30 results about "Blood compatibility" patented technology

The invention relates to an adsorbing material for blood perfusion and a preparation method thereof. The preparation method comprises the following steps: providing a hydrophobic porous carrier which comprises styrene-divinyl benzene copolymer microspheres, and introducing a coordination group on the surface of the hydrophobic porous carrier through chemical modification. The average pore size of the hydrophobic porous carrier is 2-50 nm, and the specific surface area of the hydrophobic porous carrier is greater than or equal to 500 m < 2 > / g; the coordination group is selected from at least one of iminodiacetic acid (IDA), ethylenediaminetetraacetic acid (EDTA) and N, N, N-tricarboxymethyl ethylenediamine (TED). The prepared adsorption material is high in A beta removal capacity, has certain removal capacity on heavy metal ions, is good in blood compatibility and excellent in anticoagulation performance, and is an ideal material for preparing a blood perfusion device.

The utility model discloses an impeller rotor of an axial flow blood pump, which comprises a hub, blades, a shaft hole and back blades, and the outer diameter of the hub is gradually increased from the head to the tail; each blade comprises a blade root close to the hub, a blade tip away from the hub, a blade front edge and a blade tail edge, and the two blades are arranged on the surface of the hub in a central symmetry mode. The shaft hole is formed in the tail end face of the impeller rotor and can be used for installing an impeller shaft. The back blades are arranged on the end face of the tail of the impeller rotor and arranged outside the shaft hole in a surrounding mode. The impeller is simple in structure, the blood low-speed area disturbance effect of the near wall face of the impeller shaft can be improved, and therefore the risk that blood forms thrombus between the impeller rotor and the bearing is reduced, and the blood compatibility of the blood pump is improved.

The application discloses a high-loading MXene-encapsulated magnetic porous microcapsule for adsorption and a preparation method and application thereof, and belongs to the field of biomedical materials, and the preparation method comprises the following steps: in step one, a hydrogel precursor solution doped with magnetic nanoparticles is used as an external phase, and a MXene dispersion liquid is used as an inner phase, and a microfluidic coaxial electrospraying device is used to generate monodisperse core-shell droplets with uniform sizes; in step two, the monodisperse core-shell droplets prepared in step one are subjected to freezing pretreatment, and then are crosslinked with divalent metal ions, so that double gelation of the core layer and the shell layer is triggered, and hydrogel microspheres with a core-shell structure are obtained; and in step three, the hydrogel microspheres with the core-shell structure obtained in step two are subjected to freeze drying, and high-loading MXene-encapsulated magnetic porous microcapsules are obtained. The application has excellent blood compatibility and high adsorption capacity, and is outstanding in removing uremic toxins including creatinine, urea and uric acid, and is a kind of adsorbent which is both efficient and safe.

The present application relates to the biomedical technology field, especially to a kind of decellularized pig pericardium and POSS-PEG-CHO cross-linked biological nanocomposite material and its preparation method and application.The present application is based on Schiff base reaction, and the star-shaped eight-arm eight-functionalized POSS-based benzaldehyde end-capped polyethylene glycol is used to cross-link the decellularized pig pericardium, and the POSS-PEG-PP biological nanocomposite material is successfully prepared.Compared with GLUT-PP, the POSS-PEG-PP provided by the present application presents more compact fiber arrangement, and the mechanical property is also better.In vitro experiment shows that POSS-PEG-PP has excellent cell compatibility, endothelialization capacity and blood compatibility.In vivo evaluation further confirms that the material has significant anti-inflammatory and anti-calcification properties.Through RNA sequencing analysis of subcutaneous implant, it is found that the changes of AMPK and IL-17 signal pathways play an important role in the process of POSS-PEG-PP regulating inflammation and immune response.Therefore, POSS-PEG-PP shows good application prospect in the field of biological heart valve, and is expected to become a very potential alternative material.

The invention relates to a blood shearing device and a blood compatibility evaluation method. The blood shearing device comprises an objective table, a fixing support, a supporting beam, a stator, a rotor and a driving source. The device can simultaneously adjust the roughness and wettability of the material surface, breaks through the limitation that only a single factor can be researched in the prior art, and provides a more comprehensive platform for systematically evaluating the blood compatibility; in the experimental method, red blood cell hemolysis is detected, and the degradation condition of plasma protein is evaluated synchronously, so that the overall injury mode of blood components under the action of an artificial surface can be reflected more truly. Experimental basis can be provided for material selection and surface optimization of blood contact type medical instruments such as an artificial heart pump, an ECMO and a hemodialysis machine, the clinical complication risk can be reduced, and development of artificial organs and blood purification technologies is promoted.

The invention provides a ventricular assist device and a blood pump thereof. The blood pump comprises a pump shell and an impeller, the impeller comprises a rotor part and a plurality of blades arranged on the rotor part, the blood pump further comprises a flow guide cone arranged basically opposite to the blood inlet, the front edge of at least one blade extends towards the radial inner side to the position above the flow guide cone, and the front edge of at least one blade extends towards the radial inner side to the position above the flow guide cone. The lower side of the front edge of at least one blade is provided with an avoiding part, the radius of the flow guide cone is defined as RC, the height of the flow guide cone is defined as HC, and a cylinder with the central axis of the blood inlet as the axis, the top face passing through the cone top of the flow guide cone, the radius of the cylinder is RC, and the height of the cylinder is HC is obtained. And the avoiding part is constructed to enable the at least one blade to avoid the space occupied by the cylinder. According to the blood pump, blood cavitation can be reduced or avoided while high hydraulic performance is maintained, blood damage is reduced, and blood compatibility is improved.

The present disclosure relates to cells for intravascular transplantation having hemocompatibility in which the blood coagulation mechanism and thrombosis reaction are inhibited by artificially modifying the F3 gene encoding CD142 that is an initiator of blood coagulation, using gene scissors technology to reduce or suppress the expression or activity of CD142, a method of producing the same, and a use thereof for preventing or treating liver disease and diabetes.

The present disclosure relates to semipermeable membranes comprising a base membrane and a coating with a vinyl polymer derived from vinyl monomers carrying an acid group and grafted onto the surface of the base membrane by radiation induced graft copolymerization (RIGC), thereby introducing a coating carrying negative charges. The coated membranes are especially suitable for blood purification applications as they are characterized by an increased selectivity and excellent blood compatibility and an excellent hemocompatibility due to the careful selection of the vinyl monomers used for the coating process and the introduction of negative charges. The invention also relates to a production process for said coated membranes and to their use in hemodialysis devices and in medical applications such as extracorporeal blood purification.

An optical assembly for placement on a medical device. The optical assembly has a diaphragm suspended over and above an optical cavity. The optical cavity has sensor dots formed thereon. The diaphragm is covered with a biocompatible platinum silicide layer.

The invention provides bimodal imaging down-conversion nanoparticles for near-infrared two-region fluorescence imaging and magnetic resonance imaging as well as a preparation method and application of the bimodal imaging down-conversion nanoparticles. The nano-particle is composed of a hexagonal beta-phase NaGdF4 main lattice structure and an amorphous coating on the surface, the main lattice structure of the NaGdF4 is uniformly doped NaGdF4: Nd < 3 + > x, Yb < 3 + > y and Er < 3 + > z; wherein Nd < 3 + > is used as a sensitizer, Yb < 3 + > is used as a medium ion, Er < 3 + > is used as an emission ion, and Gd < 3 + > is used for providing MRI contrast. According to the hexagonal beta-phase NaGdF4 main lattice provided by the invention, effective energy transfer among doped ions is realized, and strong infrared second-region fluorescence intensity is generated under 808nm excitation. Meanwhile, the uniform distribution of Gd < 3 + > ions endows the nanoparticles with a high T1 relaxation rate, and realizes deep tissue anatomical functional imaging. DCNPs is subjected to surface modification through Pluronic F-127, so that the nanoparticles have low cytotoxicity and good blood compatibility, and the surface can be conveniently subjected to functional modification, such as connection with a targeting ligand or a biomolecule, so that targeted imaging of specific tissues or pathological parts is realized.

The application provides a blood perfusion adsorbent with low protein adsorption, a preparation method thereof and a blood perfusion device, and belongs to the technical field of blood purification adsorbents. The application introduces vinyl silicone oil into the adsorbent, the vinyl silicone oil has low surface energy, excellent anti-protein adsorption performance and tissue and blood compatibility, and the surface of the cross-linked silicone oil modified adsorption resin prepared through suspension polymerization has a pore structure, so that the adsorbent has good blood compatibility, medium and large molecule toxin adsorption performance and anti-protein adsorption performance. The cross-linked silicone oil modified adsorption resin is further subjected to cross-linking reaction to obtain an ultra-high cross-linked silicone oil modified adsorption resin, and the ultra-high cross-linked silicone oil modified adsorption resin still has anti-protein adsorption performance.

The application discloses a kind of nanocomposite HA / PEI / Fe3O4@siRNA and its preparation method and application, belong to antitumor drug technical field.The application successfully prepared nanocomposite HA / PEI / Fe3O4@siGPX4, serum stability is high, blood compatibility is good, when reaching tumor acid microenvironment, siGPX4 can be efficiently released, and then play antitumor effect, can specifically target triple-negative breast cancer cell, greatly improve the internalization ability of MDA-MB-468 cell to it, significantly improve the delivery efficiency of siGPX4;Under the condition that there is H2O2, the nanocomposite can down-regulate the expression of GPX4, the released ferrous ion and H2O2 occur Fenton reaction, cause intracellular ROS significantly increase, cause mitochondrial membrane potential to drop, and then trigger ferroptosis, significantly inhibit MDA-MB-468 cell proliferation, to play antitumor effect.

This invention discloses a Mo-Mn biodegradable molybdenum alloy, its preparation method, and its applications. The alloying elements include Mo and Mn, with Mn accounting for >0-30% by mass, and the remainder being Mo. Manganese-doped molybdenum powder is prepared by wet chemical methods or mechanical alloying. The manganese-doped molybdenum powder is then subjected to hot pressing sintering or multi-step spark plasma sintering to obtain the Mo-Mn alloy. The Mo-Mn biodegradable molybdenum alloy of this invention possesses excellent mechanical properties, providing long-term effective mechanical support in vivo, and exhibits good cell compatibility, blood compatibility, and tissue / organ compatibility, making it suitable for use as a biomedical implant.

The invention relates to the technical field of biomedical materials, in particular to a surface modification method of a poly (4-methylpentene) (PMP) hollow fiber membrane, the blood compatibility of the material is synergistically improved through a polydopamine (PDA) coating and a zwitter-ion grafting technology, and the surface modification method is suitable for blood contact instruments such as extracorporeal membrane oxygenation (ECMO) and the like. The invention provides a dopamine-mediated zwitterionic modified PMP membrane, which comprises a PMP membrane and a modification layer on the surface of the PMP membrane, and the modification layer comprises a polydopamine intermediate layer formed on the surface of the PMP membrane through dopamine in-situ oxidation auto-polymerization and a zwitterionic polymer brush grafted on the polydopamine intermediate layer.

A hemostatic material with near-infrared light-controlled shape memory properties, its preparation method, and its application. Due to the shape memory effect, the sponge's shape can be restored to 90% within 25 seconds. By switching the near-infrared light source on and off, the sponge's expansion can be controlled and adjusted. The sponge's hemostatic ability has been verified in vitro and in vivo. As expected, compared with commercial medical gelatin sponges with insufficient expansion capacity and commercial medical PVA sponges with excessive expansion capacity, the PDA-TPI-PU shape memory sponge can quickly and effectively control bleeding under near-infrared light irradiation, showing potential application prospects as a hemostatic material. With excellent mechanical properties, blood compatibility, cytocompatibility, and photothermal conversion performance, the PDA-TPI-PU sponge provides a new approach to using light-controlled shape memory materials as coagulation materials for treating incompressible bleeding.

The invention belongs to the cross field of chemistry, materials, biology and pharmacy, and particularly relates to a pH response chemotherapy and photo-thermal combined treatment drug delivery carrier and a preparation method and application thereof. The drug delivery carrier MOF-CPT-PDA-PEG constructed in the invention can realize chemotherapy-photo-thermal synergistic treatment and has good photo-thermal conversion ability, in vitro experiments show that drug release has pH and photo-thermal dual response characteristics, the hemolysis rate is lower than 5% (5-500 [mu] g / mL), the protein adsorption amount is smaller than 140 [mu] g / mg, and excellent blood compatibility is shown; cell experiments show that the survival rate of 4T1 cells is reduced to 17% through combination of MOF-CPT-PDA-PEG and illumination, the tumor inhibition effect is remarkably enhanced, and great potential is achieved in chemotherapy-photothermal combined cancer treatment. The method is green and safe, the preparation process is simple and controllable, the method is suitable for large-scale production, practical applicability is achieved, and economic and social benefits are remarkable.

The invention discloses application of an acellular matrix material as a tissue damage or tumor targeting probe or carrier. A preparation method of the acellular matrix material comprises the following steps: pretreating fish tissues; performing decellularization treatment on the pretreated fish tissue to obtain a decellularized fish tissue material; the preparation method comprises the following steps: freeze-drying, grinding and digesting the decellularized fish tissue material, then carrying out ultrafiltration and centrifugation to intercept filtrate with the molecular weight of less than 50KDa, and freeze-drying to obtain the decellularized matrix material. The acellular matrix material disclosed by the invention has good blood compatibility and has a targeting effect on tissue injury, especially myocardial injury parts, diabetic nephropathy tissues or tumors.

The application discloses a multifunctional composite artificial blood vessel and a preparation method thereof. The artificial blood vessel is a three-layer structure, comprising an inner layer, a middle layer and an outer layer. The inner layer, the middle layer and the outer layer are tightly combined and inseparable. The artificial blood vessel port is a hollow cylindrical structure. The inner layer is a hydrophilic inner layer. The middle layer is composed of a dense layer and a spiral ring support structure. The outer layer is an electrospinning layer. The composite artificial blood vessel comprises three layers: the inner layer is an electrospinning layer with good blood compatibility; the middle layer is a dense layer for providing mechanical properties and providing certain mechanical strength for the artificial blood vessel; and the outer layer is a fiber layer for contacting with tissues. The composite artificial blood vessel has good anti-leakage and anti-bending properties. In addition, compared with a traditional ePTFE blood vessel, the blood vessel has excellent blood compatibility and good flexibility. The method is simple to operate and suitable for commercial scale production. The inner diameter size range can be adjusted.

This invention relates to a flexible electronic skin composite film with both humidity response and driving functions, and its preparation method. The composite film is a monolayer homogeneous polymer blend film prepared by solution blending chitosan and polyquaternium-7, forming a stable three-dimensional network structure through hydrogen bonding between chitosan and polyquaternium-7 molecules. The composite film of this invention possesses high transparency, high flexibility, strong skin adhesion, rapid humidity response, and efficient humidity driving performance. It can respond to minute humidity differences and human physiological humidity, efficiently converting the chemical energy of humidity into mechanical energy. It also exhibits broad-spectrum antibacterial properties, excellent blood compatibility, and biosafety, perfectly meeting the long-term wear and use requirements of flexible electronic skin.

The present application belongs to the technical field of biomedical metals, and particularly relates to a preparation method of TWIP steel medical material for degradable clamps, wherein the TWIP steel medical material comprises the following components in percentage by mass: Mn: 30-40%, Al: 3-6%, Ge: 3-6%, X: 0-2%, and the balance of Fe, wherein X is one or more of Cu, Ag, Zn, Ca, Sr, Li, Ti, Zr, Au and Mg. The TWIP steel medical material prepared by the method has higher mechanical properties, degradable plastic that is more suitable for wound healing, more excellent blood compatibility, cell compatibility and antibacterial performance, and is expected to become a potential degradable biomedical material.

The present application relates to a kind of double-layer microneedle patch and its preparation method and application, including drug delivery unit and adhering unit, drug delivery unit is GCM-MN microneedle array, and adhering unit is CSH hydrogel patch, when using, first GCM-MN microneedle array is through pressure on wound, then CSH hydrogel patch is covered on GCM-MN microneedle array.The CSH hydrogel patch in the present application is conducive to creating a moist healing environment, has excellent adhesive stability and skin adaptability, provides adherent barrier for wound, GCM-MN microneedle array has good cell compatibility, cell affinity, blood compatibility and biodegradability.With the degradation of microneedle array in wound, encapsulated GCM nanoparticles are continuously released, and in-depth wound site.It can be seen that the double-layer microneedle patch of the present application has great clinical application potential in the field of infectious wound treatment.

The present invention provides a preparation method of a material for a puncture-resistant artificial blood vessel. The artificial blood vessel prepared by the method comprises two layers: the dense outer layer and the electrospun inner layer, the structures of these two layers are combined tightly and are inseparable, so that the properties of blood oozing resistance and repeated puncture resistance required by the artificial blood vessel can be provided. The puncture-resistant artificial blood vessel provided by the present invention has excellent biocompatibility, blood compatibility and flexibility and has the functions of blood oozing resistance and repeated puncture resistance. The method provided by the present invention has the characteristics such as convenience in operation, simplicity in production process and liability to the realization of large scale.

This application relates to the field of medical device technology and provides an interventional ventricular assist device, including an interventional tube, a motor assembly, an infusion cylinder, and an impeller assembly. The interventional tube has an inlet and an outlet. The impeller assembly includes an impeller housed within the interventional tube, and the impeller is capable of rotation to allow liquid to enter the interventional tube from the inlet and flow out from the outlet. The motor assembly generates a rotating magnetic field to drive the impeller to rotate. The infusion cylinder allows perfusion fluid to be injected into the interventional tube, and the perfusion fluid injected through the infusion cylinder provides a thrust to the impeller assembly, enabling the impeller to suspend and rotate within the interventional tube under the combined action of the motor assembly and the perfusion fluid. The interventional ventricular assist device provided by this application enables the impeller to be suspended, avoiding mechanical collisions with the impeller, reducing the risk of blood compatibility issues, and preventing thrombus formation at the bearing.

The application provides a metal organic framework composite adsorbent, a preparation method thereof and a blood perfusion device, and belongs to the technical field of blood purification adsorption materials. The metal organic framework composite adsorbent provided by the application is a metal organic framework material-polysulfone material composite ball. The metal organic framework material has excellent adsorption for various toxins, the polysulfone material has good biocompatibility, mechanical strength, processing adaptability and sterilization capacity, so that the metal organic framework composite adsorbent has good blood compatibility and adsorption for toxins, and the adsorbent has less particle shedding, and is suitable for the field of whole blood perfusion. The results of examples show that the metal organic framework composite adsorbent provided by the application has excellent adsorption performance for p-cresol sulfate, indole acetic acid, bilirubin, bile acid and endotoxin, and shows excellent blood compatibility.

The invention relates to a pulse condition blood pump blood compatibility evaluation method and system based on hardware-in-the-loop, and the simulation authenticity of a lumped parameter model on human body circulation adjustment and valve dynamic behaviors is remarkably improved by introducing a dynamic physiological feedback mechanism and a nonlinear valve model; real blood pump flow is coupled to model iteration in real time through the hardware-in-loop technology, and closed-loop bidirectional interaction between the blood pump and the virtual human body is achieved; meanwhile, a low-blood-volume loop and a pneumatic flexible loading mode are adopted, extra blood damage introduced by the loop is greatly reduced, the experiment uncertainty and the system error are remarkably reduced, and the repeatability and the comparability of a test result are greatly improved, so that high-fidelity and high-controllability evaluation of the blood compatibility of the blood pump under the pulse working condition is ensured.

The application discloses a composite membrane based on MOF modification, a preparation method and application in an ECCO2R system, and belongs to the technical field of gas separation membranes. The composite membrane is prepared by immersing a PMP hollow fiber membrane used in the ECCO2R system in a Pebax casting solution doped with MOF porous nanomaterials to perform membrane coating, the MOF porous nanomaterials are amino-functionalized ZIF-8 nanoparticles, and the Pebax comprises polyamide-polyether blocks. The composite membrane exhibits excellent CO2 / O2 selectivity in the ECCO2R system, has excellent carbon dioxide removal performance, and has good blood compatibility and biocompatibility, and is favorable to improving the carbon dioxide precipitation capacity of the membrane lung on human blood.

The invention provides a foldable guide pipe pump and an impeller thereof, the impeller comprises a hub and a plurality of blades, the hub is rotatably and radially supported at the near end part and the far end part of the hub respectively, and the impeller has a compressed state and a natural unfolding state; and when the impeller is in a natural unfolding state, the diameter of the far-end endpoint of each blade is smaller than that of the near-end endpoint of each blade. The impeller can reduce or avoid blood cavitation, reduce blood damage and improve blood compatibility on the premise of maintaining high hydraulic performance.

The application relates to the technical field of medical devices, and provides a negative-pressure gas leakage resistant artificial blood vessel and a preparation method and application thereof. The negative-pressure gas leakage resistant artificial blood vessel is an expanded polytetrafluoroethylene artificial blood vessel provided with a thermoplastic polyurethane coating on the surface; compared with the expanded polytetrafluoroethylene artificial blood vessel, the negative-pressure gas leakage resistant artificial blood vessel has lower porosity. The thermoplastic polyurethane coating realizes continuous and dense coverage on the surface of the expanded polytetrafluoroethylene artificial blood vessel, effectively fills part of the micropore structure of the expanded polytetrafluoroethylene artificial blood vessel, the negative-pressure gas leakage resistant performance is significantly improved, the thermoplastic polyurethane coating has no cytotoxicity, has good biological safety, does not introduce additional hemolysis risk, and has good blood compatibility. The application provides a new technical selection for solving the problem of gas barrier integrity of a mechanical circulation support system pipeline, and is expected to be widely applied in the manufacturing of medical devices.

The application relates to a preparation method of a biomaterial fabric composite film, and relates to a material for medical implants. The method solves the problems of free edge tearing defects of high polymer polymer leaflets under long-term fatigue cycle load, fiber wear and breakage of fabric leaflets and non-developing property. Method 1: different fiber bundles and developing materials are used to weave a fabric middle layer; a film protection layer is prepared; two film protection layers with different thicknesses are respectively hot-pressed on the two sides of the fabric middle layer, and cutting is performed to complete the film. Method 2: fiber bundles and developing materials are woven and cut to obtain a fabric middle layer; a film protection layer is prepared and cut; the film protection layer is pasted on the two sides of the fabric middle layer to complete the film. The material has good blood compatibility, can guarantee high wear resistance, tear resistance and fatigue resistance, and will not change the original geometric design size under long-term cycle load. The fabric composite film in the application is suitable for valve materials.

The application discloses an in-vitro testing device for a micro interventional pump, which comprises an inlet section, a clamping section and an outlet section which are independently designed and hollow inside, the inner diameters of the inlet section and the outlet section are consistent with the inner diameter of a real blood vessel at an implantation position to simulate a mechanical environment in a human body, the clamping section is detachably connected between the inlet section and the outlet section to facilitate installation and replacement, different lengths or cross-sectional shapes of the outlet section are replaced according to the blood vessel morphology at the implantation position to adapt to different testing simulation requirements, the clamping section is curved and the curvature is adapted to the curvature of the micro interventional pump, flexible clamping blocks are arranged inside the clamping section for clamping the micro interventional pump, and sensor interfaces for connecting testing sensors such as pressure sensors and temperature sensors are arranged outside the inlet section and the outlet section. The device can be used for in-vitro testing of various micro interventional pumps, the hemodynamic characteristics of the testing environment are consistent with physiological conditions, the blood compatibility is good, and the device can meet the requirements of in-vitro hemolysis experiments and particle image velocimetry experiments.