647 results about "Blood compatibility" patented technology

A composition comprising in admixture with a polymer, preferably a polyurethane, and a compatible surface-modifying macromolecule having (i) a central portion of a segmented block oligomeric copolymer comprising at least one polar hard segment, and (ii) PROPORTIONAL - omega terminal polyfluoro oligomeric groups, in a surface modifying enhancing amount. The composition is of use in providing articles having improved surface properties, particularly, medical devices having improved resistance to enzyme degradation with acceptable blood compatibility.

A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.

Provided are a polysulfone type blood-purifying membrane which is improved in blood compatibility and separation properties and less in polyvinyl pyrrolidone eluting in the internal surface of the hollow fiber membrane, as well as a process for producing the same.

Fistly, said ivnention utilizes polyamine aminolyzed polyester polymer surface to obtain polymer whose surface has free amine group, then uses acid to make acidification to make polymer surface possess positive charge, and utilzies electrostatic attraction layer-to-layer self-assembling method to alternatively assemble single layer or several layers of different polyanions and polycations with biological activity on its surface, and these biological activity polyelectrolytes which are layer-to-layer self-assembled still retain their original biological activity so as to obtain the invented plane membrane and three-D porous support material with cell compatibility and its product.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

The invention discloses a covered stent, which comprises a support structure and a tectorial membrane unit, and is characterized in that: the tectorial membrane unit comprises an inner-layer tectorial membrane and an outer-layer tectorial membrane which coats the support structure; the outer-layer membrane coats on the outer side of the inner-layer tectorial membrane; the inner-layer tectorial membrane is a biological membrane with good blood compatibility, and the outer-layer tectorial membrane is a biological membrane which is easy to induce the formation of thrombus; the inner-layer tectorial membrane contacting blood has good blood compatibility, can effectively reduce the formation of the thrombus, and maintains normal blood flowing channels; and the outer-layer tectorial membrane can induce the formation of the thrombus in aneurysm or thrombus of bleeding parts, promotes the aneurysm to be quickly activated and reduced, reduces the mass effect in vivo, simultaneously effectively adheres endothelial cells, promotes differentiation and proliferation of cells, quickens the endothelialization of lesion parts of vessels, and can more effectively treat vascular diseases such as the aneurysm and the like.

The invention provides a high-nitrogen austenitic stainless steel material for a vascular stent, which comprises the following chemical components in percentage by weight: 16-20% of Cr, 12-20% of Mn, 1-3% of Mo, 0.5-2% of Cu, no more than 0.05% of Ni, 0.7-1.2% of N, 0.5-8% of W, 0.05-0.5% of RE, no more than 0.08% of C, 0.3-4% of Si, no more than 0.010% of S, no more than 0.02% of P and the balance of Fe, wherein RE is a rare-earth element. The high-nitrogen stainless steel provided by the invention is mainly used for vascular stent processing; the elements of copper, nitrogen and rare earth are added to increase the blood compatibility of the stainless steel; and the tungsten alloy is added to increase the density of the stainless steel. The stainless steel has excellent visibility under X rays, contains no potential toxic element nickel, can be used in the aspects of surgical implants, medical appliances, food and catering appliances, jewelry and other stainless steel products which are always in contact with a human body, and can also be used in the fields of chemical engineering, environment protection and the like.

A composition includes a polycarbonate-polysiloxane block copolymer that has at least one polycarbonate block and at least one polysiloxane block, and a surface modifying agent that includes at least one polysiloxane segment. Increased levels of the surface modifying agent can be incorporated without compromising high transmittance and low haze. The compositions also exhibit improved hemocompatibility and are therefore useful for a variety of articles that may contact blood.

An endotoxin adsorbent used for blood perfusion is prepared from agat through adding the aqueous solution to the liquid mixture of toluene and CCl4 to obtain spherical agar, activating by epoxy chloropropane under alkaline condition, reacting on diamine and then on glutaraldehyde to obtain high-strength agar beads used as the carrier of adsorbent, reacting on the amino contained ligand (polymyxin B), and reducing by NaBH4. Its advantages are high compatibility to blood and high effect on absorbing endotoxin from blood.

Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.

The invention discloses a dopamine-based method for improving surface hydrophilicity and biocompatibility of a medical polyurethane material. The method comprises the following steps: carrying out pretreatment on a medical polyurethane material by using dopamine so as to obtain a site with proper surface roughness and abundant reaction activity; putting the medical polyurethane material subjected to dopamine pretreatment into hydrophilic membrane concentrate, and carrying out heating reaction for 4-8 hours; and fully cleaning and drying the reaction product. According to the method disclosed by the invention, a layer of film is prepared on the material surface on the basis of the dopamine, and the prepared film has high hydrophily, the blood compatibility can be improved, the damage to tissue is reduced, the film has good stability, and low water contact angle and high hydrophily of a sample can be kept for a long period of time.

The invention relates to a copper sulfide/mesoporous silicon dioxide core-shell nano material as well as a preparation method and an application thereof. The chemical formula of the core-shell nano material is Cu9S5/mSiO2-PEG. The preparation method comprises the following steps of: (1) raising the temperature of oleylamine under the protection of nitrogen; adding a mixed solution of copper dibutyldithiocarbamate and the oleylamine and dispersing the mixed solution into chloroform to prepare a D solution; (2) dissolving a surfactant into water; raising the temperature and adding the D solution to prepare an E solution; and (3) taking the E solution and adding ethanol; raising the temperature and adding an NaOH solution; immediately adding TEOS (Tetraethylorthosilicate) and reacting; adding PEG-silane; continually reacting and carrying out hydrothermal reaction; and adding into a scrubbing solution to centrifuge and wash to obtain the product. The copper sulfide/mesoporous silicon dioxide core-shell nano material is applied to near-infrared photo-thermal treatment, anti-cancer drugs, chemotherapy of tumors and infrared heat imaging. The nano material disclosed by the invention has very low cell toxicity and very high blood compatibility; and the united effects of thermal therapy and the chemotherapy are good.

This invention relates to a body fluid degradative medicinal implant and its preparation method. The implant is prepared from Mg-Ca rafting wherein, Mg content is 7-10 weight parts (excluding 10); and Ca content is 0-3 (excluding 0). It is proven by in vitro and in vivo studies, the implant has the advantages of no toxicity, and good organization consistency and sanguis consistency.

The invention discloses a method for immobilizing VEGF-carried heparin/polylysine nanoparticles on a Ti surface, which comprises the following steps: by utilizing the characteristic that Hep and PLL can produce static interactions to form nanoparticles, mixing VEGF-carried Hep and PLL to form VEGF-carried nanoparticles; preparing a DM coating on the Ti material surface; and by utilizing the characteristic that the DM and primary amino group can generate Michael addition and Schiff base reaction, immobilizing the amino-containing nanoparticles onto the sample surface in a covalent mode, thereby constructing the biologically modified surface with anticoagulation and endothelium promotion functions. By constructing a nanoparticle modifying layer with anticoagulation and endothelium promotion characteristics on the Ti surface, the invention obviously improves the blood compatibility and endothelium injury restorability of the material.

In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

The invention relates to a high-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in an organism, belonging to the technical field of biological materials. The material of the invention comprises the following components in percentage by weight: 1-4% of Nd, 0.1-1.0% of Zn, 0.1-1.0% of Ag, 0.3-0.8% of Zr and balance of Mg. The invention strengthens magnesium alloy through alloy elements, refines grains, improves plasticity, and further strengthens the magnesium alloy through extrusion deformation and heat treatment processes. The corrosion rate of the magnesium alloy provided by the invention in the simulated body fluid is 0.22-0.28mm/year, meeting the requirement of the implanted material for the corrosion rate; and the material of the invention does not have obvious cytotoxicity and has good blood compatibility, thereby meeting the requirements of the implanted material for biological compatibility. The high-plasticity medium-strength magnesium alloy provided by the invention can be used for support intravascular stent materials, and the high-strength medium-plasticity magnesium alloy provided by the invention can be used for implanted materials in orthopaedics.

The invention discloses a method for preparing an artificial blood vessel with a micro-nano biomimic intima structure by utilizing an electrospinning technology. The method mainly comprises the following steps of preparing a macromolecular polymer solution; preparing an alignment electrospun fibrous membrane; stretching the alignment electrospun fibrous membrane; preparing an artificial blood vessel; performing characterization by using a scanning electron microscope; and determining blood compatibility. The artificial blood vessel prepared by the method has an intima imitation alignment microstructure, so that the blood compatibility of the artificial blood vessel meets a requirement on clinical anticoagulation performance, and a new way for the preparation of a novel artificial blood vessel is provided. In addition, the adoption of an anticoagulant is avoided, and the blood compatibility of the artificial blood vessel is improved only by a surface microstructure effect, so that side effects caused by the anticoagulant are reduced, and the method has broad application prospect in the field of medical clinical blood vessel transplantation.

The present invention provides a modified substrate including a hydrophilic polymer wherein the soluble hydrophilic polymer ratio is 15 weight percent or less and the number of adhered human blood platelets is 10/4.3×10³ μm² or less. In addition, the present invention provides a method for producing a modified substrate including a step of irradiating the substrate with radiation while the substrate is brought into contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. The present invention provides a modified substrate having high hematologic compatibility wherein the hydrophilic polymer is immobilized on the surface of the substrate, and a method for producing the same.

A polyurethane material containing F in side chain is prepared through alternative polymerization between the flexible chain segment consisting of polyether diol and/or polycarbonate diol and the rigid chain segment consisting of diisocyanate and chain-enlarging agent. Its advantages are high biologic stability and compatibility and high elasticity, strength and resistance to oxidizing and hydrolysis. It can be used for preparing artificial blood vessel, heart valve, etc.