Mg-Zn-Y-Nd alloy for novel biodegradable vascular stents and preparation method thereof

A mg-zn-y-nd, biodegradable technology, applied in stents, prostheses, medical science, etc., can solve the problems of fast corrosion rate and low plasticity, achieve the goal of reducing corrosion rate, uniform corrosion and improving mechanical properties Effect

Active Publication Date: 2011-10-19
JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide a kind of Mg-Zn-Y for biodegradable vascular stents with excellent corrosion resistance and good plasticity to solv

Method used

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  • Mg-Zn-Y-Nd alloy for novel biodegradable vascular stents and preparation method thereof
  • Mg-Zn-Y-Nd alloy for novel biodegradable vascular stents and preparation method thereof
  • Mg-Zn-Y-Nd alloy for novel biodegradable vascular stents and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0046] Example 1

[0047] The method for preparing extruded Mg-1Zn-0.23Y-0.5Nd magnesium alloy comprises the following steps:

[0048] (1) Determine the alloy composition and prepare materials:

[0049] Before smelting, calculate the quality of each alloy element required in advance; then use the pallet balance to weigh and prepare according to the calculated results; the content of each element (percentage by weight) in the Mg-1Zn-0.23Y-0.5Nd alloy is: Zn 1 %, Y 0.23%, Nd 0.5%, and the balance is Mg. Among them, Zn and Nd elements have a burning loss rate, and the excess is 20%; Y and Nd are added by Mg-25wt%Y and Mg-25wt%Nd master alloys respectively ; The charge required for smelting 1000g Mg-1Zn-0.23Y-0.5Nd alloy is as follows:

[0050] High-purity magnesium ingot: 954.8g

[0051] High-purity zinc ingot: 12g

[0052] Mg-25wt%Y master alloy: 9.2g

[0053] Mg-25wt%Nd master alloy: 24g;

[0054] (2) Preparation of ordinary solidified Mg-1Zn-0.23Y-0.5Nd magnesium alloy: ...

Example Embodiment

[0070] Example 2

[0071] The method for preparing extruded Mg-2Zn-0.46Y-0.5Nd magnesium alloy comprises the following steps:

[0072] (1) Determine the alloy composition and prepare materials:

[0073] Before smelting, calculate the mass of each alloy element required in advance; then use the tray balance to weigh and prepare according to the calculated result; the content (weight percentage) of each element in the Mg-2Zn-0.46Y-0.5Nd alloy is: Zn 2 %, Y 0.46%, Nd 0.5%, and the balance is Mg. Among them, Zn and Nd elements have an excessive burning loss rate of 20%; Y and Nd are added with Mg-25wt%Y and Mg-25wt%Nd master alloys respectively; The charge required for smelting 1000g Mg-2Zn-0.46Y-0.5Nd magnesium alloy is as follows:

[0074] High-purity magnesium ingot: 933.6g

[0075] High-purity zinc ingot: 24g

[0076] Mg-25wt%Y master alloy: 18.4g

[0077] Mg-25wt%Nd master alloy: 24g;

[0078] (2) Preparation of ordinary solidified Mg-2Zn-0.46Y-0.5Nd magnesium alloy:

...

Example Embodiment

[0086] Example 3

[0087] The method for preparing subrapidly solidified Mg-2Zn-0.46Y-0.5Nd magnesium alloy comprises the following steps:

[0088] (1) Determine the alloy composition and prepare materials:

[0089] With embodiment 2 step (1);

[0090] (2) Preparation of ordinary solidified Mg-2Zn-0.46Y-0.5Nd magnesium alloy:

[0091] With embodiment 2 step (2);

[0092] (3) Preparation of sub-rapid solidification Mg-2Zn-0.46Y-0.5Nd magnesium alloy:

[0093] The preparation of the sub-rapid solidification alloy sample adopts the method of water-cooled copper mold injection; during the preparation process, the heating equipment used is: GP30-CW7 induction heating equipment, copper mold (wall thickness 25mm and internal hollow diameter 2mm), SP009 Strip machine, quartz tube (the diameter of the melt spraying port at the bottom of the quartz tube is Φ1mm); firstly, the common solidified Mg-2Zn-0.46Y-0.5Nd magnesium alloy prepared in step (2) is made into small pieces, And po...

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Abstract

The invention belongs to the field of preparation of magnesium alloy biological medical materials and particularly relates to a Mg-Zn-Y-Nd alloy for biodegradable vascular stents and a preparation method thereof. The Mg-Zn-Y-Nd alloy comprises the following components in percentage by weight: 1 to 3 percent of Zn, 0.23 to 0.69 percent of Y, 0.5 to 1 percent of Nd and the balance of Mg, wherein the weight percentage content of Zn and the weight percentage content of Y meet a condition that the molar ratio of Zn to Y is kept at 6:1 constantly and the weight percentage content ratio of Y to N is smaller than 1. The preparation method comprises: preparing charging materials according to the composition of the Mg-Zn-Y-Nd alloy and the condition that the weight percentage content of the Zn and the weight percentage content of Nd is 20 to 30 percent more than those required, and smelting to obtain common Mg-Zn-Y-Nd alloy, wherein the charging materials of Mg, Zn, Y and Nd are high-purity magnesium ingots, high-purity zinc ingots, Mg-Y intermediate alloy and Mg-Nd intermediate. The Mg-Zn-Y-Nd alloy disclosed by the invention has high corrosion resistance and high plasticity.

Description

technical field [0001] The invention belongs to the field of preparation of magnesium alloy biomedical materials, and in particular relates to a novel Mg-Zn-Y-Nd magnesium alloy for biodegradable vascular stents and a preparation method thereof. Background technique [0002] Vascular stent implantation is a new technology of interventional therapy that has developed rapidly in the past 10 years. Tiny tubular stents can expand the embolized blood vessels caused by fat accumulation. Clinical conditions such as myocardial ischemia and coronary heart disease can be cured immediately after surgery. Relief, saving lives, and the patient can be discharged on foot after 24 hours, the curative effect is remarkable. In response to the different treatment needs of different vascular lesions, scientific researchers in materials, biology, medicine and other related fields have conducted interdisciplinary cooperation to jointly develop new vascular stents with superior performance, and ha...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C1/03A61L27/04A61L27/58A61F2/82
Inventor 关绍康王俊王利国朱世杰王彬胡俊华吴琼
Owner JIANGSU FENGYUAN MEDICAL DEVICES CO LTD
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