100 results about "Diabetic wound" patented technology

Present invention features methods for induction of angiogenesis by administration of lysine (l-&d-) or lysine oligomers (molecular weight approx between 500 and 2500), both homo and hetero-oligomers, consisting of either l-or d- or both enantiomers. Induction of Angiogenesis by the methods of the invention can be use in therapeutic angiogenesis, in, for example, treatment of ischaemic conditions and syndromes, such as chronic wounds (e.g diabetic wounds and ulcers, bed sores and other pressure sores, burns of various degrees and extents etc.) as well as coronary and cerebral ischaemia and peripheral vascular ischaemic conditions. Induction of angiogenesis by the described methods also will be useful in inducing/enhancing radiosesitivity in some solid tumors.

The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provides methods of treating or preventing peripheral nervous system neuropathies. Peripheral nervous system neuropathies may but need not be diabetic neuropathies, and may but need not be associated with a diabetic wound. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions and methods, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.

The invention belongs to the field of a biological material and discloses a controlled medicine release orientated porous composite electrospun fibrous membrane. Poly-L-lactic acid serves as a matrixand has a single orientated structure, nanopores are distributed in the surface of fiber, and medicine loaded mesoporous silicon dioxide nanoparticles are distributed in the fiber. The fibrous membrane is prepared by a mixed electrostatic spinning technology, and the process is simple and easy to control. The multi-stage nano-structure, the controlled release medicines and Si ions generate a synergistic effect and can promote the angiogenesis of a wound area, so that the controlled medicine release orientated porous composite electrospun fibrous membrane accelerates the healing of diabetes wound and can serve as novel wound repair dressing.

The invention relates to a self-healing injectable hydrogel dressing for restoring a diabetic wound as well as a preparation method and application thereof. The preparation method is simple, free fromresidue of organic solvent, mild in reaction conditions, simple in operation and low in raw material cost at the same time. Meanwhile, the experiment result shows that the self-healing injectable hydrogel dressing for restoring the diabetic wound has excellent temperature sensitivity, self-healing performance and injectable performance, and can significantly accelerate the healing of the diabeticwound.

The invention discloses a preparation method of gelatin microspheres and an application thereof. The preparation process comprises the following steps: S1. a gelatin aqueous solution is used as the internal phase; an oil phase is an external phase, and the flow rates of the inner and outer phases are respectively controlled by a microfluidic device to be 1 to 10 [mu]L/min and 20 to 200 [mu]L/min;and the external phase is the collected phase, and the micro-droplets are collected; and S2. the collected micro-droplets are gelatinized at 4 to 12 DEG C, the oil phase on the surface is removed, anda crosslinking reaction is carried out with a genipin solution for 1 h, and after the reaction is completed, the gelatin microspheres are obtained by separation. The gelatin microsphere of the invention not only has a simple preparation process, is safe to the cells, is non-toxic, and has certain mechanical strength, can load the cells well, does not affect the activity of the cells, and can be applied as a cell carrier; the gelatin microsphere has a certain promoting effect on the healing of diabetic wounds and the formation of wound blood vessels, also has a good degradation effect, and canbe used as an accelerator drug for wound healing and blood vessel formation.

The invention provides a bacterial cellulose hydrogel dressing for a diabetic wound surface and a preparation method thereof. The hydrogel dressing comprises carboxylation bacterial cellulose and amination glucose oxidase, and the carboxylation bacterial cellulose and the amination glucose oxidase are in amido bond connection. The hydrogel dressing further comprises plerixafor; the plerixafor is loaded inside the hydrogel dressing. Glucose oxidase is grafted to the surface of the hydrogel dressing through amido bonds, the gluconic effect in the wound surface can be lowered, and glucose oxidasecannot enter blood circulation; meanwhile, the stem cell mobilizing drug AMD3100 is loaded in the modified cellulose dressing through the physical adsorption effect, the medicine can be released intobody fluid when the dressing makes contact with the wound surface, and the drug is used for prompting generation of new vessels at the wound surface.

The method of treating diabetic wounds using biosynthesized nanoparticles includes administering an effective amount of silver and gold nanoparticles to a patient in need thereof. The silver and gold nanocomposite is prepared by ‘biosynthesis”, i.e., by providing a first aqueous solution of a noble metal salt or a noble metal oxide; providing a second solution of an aqueous plant extract, and combining the first solution and the second solution to produce a solution including nanoparticles of the noble metal. The second solution includes a plant extract obtained from Solenostemma argel, Trigonella foenum-graecum and Cinnamomum cassia. The metal salt can include silver nitrate (AgNO₃) and chloroauric acid (HAuCl₄). Nanoparticles of gold and nanoparticles of silver are prepared separately, and then mixed to obtain a composition containing a gold and silver nanocomposite.

The invention discloses a gel for skin wound repair. The gel comprises a hydrogel matrix, wherein the hydrogel matrix is boiled and sterilized for 30 min so as to prepare a gel with a concentration of2% at 20 DEG C, and then nicotinamide mononucleotide is added so as to prepare the gel with a concentration of 2-6. Compared with the prior art, the gel has the advantages that the gel can rapidly repair a diabetic wound surface, is high in pertinence and remarkable in curative effect, and allows a wound to be quickly healed.

The invention provides a preparation method of nano-composite hydrogel and application of the nano-composite hydrogel in promoting healing of diabetic wounds. The method comprises the following steps: preparing a functionally modified natural high-molecular polymer and functional metal oxide nanoparticles, mixing the functionally modified natural high-molecular polymer solution with the functional metal oxide nanoparticles, and finally preparing the nano composite hydrogel by means of enzymatic crosslinking and photo-crosslinking. The hydrogel prepared by the method has multiple functions, and can be used for adjusting the pathological microenvironment of the diabetic wound to promote the healing of the diabetic wound.

The invention relates to a two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel for promoting wound healing of infectious diabetes mellitus and a preparation method thereof, the two-dimensional MXene-inorganic-organic hybrid multifunctional hydrogel is a polyether-p-hydroxybenzaldehyde aqueous solution, a branched cationic polymer aqueous solution, a 3, 3 '-dihydroxybenzaldehyde aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution, a cationic polymer aqueous solution and a water solution. The preparation method comprises the following steps: mixing a 3, 3 '-dithiobis (propionyl hydrazide) (DTPH) aqueous solution and a dopamine modified MXene-bioactive inorganic material aqueous solution according to a volume ratio of (14-18): (1-6): (1-4): (1-4), and carrying out a Schiff base reaction to obtain the FGDM hydrogel. The FGDM hydrogel is injectable, self-healing and conductive, has temperature and oxidation reduction dual responsiveness, ROS (reactive oxygen species) removal capability, rapid hemostasis capability, good biocompatibility, relatively strong tissue adhesion and antibacterial property, and can promote the repair of infectious skin wounds of diabetic mice. The preparation method is simple, free of organic solvent residues, environment-friendly, convenient to operate and low in raw material cost.

The invention belongs to the technical field of medicinal chemistry, and discloses a medicine composition for treating skin wounds and a medicinal preparation thereof. The medicine composition provided by the invention comprises the components in parts by weight: 0.05-6.0 parts of polysaccharide, 0.3-2.0 parts of boric acid and 0.002-1.0 part of chlorhexidine acetate, wherein the polysaccharide is oligopolysaccharide and/or oligopolysaccharide derivative. The medicine composition provided by the invention has a significant effect on treatment of skin wounds, can effectively control the wound area and promote the healing of the wound, and can be used for treating the diabetic wound and other skin wounds; the medicine composition can be prepared into multiple medicinal preparations and is convenient to use; moreover, the popularization and application of the medicine composition can be facilitated.

The embodiment of the invention discloses ointment for treating bedsore, diabetic wound and scald. The ointment comprises the following components in percentage by weight: 1.5 to 6.5 percent of sulfanilamide crystal, 1.5 to 6.5 percent of sulfadiazine, 2.0 to 10.0 percent of zinc oxide, 0.4 to 4.0 percent of cod liver oil, 0.1 to 3.0 percent of racanisodamine, 0.02 to 1.4 percent of borneol, 5.0 to 30.0 percent of herba violae, and the balance of medical vaseline. By adopting the ointment, tissue permeability at the afflicted part of a patient can be enhanced, moisture evaporation of the ointment is reduced, the acting time of the medicament at the afflicted part is prolonged, bacteria at the afflicted part are inhibited, local microcirculation is obviously improved, discontinuity during capillary blood perfusion is avoided, and healing of the afflicted part is promoted.

This invention relates to a new topical gel formulation of the drug Esmolol hydrochloride for treatment of chronic wounds such as diabetic wounds, burn wounds, venous ulcers and pressure ulcers.

The invention discloses a preparation method for an injection for treating diabetic wounds and a product thereof. The preparation method comprises the following steps: (1) a solution which contains mesenchymal stem cells is prepared; (2) a mixed solution of type I collagen solution and laminin is prepared; (3) the mixed solution and the solution containing the mesenchymal stem cells are mixed andsufficiently and uniformly dispersed, and thereby the injection for treating diabetic wounds is obtained. According to the invention, the type I collagen and the laminin are mainly utilized to wrap the mesenchymal stem cells, the activity of the mesenchymal stem cells is protected, and thereby the problem that the therapeutic effect is weakened as time goes by in the process of treatment is avoided; moreover, the type I collagen and the laminin can cooperate with the mesenchymal stem cells, and thereby the therapeutic effect is further enhanced.

The invention discloses rADSCs loaded gelatin microspheres and a preparation method and application thereof. The preparation process comprises the steps of using mixed liquor of fat stem cells and a gelatin aqueous solution as an inner phase, using an oil phase as an outer phase, and through a micro-fluidic device, preparing microdroplets; and then enabling gelatinized microdroplets to have a cross-linking reaction with a genipin solution so as to obtain the rADSCs loaded gelatin microspheres. According to the rADSCs loaded gelatin microspheres, live rADSCs is encapsulated in situ, besides, high activity of the rADSCs can be maintained, so that healing of wounds of diabetes and formation of wound blood vessels can be well promoted. Besides, the rADSCs loaded gelatin microspheres further have good degradation effects, and during wound healing, rADSCs loaded gelatin microspheres are just basically degraded completely. The rADSCs loaded gelatin microspheres concurrently have favorable wound healing effect, blood vessel formation effect and degradation effect, have tremendous application prospects in the respects of wound healing and blood vessel formation, and can be prepared into wound healing medicines and blood vessel formation medicines for application.

The invention discloses a preparation method of degradable antibacterial hemostatic hydrogel capable of promoting diabetic wound repair. The hydrogel with a three-dimensional network structure is prepared from dopamine (DA) grafted oxidized natural polysaccharide and jellyfish collagen (JC) through a cross-linking agent. The hydrogel prepared by the invention not only has excellent tissue adhesion performance, antibacterial performance and hemostasis performance, but also has very strong water retention capacity, provides a moist environment for wound healing of diabetes mellitus, and accelerates wound healing. The invention has the advantages that: 1, the prepared degradable hydrogel with antibacterial and hemostatic functions for repairing the diabetic wound surface does not need to be additionally added with antibiotics when being used for treating the diabetic wound surface, so that the generation of drug resistance is avoided; 2, the used collagen is derived from plankton in an aquatic environment, and compared with animal-derived collagen, outbreak of zoonosis (mad cattle disease, porcine brucellosis, inhalable anthrax and the like) and some potential virus transmission risks are avoided;

The invention discloses a traditional Chinese medicine composition capable of curing diabetes wound fester and continuously reducing blood sugar, which is manufactured by following materials by parts of weight: 100 to 180 parts of astragalus mongholicus, 80 to 120 parts of coptis chinensis, 300 to 600 parts of honeysuckle and 50 to 80 parts of cassia twig. The traditional Chinese medicine composition has the advantages of being efficient, non-toxic, wide in medicine source, convenient to use, economical and capable of curing diabetes wound fester. Diabetes wound is not prone to relapse after being cured by the traditional Chinese medicine composition. The traditional Chinese medicine composition also has the functions of continuous reducing fasting blood glucose of diabetes patients and improving oral glucose tolerance.

The invention provides a traditional Chinese medicine composition for promoting healing of diabetic wounds. The composition is prepared by the following raw materials in parts by weight: 8-16 parts of notoginseng, 38-46 parts of scutellaria roots, 0.1-2 parts of borneol, and 0.1-0.5 parts of aquilaria wood essential oil. A preparation method comprises the following steps: 1. notoginseng and scutellaria roots are weighed in proportion, drying and crushing are carried out, and the materials are sieved by a 200 mesh sieve; 2. notoginseng powder and scutellaria roots are added into distilled water, immersion is carried out for 0.5 hours, ultrasonic treatment is carried out at 50 DEG C for 1 hour, and filtering is carried out; filter residues are added into ethanol whose concentration is 50% according to a proportion 1:10, ultrasonic treatment is carried out for 30 minutes, filtering and combination of filtrate are carried out, the filtrate is added into a rotary evaporator for condensation, and freeze drying is carried out; 3. according to a proportion, the aquilaria wood essential oil is diluted in 50 parts of a physiological saline solution of 5% propylene glycol; 4. according to a proportion, the borneol is added into an extract product, the solution of aquilaria wood is added according to a proportion, and after uniform stirring, the traditional Chinese medicine composition paste agent is obtained. The traditional Chinese medicine composition can accelerate healing of wounds of rats with diabetes.

The invention discloses an external medicine composition for treating traumata and skin and external diseases. The external medicine composition is mainly prepared from seven medicines including honeysuckle, angelica sinensis, smoked plum, gallnuts, terminalia chebula retz, rheum officinale and golden cypress, and all of the monarch, minister, assistant and guide medicines are combined, so as to achieve the effects of promoting blood circulation, diminishing swelling, detoxifying and promoting granulation. The selected medicine are fewer but better, according to the principle that both symptoms and root causes can be treated when diseases are treated, fewer fine traditional Chinese medicines are selected, and the requirements of economy, greenness and the like are satisfied. The medicine composition can be used for curing the traumata, the skin and external diseases, diabetic wounds and skin and external diseases which are difficult to heal and can be used for treating hordeolum, paronychia, acne and dental ulcer, and the wounds almost have no scar.

The invention discloses firstly non-coding RNA for treating delayed healing of diabetic wounds and diabetes-related complications and application of the non-coding RNA. Upon animal experiments, the non-coding RNA disclosed by the invention is proved to be effective on promoting healing of diabetic wounds, and the non-coding RNA is of great significance for the treatment of delayed healing of wounds in patients of diabetes and for the treatment of ulcer, erosion, gangrene and diabetic foot caused by the diabetes.

The invention discloses a nanofiber for treating a bacterial infection diabetes wound surfaceand a preparation method and application thereof. The nano-fiber comprises a core curcumin nano-crystal and a shell polydopamine nano-tube. The used natural product curcumin has good biological safety, can induce M2 type polarization of macrophages, and further promotes wound healing. The polydopamine material has the advantages of excellent biocompatibility, good near-infrared conversion performance, remarkable photo-thermal antibacterial effect and the like. The nanofiber is simple in preparation process, low in cost, good in repeatability and suitable for large-scale production. The prepared nanofiber has good antibacterial and diabetes wound repair promoting capabilities, and has very high clinical application value.