719results about How to "Good blood compatibility" patented technology

The invention discloses a Zn-Mg zinc alloy and a preparation method and application thereof. The zinc alloy contains Zn and Mg; and the weight percentage of Mg in the zinc alloy is 0-20%, 0 not included. The zinc alloy further contains microelements which are at least one of strontium, calcium, silicon, phosphorus, lithium, silver, tin and rare earth elements; and in the zinc alloy, the mass percentage of the microelements is 0-3%, 0 not included. The mechanical performance of the Zn-Mg zinc alloy accords with the strength and toughness requirements of a medical implant material; the Zn-Mg zinc alloy is non-toxic, has excellent histocompatibility and blood compatibility, and can be degraded in vivo; and metal ions obtained from dissolving can be absorbed and used by living bodies to promote bone growth, or can be removed from the bodies through metabolism.

In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.

The invention discloses a method for preparing a lubricant coating on the surface of polymer materials of a medical catheter, which comprises the following steps: (A), pretreating the surface of the polymer materials of the medical catheter, so as to obtain hydrophilic adsorption active sites; (B), soaking the pretreated polymer materials of the medical catheter in step (A) into a prepared precursor solution of the lubricant coating for adsorption; and (C), performing grafting reaction on the soaked polymer materials of the medical catheter in step (B), and washing and drying the polymer materials of the medical catheter. The method can be widely used for preparing medical polymer materials and coating materials on the surface of a medical apparatus.

The invention belongs to the field of preparation of magnesium alloy biological medical materials and particularly relates to a Mg-Zn-Y-Nd alloy for biodegradable vascular stents and a preparation method thereof. The Mg-Zn-Y-Nd alloy comprises the following components in percentage by weight: 1 to 3 percent of Zn, 0.23 to 0.69 percent of Y, 0.5 to 1 percent of Nd and the balance of Mg, wherein the weight percentage content of Zn and the weight percentage content of Y meet a condition that the molar ratio of Zn to Y is kept at 6:1 constantly and the weight percentage content ratio of Y to N is smaller than 1. The preparation method comprises: preparing charging materials according to the composition of the Mg-Zn-Y-Nd alloy and the condition that the weight percentage content of the Zn and the weight percentage content of Nd is 20 to 30 percent more than those required, and smelting to obtain common Mg-Zn-Y-Nd alloy, wherein the charging materials of Mg, Zn, Y and Nd are high-purity magnesium ingots, high-purity zinc ingots, Mg-Y intermediate alloy and Mg-Nd intermediate. The Mg-Zn-Y-Nd alloy disclosed by the invention has high corrosion resistance and high plasticity.

The invention relates to a medical apparatus, in particular to an anticoagulant stainless steel coronary support which is made from a high-nitrogen nickel-free austenitic stainless steel material with good blood compatibility. The support is of tubular structure with a mesh surface which is formed by orderly arranging a unit figure on the side surface of a tube along the circumference and axial direction, the primary supporting function is provided by U-shaped corrugated mesh wires extending along the axial direction, the corrugated mesh wires are connected into a whole body by soft mesh wires arranged at intervals, and the diameter of the mesh wire (width or thickness) is 40-100mum; and the surface of the support is passivated and coated with a medication. The anticoagulant stainless steel support has the advantages of good mechanical properties, good flexibility and good anticoagulant property, and can be used as a support for cardiovascular and cerebrovascular systems or a support for other cavity bodies.

The invention discloses an endotoxin adsorbent used in hemoperfusion, and a preparation method thereof. The preparation method comprises the following steps: a porous carrier is prepared; the carrier is polystyrene divinylbenzene resin or polymethyl methacrylate resin, wherein the pore size of the resin is 5-50nm and the specific surface area of the resin is no less than 500m<2> / g; residual double bonds of the carrier resin are subjected to epoxidation modification; and ligands are immobilized. According to the scheme of the invention, a synthesis process route is changed, such that adsorbent harmful substance residue is avoided, and adsorbent adsorption capacity is improved. Specifically, residual double bonds of the adsorption resin are subjected to epoxidation modification, such that the epoxy group amount is increased; with the epoxy groups, hydrophobic tethers are added, such that ligand movement capacity is improved, and the adsorbent is provided with a good endotoxin adsorption effect; and resin pore size and specific surface area are controlled, such that the adsorption amount and removal rate of the adsorbent upon cytokines are ensured.

A bushing-type permanent magnetic impeller shaft bleeding pump, which is used for heart boosting and the boosting method of the bleeding pump are provided. A rotor of the bleeding pump is a whole magnetic impeller or an impeller with magnetic vanes, which greatly improves a magnetic field intensity of a bleeding pump air gap. A defending, a packing and a biochemical treatment are taken on the surface of the impeller. A tube cavity of the bleeding pump is made from a material with good blood compatibleness. A pre-diversion system structure is simplified, and a pre-diversion wimble is supported by a single cantilever, which are all in favor of preventing a thrombosis. The boosting method adopts a serial-type connection of an axial bleeding pump and ventricles of heart (left ventricle, right ventricle or double ventricles) and requests that an appearance of the bleeding pump is a geometrical shape of as ascending aorta or a main pulmonary artery which is fit for implantation, and the tube cavity and an artificial blood vessel caliber match with a natural blood vessel. In order to prevent a pumping action of the bleeding pump reduces a perfusion pressure of a coronary artery, a coronary artery and aorta bypass transplantation can be performed.

The invention discloses a nanofiber vascular prostheses and a preparation method. The preparation method is as follows: mixing the solution of gelatin and glacial acetic acid with the aqueous solution of a crosslinker evenly to pre-crosslink the solution of gelatin and glacial acetic acid, adding heparin sodium aqueous solution to prepare spinning dope and collecting the formed fibers on a collecting roll by using the electrospinning process to form a nanofiber nonwoven membrane tube; dissolving polyurethane into the mixed solvent of tetrahydrofuran and N,N-dimethylformamide to prepare polyurethane spinning dope and continuously collecting the formed fibers on the collecting roll which has collected the nanofiber nonwoven membrane tube by using the electrospinning process; and taking off the nanofiber nonwoven membrane tube covered by the polyurethane fiber nonwoven membrane tube structure from the collecting roll and then soaking the nanofiber nonwoven membrane tube into the aqueous solution of a post-crosslinker to carry out post-crosslinking treatment, thus preparing the nanofiber vascular prostheses. The inner layer of the vascular prostheses of the invention can improve the blood compatibility and the outer layer has biological stability and can improve the physical and mechanical properties.

The invention relates to a copper-bearing compound coating on a metal component of a medical device and a preparation method thereof. The preparation method comprises the following steps of step one, washing the surface of the metal component of the medical device; step two, putting the metal component of the medical device into a vacuum chamber and performing pretreatment on the metal component; and step three, generating copper ions in the vacuum chamber, causing the copper ions to move towards the surface of the metal component of the medical device under the action of bias for combination with ions of another element in the vacuum chamber, and reacting on the surface of the metal component of the medical device for the formation of the copper-bearing compound coating. The copper-bearing compound coating on the metal component of the medical device provided by the invention not only is good in blood compatibility, but also can prevent the cells from growing on the device surface for the realization of inhibition on the material surface endothelialization; and additionally, the invention also relates to the medical device.

The invention discloses a method for preparing a polyvinylidene fluoride affinity membrane using amino acid as a ligand. The affinity membrane is prepared by hydrophilically modifying a polyvinylidene fluoride hollow fiber membrane and grafting the amino acid ligand. The grafting amount of the amino acid is 150 to 250mg / g for each membrane. The invention also discloses application of the affinity membrane in removing endotoxin in blood plasma, which removes the endotoxin in the blood plasma by a dynamic absorption means. The polyvinylidene fluoride affinity membrane prepared by the method has stable performance, good bio-compatibility and high endotoxin removing efficiency, and can be used for whole blood perfusion as well as blood plasma perfusion.

The invention provides a method for manufacturing artificial blood vessels with double-layered structures and application of the artificial blood vessels, and discloses a method for manufacturing artificial blood vessels with double-layered structures and a method for applying the artificial blood vessels. The method for manufacturing the artificial blood vessels with the double-layered structures includes a first step, manufacturing inner oriented micron fiber layers of the artificial blood vessels with the double-layered structures; a second step, manufacturing outer random nano-fiber layers of the artificial blood vessels with the double-layered structures. The method for applying the artificial blood vessels includes transplanting the double-layered artificial blood vessels in situ so as to replace lesion blood vessels. The methods have the advantages that vascular smooth muscle cells can be induced in vivo by oriented micron fibers of the inner layers of the artificial blood vessels to be regenerated just like oriented structures of natural blood vessels, sufficient suture strength and mechanical properties of the blood vessels can be guaranteed by the outer random nano-fiber layers, and accordingly the artificial blood vessels can be used for repairing and replacing the lesion natural blood vessels; the double-layered artificial blood vessels have excellent application prospects in the field of medical clinical vascular transplantation.

The invention relates to a hollow fiber ultrafiltration composite membrane composed of the components in the following weight percent: 15-25% of membrane material, 5-15% of pore-making agent, 55-75% of organic solvent and 5-10% of lithium chloride; the membrane material is a mixture of chitosan and one of polysulfone, polyether sulfone, polyacrylonitrile, polymethyl methacrylate, or cellulose triacetate, wherein the chitosan accounts for 1-5% of the total weight of the raw material, and the average molecular weight of chitosan ranges from 300,000 to 1,000,000; the pore-making agent is one of polyvinylpyrrolidone, polyethyleneglycol, or polyvinyl alcohol, or a mixture thereof; and the organic solvent is one of N-methyl-2-pyrrolidone, dimethyl fomamide, dimethyl acetamide, or dimethyl sulfoxide. The invention has good bioactivity, biocompatibility, anti-coagulation property and other properties.

The invention discloses a method for preparing an artificial blood vessel with a micro-nano biomimic intima structure by utilizing an electrospinning technology. The method mainly comprises the following steps of preparing a macromolecular polymer solution; preparing an alignment electrospun fibrous membrane; stretching the alignment electrospun fibrous membrane; preparing an artificial blood vessel; performing characterization by using a scanning electron microscope; and determining blood compatibility. The artificial blood vessel prepared by the method has an intima imitation alignment microstructure, so that the blood compatibility of the artificial blood vessel meets a requirement on clinical anticoagulation performance, and a new way for the preparation of a novel artificial blood vessel is provided. In addition, the adoption of an anticoagulant is avoided, and the blood compatibility of the artificial blood vessel is improved only by a surface microstructure effect, so that side effects caused by the anticoagulant are reduced, and the method has broad application prospect in the field of medical clinical blood vessel transplantation.

A polyurethane material containing F in side chain is prepared through alternative polymerization between the flexible chain segment consisting of polyether diol and / or polycarbonate diol and the rigid chain segment consisting of diisocyanate and chain-enlarging agent. Its advantages are high biologic stability and compatibility and high elasticity, strength and resistance to oxidizing and hydrolysis. It can be used for preparing artificial blood vessel, heart valve, etc.

The invention relates to a preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber. The method comprises the following steps of: (1) dissolving PLGA into a THF (Tetrahydrofuran) / DMF (Dimethyl Formamide) mixed solvent, and stirring for fully dissolving the PLGA to obtain a PLGA electrostatic spinning solution; (2) uniformly dispersing the LAP into the PLGA electrostatic spinning solution while stirring to obtain a PLGA / LAP electrostatic spinning solution; and (3) performing electrostatic spinning by using the PLGA / LAP electrostatic spinning solution to obtain a PLGA / LAP composite nanofiber felt and drying. The process of the method is simple, a product is easy to prepare, and the PLGA and LAP used have low costs; and the prepared LAP-doped polylactic acid-glycolic acid nanofiber has high mechanical property, high thermal stability, high blood compatibility and high biocompatibility, and has a wide application prospect in the fields of medicament carriers, tissue engineering bracket materials and the like.

The invention discloses an amphiphilic triblock copolymer with a structural general formula represented as the following. In the formula, when M1 is vinylpyrrolidone and M2 is acrylic acid, M3 is styrene or acrylonitrile or methyl methacrylate; or when M1 is vinylpyrrolidone and M2 is a chemical bond, M3 is styrene or acrylonitrile. m, n, p, q, are all lager than 1. A number-average molecular weight of the copolymer is 30000 to 100000, a glass-transition temperature of the copolymer is 90-180 DEG C, and a decomposition temperature of the copolymer is 180-430 DEG C. The invention also discloses a preparation method of the copolymer, and a polyethersulfone hollow fiber membrane blend-modified by using the amphiphilic triblock copolymer. The amphiphilic triblock copolymer provided by the invention is insoluble in water. When the amphiphilic triblock copolymer is blended with polyethersulfone and is prepared into a polyethersulfone hollow fiber membrane, the amphiphilic triblock copolymeris hard to precipitate. Therefore, the polyethersulfone hollow fiber membrane is provided with permanent hydrophilicity, protein pollution resistance and excellent blood compatibility. The polyethersulfone hollow fiber membrane can be used in the field of blood purification. The preparation method provided by the invention is simple, and is easy to operate. With the method, industrialization is easy to realize.

The invention discloses an in-situ polymerization mico-crosslinking polyvinylpyrrolidone modified polyether sulfone hollow fiber membrane and a preparation method and a use thereof. The preparation method is characterized by comprising the following steps: adding 10-25 parts of polyether sulfone and 90-75 parts of solvent into a reaction kettle, adding vinyl pyrrolidone accounting for 2-20% of mass of the polyether sulfone solution after the polyether sulfone is dissolved, carrying out a polymerization reaction for 2-24 hours at a temperature of 50-95 DEG C in the presence of a crosslinking agent and an initiator to obtain a polyvinylpyrrolidone modified polyether sulfone solution, stewing to cure the polyvinylpyrrolidone modified polyether sulfone solution to prepare modified polyether sulfone spinning dope, and directly mico-crosslinking polyvinylpyrrolidone between polyether sulfone lattice chains; and preparing a modified polyether sulfone hollow fiber membrane with hydrophilia, protein pollution resistance and anticoagulant function by utilizing a dry spraying-wet spinning method. The membrane is made into a filter and has excellent blood compatibility to be used for purifying blood, and the anti-protein pollution recovery rate is increased from 50% to 95%; the albumin adsorption is decreased from 20 micrograms / cm<2> to 5 micrograms / cm<2>; the activated partial thromboplastin time is increased from 50 seconds to 96 seconds.

The invention discloses an ultra-small MoS2 nanosheet. The surface of the MoS2 nanosheet is modified with polyvinylpyrrolidone, and the diameter of the modified MoS2 nanosheet ranges from 15 nm to 25 nm. The invention further discloses a preparation method of the ultra-small MoS2 nanosheet. The preparation method comprises the following steps: a sulfur source and a molybdenum source are dissolved in water and stirred until the resources are completely dissolved; polyvinylpyrrolidone is dissolved in the solution of the sulfur source and the molybdenum source; the solution is transferred into a stainless steel reaction kettle with a polyphenyl lining for closed reaction, a reaction product is washed with an ethanolamine water solution and distilled water, and the ultra-small MoS2 nanosheet with the surface modified with polyvinylpyrrolidone is obtained. The invention further provides an application of the ultra-small MoS2 nanosheet as a photo-thermal conversion material. The ultra-small MoS2 nanosheet has good colloid stability, photo-thermal conversion capacity and photo-acoustic imaging capacity and has broad application prospect in the fields of tumor treatment and the like.

The preparation method includes the following steps: modifying hepatic target compound onto degradable polymer (chitosan, polylysine, glucosan, agar, polyglutamic acid-benzyl ester, polyalanine) with biological compatibility, and adopting ion exchange or ultrasonic emulsification process to obtain the invented nano hepatic target bio-degradable medicine carrier material. The hepatic target nano particle solution has good target performance for liver, the medicine enriched rate in the liver can be up to 75%, and its slowly-released administration can be up to above 15 days.

The invention discloses a Zn-Li series zinc alloy as well as a preparation method and application thereof. The Zn-Li series zinc alloy comprises Zn and Li; and based on weight percent, the mass percent content of the Li in the zinc alloy accounts for 0 to 30%, but not including 0. The preparation method of the Zn-Li series zinc alloy comprises the following steps: (1) mixing the Zn and the Li to obtain a mixture; (2) treating the mixture according to the following step a) or step b) and then cooling the mixture to obtain the zinc alloy: a) under the protection of a CO2 and SF6 atmosphere, carrying out smelting or sintering on the mixture; and b) under the protection of a vacuum atmosphere, dissolving hydrogen gas into the mixture and carrying out the smelting. The zinc alloy prepared by the preparation method disclosed by the invention has an excellent mechanical property and can provide a long-term effective supporting force in vivo; and the zinc alloy has excellent cellular compatibility, blood compatibility and tissue and organ compatibility and can be used for preparing biomedical implant materials.

A hydrophilic copolymer is designed and synthesized by copolymerization of an acidic monomer and a second hydrophilic monomer. The copolymer is non-thrombogenic, hydrophilic and incorporates reactive functional groups. The copolymer can then be covalently attached to a primer / base coat through its functional groups, to form a durable lubricious coating on medical devices. A coating formed of the polymer on a surface is non-thrombogenic and non-cytotoxic. The coating shows good stability in gamma ray, e-beam and ethylene oxide sterilization.

The invention relates to a highly ticoagulant cellulose membrane material, wherein an amphichroic ionomer layer is grafted on the surface of a cellulose membrane, and a 'brush'-shaped amphichroic ionomer layer is formed on the surface of the cellulose membrane. The cellulose membrane with good biocompatibility is prepared by grafting of amphichroic ionic molecules on the surface of the material. The neat 'brush'-shaped amphichroic ionomer layer is formed on the surface of cellulose, so that the defects on the surface of the material are overcome, and the action between the material and biomacromolecules is further reduced, thereby nonspecific protein absorption and blood platelet adhesion are reduced to the maximum degree. Therefore, the cellulose membrane material has high nonspecific protein absorption resistance and high ticoagulant performance. The invention discloses a method for manufacturing the highly ticoagulant cellulose membrane material.

The invention discloses a Zn-Ca series zinc alloy as well as a preparation method and application of the Zn-Ca series zinc alloy. The zinc alloy comprises Zn and Ca, wherein the mass percent of Ca in the zinc alloy ranges from 0% to 30%, but is not equal to 0. The zinc alloy also comprises trace elements including Si, P, Li, Ag, Sn and at least one selected from rare earth elements, wherein the mass percent of the trace elements ranges from 0% to 3%, but is not equal to 0. The mechanical property of the Zn-Ca series zinc alloy disclosed by the invention meets the requirements for strength and toughness of a medical implant material, is nontoxic and favorable in tissue compatibility and blood compatibility, can be degraded by using body fluid and can be applied to preparation of medical implants; and the dissolved metal ions can be absorbed and utilized by living bodies to promote bone growth or can be discharged out of bodies through metabolism.

The invention discloses a preparation method and application of a heparan polyurethane blended modified polyethersulfone hollow fiber membrane. The preparation method is characterized by comprising the following steps of: adding 10 to 25 weight parts of diphenylmethane diisocyanate, 5 to 13 weight parts of dimethylolpropionic acid and 62 to 85 weight parts of solvent into a dissolving kettle, performing reaction for 4 to 12 hours at a temperature of 70 to 90 DEG C, washing the product with methanol and distilled water and drying to obtain carboxyl-containing polyurethane; adding 10 weight parts of polyurethane into 100 weight parts of concentrated sulfuric acid to carry out sulfonation to obtain polyurethane containing carboxyl and a sulfonic acid group; adding 1 to 10 weight parts of heparan polyurethane, 10 to 25 weight parts of polyethersulfone and 70 to 89 weight parts of solvent into the dissolving kettle to dissolve for 2 to 24 hours at a temperature of 75 to 95 DEG C so as to obtain hollow fiber membrane spinning dope; and preparing the hollow fiber membrane with excellent blood compatibility, permanent hydrophilicity, capacity of resisting to protein pollution and an anticoagulation function by adopting a dry spraying and wet spinning technology.

The present invention features that the bilirubin adsorbent is synthesized by selecting well biocompatible polystyrene-divinylbenzene copolymer as carrier, PHEMA as coating agent, epichlorohydrin for activating the functional hydroxy radical of PHEMA, and glutaraldehyde as cross-linking agent for cross-linking functional cyclodextrin molecule. The bilirubin adsorbent has biocompatibility and adsorption capacity superior to active carbon and cationic resin adsorbing material, and has no adsorbent molecule falling resulting in immunological dysfunction. Animal experiment shows that the novel bilirubin adsorbent may be used to eliminate bilirubin from blood, blood plasma and albumin solution effectively.

The invention relates to an anti-coagulation anti-bacterial biomedical material and a preparation method thereof in particular. The anti-coagulation anti-bacterial material is a composite material prepared by mixing a heparinized anti-coagulation material which is obtained by performing heparinization on an amidogen-containing natural biological material by a chemical covalent grafting method and an anti-bacterial material which takes chitosan as a substrate. The difunctional anti-coagulation anti-bacterial material of the invention has not only high blood compatibility, but also very good anti-staphylococcus aureus function. The novel material has double functions of anti-coagulation and antibacterium for the first time, and has a broad application prospect in clinical vascular repair.

The invention relates to endotoxin adsorbing material for curing endotoxemia in the bioseparation and the biomedical engineering fields. The adsorbing material which takes sepharose gel as a carrier is coupled with spacer arm molecules through the activating reaction, and then is coupled with two groups of quarternary ammonium salt cations and dewatering molecules as functional groups to be prepared. The adsorbing material is simultaneously coupled with the two groups of functional groups mutually effected with endotoxin, and further the adsorbing selectivity of the adsorbing material to the endotoxin is improved. The physicochemical property of the adsorbing material is steady, and the adsorbing material has good blood compatibility, thereby being able to used for removing the endotoxin in blood plasma, and curing the endotoxemia. The preparation process of the adsorbing material is simple, the preparation cost is low, and the adsorbing material belongs to the novel endotoxin adsorbing material.