, preparing raw materials; s2, preparing the component A; s3, preparing the component B; s4, preparing a component C; s5, a mixing process; and S6, adding a component D and carrying out post-treatment. The herbal components form a synergistic effect network and act on a skin grease secretion system in a targeted manner, grease secretion is balanced from the source by adjusting the biological activity of sebaceous gland cells, meanwhile, biological signal channels related to skin anti-inflammation, moisturizing and tightening are activated, and the multiple-effect-in-one skin care effect is achieved.

The invention relates to the field of skin care and medical cosmetology, and discloses a long-acting moisturizing and barrier repairing type exosome active gel and a preparation method thereof, and the gel comprises the following components by mass: 2-5 parts of exosome; 3 to 7 parts of trehalose; 2 to 6 parts of glycerol; 1 to 2 parts of polyvinyl acrylate; 0.5 to 1.5 parts of octyl glucoside; 0.8 to 1.5 parts of sodium hyaluronate; 0.2 to 0.5 part of low molecular peptide; 1 to 3 parts of polyacrylamide; and 0.02 to 0.05 part of a tea polyphenol antioxidant. According to the invention, through synergistic repair of the exosome and the low-molecular peptide, dual moisturizing of the trehalose and the glycerol, a thickening system is innovated to improve the stability, and the tea polyphenol antioxidant is combined, so that deep repair, lasting moisturizing, skin feeling optimization and aging resistance are effectively realized, and multiple bottleneck problems of a traditional skin care technology are comprehensively solved.

The invention discloses a multi-effect sodium hyaluronate composite gel, a preparation method thereof and application of the multi-effect sodium hyaluronate composite gel in cosmetology, and belongs to the technical field of plastic surgery and general surgery implants. The multi-effect sodium hyaluronate composite gel is prepared from sodium hyaluronate gel and agarose mixed gel. The multi-effect sodium hyaluronate composite gel prepared by the invention not only can moisturize skin and supplement collagen, has the effects of whitening, resisting oxidation and resisting inflammation, but also effectively solves the problem that sodium hyaluronate, collagen and PDRN are easy to degrade, so that the beautifying effect is more long-acting, and the effect is more obvious. Therefore, the implant has better application prospect and value in the fields of plastic and aesthetic surgery and general surgical implants.

The invention provides an elastin peptide-containing composition as well as a preparation method and application thereof. The elastin peptide-containing composition comprises elastin peptide, camel milk active small molecule peptide and water lily oligopeptide in a mass ratio of 1: (1-3): (1.8-2.5). The elastin peptide, the camel milk active small molecule peptide and the water lily oligopeptide which are obtained through a specific treatment mode are compounded according to a specific proportion, synthesis of aquaporin AQP3 can be promoted, the content of sodium hyaluronate is increased, and the free radical scavenging activity is improved. The composition containing the elastin peptide can quickly and efficiently improve the skin state, repair the skin, delay the skin aging, enhance the skin function and recover the elasticity. The composition containing elastin peptide can promote the proliferation and growth of fibroblasts, improve the cell viability and promote the healing of skin wounds, and is non-toxic to cells.

The invention relates to a composition of polyester particles and sodium hyaluronate, which is prepared by the following steps: preparing PCL (Polycaprolactone) microspheres with the particle size of 20-50 microns by an emulsion method; hA is selected, and a PBS buffer solution is used for preparing an HA solution; repeatedly freezing and thawing in a refrigerator at-80 DEG C for 3 times to form micro-crosslinked HA gel; and mixing the microspheres and the micro-crosslinked HA gel according to a mass ratio of 25: 75. The invention provides a technology of taking the physically micro-crosslinked HA as a suspension carrier, so that the polyester particles or microspheres can be stably suspended in an HA solution system without a chemical crosslinking agent, and an injection product has better biocompatibility and safety. HA which does not contain a chemical cross-linking agent and polyester particles / microspheres are mixed to serve as a medical beauty filling system, and the problem of stable suspension of the polyester particles / microspheres in the HA is solved by performing physical micro-crosslinking on the HA.

The invention relates to a poly-(2-oxazoline) epoxy derivative and application thereof, and belongs to the technical field of crosslinking. The invention provides a poly-(2-oxazoline) epoxy derivative, which is completely different from existing cross-linking agents such as 1, 4-butanediol diglycidyl ether (BDDE), divinyl sulfone, glycidyl methacrylate and the like in structure, and has the advantages that the structure is simple; the polymer can be used as a cross-linking agent for cross-linking natural high-molecular polymers such as polysaccharide (such as hyaluronic acid) and protein and synthetic high-molecular polymers such as polyethylene glycol and polyvinyl alcohol. Compared with an existing cross-linking agent, the poly-(2-oxazoline) epoxy derivative has the advantages that the poly-(2-oxazoline) epoxy derivative can be easily subjected to a cross-linking reaction with high-molecular polymers such as hyaluronic acid, the prepared cross-linked substances such as sodium hyaluronate gel are more stable and uniform, the performance of the prepared cross-linked substances is easier to regulate and control and the like, and the poly-(2-oxazoline) epoxy derivative has a great application prospect.

The invention relates to the technical field of cosmetics, and particularly discloses a composition with after-sun repairing and whitening effects and a preparation method thereof. According to the present invention, various efficient components such as the ergothioneine compound, the acetylchitosamine, the nicotinamide, the sodium hyaluronate, the inositol, the aloe vera extract, the glycerophosphoinositide choline salt, the tetrahydromethylpyrimidine carboxylic acid, the oat beta-glucan compound, the citrus peel extract compound and the skin brightening agent are scientifically matched; according to the present invention, the excellent after-sun repairing and whitening effect is achieved, the comprehensive after-sun skin care is achieved, the skin state can be improved, and the skin health degree can be improved. The application creatively finds that when the glycerophosphoinositide choline salt, the citrus peel extract compound and the skin brightening agent are compounded, the effects of the composition in the aspects of after-sun repairing and whitening can be improved at the same time, and the comprehensive effect is relatively good.

The invention belongs to the technical field of medical cosmetology and plastic surgery, and particularly relates to a hydroxyapatite microsphere facial skin filling agent for injection and a preparation method thereof. Hydroxyapatite microspheres and sodium hyaluronate are uniformly mixed, a cross-linking agent is added, and cross-linked sodium hyaluronate-hydroxyapatite core-shell structure microsphere particles which take hydroxyapatite microspheres as cores and cross-linked sodium hyaluronate as shells and are of a soft-in-hard structure can be obtained through dialysis and particle grading. The cross-linked sodium hyaluronate is used as a core-shell structure, so that the hydroxyapatite is locked in the cross-linked sodium hyaluronate, agglomeration is effectively avoided, the extrusion resistance can be well reduced by the soft-wrapped-hard core-shell structure, and the propulsive force is smaller. All the components in the hydroxyapatite microsphere facial skin filler for injection have better biocompatibility, so that the rejection of the filler in a body is reduced, and the skin problems of allergy, redness, swelling, small lumps and the like after injection and filling are effectively avoided.

The invention discloses glycerin entrapped with recombinant human collagen III and a preparation method and application thereof, and belongs to the technical field of medicines and cosmetics, the glycerin entrapped with recombinant human collagen III comprises phospholipid, glycerin, Tween 80, chitosan quaternary ammonium salt, sodium hyaluronate, recombinant human collagen III and a PBS buffer solution. Glycerin which has high deformation performance and can effectively penetrate through the stratum corneum is prepared, and double-layer modification of chitosan quaternary ammonium salt and sodium hyaluronate is carried out on the glycerol to deliver the recombinant human-derived III-type collagen, so that the problems that the recombinant human-derived III-type collagen is high in hydrophilicity, large in molecular weight and difficult to penetrate through the stratum corneum of the skin can be effectively solved; the bioavailability and the percutaneous penetration of the recombinant human III type collagen are obviously improved.

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.

The invention relates to a wound repair spray, and relates to the field of medical wound repair. The wound repair spray comprises a humectant, ethylhexylglycerin, recombinant collagen, a preservative, a pH buffer agent, water and sodium hyaluronate with the molecular weight of 2000 Da to 10000 Da, and the prepared wound repair spray is fine and soft in atomization effect, uniform and dispersed in spray, moderate in force, suitable for being immediately used after an operation and on sensitive skin, free of toxic and side effects and free of side effects. A good wet healing environment can be provided for wound repair, the healing time of the wound is shortened, and the repair performance is improved.

The invention relates to the technical field of whitening essence, and discloses whitening essence suitable for sensitive skin and a preparation method thereof.The whitening essence suitable for sensitive skin is prepared from, by mass, 2%-3% of prinsepia utilis royle oil, 1%-2% of portulaca oleracea extract, 1.5% of camellia yunnanensis flower extract, 0.5% of panax notoginseng root extract, 3% or less of nicotinamide, 1% or less of 1, 2-propylene glycol and the balance deionized water. 1%-1.5% of 1, 2-hexanediol, 0.1%-0.3% of sodium hyaluronate and 60%-70% of deionized water. According to the whitening essence suitable for the sensitive skin and the preparation method of the whitening essence, through the synergistic combination of prinsepia utilis royle oil (barrier repair), purslane (anti-inflammatory), camellia japonica (tyrosinase inhibition) and pseudo-ginseng (microcirculation improvement), melanogenesis is inhibited through multiple channels, the sensitive skin is relieved synchronously, nicotinamide (3%) is compounded with the prinsepia utilis royle oil, and the skin whitening effect is achieved. The synergism of whitening and barrier repair is enhanced through a dual mechanism of promoting ceramide synthesis and inhibiting melanin transport, and the problems that a traditional whitening agent has different degrees of irritation, allergy phenomena such as skin redness, swelling and pain are easily caused by improper use, and a skin intolerance phenomenon exists are solved.

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The invention relates to the technical field of biomedical materials, and discloses an electret electrostatic therapy membrane and a preparation process thereof.The electret electrostatic therapy membrane is prepared from, by mass, 15%-20% of fluorinated polyether ester, 10%-20% of a composite nano-fiber material, 10%-20% of a composite nano-fiber material, 10%-20% of a composite nano-fiber material and the balance water. 1%-2% of carboxymethyl chitosan; 2-5% of nano cerium oxide particles with the particle size of 50-100 nm; 0.5-1.0% of graphene quantum dots, the particle size of which is 5-10 nm; 1%-2% of sodium hyaluronate; the components are prepared into a film through an electrostatic spinning method, electret performance is given to the film through a charge injection process, finally, the film body is attached to a flexible silica gel adhesion layer, and the flexible silica gel adhesion layer is externally coated with a peelable protective film so that the structural integrity can be kept before the flexible silica gel adhesion layer is used. The composite membrane body disclosed by the invention shows excellent adhesion, charge activation capability and thermal response performance in applications of electrostatic therapy, dielectric assisted stimulation and the like, and has good multi-scene adaptability and clinical application potential.

The invention provides a method for preparing ultra-small molecular zinc hyaluronate, and relates to the field of hyaluronate. The method comprises the following steps: carrying out enzymolysis on macromolecular sodium hyaluronate by using leech hyaluronidase to obtain ultra-small molecular sodium hyaluronate; the method comprises the following steps: adsorbing ultra-small molecular sodium hyaluronate by using anion exchange resin, eluting by using a zinc salt solution, and reacting the obtained eluent to obtain ultra-small molecular zinc hyaluronate; the average molecular weight of the ultra-small molecular sodium hyaluronate is 600 Da to 1000 Da. The whole process is simple, the obtained ultra-small molecular zinc hyaluronate is high in zinc content, free of sodium ion residues and high in preparation yield, an organic solvent is not needed in the whole production process, and the method is suitable for industrial production.

The invention provides retinyl sodium hyaluronate and a composition thereof, which are applied to the fields of cosmetics and medicines. The retinoyl sodium hyaluronate is characterized in that all-trans retinoic acid and 13-cis-retinoic acid are esterified with sodium hyaluronate according to a molar ratio of (1.5-3.0): 1, and the esterification degree is 1%-12%; the composition disclosed by the invention is characterized by comprising retinyl sodium hyaluronate and a polyhydric alcohol compound in a mass ratio of 1: (1-10). The sodium retinoyl hyaluronate has a remarkable effect of preventing and treating acne, and the composition is beneficial to improving the stability of the sodium retinoyl hyaluronate and prolonging the validity period of a raw material product of the sodium retinoyl hyaluronate. The retinyl sodium hyaluronate and the composition thereof can be used for preparing cosmetics and medical products for whitening, resisting aging, controlling oil and removing acnes.

The invention relates to a moisturizing and wrinkle fading composition containing recombinant collagen and application of the moisturizing and wrinkle fading composition. The moisturizing and wrinkle fading composition containing the recombinant collagen comprises dipalmitoyl hydroxyproline, butyrospermum parkii fruit fat unsaponifiable matter, sodium hyaluronate, palmitoyl tripeptide-1 and the recombinant collagen. The invention creatively finds that the composition consisting of the dipalmitoyl hydroxyproline, the butyrospermum parkii fruit fat unsaponifiable matter, the sodium hyaluronate, the palmitoyl tripeptide-1 and the recombinant collagen can deeply nourish the skin, especially the lip skin, effectively lock moisture and relieve dryness, and also can remarkably lighten cheilogramma and repair damaged skin, so that the composition has the effects of nourishing the skin, especially the lip skin. And the five components have a certain synergistic effect on the effects, so that the lip care product is suitable for lip care products, and is mild, non-irritant and good in stability.

The invention belongs to the technical field of functional foods and health foods, and particularly relates to an anti-saccharification and anti-aging aronia melanocarpa fruit composition and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 150 to 400 parts of aronia melanocarpa fruit fermentation liquor, 10 to 80 parts of lycium ruthenicum, 10 to 80 parts of ginseng, 0.5 to 2.5 parts of grape seed extract, 10 to 70 parts of collagen peptide, 0.5 to 4 parts of sodium hyaluronate, 0.1 to 0.8 part of resveratrol and 0.03 to 0.3 part of yeast extract. The content of type I collagen peptide in the skin is increased, the generation of in-vitro anti-glycation end products is inhibited, and the anti-glycation and anti-aging effects are achieved.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention discloses a medical sodium hyaluronate skin repair gel and a preparation method thereof, and mainly relates to the technical field of hyaluronic acid, the medical sodium hyaluronate skin repair gel comprises the following components: sodium hyaluronate, a synergist, glycerol, carbomer, 1, 3-butanediol, triethanolamine and water. Compared with the prior art, the medical sodium hyaluronate skin repair gel prepared by the invention can relieve erythema, pruritus and other symptoms caused by skin inflammation; the wound dressing can also be used for nursing non-chronic wounds, such as superficial wounds, sutured wounds after operations, mechanical wounds and the like; meanwhile, a bacteriostatic environment for wound healing is kept, and skin repair is accelerated; the scar hyperplasia phenomenon in the skin wound repairing process is reduced.

The invention discloses composite gel for osteochondral repair as well as a preparation method and application of the composite gel. Main raw materials of the composite gel are regenerated silk fibroin (RSF) and recombinant humanized III-type collagen (rhCol-III), and auxiliary raw materials of the composite gel are sodium hyaluronate (HA), fibrinogen and thrombin. The preparation method comprises the following steps: firstly, mixing an RSF solution with an rhCol-III solution, obtaining RSF-rhCol particles through a freeze drying technology and mechanical pulverization, dispersing the particles in an HA solution to obtain composite gel, mixing the gel with a thrombin solution, catalyzing fibrinogen to be split and converted into fibrin by thrombin, and performing freeze drying to obtain the rhCol-RhCol-RhCol-RhCol-RhCol-RhCol-RhCol. And crosslinking the fibrous protein monomer to obtain the injectable composite gel preparation capable of immediately gelling. The prepared RSF-rhCol composite gel can adapt to a defect area, has a certain adhesion effect, has excellent biocompatibility, promotes migration of bone marrow mesenchymal stem cells, induces cell differentiation and promotes cartilage tissue regeneration.

The invention belongs to the technical field of cosmetics, and discloses skin-tightening and anti-wrinkle essence. The skin-tightening anti-wrinkle essence is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of acetyl hexapeptide-8, 2.0 to 3.0 percent of palmitoyl pentapeptide-4, 3.0 percent of hydroxypropyl tetrahydropyrantriol, 2.0 percent of lipidosome-coated vitamin C ethyl ether, 0.5 percent of resveratrol PLGA microspheres, 0.8 percent of ceramide NP, 1.2 percent of pachymaran, 5.0 percent of glyceryl polyether-26, 0.3 percent of sodium hyaluronate, 0.5 percent of p-hydroxyacetophenone and 1, 3-propanediol, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate and the balance of water. The 1, 2-hexanediol accounts for 0.6%, and the balance is deionized water. Multi-target anti-wrinkle, deep moisturizing and long-acting repairing are achieved by scientifically compounding active ingredients such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 and combining a lipidosome wrapping technology and a nano-microsphere slow release technology, the preparation process comprises the steps of lipidosome homogenization, nano-microsphere multiple emulsion method and low-temperature emulsification, the ingredient stability and transdermal efficiency are ensured, and the skin care effect is good. Experiments prove that the essence can significantly improve skin elasticity and reduce wrinkles, and has a significant anti-aging effect.