16 results about "Blood compatibility" patented technology

The invention relates to a blood shearing device and a blood compatibility evaluation method. The blood shearing device comprises an objective table, a fixing support, a supporting beam, a stator, a rotor and a driving source. The device can simultaneously adjust the roughness and wettability of the material surface, breaks through the limitation that only a single factor can be researched in the prior art, and provides a more comprehensive platform for systematically evaluating the blood compatibility; in the experimental method, red blood cell hemolysis is detected, and the degradation condition of plasma protein is evaluated synchronously, so that the overall injury mode of blood components under the action of an artificial surface can be reflected more truly. Experimental basis can be provided for material selection and surface optimization of blood contact type medical instruments such as an artificial heart pump, an ECMO and a hemodialysis machine, the clinical complication risk can be reduced, and development of artificial organs and blood purification technologies is promoted.

The present disclosure relates to cells for intravascular transplantation having hemocompatibility in which the blood coagulation mechanism and thrombosis reaction are inhibited by artificially modifying the F3 gene encoding CD142 that is an initiator of blood coagulation, using gene scissors technology to reduce or suppress the expression or activity of CD142, a method of producing the same, and a use thereof for preventing or treating liver disease and diabetes.

The present disclosure relates to semipermeable membranes comprising a base membrane and a coating with a vinyl polymer derived from vinyl monomers carrying an acid group and grafted onto the surface of the base membrane by radiation induced graft copolymerization (RIGC), thereby introducing a coating carrying negative charges. The coated membranes are especially suitable for blood purification applications as they are characterized by an increased selectivity and excellent blood compatibility and an excellent hemocompatibility due to the careful selection of the vinyl monomers used for the coating process and the introduction of negative charges. The invention also relates to a production process for said coated membranes and to their use in hemodialysis devices and in medical applications such as extracorporeal blood purification.

An optical assembly for placement on a medical device. The optical assembly has a diaphragm suspended over and above an optical cavity. The optical cavity has sensor dots formed thereon. The diaphragm is covered with a biocompatible platinum silicide layer.

The application discloses a kind of nanocomposite HA / PEI / Fe3O4@siRNA and its preparation method and application, belong to antitumor drug technical field.The application successfully prepared nanocomposite HA / PEI / Fe3O4@siGPX4, serum stability is high, blood compatibility is good, when reaching tumor acid microenvironment, siGPX4 can be efficiently released, and then play antitumor effect, can specifically target triple-negative breast cancer cell, greatly improve the internalization ability of MDA-MB-468 cell to it, significantly improve the delivery efficiency of siGPX4;Under the condition that there is H2O2, the nanocomposite can down-regulate the expression of GPX4, the released ferrous ion and H2O2 occur Fenton reaction, cause intracellular ROS significantly increase, cause mitochondrial membrane potential to drop, and then trigger ferroptosis, significantly inhibit MDA-MB-468 cell proliferation, to play antitumor effect.

This invention discloses a Mo-Mn biodegradable molybdenum alloy, its preparation method, and its applications. The alloying elements include Mo and Mn, with Mn accounting for >0-30% by mass, and the remainder being Mo. Manganese-doped molybdenum powder is prepared by wet chemical methods or mechanical alloying. The manganese-doped molybdenum powder is then subjected to hot pressing sintering or multi-step spark plasma sintering to obtain the Mo-Mn alloy. The Mo-Mn biodegradable molybdenum alloy of this invention possesses excellent mechanical properties, providing long-term effective mechanical support in vivo, and exhibits good cell compatibility, blood compatibility, and tissue / organ compatibility, making it suitable for use as a biomedical implant.

The invention relates to the technical field of biomedical materials, in particular to a surface modification method of a poly (4-methylpentene) (PMP) hollow fiber membrane, the blood compatibility of the material is synergistically improved through a polydopamine (PDA) coating and a zwitter-ion grafting technology, and the surface modification method is suitable for blood contact instruments such as extracorporeal membrane oxygenation (ECMO) and the like. The invention provides a dopamine-mediated zwitterionic modified PMP membrane, which comprises a PMP membrane and a modification layer on the surface of the PMP membrane, and the modification layer comprises a polydopamine intermediate layer formed on the surface of the PMP membrane through dopamine in-situ oxidation auto-polymerization and a zwitterionic polymer brush grafted on the polydopamine intermediate layer.

The invention discloses application of an acellular matrix material as a tissue damage or tumor targeting probe or carrier. A preparation method of the acellular matrix material comprises the following steps: pretreating fish tissues; performing decellularization treatment on the pretreated fish tissue to obtain a decellularized fish tissue material; the preparation method comprises the following steps: freeze-drying, grinding and digesting the decellularized fish tissue material, then carrying out ultrafiltration and centrifugation to intercept filtrate with the molecular weight of less than 50KDa, and freeze-drying to obtain the decellularized matrix material. The acellular matrix material disclosed by the invention has good blood compatibility and has a targeting effect on tissue injury, especially myocardial injury parts, diabetic nephropathy tissues or tumors.

The application discloses a multifunctional composite artificial blood vessel and a preparation method thereof. The artificial blood vessel is a three-layer structure, comprising an inner layer, a middle layer and an outer layer. The inner layer, the middle layer and the outer layer are tightly combined and inseparable. The artificial blood vessel port is a hollow cylindrical structure. The inner layer is a hydrophilic inner layer. The middle layer is composed of a dense layer and a spiral ring support structure. The outer layer is an electrospinning layer. The composite artificial blood vessel comprises three layers: the inner layer is an electrospinning layer with good blood compatibility; the middle layer is a dense layer for providing mechanical properties and providing certain mechanical strength for the artificial blood vessel; and the outer layer is a fiber layer for contacting with tissues. The composite artificial blood vessel has good anti-leakage and anti-bending properties. In addition, compared with a traditional ePTFE blood vessel, the blood vessel has excellent blood compatibility and good flexibility. The method is simple to operate and suitable for commercial scale production. The inner diameter size range can be adjusted.

This invention relates to a flexible electronic skin composite film with both humidity response and driving functions, and its preparation method. The composite film is a monolayer homogeneous polymer blend film prepared by solution blending chitosan and polyquaternium-7, forming a stable three-dimensional network structure through hydrogen bonding between chitosan and polyquaternium-7 molecules. The composite film of this invention possesses high transparency, high flexibility, strong skin adhesion, rapid humidity response, and efficient humidity driving performance. It can respond to minute humidity differences and human physiological humidity, efficiently converting the chemical energy of humidity into mechanical energy. It also exhibits broad-spectrum antibacterial properties, excellent blood compatibility, and biosafety, perfectly meeting the long-term wear and use requirements of flexible electronic skin.

The present application belongs to the technical field of biomedical metals, and particularly relates to a preparation method of TWIP steel medical material for degradable clamps, wherein the TWIP steel medical material comprises the following components in percentage by mass: Mn: 30-40%, Al: 3-6%, Ge: 3-6%, X: 0-2%, and the balance of Fe, wherein X is one or more of Cu, Ag, Zn, Ca, Sr, Li, Ti, Zr, Au and Mg. The TWIP steel medical material prepared by the method has higher mechanical properties, degradable plastic that is more suitable for wound healing, more excellent blood compatibility, cell compatibility and antibacterial performance, and is expected to become a potential degradable biomedical material.

The present invention provides a preparation method of a material for a puncture-resistant artificial blood vessel. The artificial blood vessel prepared by the method comprises two layers: the dense outer layer and the electrospun inner layer, the structures of these two layers are combined tightly and are inseparable, so that the properties of blood oozing resistance and repeated puncture resistance required by the artificial blood vessel can be provided. The puncture-resistant artificial blood vessel provided by the present invention has excellent biocompatibility, blood compatibility and flexibility and has the functions of blood oozing resistance and repeated puncture resistance. The method provided by the present invention has the characteristics such as convenience in operation, simplicity in production process and liability to the realization of large scale.

The invention relates to a pulse condition blood pump blood compatibility evaluation method and system based on hardware-in-the-loop, and the simulation authenticity of a lumped parameter model on human body circulation adjustment and valve dynamic behaviors is remarkably improved by introducing a dynamic physiological feedback mechanism and a nonlinear valve model; real blood pump flow is coupled to model iteration in real time through the hardware-in-loop technology, and closed-loop bidirectional interaction between the blood pump and the virtual human body is achieved; meanwhile, a low-blood-volume loop and a pneumatic flexible loading mode are adopted, extra blood damage introduced by the loop is greatly reduced, the experiment uncertainty and the system error are remarkably reduced, and the repeatability and the comparability of a test result are greatly improved, so that high-fidelity and high-controllability evaluation of the blood compatibility of the blood pump under the pulse working condition is ensured.

The invention provides a foldable guide pipe pump and an impeller thereof, the impeller comprises a hub and a plurality of blades, the hub is rotatably and radially supported at the near end part and the far end part of the hub respectively, and the impeller has a compressed state and a natural unfolding state; and when the impeller is in a natural unfolding state, the diameter of the far-end endpoint of each blade is smaller than that of the near-end endpoint of each blade. The impeller can reduce or avoid blood cavitation, reduce blood damage and improve blood compatibility on the premise of maintaining high hydraulic performance.

The application relates to the technical field of medical devices, and provides a negative-pressure gas leakage resistant artificial blood vessel and a preparation method and application thereof. The negative-pressure gas leakage resistant artificial blood vessel is an expanded polytetrafluoroethylene artificial blood vessel provided with a thermoplastic polyurethane coating on the surface; compared with the expanded polytetrafluoroethylene artificial blood vessel, the negative-pressure gas leakage resistant artificial blood vessel has lower porosity. The thermoplastic polyurethane coating realizes continuous and dense coverage on the surface of the expanded polytetrafluoroethylene artificial blood vessel, effectively fills part of the micropore structure of the expanded polytetrafluoroethylene artificial blood vessel, the negative-pressure gas leakage resistant performance is significantly improved, the thermoplastic polyurethane coating has no cytotoxicity, has good biological safety, does not introduce additional hemolysis risk, and has good blood compatibility. The application provides a new technical selection for solving the problem of gas barrier integrity of a mechanical circulation support system pipeline, and is expected to be widely applied in the manufacturing of medical devices.

The application discloses an in-vitro testing device for a micro interventional pump, which comprises an inlet section, a clamping section and an outlet section which are independently designed and hollow inside, the inner diameters of the inlet section and the outlet section are consistent with the inner diameter of a real blood vessel at an implantation position to simulate a mechanical environment in a human body, the clamping section is detachably connected between the inlet section and the outlet section to facilitate installation and replacement, different lengths or cross-sectional shapes of the outlet section are replaced according to the blood vessel morphology at the implantation position to adapt to different testing simulation requirements, the clamping section is curved and the curvature is adapted to the curvature of the micro interventional pump, flexible clamping blocks are arranged inside the clamping section for clamping the micro interventional pump, and sensor interfaces for connecting testing sensors such as pressure sensors and temperature sensors are arranged outside the inlet section and the outlet section. The device can be used for in-vitro testing of various micro interventional pumps, the hemodynamic characteristics of the testing environment are consistent with physiological conditions, the blood compatibility is good, and the device can meet the requirements of in-vitro hemolysis experiments and particle image velocimetry experiments.