61 results about "Blood compatibility" patented technology

The invention provides a gamma-polyglutamic acid electrostatic compound. The gamma-polyglutamic acid electrostatic compound is formed by compounding gamma-polyglutamic acid and an antibacterial surfactant with positive charges. Compared with the prior art, the gamma-polyglutamic acid electrostatic compound provided by the invention is constructed through electrostatic interaction, not only has good cell compatibility and blood compatibility, but also has excellent broad-spectrum antibacterial property, can be uniformly coated on the surfaces of medical instruments with different base materials, shapes and sizes, is stable in combination, and can be applied to medical instruments with different shapes and sizes. The coating process has universality and is suitable for solving the problem of pollution of current medical instruments, prolonging the service life of the medical instruments and solving the problem of coating stability of the surfaces of inner and outer cavities of complex instruments.

The invention discloses an intracranial thrombus aspiration catheter and a preparation method thereof, and belongs to the technical field of medical instruments, the catheter comprises a PTFE lining, a reinforcing layer (including a coil layer and a braid layer), an outer plastic layer designed in a segmented manner, a platinum-iridium alloy developing ring and a coating. The preparation method comprises the steps of PTFE lining extrusion, coil winding, braid layer covering, segmented plastic layer forming, developing ring embedding and fixing and coating treatment and surface functionalization. Compared with the prior art, by optimizing the formula and process of the coating, the adhesive force of the coating is remarkably improved, falling is prevented, meanwhile, the surface hydrophilicity is enhanced, thrombus adhesion is reduced, and blood compatibility and operation performance are improved. In addition, the flexibility, the kink resistance and the collapse resistance of the catheter are improved through the multi-layer structural design, and the stability and the effectiveness of the catheter in a complex blood vessel environment are ensured.

The invention relates to the technical field of biomedicine, in particular to a cross-linked modified artificial valve and a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing a novel compound POSS-PEG-NHS, and carrying out esterification reaction on a-NHS group of the compound and a-NH2 group on the surface of the decellularized porcine valve to realize covalent binding; then, an inherent reducing agent glutathione in an organism is added, and the cross-linked modified artificial valve PPN-GSH-AV is obtained. The valve shows excellent cell safety and blood compatibility, and has obvious advantages compared with a traditional glutaraldehyde cross-linked valve. In-vivo experiments show that the PPN-GSH-AV has high biological safety and histocompatibility, and can effectively reduce immunological rejection. In addition, the valve can relieve oxidative stress of macrophages and promote M2 type transformation, so that inflammatory response is relieved. In clinical application, the PPN-GSH-AV shows a good anti-inflammatory effect and excellent anti-calcification performance, in-vitro pulsating flow test results meet international standards, and the PPN-GSH-AV has clinical transformation potential and wide application prospects.

The invention relates to a double-layer microneedle patch and a preparation method and application thereof.The double-layer microneedle patch comprises a drug delivery unit and an adhesion unit, the drug delivery unit is a GCM-MN microneedle array, the adhesion unit is a CSH hydrogel patch, and when the double-layer microneedle patch is used, firstly, the GCM-MN microneedle array acts on a wound through pressure, and then the CSH hydrogel patch covers the GCM-MN microneedle array. The CSH hydrogel patch is beneficial to creating a wet healing environment, has excellent adhesion stability and skin adaptability and provides an adhesion barrier for a wound, and the GCM-MN microneedle array has good cell compatibility, cell affinity, blood compatibility and biodegradability. Along with the degradation of the microneedle array at the wound, the packaged GCM nanoparticles are continuously released and go deep into the wound. Therefore, the double-layer microneedle patch disclosed by the invention has huge clinical application potential in the field of infectious wound treatment.

A blood purifier includes a porous molded body; exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and can be safely used. A blood purifier includes a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L / D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction.

The utility model relates to the field of medical instruments, and discloses a cardiovascular medical instrument half in-vitro blood compatibility testing device which comprises testing equipment, a placing groove is formed in the right side of the front surface of the testing equipment, a second rectangular groove is formed in the inner wall of the placing groove, and a clamping assembly is arranged on the inner wall of the second rectangular groove. A limiting assembly is arranged on the front surface of the clamping assembly, a third rectangular groove is formed in the bottom end of the inner wall of the containing groove, an adjusting assembly is arranged on the inner wall of the third rectangular groove, the clamping assembly comprises a sliding block, the rear surface of the sliding block is slidably connected to the inner wall of the second rectangular groove, and a platform is fixedly connected to the front surface of the sliding block. The inner wall of the bottom end of the platform is rotationally connected with a rotating plate. According to the blood sample detection device, by arranging the clamping assembly, a blood sample can be fixed, the detection stability is improved, meanwhile, under the cooperation of the limiting assembly, the clamping assembly can be prevented from loosening in the clamping process, and the clamping stability is improved.

The invention discloses a nanocomposite HA / PEI / Fe3O4 (at) siRNA and a preparation method and application thereof, and belongs to the technical field of antitumor drugs. The nano-composite HA / PEI / Fe3O4 coated siGPX4 is successfully prepared, the serum stability is high, the blood compatibility is good, siGPX4 can be efficiently released when the nano-composite reaches a tumor acidic microenvironment, then the anti-tumor effect is exerted, triple negative breast cancer cells can be specifically targeted, the internalization ability of MDA-MB-468 cells on the nano-composite is greatly improved, and the delivery efficiency of siGPX4 is remarkably improved; in the presence of H2O2, the nano-composite can down-regulate expression of GPX4, released ferrous ions and H2O2 are subjected to Fenton reaction, ROS in cells is remarkably increased, mitochondrial membrane potential is reduced, ferroptosis is triggered, MDA-MB-468 cell proliferation is remarkably inhibited, and the anti-tumor effect is achieved.

The invention relates to an adsorbing material for blood perfusion and a preparation method thereof. The preparation method comprises the following steps: providing a hydrophobic porous carrier which comprises styrene-divinyl benzene copolymer microspheres, and introducing a coordination group on the surface of the hydrophobic porous carrier through chemical modification. The average pore size of the hydrophobic porous carrier is 2-50 nm, and the specific surface area of the hydrophobic porous carrier is greater than or equal to 500 m < 2 > / g; the coordination group is selected from at least one of iminodiacetic acid (IDA), ethylenediaminetetraacetic acid (EDTA) and N, N, N-tricarboxymethyl ethylenediamine (TED). The prepared adsorption material is high in A beta removal capacity, has certain removal capacity on heavy metal ions, is good in blood compatibility and excellent in anticoagulation performance, and is an ideal material for preparing a blood perfusion device.

The invention discloses a preparation method and application of gel bio-ink for 3D printing of a small-diameter artificial blood vessel. The preparation method comprises the following steps: providing methylacryloylated recombinant collagen; providing methacrylated hyaluronic acid; the gel bio-ink for preparing the 3D printing small-diameter artificial blood vessel is obtained by taking methylacryloylated recombinant collagen and methylacryloylated hyaluronic acid as raw materials. The gel bio-ink has a strong photocuring characteristic and has a shear thinning characteristic required by bio-printing, an artificial blood vessel stent with the diameter of 6 mm and the height of 1 cm can be successfully prepared through a photocuring 3D printing technology, and the artificial blood vessel stent meets the size requirement of small-diameter blood vessels. An intravascular stent printed by using the gel bio-ink has the advantages of good blood compatibility, effective promotion of rapid endothelialization of the stent, prevention of vascular restenosis and the like, is a potential candidate of a small-caliber blood vessel substitute in the future, and has a wide application prospect in the artificial blood vessel market.

The utility model discloses an impeller rotor of an axial flow blood pump, which comprises a hub, blades, a shaft hole and back blades, and the outer diameter of the hub is gradually increased from the head to the tail; each blade comprises a blade root close to the hub, a blade tip away from the hub, a blade front edge and a blade tail edge, and the two blades are arranged on the surface of the hub in a central symmetry mode. The shaft hole is formed in the tail end face of the impeller rotor and can be used for installing an impeller shaft. The back blades are arranged on the end face of the tail of the impeller rotor and arranged outside the shaft hole in a surrounding mode. The impeller is simple in structure, the blood low-speed area disturbance effect of the near wall face of the impeller shaft can be improved, and therefore the risk that blood forms thrombus between the impeller rotor and the bearing is reduced, and the blood compatibility of the blood pump is improved.

The application discloses a high-loading MXene-encapsulated magnetic porous microcapsule for adsorption and a preparation method and application thereof, and belongs to the field of biomedical materials, and the preparation method comprises the following steps: in step one, a hydrogel precursor solution doped with magnetic nanoparticles is used as an external phase, and a MXene dispersion liquid is used as an inner phase, and a microfluidic coaxial electrospraying device is used to generate monodisperse core-shell droplets with uniform sizes; in step two, the monodisperse core-shell droplets prepared in step one are subjected to freezing pretreatment, and then are crosslinked with divalent metal ions, so that double gelation of the core layer and the shell layer is triggered, and hydrogel microspheres with a core-shell structure are obtained; and in step three, the hydrogel microspheres with the core-shell structure obtained in step two are subjected to freeze drying, and high-loading MXene-encapsulated magnetic porous microcapsules are obtained. The application has excellent blood compatibility and high adsorption capacity, and is outstanding in removing uremic toxins including creatinine, urea and uric acid, and is a kind of adsorbent which is both efficient and safe.

The present application relates to the biomedical technology field, especially to a kind of decellularized pig pericardium and POSS-PEG-CHO cross-linked biological nanocomposite material and its preparation method and application.The present application is based on Schiff base reaction, and the star-shaped eight-arm eight-functionalized POSS-based benzaldehyde end-capped polyethylene glycol is used to cross-link the decellularized pig pericardium, and the POSS-PEG-PP biological nanocomposite material is successfully prepared.Compared with GLUT-PP, the POSS-PEG-PP provided by the present application presents more compact fiber arrangement, and the mechanical property is also better.In vitro experiment shows that POSS-PEG-PP has excellent cell compatibility, endothelialization capacity and blood compatibility.In vivo evaluation further confirms that the material has significant anti-inflammatory and anti-calcification properties.Through RNA sequencing analysis of subcutaneous implant, it is found that the changes of AMPK and IL-17 signal pathways play an important role in the process of POSS-PEG-PP regulating inflammation and immune response.Therefore, POSS-PEG-PP shows good application prospect in the field of biological heart valve, and is expected to become a very potential alternative material.

The invention provides a preparation method and application of a non-specific protein adsorption resistant coating based on a normal-pressure low-temperature plasma enhanced chemical vapor deposition technology. According to the preparation method, the stable protein nonspecific adsorption resisting ultrathin coating can be rapidly modified on the surface of the substrate in a normal-pressure environment, and a covalent bond is formed with the surface of the substrate. The preparation method of the non-specific protein adsorption resistant coating provided by the invention is simple to operate and wide in applicable material range, the biocompatibility and blood compatibility of the surface of a medical instrument can be improved, and the problems of coagulation and thrombus caused by non-specific protein adsorption, biological membrane infection caused by bacteria attachment growth and the like are reduced; and the stable covalent bond combination and the ultrathin coating reduce the risk caused by coating falling in the use process.

The invention relates to a blood shearing device and a blood compatibility evaluation method. The blood shearing device comprises an objective table, a fixing support, a supporting beam, a stator, a rotor and a driving source. The device can simultaneously adjust the roughness and wettability of the material surface, breaks through the limitation that only a single factor can be researched in the prior art, and provides a more comprehensive platform for systematically evaluating the blood compatibility; in the experimental method, red blood cell hemolysis is detected, and the degradation condition of plasma protein is evaluated synchronously, so that the overall injury mode of blood components under the action of an artificial surface can be reflected more truly. Experimental basis can be provided for material selection and surface optimization of blood contact type medical instruments such as an artificial heart pump, an ECMO and a hemodialysis machine, the clinical complication risk can be reduced, and development of artificial organs and blood purification technologies is promoted.

The invention belongs to the field of medical treatment, and particularly relates to a preparation method of a blood perfusion diagnosis and treatment device based on guanosine supramolecular gel, which comprises the following steps: preparing guanosine-boric acid supramolecular hydrogel combined with TMPyP, the guanosine-boric acid supramolecular hydrogel being GB hydrogel; the GB hydrogel combined with the TMPyP probe is attached to the surface of the U-shaped optical fiber; the optical fiber attached with the GB hydrogel is immersed in a lead ion solution for adsorption, meanwhile, the adsorption amount is monitored through electrical and optical bimodal signals, after adsorption is completed, adsorbed lead ions can be replaced for regeneration, and cyclic adsorption is achieved. The adsorption material for blood perfusion, which has high selectivity, excellent blood compatibility, reproducibility and fluid shearing resistance, is integrated with an optical fiber detection device, so that the integration of treatment and monitoring is realized; the GB hydrogel realizes selective adsorption and real-time monitoring of heavy metal ions through a G4 tetramer structure unit.

The present invention belongs to the technical field of biomedical materials, and in particular relates to a degradable zinc-based medical material with a double-layer structure and a preparation method thereof, comprising the steps of: S1, material selection: selecting a pure zinc or Zn-X alloy / composite material in a cast, hot-extruded or hot-rolled state with a thickness of 2 to 15 mm for standby use; S2, removing surface oxide scale: removing the oxide scale on the surface of the plate selected in step S1; S3, stir friction treatment: using a needle-free stirring head to stir friction treatment the plate; S4, hot rolling treatment: cutting the effective deformation area of the stir friction treatment and performing hot rolling treatment, and air cooling to room temperature after the hot rolling treatment to obtain the degradable zinc-based medical material with a double-layer structure. The degradable zinc-based medical material with a double-layer structure has the advantages of good mechanical properties, suitable degradation performance, good blood compatibility and cell compatibility, and excellent antibacterial properties.

The invention belongs to the technical field of biomedical materials, and particularly relates to a degradable zinc-based medical material with a double-layer tissue structure and a preparation method thereof, and the preparation method comprises the following steps: S1, material selection: selecting a pure zinc or Zn-X alloy / composite material plate with the thickness of 2-15mm in an as-cast, hot-extruded or hot-rolled state for later use; s2, surface oxide skin removal: the oxide skin on the surface of the plate selected in the step S1 is removed; s3, stirring friction treatment, wherein a needle-free stirring head is adopted for conducting stirring friction treatment on the plate; and S4, hot rolling treatment: cutting the effective deformation area subjected to stirring friction treatment for hot rolling treatment, and air-cooling to room temperature after hot rolling treatment to obtain the degradable zinc-based medical material with the double-layer tissue structure. The degradable zinc-based medical material with the double-layer tissue structure has the advantages of being good in mechanical property, appropriate in degradation property, good in blood compatibility and cell compatibility and excellent in antibacterial property.

The invention provides a ventricular assist device and a blood pump thereof. The blood pump comprises a pump shell and an impeller, the impeller comprises a rotor part and a plurality of blades arranged on the rotor part, the blood pump further comprises a flow guide cone arranged basically opposite to the blood inlet, the front edge of at least one blade extends towards the radial inner side to the position above the flow guide cone, and the front edge of at least one blade extends towards the radial inner side to the position above the flow guide cone. The lower side of the front edge of at least one blade is provided with an avoiding part, the radius of the flow guide cone is defined as RC, the height of the flow guide cone is defined as HC, and a cylinder with the central axis of the blood inlet as the axis, the top face passing through the cone top of the flow guide cone, the radius of the cylinder is RC, and the height of the cylinder is HC is obtained. And the avoiding part is constructed to enable the at least one blade to avoid the space occupied by the cylinder. According to the blood pump, blood cavitation can be reduced or avoided while high hydraulic performance is maintained, blood damage is reduced, and blood compatibility is improved.

The present disclosure relates to cells for intravascular transplantation having hemocompatibility in which the blood coagulation mechanism and thrombosis reaction are inhibited by artificially modifying the F3 gene encoding CD142 that is an initiator of blood coagulation, using gene scissors technology to reduce or suppress the expression or activity of CD142, a method of producing the same, and a use thereof for preventing or treating liver disease and diabetes.

The invention relates to the field of materials, and particularly discloses a chitosan-based blood perfusion adsorbent as well as a preparation method and application thereof. According to the blood perfusion adsorbent, modified chitosan microspheres serve as a carrier, after chicoric acid is grafted on the surfaces of the modified chitosan microspheres, manganese dioxide nano-enzyme is immobilized, and the composite adsorbent is formed. According to the blood perfusion adsorbent provided by the invention, the manganese dioxide nano-enzyme is immobilized on the surface, so that active oxygen can be efficiently removed, and meanwhile, various free radicals can be removed; the chitosan microsphere has high adsorption capacity, can synergistically and effectively adsorb inflammatory factors in blood with the chitosan microsphere after being immobilized on the surface of the chitosan microsphere, improves the blood purification effect, has blood compatibility and safety, and can be used for blood purification treatment of patients with inflammations.

The present disclosure relates to semipermeable membranes comprising a base membrane and a coating with a vinyl polymer derived from vinyl monomers carrying an acid group and grafted onto the surface of the base membrane by radiation induced graft copolymerization (RIGC), thereby introducing a coating carrying negative charges. The coated membranes are especially suitable for blood purification applications as they are characterized by an increased selectivity and excellent blood compatibility and an excellent hemocompatibility due to the careful selection of the vinyl monomers used for the coating process and the introduction of negative charges. The invention also relates to a production process for said coated membranes and to their use in hemodialysis devices and in medical applications such as extracorporeal blood purification.

An optical assembly for placement on a medical device. The optical assembly has a diaphragm suspended over and above an optical cavity. The optical cavity has sensor dots formed thereon. The diaphragm is covered with a biocompatible platinum silicide layer.

The invention provides bimodal imaging down-conversion nanoparticles for near-infrared two-region fluorescence imaging and magnetic resonance imaging as well as a preparation method and application of the bimodal imaging down-conversion nanoparticles. The nano-particle is composed of a hexagonal beta-phase NaGdF4 main lattice structure and an amorphous coating on the surface, the main lattice structure of the NaGdF4 is uniformly doped NaGdF4: Nd < 3 + > x, Yb < 3 + > y and Er < 3 + > z; wherein Nd < 3 + > is used as a sensitizer, Yb < 3 + > is used as a medium ion, Er < 3 + > is used as an emission ion, and Gd < 3 + > is used for providing MRI contrast. According to the hexagonal beta-phase NaGdF4 main lattice provided by the invention, effective energy transfer among doped ions is realized, and strong infrared second-region fluorescence intensity is generated under 808nm excitation. Meanwhile, the uniform distribution of Gd < 3 + > ions endows the nanoparticles with a high T1 relaxation rate, and realizes deep tissue anatomical functional imaging. DCNPs is subjected to surface modification through Pluronic F-127, so that the nanoparticles have low cytotoxicity and good blood compatibility, and the surface can be conveniently subjected to functional modification, such as connection with a targeting ligand or a biomolecule, so that targeted imaging of specific tissues or pathological parts is realized.

The application provides a blood perfusion adsorbent with low protein adsorption, a preparation method thereof and a blood perfusion device, and belongs to the technical field of blood purification adsorbents. The application introduces vinyl silicone oil into the adsorbent, the vinyl silicone oil has low surface energy, excellent anti-protein adsorption performance and tissue and blood compatibility, and the surface of the cross-linked silicone oil modified adsorption resin prepared through suspension polymerization has a pore structure, so that the adsorbent has good blood compatibility, medium and large molecule toxin adsorption performance and anti-protein adsorption performance. The cross-linked silicone oil modified adsorption resin is further subjected to cross-linking reaction to obtain an ultra-high cross-linked silicone oil modified adsorption resin, and the ultra-high cross-linked silicone oil modified adsorption resin still has anti-protein adsorption performance.

The application discloses a kind of nanocomposite HA / PEI / Fe3O4@siRNA and its preparation method and application, belong to antitumor drug technical field.The application successfully prepared nanocomposite HA / PEI / Fe3O4@siGPX4, serum stability is high, blood compatibility is good, when reaching tumor acid microenvironment, siGPX4 can be efficiently released, and then play antitumor effect, can specifically target triple-negative breast cancer cell, greatly improve the internalization ability of MDA-MB-468 cell to it, significantly improve the delivery efficiency of siGPX4;Under the condition that there is H2O2, the nanocomposite can down-regulate the expression of GPX4, the released ferrous ion and H2O2 occur Fenton reaction, cause intracellular ROS significantly increase, cause mitochondrial membrane potential to drop, and then trigger ferroptosis, significantly inhibit MDA-MB-468 cell proliferation, to play antitumor effect.

This invention discloses a Mo-Mn biodegradable molybdenum alloy, its preparation method, and its applications. The alloying elements include Mo and Mn, with Mn accounting for >0-30% by mass, and the remainder being Mo. Manganese-doped molybdenum powder is prepared by wet chemical methods or mechanical alloying. The manganese-doped molybdenum powder is then subjected to hot pressing sintering or multi-step spark plasma sintering to obtain the Mo-Mn alloy. The Mo-Mn biodegradable molybdenum alloy of this invention possesses excellent mechanical properties, providing long-term effective mechanical support in vivo, and exhibits good cell compatibility, blood compatibility, and tissue / organ compatibility, making it suitable for use as a biomedical implant.

The invention relates to the technical field of biomedical materials, in particular to a surface modification method of a poly (4-methylpentene) (PMP) hollow fiber membrane, the blood compatibility of the material is synergistically improved through a polydopamine (PDA) coating and a zwitter-ion grafting technology, and the surface modification method is suitable for blood contact instruments such as extracorporeal membrane oxygenation (ECMO) and the like. The invention provides a dopamine-mediated zwitterionic modified PMP membrane, which comprises a PMP membrane and a modification layer on the surface of the PMP membrane, and the modification layer comprises a polydopamine intermediate layer formed on the surface of the PMP membrane through dopamine in-situ oxidation auto-polymerization and a zwitterionic polymer brush grafted on the polydopamine intermediate layer.

A hemostatic material with near-infrared light-controlled shape memory properties, its preparation method, and its application. Due to the shape memory effect, the sponge's shape can be restored to 90% within 25 seconds. By switching the near-infrared light source on and off, the sponge's expansion can be controlled and adjusted. The sponge's hemostatic ability has been verified in vitro and in vivo. As expected, compared with commercial medical gelatin sponges with insufficient expansion capacity and commercial medical PVA sponges with excessive expansion capacity, the PDA-TPI-PU shape memory sponge can quickly and effectively control bleeding under near-infrared light irradiation, showing potential application prospects as a hemostatic material. With excellent mechanical properties, blood compatibility, cytocompatibility, and photothermal conversion performance, the PDA-TPI-PU sponge provides a new approach to using light-controlled shape memory materials as coagulation materials for treating incompressible bleeding.

The present invention discloses a spiral centrifugal impeller, comprising a hub and at least one continuous spiral blade coaxially arranged with the hub and fixedly mounted on the hub, the hub is provided with a through hole coaxial with the spiral blade, each spiral centrifugal blade comprises a working surface and a back surface, the working surface is a three-dimensional space curved surface, the contour line of the working surface comprises an inlet edge, an outer edge line, a hub line and an outlet edge, the inlet edge and the outlet edge are arranged in a straight line, the thickness section of the spiral centrifugal blade is narrowed along the direction from the outer edge to the hub, the working surface and the back surface are connected by a connecting surface at the outer edge line, the connecting surface is inclined up and down along the direction from the back surface to the working surface and has an inclination angle α, the inclination angle α gradually decreases to 0° in the spiral direction from the inlet edge to the outlet edge, and the length of the outlet edge is less than the length of the inlet edge. The present invention includes at least the following advantages: it can avoid the occurrence of hemolysis and greatly improve the blood compatibility of the blood pump.

The invention belongs to the cross field of chemistry, materials, biology and pharmacy, and particularly relates to a pH response chemotherapy and photo-thermal combined treatment drug delivery carrier and a preparation method and application thereof. The drug delivery carrier MOF-CPT-PDA-PEG constructed in the invention can realize chemotherapy-photo-thermal synergistic treatment and has good photo-thermal conversion ability, in vitro experiments show that drug release has pH and photo-thermal dual response characteristics, the hemolysis rate is lower than 5% (5-500 [mu] g / mL), the protein adsorption amount is smaller than 140 [mu] g / mg, and excellent blood compatibility is shown; cell experiments show that the survival rate of 4T1 cells is reduced to 17% through combination of MOF-CPT-PDA-PEG and illumination, the tumor inhibition effect is remarkably enhanced, and great potential is achieved in chemotherapy-photothermal combined cancer treatment. The method is green and safe, the preparation process is simple and controllable, the method is suitable for large-scale production, practical applicability is achieved, and economic and social benefits are remarkable.