2706 results about "Sodium hyaluronate" patented technology

Compositions comprising a glycosaminoglycan (e.g., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e.g., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e.g., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, hydroxyl propyl methyl cellulose, hydroxy propyl ethyl cellulose, hydroxy propyl cellulose, methyl cellulose, polylysine, polyhistidine, polyhydroxy proline, poly ornithine, polyvinyl pyrolidone, polyvinyl alcohol, chitosan, etc.) and iii) long chain Nitrogen containing polymers (e.g., Polylysine, Polyvinylpyrrolidone, and polyvinyl alcohol). The invention also includes methods for using such compositions (e.g., as substance delivery materials, tissue fillers or bulking agents, as moistening or hydrating agents, etc.)

The invention discloses whitening and freckle-removing cream and a preparation method thereof. The whitening and freckle-removing cream comprises water, butanediol, caprylic/capric triglyceride, isohexadecane, glycerol, cyclopentasiloxane, butyrspermum parkii butter, trehalose, cetearyl olivate, sorbitan olivate, cetearyl alcohol, cetearyl glucoside, magnolia sieboldii extract, citrus peel extract, hydrogenated lecithin, phytosterol, bisabolol, tocopheryl acetate, glycyrrhiza glabra root extract, thymus serpyllum extract, panthenol, sodium hyaluronate and the like. The whitening and freckle-removing cream disclosed by the invention can be used for inhibiting tautomerase activity of tyrosinase and dopachrome and hindering polymerization of DHI; the formation of melanin in a body is inhibited, the regeneration capability of pigment cells is improved, the pigment deposition is reduced and pigment cell detachment is promoted; the self-immunity of the cells is enhanced, and the skin elasticity and a metabolism function are improved; and the self-protection capability of skins is improved and the safe whitening and freckle-removing effects are realized.

An ophthalmic composition includes oil globules dispersed in an aqueous phase. The globules include a surfactant component, a polar oil component that includes an Omega-3 fatty acid and a viscosity modifying agent. The surfactant to oil ratio produces an average size of globules of about 0.1 microns or less. The viscosity is at least as viscous as 0.25% 800K sodium hyaluronate. The composition can be used for treatment of dry eye. The compositions are stable and can have anti-microbial activity sufficient for use as contact lens disinfecting solutions.

The invention belongs to the technical field of cosmetics, and in particular relates to a moisturizing essence lotion and a preparation method of the moisturizing essence lotion. The moisturizing essence lotion is prepared from the following components in percentage by weight: 0.00003%-25.5% of sodium hyaluronate, 0.00001%-20% of sodium acetylated hyaluronate, 0.00001%-20% of hydrolyzed hyaluronic acid, 0.001%-1% of a thickener, 0.5%-40% of a moisturizer, 0.1%-30% of a skin efficacy agent, and the balance of deionized water. The essence lotion provided by the invention can regulate the cell viability of the skin essentially, so as to achieve the effects of whitening the skin, resisting wrinkles and resisting skin aging, especially, for the inflammatory skin such as pimple and acne, the moisturizing essence lotion can inhibit the activity of bacteria on the surface of the skin, so that the inflammation can be alleviated.

The invention discloses whitening and freckle-removing cream. The cream is mainly prepared from glycerin, ethylhexyl palmitate, caprylic/capric triglyceride, isononyl isononanoate, polydimethylsiloxane, 1,2-pentanediol, butyrospermum parkii butter, 1,2-hexanediol, caprylyl glycol, cetostearyl alcohol, carbomer, xanthan gum, nicotinamide, arginine, rosa damascena flower oil, citrus medica L. extract, cucumis sativus fruit extract, bearberry leaf extract, rose extract, sodium hyaluronate, methyl glucose sesqui-stearate, PEG-20 methyl glucose sesqui-stearate, glyceryl stearate, phenoxyethanol and water. A natural cosmetic is prepared from whitening components of natural plants and directly acts on the facial skin, so that the effective ingredients permeate into the basal layer of the skin to reduce and decompose existing melanin, activate cells and diminish facial freckles; and the natural cosmetic is reasonable in compatibility, so that the skin is whitened and moistened and has delicate sheen.

Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.

The invention discloses an aloe gel and a preparation method thereof. The aloe gel comprises the following components according to the weight percent: 0.10-50.00 of aloe extract, 0.00-10.00 of matricaria recutita extract, 0.00-5.00 of purslane extract, 0.00-5.00 of Alpha-bisaboll, 0.01-0.50 of sodium hyaluronate, 0.05-0.90 of allantoin, 0.05-2.50 of dipotassium glycyrrhizinate, 0.01-5.50 of Beta-hyskon, 0.30-10.00 of jellies, 0.00-5.00 of antisepticize antimicrobial, 1.00-10.00 of polylols, 0.30-3.00 of alkali liquor, 0.00-0.50 of tween-20, 0.00-10.00 of ethanol and 40.00-95.00 of de-ionized water. The aloe gel has better stability and compatibility and has the functions of preserving moisture, resisting inflammation and irritation, promoting the recovery of local slightly damaged skin, reducing the stigmatization after the damaged skin is recovered, and the like.

The invention discloses multifunctional aloe gel and a preparation method thereof. Formerly conventional aloe gel products cannot maintain good skin quality and cannot reach multiple beauty-maintaining skin-care effects. The multifunctional aloe gel provided by the invention comprises effective active components such as aloe freeze-dried powder, plant extract, compounded sodium hyaluronate, allantoin, D-panthenol, menthol, betaine, beta-glucan and the like, employs methylisothiazolinone combined with iodopropynyl butylcarbamate as an antiseptic, and employs an alkali liquid selected from solutions of potassium hydroxide or sodium hydroxide with the concentration of 5%. The product prepared by employing the preparation method provided by the invention has the good efficacy of retaining moisture, calming, resisting ageing, resisting inflammation and bacteria, alleviating stimulation, compacting skin, promoting healing of damaged skin, and the like, and is mild in properties, safe to use and excellent in moisture-retaining performance. The simultaneous usage of the multiple components not only gives full play to the effective effects of each component, but also helps to guarantee the best beauty-maintaining skin-care effect of the integral product.

The invention relates to a cross bonding sodium hyaluronate gel for injection and a preparation method thereof. The method is characterized in that sodium hyaluronate and glycidyl ether are mixed and react in alkaline solution to form water-insoluble gel, the gel is purified in deionized water and broken into particles of certain sizes; ionic strength of the deionized water is improved to contract the gel particles. The cross bonding sodium hyaluronate gel features asepsis, apyrogeneity and small and uniform particles; therefore the gel can be applied to prepare injection for beauty care and medical treatment.

The present invention provides a process for preparing cross-linked sodium hyaluronate microspheres capable of being adopted as an emboliaztion agent by adopting sodium hyaluronate as a raw material. The process comprises the following steps: preparing a sodium hyaluronate alkaline solution gel with a concentration of 10-30% g/ml; adding the sodium hyaluronate alkaline solution gel to an emulsifier-containing oil phase, and carrying out high speed emulsification through a shearing machine, wherein an emulsification speed is 500-2000 rpm, and a time is 10-20 min; adding a certain amount of a cross-linking agent, stirring for 4-6 h at a room temperature, carrying out a cross-linking reaction, and standing overnight after completing the reaction, wherein a mass percentage of the cross-linking agent in the oil phase is 0.2-2%; and adopting a water-soluble organic solvent to wash to remove the oil phase remained on the surface of the microspheres, and finally drying to obtain the cross-linked sodium hyaluronate microspheres. According to the present invention, the preparation process is simple; and the size of the obtained microspheres is suitable for routine blood vessel emboliaztion, and the obtained microspheres have characteristics of controllable particle size, good microsphere shape, easy screening, elasticity, expandibility, no toxic-side effect on human body, good biocompatibility, good biodegradability, and ensured clinical safety.

The invention discloses a moistening and repairing facial mask (named meitianfu (Chinese character) moistening and repairing facial mask, and hereinafter called moistening and repairing facial mask) and a preparation method thereof. The moistening and repairing facial mask disclosed by the invention contains the following components: water, butanediol, sodium hyaluronate, carbomer, triethanolamine, carboxymethyl beta-sodium glucosan, a witchhazel extract, a tremella fuciformis extract, an arabian jasmine flower, a german chamomile extract, deer bone collagen protein, a rosemary extract, a scoparia dulcis extract, asiaticoside, a silk extract, a sargassum fusiforme setch extract, acetyl tetrapeptide-9, palmitoyl tripeptide-5, pentapeptide-3, acetyl hexapeptide-8, phenoxyethanol and ethylhexylglycerin. The facial mask prepared by the method disclosed by the invention has the characteristics of being safe, effective and free of irritation.

The invention discloses a stem cells preparation for repairing a wound surface and preparation method thereof, wherein the stem cells preparation uses umbilical cords, placentae or mesenchymal stem cells between amniotic membranes as living cells, and is added with high polymer material sodium alginate with excellent biocompatibility, sodium hyaluronate, chitosan and hydroxyethyl starch as cell stabilizer. The stem cells preparation for repairing the wound surface has higher cell viability and is durable in action, and breaks through technical limitations of effectiveness of the mesenchymal stem cells for treating.

The invention provides plant active peptide firming facial mask essence. The essence is prepared from the following components in percentage by weight: 5-20 percent of glycerinum, 0.02-0.06 percent of sodium hyaluronate, 0.01-0.1 percent of allantoin, 0.1-0.5 percent of xanthan gum, 0.1-5 percent of oligopeptide-1, 0.1-5 percent of oligopeptide-6, 0.1-5 percent of centella asiatica extract, 0.1-5 percent of scutellaria baicalensis extract, 0.1-5 percent of astaxanthin, 0.1-5 percent of gingko leaf extract, 0.1-5 percent of houttuynia cordata extract, 0.1-5 percent of licorice root extract, 0.1-5 percent of rhodiola rosea extract, 0.1-5 percent of watermelon pulp extract, 0.1-2 percent of leuconostoc/radish root ferment filtrate and the balance of purified water. The plant active peptide firming facial mask essence has the effect of firming skin and smoothing skin fine lines in a comprehensive regulating manner.

The invention relates to cosmetics, and particularly relates to a mask fluid for skin-tendering. The mask fluid for skin-tendering disclosed by the invention comprises the following components in percentage by mass: 2.5-3.5% of 1,3-butanediol, 0.15-0.25% of xanthan gum, 0.04-0.06% of disodium edentate, 4-6% of glycerin, 0.05-1.2% of dipotassium glycyrrhizinate, 1.5-3.5% of 1,2-pentanediol, 0.03-0.2% of sodium hyaluronate, 3-35% of aloe barbadensis leaf juice, 1-15% of tremella extract, 0.5-6% of purslane extract, 0.4-7% of beta-glucose, 0.5-6% of chamomile extract, 0.5-6% of honey, and 0.1-0.25% of chlorphenesin. Compared with the prior art, the mask fluid for skin-tendering disclosed by the invention has the advantages of anti-aging, anti-wrinkling and skin-tendering; and the mask fluid also has the advantages of repairing the sunburned skin, soothing sensitivity, and the like.

The invention discloses whitening and freckle-removing cream which comprises water, hydrogenated polydecene, butanediol, glycerol, ethylhexyl palmitate, isopropyl palmitate, ceteareth-25, ceteareth-6,C12-15 alcohol-benzene formic ester, cetostearyl alcohol, polydimethylsiloxane, magnesium ascorbyl phosphate, simmondsia chinensis seed oil, preservatives, tocopheryl acetate, arbutin, xanthan gum, bisabolol, allantoin, essence, EDTA (ethylene diamine tetraacetic acid) disodium, glycyrrhiza glabra root extracts, sodium hyaluronate and citric acid. Whitening active components such as the glycyrrhiza glabra root extracts, the magnesium ascorbyl phosphate and the arbutin are added in a formula, the whitening and freckle-removing cream can penetrate into skin bottoms, melanogenesis is continuously inhibited, melanin decomposition is accelerated, skins are thoroughly whitened from inside to outside, and rapid whitening and freckle-removing effects are achieved. The magnesium ascorbyl phosphateand vitamin E achieve synergistic effects, and the whitening and freckle-removing effects are better.

The invention discloses a dressing composition used for inhibiting scars and accelerating wound healing and application thereof. The dressing composition consists of chitosan, acidic polysaccharide and panax notoginseng saponins in a weight proportion of 100:10-50:10-100, wherein the chitosan is selected from chitosan, chitosan lactate, acetate and hydrochloride; the acidic polysaccharide is selected from sodium carboxymethyl chitosan, sodium hyaluronate, zinc hyaluronate, sodium alginate and sodium carboxymethyl cellulose; and the panax notoginseng saponins accounts for no less than 40.0 percent of the total weight of ginsenosides Rg1 and Rb1. The formulations of the dressing composition are xerogel powder, capsules, gel membranes, hydrogels and fiber coatings. The dressing composition is used for wounds, burns, scalds, crush injuries, skin ulcers, gastroenteric ulcers and no healing of the wounds, has the advantages of rapid hemostasis, exudate reduction, moisturizing, air permeability, bacteriostasis, inflammation diminishing, itch relieving, no adhesion, effective inhibition of scarring, remarkable reduction of wound healing time and no need of replacing dressings, so that thedressing composition basically meets requirements of perfect functional external dressings.

The invention discloses a cosmetic and a preparation method thereof. The cosmetic is prepared from five components of A, B, C, D and E. The cosmetic is composed of thirty raw materials including deionized water, hydroxyethyl cellulose, allantoin, carbopol U20, propanediol, 1,3-butanediol, sodium hyaluronate, an aloe vera extract, a natto extract, asiaticoside, vitamin C, bisabolol, an amino acid humectant, D-panthenol, VC ethyl ether, nicotinamide, glabridin, tranexamic acid, ceramide, algal polysaccharide, glucan, dipotassium glycyrrhizinate, an epidermal growth factor (EGF), triethanolamine, isothiazolinone, essence, squalane, jojoba oil, vitamin E oil and crystal sparkling pearl powder. The cosmetic has the functions of making skins fine and smooth, brightening the skins, repairing sensitive skins, controlling oil, toning skins and modifying skin blemishes, has no side effect or no dependence, and does not threaten health of a human body.

The invention discloses a high-effective moisture-keeping sodium hyaluronate stock solution comprising a sodium hyaluronate, characterized in that the solution is composed of high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton and low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton which are mixed by proportion, wherein, the high molecular weight sodium hyaluronate with average molecular weight more than 2. 6 million Dalton is of 0. 1 to 0. 5 parts by weight, the low molecular weight sodium hyaluronate with average molecular weight lower than 10 thousand Dalton is of 0. 5 to 1. 0 parts by weight, the rest is 100 parts of distilled water, the distilled water. especially can be chose for double distilled waters. The high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention can effectively permeate into a corium layer to promote blood microcirculation, be beneficial to nutrient substance absorption of the skin, with beautification anti-wrinkle health care action; the high-effective moisture-keeping sodium hyaluronate stock solution provided by the invention has strong flexibility and wetting property, can be coated on the skin surface to form a layer of moisture-keeping ventilated membrane for keeping the skin nourishing, moistening and glossy.

The invention provides a cosmetic composition which can smooth fine lines and wrinkles, impart firmness and elasticity to the facial skin, and make fine lines and wrinkles less noticeable, all within a short period of time. The cosmetic composition is in a hydrogel form and contains sodium hyaluronate, modified cornstarch, and pullulan, particularly in amounts of 0.1 to 1.0 wt. %, 0.5 to 5.0 wt. %, and 0.1 to 3.0 wt. %, respectively. The composition may further contain a dispersant.

The invention belongs to the technical field of cosmetics, and particularly discloses a matrix with skin barrier repairing and anti-aging effects. The matrix is prepared from, by mass, 3-4% of 1,2-pentanediol, 10-15% of methyl propanediol, 1-2% of sodium hyaluronate, 3-5% of myrothamnus flabellifolia leaf/stem extracts, 10-15% of hydrolysis elastic protein, 10-20% of an anti-aging agent containing 100-200 ppm palmitoyl oligopeptide, 5-10% of tea extracts, 0.2-0.5% of a cell growth factor stock solution, 3-5% of an anti-aging agent containing 45-55 ppm neurotransmitter inhibition signal peptides, 5-10% of algae extracts and the balance water. According to the skin protection matrix, the skin barrier repairing and anti-aging effects are remarkable, the effect can be seen in a short period, and the skin barrier can be repaired when a user uses the matrix for a long time, so that wrinkles are reduced.

The invention discloses a preparation method of a dry nano-fiber facial mask. The preparation method comprises the following steps: preparing a polyvinyl alcohol water solution, a chitosan water solution, a sodium hyaluronate water solution and a nutrient solution; mixing the water solutions to form a spinning solution, carrying out multi-needle electrostatic spinning, and finally forming a layerof nano-fiber film on a facial mask non-woven fabric base material serving as a receiving screen, so as to obtain a composite fiber film; drying at 70-80 DEG C for 2-5 minutes; and carrying out slitting, formation, sealed packaging and sterilization, so as to obtain the dry nano-fiber facial mask. According to the preparation method, effective components in facial mask liquid are mixed into a polyvinyl alcohol spinning base solution, the nano-fibers are prepared by virtue of an electrostatic spinning technique and fixed on a facial mask non-woven fabric, the facial mask is taken out in use, aproper amount of purified water is sprayed to the front surface of the facial mask to adequately wet the facial mask, and then the facial mask can be applied to the face of a user. The water content is extremely low before use, and natural chitosan type antibacterial components are added, so that the guarantee period is prolonged, and the facial mask is convenient to transport and store.

The invention relates to a preparation method of 1,4-butanediol diglycidyl ether cross-linked sodium hyaluronate gel. The method comprises the steps of: by taking high-concentration sodium hyaluronate solution as reaction matrix, performing first cross-linking for a longer time under the low-temperature condition by adding less cross-linking agent, then performing secondary deep cross-linking under high-temperature condition, and finally processing and pelleting through short-time dialysis technique, thereby obtaining the sodium hyaluronate gel product. With the method, the cross-linking condition of the high-concentration cross-linking agent under the traditional high-temperature condition can be eliminated, milder secondary depth cross-linking condition is adopted, the reaction efficiency of the less cross-linking agent can be greatly improved, the residual cross-linking agent is more easily removed, and the excellent biocompatibility of the cross-linked sodium hyaluronate gel can be ensured. The method is simple in preparation technique, excellent in controllability and easier to practically produce on large scale.

The invention discloses a preparing method of injectable sodium hyaluronate gel containing microballoons. The preparing method comprises the following steps of dissolving sodium hyaluronate into purewater to obtain a solution A; adding a microballoon material into the solution A, and conducting uniform stirring to obtain a homodisperse suspension liquid B; adjusting the PH value of the suspensionliquid B to obtain a suspension liquid C; adding a crosslinking agent into the suspension liquid C, conducting uniform stirring to obtain a homodisperse suspension liquid D, after a reaction is carried out for a certain period of time, crosslinking sodium hyaluronate in the suspension liquid D to form colloid E containing the homodisperse microballoon material; smashing the colloid E to obtain gel particles F, and obtaining gel particles G through screens with different mesh numbers; removing soluble impurities and crosslinking agents in the gel particles G in a repeated soaking or dialytic mode to obtain gel particles H; utilizing a PBS buffering solution for balancing for repeatedly soaking the gel particles H to obtain gel particles I; obtaining the sodium hyaluronate gel through the procedures of semi-dehydration, filling and sterilization. By means of the preparing method, the problem that the microballoon material is deposited and gets caked is effectively solved.

The invention relates to the technical field of sodium hyaluronate gel, and especially relates to a hyaluronic acid elastomer. The hyaluronic acid elastomer is prepared by the following steps: reacting hyaluronic acid with a crosslinking agent to obtain crosslinked sodium hyaluronate gel (A); granulating the obtained crosslinked sodium hyaluronate gel (A) to obtain gel (B) and gel (C) with different particle sizes; mixing the gel (B) and gel (C) to carry out crosslinking reactions again, adjusting the pH value to a neutral area, and carrying out dialysis to obtain the hyaluronic acid elastomer. The provided hyaluronic acid elastomer has an excellent rheology performance, can be used as a cosmetic raw material, can be used to eliminate skin wrinkles physically, maintain the skin water, slowly release the effective component, and improve the feeling. The invention further discloses applications of the hyaluronic acid elastomer.

The invention discloses a cosmetic composition favorable for keeping the biological activity of an epidermal growth factor (EGF). The composition mainly comprises the EGF, hydrolyzed collagen powder, sodium hyaluronate, silk peptide powder, palmitoyl pentapeptide and carnosine. The cosmetic composition disclosed by the invention has the characteristics that polypeptides with different structures and molecules are used as main raw materials, polysaccharides are compounded, and various components are similar to the EGF in structure, thereby protecting the EGF; and under the protective action of multiple components which are reasonably combined and matched, the biological activity of the EGF in a cosmetic formula is kept.

The invention relates to the technical field of masks, and particularly relates to a Dendrobium officinale moisturizing and repair sleeping mask and a preparation method thereof. The mask comprises a phase A component and a phase B component, wherein the phase A component comprises moisturizer, emulsifier, sodium hyaluronate A and water; the phase B component comprises Dendrobium officinale extracting solution, Crocus sativus extract, ganoderma lucidum extract, agilawood extract, sodium hyaluronate B and cosolvent. The mask is prepared from Crocus sativus, ganoderma lucidum, agilawood and Dendrobium officinale, wherein the Crocus sativus achieves the main effect of activating blood circulation to dissipate blood stasis; the ganoderma lucidum and the agilawood respectively achieve the auxiliary effects of invigorating qi and calming the nerves, and promoting circulation of qi to relieve pain; the Dendrobium officinale achieves the adjuvant effect of nourishing yin and promoting salivation; and the whole composition achieves the effects of promoting flow of qi and blood circulation, dispersing blood stasis and nourishing the kidney-yin. Besides, since the Dendrobium officinale extracting solution contains abundant colloid, the loss of moisture and collagen in the skin can be supplemented, elastic fibers can be repaired, and cell tissues can be reformed, so that the original elasticity and gloss of the skin are recovered, the remarkable freckle removal effect is achieved; and under the condition of ensuring that the skin is sufficiently moisturized, the mask has a greatly improved skin repair function.

A process for preparing the sodium hyaluronate from the flermented liquid of hyaluronic acid incldues such steps as removing bacteria from said fermented liquid, enzymolyzing, depositing in alcohol, complexing, cleavaging, depositing in alcohol, ultrafiltering, depositing in alcohol, washing, dewatering and dryin. It has high molecular weight and low content of protein.

The invention discloses a composite moisturizing agent characterized in comprising, by weight, 30-50% of glycerol, 15-30% of water, 12-15% of sodium lactate, 12-15% of PCA sodium, 3-10% of allantoin, 2-5% of beta-glucan, 0.5-2.5% of polyquaternium-51, and 0-1% of sodium hyaluronate. The composite moisturizing agent composition provided by the invention has a far better effect against skin water loss than those of independent applications of single components in the composition. The composition provided by the invention has a far better effect for skin elasticity than those of independent applications of single samples. Therefore, the components provide a synergetic effect. When the composition is compounded, skin moisture retention can be improved. Also, the composition provided by the invention has a far better effect in improving skin moisture retention than reference samples such as polyethylene glycol, ceramide, collagen, and chitin. Therefore, the composite moisturizing agent provided by the invention is a high-efficiency moisturizing agent.

The invention relates to a collagen temperature-sensitive hydrogel and a preparation method thereof Soft tissue filling materials utilized in the existing plastic and beauty treatment industry have the problems of hardening, production of phyma, too fast absorption speed, and induction of chronic inflammation. American F Dalton approves successively multiple products for soft tissue filling, and main components of the products comprise bovine collagen, hyaluronic acid sodium, polymethyl methacrylate (PMMA) globules and the like. The products have good effects but can still produce cases of redness and allergy of a used position and too fast absorption. In the invention, collagen solution, chitosan acid or hyaluronic acid, and beta-sodium glycerophosphate solution are mixed according to a volume ratio of (1 to 3): (1 to 5): (1 to 2), then are stirred well at a temperature of 0 to 15 DEG C for 10 to 30 minutes and are adjusted to a pH of 7.4 to form temperature-sensitive hydrogel. The temperature-sensitive hydrogel has the advantages of good gel forming property at a temperature of 37 DEG C, gel forming time within 10 minutes, good mechanical strength, long degradation time, low immunological rejection, and favorable safety and effectiveness.

The invention discloses whitening cosmetic and a preparation method thereof. A composition of a plurality of plants is taken as a main raw material, and the whitening cosmetic mainly comprises the following components: a rice bran extract, a rhodiola rosea extract, a ginkgo leaf extract, tea polyphenol, a lemon juice concentrated liquor, chitosan, a puerarin extract, konjac powder, a sunflower faceplate extract, a sunflower seed extract, a saponin kernel, hemicelluloses and honey. In addition, the whitening cosmetic also contains the following raw materials: a little of glycerinum, 1,3-propylene glycol, squalane, sodium hyaluronate, carbomer, triethanolamine, triethanolamine, allantoin, nanometer titania, collagen powder, an antibacterial agent, a ferulic acid isooctyl ester and glutathione. The composition can be applied to a whitening formula, has the effects of whitening the skin, moisturizing, resisting bacteria and diminishing inflammation, removing free radicals, inhibiting melanin formation, and inhibiting hallachrome mutase and tyrosinase activity.