651 results about "Blood compatibility" patented technology

A composition comprising in admixture with a polymer, preferably a polyurethane, and a compatible surface-modifying macromolecule having (i) a central portion of a segmented block oligomeric copolymer comprising at least one polar hard segment, and (ii) PROPORTIONAL - omega terminal polyfluoro oligomeric groups, in a surface modifying enhancing amount. The composition is of use in providing articles having improved surface properties, particularly, medical devices having improved resistance to enzyme degradation with acceptable blood compatibility.

This disclosure encompasses a bioprosthetic heart valve having a polyphosphazene polymer such as poly[bis(trifluoroethoxy)phosphazene], which exhibits improved antithrombogenic, biocompatibility, and hemocompatibility properties. A method of manufacturing a bioprosthetic heart valve having a polyphosphazene polymer is also described.

The present invention relates to devices, articles, coatings, and methods for controlled active agent release and / or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.

Provided are a polysulfone type blood-purifying membrane which is improved in blood compatibility and separation properties and less in polyvinyl pyrrolidone eluting in the internal surface of the hollow fiber membrane, as well as a process for producing the same.

Fistly, said ivnention utilizes polyamine aminolyzed polyester polymer surface to obtain polymer whose surface has free amine group, then uses acid to make acidification to make polymer surface possess positive charge, and utilzies electrostatic attraction layer-to-layer self-assembling method to alternatively assemble single layer or several layers of different polyanions and polycations with biological activity on its surface, and these biological activity polyelectrolytes which are layer-to-layer self-assembled still retain their original biological activity so as to obtain the invented plane membrane and three-D porous support material with cell compatibility and its product.

A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

The invention discloses a covered stent, which comprises a support structure and a tectorial membrane unit, and is characterized in that: the tectorial membrane unit comprises an inner-layer tectorial membrane and an outer-layer tectorial membrane which coats the support structure; the outer-layer membrane coats on the outer side of the inner-layer tectorial membrane; the inner-layer tectorial membrane is a biological membrane with good blood compatibility, and the outer-layer tectorial membrane is a biological membrane which is easy to induce the formation of thrombus; the inner-layer tectorial membrane contacting blood has good blood compatibility, can effectively reduce the formation of the thrombus, and maintains normal blood flowing channels; and the outer-layer tectorial membrane can induce the formation of the thrombus in aneurysm or thrombus of bleeding parts, promotes the aneurysm to be quickly activated and reduced, reduces the mass effect in vivo, simultaneously effectively adheres endothelial cells, promotes differentiation and proliferation of cells, quickens the endothelialization of lesion parts of vessels, and can more effectively treat vascular diseases such as the aneurysm and the like.

The invention provides a high-nitrogen austenitic stainless steel material for a vascular stent, which comprises the following chemical components in percentage by weight: 16-20% of Cr, 12-20% of Mn, 1-3% of Mo, 0.5-2% of Cu, no more than 0.05% of Ni, 0.7-1.2% of N, 0.5-8% of W, 0.05-0.5% of RE, no more than 0.08% of C, 0.3-4% of Si, no more than 0.010% of S, no more than 0.02% of P and the balance of Fe, wherein RE is a rare-earth element. The high-nitrogen stainless steel provided by the invention is mainly used for vascular stent processing; the elements of copper, nitrogen and rare earth are added to increase the blood compatibility of the stainless steel; and the tungsten alloy is added to increase the density of the stainless steel. The stainless steel has excellent visibility under X rays, contains no potential toxic element nickel, can be used in the aspects of surgical implants, medical appliances, food and catering appliances, jewelry and other stainless steel products which are always in contact with a human body, and can also be used in the fields of chemical engineering, environment protection and the like.

In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.

A composition includes a polycarbonate-polysiloxane block copolymer that has at least one polycarbonate block and at least one polysiloxane block, and a surface modifying agent that includes at least one polysiloxane segment. Increased levels of the surface modifying agent can be incorporated without compromising high transmittance and low haze. The compositions also exhibit improved hemocompatibility and are therefore useful for a variety of articles that may contact blood.

An endotoxin adsorbent used for blood perfusion is prepared from agat through adding the aqueous solution to the liquid mixture of toluene and CCl4 to obtain spherical agar, activating by epoxy chloropropane under alkaline condition, reacting on diamine and then on glutaraldehyde to obtain high-strength agar beads used as the carrier of adsorbent, reacting on the amino contained ligand (polymyxin B), and reducing by NaBH4. Its advantages are high compatibility to blood and high effect on absorbing endotoxin from blood.

Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.

The invention discloses a dopamine-based method for improving surface hydrophilicity and biocompatibility of a medical polyurethane material. The method comprises the following steps: carrying out pretreatment on a medical polyurethane material by using dopamine so as to obtain a site with proper surface roughness and abundant reaction activity; putting the medical polyurethane material subjected to dopamine pretreatment into hydrophilic membrane concentrate, and carrying out heating reaction for 4-8 hours; and fully cleaning and drying the reaction product. According to the method disclosed by the invention, a layer of film is prepared on the material surface on the basis of the dopamine, and the prepared film has high hydrophily, the blood compatibility can be improved, the damage to tissue is reduced, the film has good stability, and low water contact angle and high hydrophily of a sample can be kept for a long period of time.

The invention relates to a copper sulfide / mesoporous silicon dioxide core-shell nano material as well as a preparation method and an application thereof. The chemical formula of the core-shell nano material is Cu9S5 / mSiO2-PEG. The preparation method comprises the following steps of: (1) raising the temperature of oleylamine under the protection of nitrogen; adding a mixed solution of copper dibutyldithiocarbamate and the oleylamine and dispersing the mixed solution into chloroform to prepare a D solution; (2) dissolving a surfactant into water; raising the temperature and adding the D solution to prepare an E solution; and (3) taking the E solution and adding ethanol; raising the temperature and adding an NaOH solution; immediately adding TEOS (Tetraethylorthosilicate) and reacting; adding PEG-silane; continually reacting and carrying out hydrothermal reaction; and adding into a scrubbing solution to centrifuge and wash to obtain the product. The copper sulfide / mesoporous silicon dioxide core-shell nano material is applied to near-infrared photo-thermal treatment, anti-cancer drugs, chemotherapy of tumors and infrared heat imaging. The nano material disclosed by the invention has very low cell toxicity and very high blood compatibility; and the united effects of thermal therapy and the chemotherapy are good.

This invention relates to a body fluid degradative medicinal implant and its preparation method. The implant is prepared from Mg-Ca rafting wherein, Mg content is 7-10 weight parts (excluding 10); and Ca content is 0-3 (excluding 0). It is proven by in vitro and in vivo studies, the implant has the advantages of no toxicity, and good organization consistency and sanguis consistency.

The invention discloses a method for immobilizing VEGF-carried heparin / polylysine nanoparticles on a Ti surface, which comprises the following steps: by utilizing the characteristic that Hep and PLL can produce static interactions to form nanoparticles, mixing VEGF-carried Hep and PLL to form VEGF-carried nanoparticles; preparing a DM coating on the Ti material surface; and by utilizing the characteristic that the DM and primary amino group can generate Michael addition and Schiff base reaction, immobilizing the amino-containing nanoparticles onto the sample surface in a covalent mode, thereby constructing the biologically modified surface with anticoagulation and endothelium promotion functions. By constructing a nanoparticle modifying layer with anticoagulation and endothelium promotion characteristics on the Ti surface, the invention obviously improves the blood compatibility and endothelium injury restorability of the material.

The invention relates to a medical apparatus, in particular to an anticoagulant stainless steel coronary support which is made from a high-nitrogen nickel-free austenitic stainless steel material with good blood compatibility. The support is of tubular structure with a mesh surface which is formed by orderly arranging a unit figure on the side surface of a tube along the circumference and axial direction, the primary supporting function is provided by U-shaped corrugated mesh wires extending along the axial direction, the corrugated mesh wires are connected into a whole body by soft mesh wires arranged at intervals, and the diameter of the mesh wire (width or thickness) is 40-100mum; and the surface of the support is passivated and coated with a medication. The anticoagulant stainless steel support has the advantages of good mechanical properties, good flexibility and good anticoagulant property, and can be used as a support for cardiovascular and cerebrovascular systems or a support for other cavity bodies.

A composition includes a polycarbonate-polysiloxane block copolymer that has at least one polycarbonate block and at least one polysiloxane block, and a surface modifying agent that includes at least one polysiloxane segment. Increased levels of the surface modifying agent can be incorporated without compromising high transmittance and low haze. The compositions also exhibit improved hemocompatibility and are therefore useful for a variety of articles that may contact blood.

A guide wire having a coil disposed over the guide wire, wherein the coil is integrally formed of a single wire and has regions of differing properties over its length. Some wire embodiments have longitudinally alternating layer segments having differing properties including radiopacity, lubricity, hydrophilicity, hemo-compatibility, flexibility, malleability, stiffness, and shape memory properties. A coil may have numerous distinct property segments, while being formed from only a single wire and requiring only two points for affixation to the guide wire.

A bushing-type permanent magnetic impeller shaft bleeding pump, which is used for heart boosting and the boosting method of the bleeding pump are provided. A rotor of the bleeding pump is a whole magnetic impeller or an impeller with magnetic vanes, which greatly improves a magnetic field intensity of a bleeding pump air gap. A defending, a packing and a biochemical treatment are taken on the surface of the impeller. A tube cavity of the bleeding pump is made from a material with good blood compatibleness. A pre-diversion system structure is simplified, and a pre-diversion wimble is supported by a single cantilever, which are all in favor of preventing a thrombosis. The boosting method adopts a serial-type connection of an axial bleeding pump and ventricles of heart (left ventricle, right ventricle or double ventricles) and requests that an appearance of the bleeding pump is a geometrical shape of as ascending aorta or a main pulmonary artery which is fit for implantation, and the tube cavity and an artificial blood vessel caliber match with a natural blood vessel. In order to prevent a pumping action of the bleeding pump reduces a perfusion pressure of a coronary artery, a coronary artery and aorta bypass transplantation can be performed.

The invention discloses a nanofiber vascular prostheses and a preparation method. The preparation method is as follows: mixing the solution of gelatin and glacial acetic acid with the aqueous solution of a crosslinker evenly to pre-crosslink the solution of gelatin and glacial acetic acid, adding heparin sodium aqueous solution to prepare spinning dope and collecting the formed fibers on a collecting roll by using the electrospinning process to form a nanofiber nonwoven membrane tube; dissolving polyurethane into the mixed solvent of tetrahydrofuran and N,N-dimethylformamide to prepare polyurethane spinning dope and continuously collecting the formed fibers on the collecting roll which has collected the nanofiber nonwoven membrane tube by using the electrospinning process; and taking off the nanofiber nonwoven membrane tube covered by the polyurethane fiber nonwoven membrane tube structure from the collecting roll and then soaking the nanofiber nonwoven membrane tube into the aqueous solution of a post-crosslinker to carry out post-crosslinking treatment, thus preparing the nanofiber vascular prostheses. The inner layer of the vascular prostheses of the invention can improve the blood compatibility and the outer layer has biological stability and can improve the physical and mechanical properties.

The invention relates to a copper-bearing compound coating on a metal component of a medical device and a preparation method thereof. The preparation method comprises the following steps of step one, washing the surface of the metal component of the medical device; step two, putting the metal component of the medical device into a vacuum chamber and performing pretreatment on the metal component; and step three, generating copper ions in the vacuum chamber, causing the copper ions to move towards the surface of the metal component of the medical device under the action of bias for combination with ions of another element in the vacuum chamber, and reacting on the surface of the metal component of the medical device for the formation of the copper-bearing compound coating. The copper-bearing compound coating on the metal component of the medical device provided by the invention not only is good in blood compatibility, but also can prevent the cells from growing on the device surface for the realization of inhibition on the material surface endothelialization; and additionally, the invention also relates to the medical device.

In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

The invention discloses a surface modification method for a polymer separation membrane. Under the water solution condition, a dopa compound is easily oxidized by dissolved oxygen in water to generate auto-agglutination-composite reaction in order to generate a firmly attached dopa compound composite layer on the surface of the polymer separation membrane; the dopa compound composite layer contains rich catechol radicals which can form the multi-point hydrogen bonding effect with lactam radicals in polyvinylpyrrolidone, and the polyvinylpyrrolidone is firmly complexed on the surface of the separation membrane; and the polymer separation membrane immobilized with povidone-iodine on the surface can be prepared through the complexation between the polyvinylpyrrolidone and iodine. The method has simple technique, and is suitable for the polymer separation membranes with different materials and shapes; and the modified polymer separation membrane has excellent hydrophily, blood compatibility, contamination resistance and bacterial resistance, so that the important significance is given to improve the comprehensive performance of the polymer separation membrane.

The invention relates to a high-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in an organism, belonging to the technical field of biological materials. The material of the invention comprises the following components in percentage by weight: 1-4% of Nd, 0.1-1.0% of Zn, 0.1-1.0% of Ag, 0.3-0.8% of Zr and balance of Mg. The invention strengthens magnesium alloy through alloy elements, refines grains, improves plasticity, and further strengthens the magnesium alloy through extrusion deformation and heat treatment processes. The corrosion rate of the magnesium alloy provided by the invention in the simulated body fluid is 0.22-0.28mm / year, meeting the requirement of the implanted material for the corrosion rate; and the material of the invention does not have obvious cytotoxicity and has good blood compatibility, thereby meeting the requirements of the implanted material for biological compatibility. The high-plasticity medium-strength magnesium alloy provided by the invention can be used for support intravascular stent materials, and the high-strength medium-plasticity magnesium alloy provided by the invention can be used for implanted materials in orthopaedics.

The invention discloses a method for preparing an artificial blood vessel with a micro-nano biomimic intima structure by utilizing an electrospinning technology. The method mainly comprises the following steps of preparing a macromolecular polymer solution; preparing an alignment electrospun fibrous membrane; stretching the alignment electrospun fibrous membrane; preparing an artificial blood vessel; performing characterization by using a scanning electron microscope; and determining blood compatibility. The artificial blood vessel prepared by the method has an intima imitation alignment microstructure, so that the blood compatibility of the artificial blood vessel meets a requirement on clinical anticoagulation performance, and a new way for the preparation of a novel artificial blood vessel is provided. In addition, the adoption of an anticoagulant is avoided, and the blood compatibility of the artificial blood vessel is improved only by a surface microstructure effect, so that side effects caused by the anticoagulant are reduced, and the method has broad application prospect in the field of medical clinical blood vessel transplantation.

The present invention provides a modified substrate including a hydrophilic polymer wherein the soluble hydrophilic polymer ratio is 15 weight percent or less and the number of adhered human blood platelets is 10 / 4.3×103 μm2 or less. In addition, the present invention provides a method for producing a modified substrate including a step of irradiating the substrate with radiation while the substrate is brought into contact with an aqueous solution containing a hydrophilic polymer and an antioxidant. The present invention provides a modified substrate having high hematologic compatibility wherein the hydrophilic polymer is immobilized on the surface of the substrate, and a method for producing the same.

A polyurethane material containing F in side chain is prepared through alternative polymerization between the flexible chain segment consisting of polyether diol and / or polycarbonate diol and the rigid chain segment consisting of diisocyanate and chain-enlarging agent. Its advantages are high biologic stability and compatibility and high elasticity, strength and resistance to oxidizing and hydrolysis. It can be used for preparing artificial blood vessel, heart valve, etc.

The invention relates to a preparation method of laponite (LAP)-doped polylactic acid-glycolic acid (PLGA) nanofiber. The method comprises the following steps of: (1) dissolving PLGA into a THF (Tetrahydrofuran) / DMF (Dimethyl Formamide) mixed solvent, and stirring for fully dissolving the PLGA to obtain a PLGA electrostatic spinning solution; (2) uniformly dispersing the LAP into the PLGA electrostatic spinning solution while stirring to obtain a PLGA / LAP electrostatic spinning solution; and (3) performing electrostatic spinning by using the PLGA / LAP electrostatic spinning solution to obtain a PLGA / LAP composite nanofiber felt and drying. The process of the method is simple, a product is easy to prepare, and the PLGA and LAP used have low costs; and the prepared LAP-doped polylactic acid-glycolic acid nanofiber has high mechanical property, high thermal stability, high blood compatibility and high biocompatibility, and has a wide application prospect in the fields of medicament carriers, tissue engineering bracket materials and the like.