86 results about "Vascular stent" patented technology

The application provides an absorbable vascular stent covering facilitating endothelialization and a preparation method thereof, and belongs to the technical fields of biomedical materials and vascular stent covering preparation. The absorbable vascular stent covering facilitating endothelialization is prepared based on modified silk fibroin and domestic silkworm silk. The inner surface of the absorbable vascular stent covering facilitating endothelialization has a nano topological structure and a matrix-like component simulating a vascular basement membrane, and the outer surface has a micro topological structure. The absorbable vascular stent covering facilitating endothelialization has good mechanical properties and excellent endothelial cell activity, and can be used for producing a vascular stent capable of rapidly forming a new endothelial layer, maintaining stable blood flow, and inhibiting thrombosis and inflammation.

The application relates to a loading device for assisting stent sheathing and a manufacturing method thereof, which is used for sleeving on a sheath tube and comprises a first protection section with a cylindrical lumen and a protection section inner diameter D4, a second protection section with a conical lumen and connected with the first protection section at a large end side, and a loading guide section with a conical lumen and connected with the small end side of the second protection section at a second stage; the protection section inner diameter D4 is larger than the maximum outer diameter D1 of the sheath tube, and the minimum diameter D5 of the second stage is smaller than the minimum inner diameter D2 of the sheath tube. The loading device can assist the vascular stent to enter the inner cavity of the sheath tube, reduces the difficulty of stent sheathing, reduces the labor of doctors, and improves the success rate of surgery.

This invention relates to a cardiovascular stent loading sheath and a retraction system for an advancing stent sheath. The cardiovascular stent loading sheath, through the deformation-sealing opening of a deformable element disposed on the sheath tube, achieves the purpose of sealing the sheath opening after stent deployment. This ensures that when the loading sheath retracts across the stent, the sheath end opening does not snag on the stent, effectively preventing stent displacement and reducing surgical risks.

The application provides a recyclable vascular stent, and belongs to the technical field of interventional treatment instruments; the stent comprises a first stent, a second stent and a separation component; the outer side wall of the first stent is used for directly supporting a blood vessel and can automatically contract in a radial direction; the second stent is coaxially arranged on the inner side of the first stent and is used for supporting the first stent to expand in a radial direction; the separation component is arranged on the first stent and / or the second stent and is used for reducing the friction between the first stent and the second stent; when the stent is taken out, the second stent is gradually taken out from the inner side of the first stent, and the first stent automatically contracts in a radial direction in the process of losing the support of the second stent to reduce the embedding force with the side wall of the blood vessel, so that the taking out of the whole stent is facilitated; and the technical problem that the existing technology has a large resistance and is not easy to take out when the vascular stent is taken out is solved.

The invention discloses a negative Poisson's ratio stent structure for heart and cerebral vessels and an optimization method of the negative Poisson's ratio stent structure, belongs to the technical field of medical instruments, and solves the problems of axial shortening, contradiction between radial supporting force and flexibility and low calculation efficiency in an optimization process of a traditional vascular stent due to a positive Poisson's ratio effect. Wherein a bracket structure of a curved-edge concave hexagonal geometric unit is adopted, and the bracket synchronously extends in the axial direction to present a negative Poisson's ratio effect when being subjected to an expansion load in the radial direction; degradable macromolecules or degradable metals are selected as the material of the stent; according to the optimization method, candidate design is generated through parametric modeling, performance indexes are obtained through finite element simulation, a neural network agent model is trained to predict multi-target performance, a Pareto optimal solution set is obtained through optimization by adopting a multi-target optimization algorithm, and manufacturing parameters are determined through finite element review. According to the invention, the implantation precision and the positioning accuracy of the stent are improved, the mechanical property and the biocompatibility are optimized, and the design efficiency is improved.

The present application relates to a kind of transarticular vascular stents and its preparation method, transarticular vascular stent includes the first part and second part distributed along the axial direction of transarticular vascular stent;First part includes multiple first stent rings spaced apart along the axial direction of transarticular vascular stent and independent of each other and the whole surface film fixedly arranged on multiple first stent rings;Wherein, from proximal end to distal end, the distance between adjacent two first stent rings gradually increases;Second part includes multiple second stent rings spaced apart along the axial direction of transarticular vascular stent and independent of each other and multiple rows of connecting film groups sequentially arranged along the axial direction of transarticular vascular stent;Each row of connecting film groups includes multiple connecting membranes uniformly distributed along the circumferential direction of transarticular vascular stent, and both ends of each connecting membrane are respectively fixedly connected with adjacent two second stent rings;The width of the rod forming first stent ring is greater than the width of the rod forming second stent ring.

The utility model relates to the technical field of medical instruments, and provides a conveying system which comprises a shell, a finger wheel, a transmission mechanism, a catheter assembly and an intravascular stent. Part of the finger wheel and the transmission mechanism are arranged in the shell, the finger wheel is connected with the transmission mechanism, part of the catheter assembly extends out of the shell, the transmission mechanism is connected with the catheter assembly, and the catheter assembly is used for conveying an intravascular stent; when the finger wheel rotates, the transmission mechanism can be driven to act, and then the catheter assembly is driven to move to release the intravascular stent. The intravascular stent comprises a stent body, and the diameter of the stent body is gradually reduced or gradually reduced in the extension direction of the length of the stent body. According to the conveying system, the stent body is arranged to be in the hollow circular truncated cone shape or the stepped barrel shape, the conveying system can adapt to blood vessel physiological deformation with unequal diameters and taper, blood vessels can be effectively expanded and well attached to the wall, damage caused by excessive expansion to the blood vessels is avoided, and the treatment effect is guaranteed.

An intravascular device may have a first configuration during deployment and a second configuration after deployment. The first configuration has a first radial strength; and the second configuration has a second radial strength. The first radial strength is less than the second radial strength. A system may include an intravascular device; a wire extending through the intravascular device to expand or contract the intravascular device; a proximal hub coupled to the wire; a distal hub coupled to the wire; and a plurality of tethers extending from an input device and through the intravascular device. At least a portion of the plurality of tethers has electrical conductivity. Application of energy to the at least a portion of the plurality of tethers may disengage the plurality of tethers from the intravascular device and fuse a luminal segment of the plurality of tethers, extending through the intravascular device, to the intravascular device.

The application discloses a multifunctional blood vessel stent with a negative Poisson's ratio structure and a preparation method thereof, relates to the technical field of medical devices, and comprises the construction of a blood vessel stent model with a negative Poisson's ratio structure, selective laser melting additive manufacturing, chemical polishing treatment and surface biomimetic modification treatment. The stent can better adapt to the deformation of a blood vessel by virtue of the negative Poisson's ratio characteristic, reduces incompatibility caused by different deformation steps, the structure of the stent is round and smooth, blood flow turbulence and vortex at sharp corners of a traditional stent can be effectively avoided, the hemodynamic performance is improved, the risk of platelet activation and thrombosis is reduced, a surface gradient coating is prepared, multi-mechanism synergy is realized, and the formation of an endothelial layer on the surface of the stent is facilitated.

The application discloses a controllable degradation high-corrosion-resistance medical magnesium-aluminum alloy blood vessel stent and a preparation method thereof. The method comprises the following steps: subjecting magnesium alloy ingots containing Al, Zn, Ca and Mn to homogenization treatment, hot extrusion, cold drawing and recrystallization annealing to obtain low-aluminum magnesium-aluminum alloy microtubular materials containing aluminum second-phase non-continuous discrete distribution; after laser cutting, deburring, electrochemical polishing and surface activation, an inner layer rich in MgF2 and an outer layer rich in calcium and phosphorus are sequentially constructed; a polydopamine interface anchoring layer is formed, and a degradable polymer sealing liquid containing a heparinized hyaluronic acid-REDV peptide composite active component is coated to form an active flexible sealing layer after solidification. The stent obtained by the application has good corrosion resistance, controllable degradation, mechanical support retention capacity and endothelial repair promotion performance.

The application discloses a peripheral biodegradable vascular stent with a partitioned reinforced structure, which is divided into at least one double-layer reinforced area and at least one single-layer flexible area along the axial direction; the double-layer reinforced area comprises an inner-layer tube stent and an outer-layer tube stent which are coaxially sleeved, and the tube walls of the inner-layer tube stent and the outer-layer tube stent are in a hollow mesh structure; the peripheral wall of the inner-layer tube stent is provided with a plurality of radially extending connecting holes, and the inner peripheral wall of the outer-layer tube stent is provided with a plurality of radially extending connecting columns which are in one-to-one correspondence with the connecting holes and are embeddedly connected; the single-layer flexible area is in a single-layer mesh structure and has the same configuration as the outer-layer tube stent; and a smooth gradient transition structure is arranged between the double-layer reinforced area and the single-layer flexible area. The application solves the problems of excessive reinforcement, sacrifice of flexibility, insufficient absolute supporting force of a single-layer structure and failure caused by different degradation steps of a multi-layer structure.

The utility model relates to the technical field of medical instruments, and discloses an intravascular stent structure capable of reducing pressure stress, the intravascular stent is of a tubular net rack structure and comprises a plurality of annular wave rods and stent connecting rods, the annular wave rods are arranged in the axial direction of the intravascular stent, a plurality of stent connecting rods are arranged on one side of each wave rod, and the stent connecting rods are arranged on the other side of each wave rod. One end of each support connecting rod is connected with an adjacent wave rod, the section of each wave rod is arranged in a wave shape, and the support is characterized in that no less than one group of pressure stress parts capable of reducing the pressure stress of the wave rods are arranged on the side surfaces of the wave rods; due to the design of the wave-shaped wave rods and the pressure stress part, the support has more elastic deformation space, when the support is stressed, the support can elastically deform to a certain degree at the fluctuation of waves and the bending part of the pressure stress part instead of directly bearing all the pressure like a rigid structure, and the elastic deformation absorbs part of the pressure, so that the stress resistance of the support is improved. Therefore, the pressure stress is reduced.

An intravascular device may have a first configuration during deployment and a second configuration after deployment. The first configuration has a first radial strength; and the second configuration has a second radial strength. The first radial strength is less than the second radial strength. A system may include an intravascular device; a wire extending through the intravascular device to expand or contract the intravascular device; a proximal hub coupled to the wire; a distal hub coupled to the wire; and a plurality of tethers extending from an input device and through the intravascular device. At least a portion of the plurality of tethers has electrical conductivity. Application of energy to the at least a portion of the plurality of tethers may disengage the plurality of tethers from the intravascular device and fuse a luminal segment of the plurality of tethers, extending through the intravascular device, to the intravascular device.

A vascular shunt stent includes a main body tube and at least one branch tube axially inserted into an inner lumen of the main body tube. The main body tube includes a tubular main membrane. At least one branch tube includes a tubular branch membrane, which is accommodated in an inner lumen of the main membrane. A first sealing film is arranged between a distal end of the main membrane and a distal end of the branch membrane to separate the inner lumen of the main membrane into a main opening and at least one first sub-opening, the first sub-opening is in sealed connection with the distal end of the branch membrane. An included angle between a plane defined by the first sub-opening is not parallel with a plane defined by the main opening.

This invention relates to the field of vascular stent fabrication technology, and discloses a method for fabricating a stent with electrodes, comprising the following steps: providing a planar stent precursor with thermally responsive deformation characteristics; forming a conductive layer on the surface of the planar precursor, and patterning the conductive layer to form at least one electrode unit and at least one conductive wire unit electrically connected to the electrode unit; forming a non-conductive material layer on at least a portion of the surface of the conductive layer; placing the planar precursor under constraint and heating it to a molding temperature below 300°C to soften the planar precursor, cause a shape memory phase transition or crystal structure transformation, and shape it into a stent structure using a mold; wherein, the non-conductive material layer maintains structural integrity and insulation properties at the molding temperature, the non-conductive material layer has windows for exposing the electrode unit, and the non-conductive material layer covers the conductive wire unit, thus avoiding thermal damage to the non-conductive material layer caused by high-temperature processes.

The utility model discloses a cutting tool for a cardiovascular stent tectorial membrane. The cutting tool comprises a bottom plate, a pressing plate is arranged above the bottom plate; the bottom plate is hinged to one side of the pressing plate and is used for pressing a film laminating sheet; a plurality of slotted holes are formed in the pressing plate, so that the upper end of the film covering sheet is communicated with the outside, and the pressed film covering sheet is cut at the slotted holes through a cutter; when the cutting tool is used for cutting cardiovascular stent membranes of different specifications, a cutter is directly used for cutting along the slotted hole of the pressing plate in the using process of the cutting tool, a ruler does not need to be used for marking scribed lines of different specifications on the whole membrane piece, the process is simplified, time is saved, the situation that the ruler needs to be used for comparison is avoided, and the production efficiency is improved. And the situation that scratches are easily caused when a cutter is used for cutting along the scribed lines is avoided, and the production safety coefficient is improved.

The invention provides a separable microcatheter and stent conveying system and method, and belongs to the technical field of neural intervention and vascular intervention. The system comprises a separable micro-catheter which is formed by detachably connecting a near-section micro-catheter (1) and a far-section micro-catheter (2) through a physical clamping structure; the stent conveying system comprises a conveying guide wire (3) and an intravascular stent (4), and the conveying guide wire (3) is provided with an anchoring stent (31) matched with the limiting cavity of the far-section micro catheter (2). The guide wire, the catheter and the stent conveying system are integrated, so that the vascular interventional operation process is obviously optimized. The system adopts a separable microcatheter design and a mechanical anchoring structure, so that a guide wire and a catheter do not need to be exchanged for many times in the operation process, and the number of times of instrument operation is fundamentally reduced. According to the invention, the operation time is shortened, the exposure time of an operator and a patient under X-rays is directly reduced, and the radiation dose is effectively controlled.

The invention discloses a degradable magnesium alloy intravascular stent based on bionic hydrogel and nitric oxide double-path release and a preparation method and application thereof. The method comprises the steps that a magnesium alloy base material is subjected to alkali heat treatment; immersing the treated magnesium alloy into a silane coupling agent for reaction; the photopolymerization reaction liquid is treated to the surface of the silanization modified magnesium alloy, and polymerization is conducted through ultraviolet irradiation; immersing the magnesium alloy with the hydrogel coating into a polyarginine solution, and grafting polyarginine onto the surface of the hydrogel; a sample is activated through EDC / NHS and then immersed in a selenocystamine solution for a reaction, and the bionic composite coating, with the exogenous / endogenous dual-path nitric oxide release function, of the degradable magnesium alloy intravascular stent is obtained. The invention successfully constructs the bionic coating integrating cell membrane-imitating anti-fouling and exogenous / endogenous dual-path NO release functions, and the coating effectively solves the key problems of corrosion control, thrombus formation resistance, functional re-endothelialization coordinated regulation and the like faced by the degradable magnesium alloy intravascular stent.

The utility model discloses a clamp for bearing intravascular stent for polishing and a clamping mechanism thereof, the clamp comprises a bearing assembly and a blocking sleeve, the bearing assembly is used for bearing at least one intravascular stent, the bearing assembly comprises a plurality of clamping rods, the plurality of clamping rods are detachably assembled together, at least parts of the plurality of clamping rods are arranged in parallel, and the blocking sleeve is used for blocking the blocking sleeve. Any clamping rod can be arranged in the intravascular stent in a penetrating mode, and the adjacent clamping rods can clamp and fix the intravascular stent. The blocking sleeve is arranged on the bearing assembly in a sleeving mode, can gather the multiple clamping rods together and is located at the upper end and the lower end of the intravascular stent. By means of the clamp, the production process that multiple supports are polished in polishing liquid at the same time can be achieved, the ideal support product polishing effect is achieved, and the production efficiency is improved.

The utility model discloses an optical fiber balloon catheter which comprises the following components: a catheter which comprises an inner tube and an outer tube, and the inner tube passes through the inner part of the outer tube; the balloon is located on the periphery of the far end of the catheter and can expand in the radial direction relative to the catheter, and a vascular repair promoting coating is arranged on the outer surface of the balloon; the inner tube comprises a far-end inner tube section located in the balloon, and a groove is formed in the outer wall of the far-end inner tube section; the near end of the optical fiber is connected to the laser generator, and the far end of the optical fiber is provided with a light-emitting section extending into the balloon; and the light-emitting section is embedded in the groove. The groove is formed in the outer wall of the inner tube, and the optical fiber is embedded in the groove, so that light emitted by the optical fiber can be uniformly irradiated to the surface of the balloon, the vascular repair promoting coating is activated, crosslinking of protein in the vascular wall is triggered, a natural vascular stent is formed, and the expanded blood vessel is maintained. The space occupied by the optical fiber in the radial direction of the balloon is small, the overall outer diameter of the balloon before expansion can be reduced, and the trafficability of the balloon catheter is improved.

This invention provides a vascular stent and its preparation method, belonging to the field of medical device technology. The vascular stent includes a first stent unit and a second stent unit arranged alternately along the axial direction. The first stent unit is made of a metallic material, and the second stent unit is made of a non-metallic material. Connecting components include a connector and a receiver. The connector and receiver form a preliminary mechanical connection through an interference fit. Pressure and / or heat treatment are applied to the receiver, causing it to soften, melt, or undergo thermoplastic deformation, and after cooling and solidification, it adheres tightly to the connector. This vascular stent combines the advantages of both DES and BRS, providing reliable radial support and imaging positioning capabilities in the early stages of implantation, and restoring the vessel's own elasticity through the gradual degradation of the non-metallic material in the later stages. Simultaneously, the interference fit combined with pressure and / or heat treatment achieves a reliable fixed connection between stent units of different materials, effectively preventing loosening or detachment in the later stages.

This invention provides a delivery device and system for delivering stents. The delivery device includes a sheath for receiving the stent and a support member slidably disposed within the sheath. The support member includes a pushing portion and a plurality of supporting portions disposed within the pushing portion, wherein the distal ends of at least two supporting portions are not flush with each other, so that the proximal end of the stent can be released from the support member in stages. The delivery device of this invention can effectively prevent the proximal end of the vascular stent from simultaneously springing outwards at the same moment during release, thus avoiding further damage to the surrounding vascular wall.

The invention belongs to the technical field of cardiovascular repair, and discloses a biodegradable vascular stent material for cardiovascular repair. The material comprises a medical stainless steel intravascular stent body and a composite coating coated on the surface of the medical stainless steel intravascular stent body. The inner layer contains RGD peptide modified chitosan derivatives and polyphenol substances, is used for promoting adhesion and proliferation of endothelial cells and has anti-inflammatory and anti-oxidation effects. The outer layer is a ginsenoside (MPEG)-PLGA microsphere loaded with heparin sodium, and is prepared by carrying out hydrophobic modification on ginsenoside through (2-allyl) succinic anhydride and carrying out co-loading with MPEG-PLGA, so that synergistic controlled release of anticoagulation and vascular repair promoting drugs is realized. The excellent mechanical property of the stainless steel stent is combined with the multifunctional biodegradable coating, and through the synergistic effect of the inner layer and the outer layer, endothelialization can be accelerated, smooth muscle hyperplasia can be inhibited, inflammatory response can be relieved, thrombosis can be prevented, and therefore the risk of restenosis and advanced thrombosis in the stent can be effectively reduced.

The application discloses an arterial blood vessel stent system, which comprises an inner tube, a fixed column is fixedly installed on the outer wall of the inner tube, a fixed ring is fixedly installed on one end of the fixed column, an outer tube is movably arranged at one end of the fixed ring, a blood vessel stent is arranged on the inner wall of the outer tube, a balloon catheter is movably arranged on the outer wall of the inner tube, a balloon is fixedly sleeved on the outer wall of the balloon catheter, a filter fixing plate is further fixedly installed on the outer wall of the inner tube, an embolism filter is connected to one side of the filter fixing plate, a mounting seat and a connecting shell are fixedly installed on the outer wall of the inner tube, a constraint block is rotatably installed on one side of the mounting seat, a folding capsule is connected to one side of the constraint block, the folding capsule is located between the mounting seat and the connecting shell, a plastic wire is arranged on the bottom of one side of the folding capsule in a bonding mode, and one side of the plastic wire is in contact with the side wall of the connecting shell. The device solves the problem of poor practicability.

The invention discloses an optimized design method of an enhanced polyurethane shape memory intravascular stent based on multi-scale coupling. The method comprises the following steps: firstly, constructing a microcosmic molecular dynamics model, and quantitatively screening out an optimal graphene reinforced filler content and an interface chemical modification scheme by simulating a thermomechanical cycle and interface drawing process; then establishing a cross-scale mapping process between the micromechanics data and the macroscopic constitutive model, and converting microresponse into hyperelasticity and viscoelasticity parameters required by finite element analysis; finally, the whole process of pressing, holding, fixing and releasing of the vascular stent is simulated under the macroscopic scale, and the radial supporting force and the shape recovery performance of the optimized stent are directly predicted. According to the method, a data link between material microscopic design and device macroscopic application is opened through a multi-scale simulation strategy, a traditional experiment trial and error method is effectively replaced, and the research and development efficiency and design accuracy of the intravascular stent are remarkably improved.

The invention provides an intravascular stent and a stent system, and relates to the technical field of medical instruments. According to the intravascular stent, the stent can be dynamically and continuously adjusted in vivo, the controllability of an operation can be improved, the stent can be quickly and conveniently recycled, and the difficulty of the operation can be reduced. The intravascular stent comprises a pushing assembly, a stent body and a traction assembly. Wherein at least one part of the support spirally extends in the axial direction of the pushing assembly, the pushing assembly is sleeved with the support, the far end of the support is fixed to the far end of the pushing assembly, and the near end of the support is slidably connected with the pushing assembly; the traction assembly is connected with the near end of the support. In the axial direction of the support, the traction assembly drives the near end of the support to move towards the near end of the pushing assembly, and the outer diameter of the support is reduced.

The present application relates to the technical field of medical materials, and particularly relates to a medical magnesium alloy composite material and a preparation method and application thereof. The present application regulates the degradation rate of the medical magnesium alloy composite material by regulating the thickness of the polymer-drug-loaded nanometer microsphere composite coating, the thicker the thickness, the slower the degradation rate, and the thinner the thickness, the faster the degradation rate; the present application regulates the drug release rate of the medical magnesium alloy composite material by regulating the spatial distribution of the drug-loaded nanometer microspheres in the polymer-drug-loaded nanometer microsphere composite coating, so that the drug release can be fast or slow, specifically, the more concentrated (i.e. the more) the spatial distribution of the drug-loaded nanometer microspheres, the faster the drug release. The preparation method of the present application can realize the synergistic regulation of magnesium alloy degradation and drug release, and meet the clinical application requirements of magnesium alloy vascular stent customization, such as slow release, more or less, and fast or slow degradation.

The application discloses a uniform degradation blood vessel stent based on a bionic function curve and a preparation method thereof, relates to the technical field of medical devices, and comprises the construction of a blood vessel stent model based on a bionic function curve, selective laser melting additive manufacturing of the blood vessel stent model and surface treatment on a zinc blood vessel stent structure. The zinc blood vessel stent structure can not only realize good mechanical support function, but also still provide strong stability in the material degradation process. The bionic configuration naturally avoids sharp corners of a traditional structure, can guide blood flow to smoothly pass, effectively inhibits the generation of turbulence and vortexes, and in addition, the subsequent degradation behavior of the metal zinc blood vessel stent structure is made more uniform through surface treatment, and local failure does not occur in the degradation process.

A vascular stent, which includes: a stent body including a plurality of ring-shaped units arranged at intervals and a connecting portion connecting all the ring-shaped units into a tubular structure, wherein the tubular structure has a first covered segment and a second covered segment that are provided with membrane, and an exposed segment configured for engaging the first covered segment and the second covered segment. The vascular stent is reliable in installation, which is beneficial to reduce pre-operation and post-operation adjustment work. The stent system can realize the reliable installation of the vascular stent, which is beneficial to improve the quality of the operation and reduce the operation time.

The invention discloses a composite material for preparing a flexible, dredged and degradable lymphatic vein anastomosis stent as well as a process and application thereof. The material is a functionally gradient composite fiber felt constructed based on a coaxial electrospinning technology, and comprises a structural skeleton matrix, an intelligent drug release system and a surface functionalization system. The structural framework matrix comprises a PLGA (poly (lactic-co-glycolic acid)) and PLLA blend, magnesium-based nanoparticles and nano tantalum powder; the intelligent drug release system comprises an environmental response type hydrogel carrier, rapamycin and heparin sodium; the surface functionalization system is covalently grafted RGD polypeptide. The preparation method comprises the steps of raw material pretreatment, composite spinning solution preparation, core-shell fiber preparation, integrated enhanced stabilization treatment, surface functional modification and sterilization. Through a unique material formula and process design, integration of multiple functions of flexible supporting, degradation controllability, intelligent drug release, endothelialization promotion, development and the like is achieved, and the problem of adaptability of a traditional intravascular stent in lymphatic vein anastomosis is effectively solved.